{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T03:49:34Z","timestamp":1791085774227,"version":"4.1.0"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2008,5,1]],"date-time":"2008-05-01T00:00:00Z","timestamp":1209600000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of the American Dental Association"],"published-print":{"date-parts":[[2008,5]]},"DOI":"10.14219\/jada.archive.2008.0351","type":"journal-article","created":{"date-parts":[[2014,1,8]],"date-time":"2014-01-08T20:07:04Z","timestamp":1389211624000},"page":"18S-24S","source":"Crossref","is-referenced-by-count":300,"special_numbering":"S2","title":["Salivary flow patterns and the health of hard and soft oral tissues"],"prefix":"10.1016","volume":"139","author":[{"given":"Colin","family":"Dawes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.14219\/jada.archive.2008.0351_bib1","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1152\/jappl.1955.7.5.508","article-title":"Rate of secretion of individual salivary gland pairs of man under conditions of reduced exogenous stimulation","volume":"7","author":"Schneyer","year":"1955","journal-title":"J Appl Physiol"},{"issue":"6","key":"10.14219\/jada.archive.2008.0351_bib2","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1152\/jappl.1955.7.6.609","article-title":"Rate of secretion of exogenously stimulated salivary gland pairs of man","volume":"7","author":"Schneyer","year":"1955","journal-title":"J Appl Physiol"},{"issue":"3","key":"10.14219\/jada.archive.2008.0351_bib3","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/0003-9969(62)90032-8","article-title":"Parotid fluid flow rate as related to whole saliva volume","volume":"7","author":"Shannon","year":"1962","journal-title":"Arch Oral Biol"},{"issue":"3","key":"10.14219\/jada.archive.2008.0351_bib4","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/0003-9969(73)90156-8","article-title":"The contribution of oral minor mucous gland secretions to the volume of whole saliva in man","volume":"18","author":"Dawes","year":"1973","journal-title":"Arch Oral Biol"},{"issue":"7","key":"10.14219\/jada.archive.2008.0351_bib5","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/S0003-9969(97)00045-9","article-title":"The intra-oral distribution of unstimulated and chewing-gum-stimulated parotid saliva","volume":"42","author":"Sas","year":"1997","journal-title":"Arch Oral Biol"},{"issue":"8","key":"10.14219\/jada.archive.2008.0351_bib6","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1177\/154405910708600802","article-title":"Saliva: a dynamic proteome","volume":"86","author":"Helmerhorst","year":"2007","journal-title":"J Dent Res"},{"key":"10.14219\/jada.archive.2008.0351_bib7","series-title":"Saliva and Oral Health","first-page":"32","article-title":"Factors influencing salivary flow rate and composition","author":"Dawes","year":"2004"},{"issue":"1","key":"10.14219\/jada.archive.2008.0351_bib8","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1177\/00220345560350010301","article-title":"Rate of flow of human parotid, sublingual, and submaxillary secretions during sleep","volume":"35","author":"Schneyer","year":"1956","journal-title":"J Dent Res"},{"issue":"3","key":"10.14219\/jada.archive.2008.0351_bib9","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1111\/j.1600-0528.1997.tb00928.x","article-title":"Prevalence of perceived symptoms of dry mouth in an adult Swedish population: relation to age, sex and pharmacotherapy","volume":"25","author":"Nederfors","year":"1997","journal-title":"Community Dent Oral Epidemiol"},{"issue":"suppl 9","key":"10.14219\/jada.archive.2008.0351_bib10","first-page":"15S","article-title":"Dry mouth and its effects on the oral health of elderly people","volume":"138","author":"Turner","year":"2007","journal-title":"JADA"},{"issue":"1","key":"10.14219\/jada.archive.2008.0351_bib11","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/j.1741-2358.1997.00033.x","article-title":"A reference guide to drugs and dry mouth: 2nd edition","volume":"14","author":"Sreebny","year":"1997","journal-title":"Gerodontology"},{"issue":"1","key":"10.14219\/jada.archive.2008.0351_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0003-9969(88)90089-1","article-title":"The effects of different foods and concentrations of citric acid on the flow rate of whole saliva in man","volume":"33","author":"Watanabe","year":"1988","journal-title":"Arch Oral Biol"},{"issue":"10","key":"10.14219\/jada.archive.2008.0351_bib13","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/0003-9969(88)90010-6","article-title":"A comparison of the effects of tasting and chewing foods on the flow rate of whole saliva in man","volume":"33","author":"Watanabe","year":"1988","journal-title":"Arch Oral Biol"},{"issue":"8","key":"10.14219\/jada.archive.2008.0351_bib14","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.archoralbio.2004.02.007","article-title":"The effects of prolonged gum chewing on salivary flow rate and composition","volume":"49","author":"Dawes","year":"2004","journal-title":"Arch Oral Biol"},{"issue":"2","key":"10.14219\/jada.archive.2008.0351_bib15","first-page":"55","article-title":"Discovery of oral fluid biomarkers for human oral cancer by mass spectrometry","volume":"4","author":"Hu","year":"2007","journal-title":"Cancer Genomics Proteomics"},{"issue":"6","key":"10.14219\/jada.archive.2008.0351_bib16","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1002\/pmic.200401037","article-title":"Large-scale identification of proteins in human salivary proteome by liquid chromatography\/mass spectrometry and two-dimensional gel electrophoresis-mass spectrometry","volume":"5","author":"Hu","year":"2005","journal-title":"Proteomics"},{"issue":"6","key":"10.14219\/jada.archive.2008.0351_bib17","doi-asserted-by":"crossref","first-page":"2152","DOI":"10.1021\/pr060580k","article-title":"Identification of protein components in in vivo human acquired enamel pellicle using LC-ESI-MS\/MS","volume":"6","author":"Siqueira","year":"2007","journal-title":"J Proteome Res"},{"issue":"8","key":"10.14219\/jada.archive.2008.0351_bib18","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/0003-9969(95)00037-P","article-title":"The flow rate and electrolyte composition of whole saliva elicited by the use of sucrose-containing and sugar-free chewing-gums","volume":"40","author":"Dawes","year":"1995","journal-title":"Arch Oral Biol"},{"issue":"3","key":"10.14219\/jada.archive.2008.0351_bib19","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1159\/000077760","article-title":"How much saliva is enough for avoidance of xerostomia?","volume":"38","author":"Dawes","year":"2004","journal-title":"Caries Res"},{"issue":"3","key":"10.14219\/jada.archive.2008.0351_bib20","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/0003-9969(73)90157-X","article-title":"The composition of human lip mucous gland secretions","volume":"18","author":"Dawes","year":"1973","journal-title":"Arch Oral Biol"},{"issue":"9","key":"10.14219\/jada.archive.2008.0351_bib21","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.archoralbio.2007.03.002","article-title":"Solubility of calcium fluoride and fluorapatite by solid titration","volume":"52","author":"Pan","year":"2007","journal-title":"Arch Oral Biol"},{"issue":"5","key":"10.14219\/jada.archive.2008.0351_bib22","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1111\/j.1600-0765.1991.tb01728.x","article-title":"Urea concentration in minor mucous gland secretions and the effect of salivary film velocity on urea metabolism by Streptococcus vestibularis in an artificial plaque","volume":"26","author":"Macpherson","year":"1991","journal-title":"J Periodontal Res"},{"issue":"5","key":"10.14219\/jada.archive.2008.0351_bib23","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/0003-9969(64)90015-9","article-title":"The pH of dental plaques in the different areas of the mouth before and after meals and their relationship to the pH and rate of flow of resting saliva","volume":"9","author":"Kleinberg","year":"1964","journal-title":"Arch Oral Biol"},{"issue":"5","key":"10.14219\/jada.archive.2008.0351_bib24","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1177\/00220345840630050201","article-title":"The volume of saliva in the mouth before and after swallowing","volume":"63","author":"Lagerl\u00f6f","year":"1984","journal-title":"J Dent Res"},{"issue":"8","key":"10.14219\/jada.archive.2008.0351_bib25","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1177\/00220345870660080201","article-title":"The surface area of the adult human mouth and thickness of the salivary film covering the teeth and oral mucosa","volume":"66","author":"Collins","year":"1987","journal-title":"J Dent Res"},{"issue":"6","key":"10.14219\/jada.archive.2008.0351_bib26","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/S0003-9969(98)00022-3","article-title":"Oral mucosal wetness in hypo- and normosalivators","volume":"43","author":"Wolff","year":"1998","journal-title":"Arch Oral Biol"},{"issue":"11","key":"10.14219\/jada.archive.2008.0351_bib27","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1177\/00220345890680110201","article-title":"Estimation of the velocity of the salivary film at some different locations in the mouth","volume":"68","author":"Dawes","year":"1989","journal-title":"J Dent Res"},{"issue":"5","key":"10.14219\/jada.archive.2008.0351_bib28","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1177\/00220345930720050401","article-title":"The distribution of saliva and sucrose around the mouth during the use of chewing gum and the implications for the site-specificity of caries and calculus deposition","volume":"72","author":"Dawes","year":"1993","journal-title":"J Dent Res"},{"key":"10.14219\/jada.archive.2008.0351_bib29","series-title":"Saliva and Oral Health","first-page":"71","article-title":"Salivary clearance and its effects on oral health","author":"Dawes","year":"2004"},{"issue":"5","key":"10.14219\/jada.archive.2008.0351_bib30","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/S0003-9969(03)00014-1","article-title":"Estimates, from salivary analyses, of the turnover time of the oral mucosal epithelium in humans and the number of bacteria in an edentulous mouth","volume":"48","author":"Dawes","year":"2003","journal-title":"Arch Oral Biol"},{"issue":"11","key":"10.14219\/jada.archive.2008.0351_bib31","first-page":"722","article-title":"What is the critical pH and why does a tooth dissolve in acid?","volume":"69","author":"Dawes","year":"2003","journal-title":"J Can Dent Assoc"},{"issue":"suppl 3","key":"10.14219\/jada.archive.2008.0351_bib32","first-page":"1","article-title":"Enamel-apatite solubility: investigations into the calcium phosphate equilibrium between enamel and saliva and its relation to dental caries","volume":"8","author":"Ericsson","year":"1949","journal-title":"Acta Odontol Scand"},{"issue":"4 suppl 1","key":"10.14219\/jada.archive.2008.0351_bib33","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1111\/j.1875-595X.2005.tb00066.x","article-title":"Erosion: chemical and biological factors of importance to the dental practitioner","volume":"55","author":"Zero","year":"2005","journal-title":"Int Dent J"},{"issue":"11","key":"10.14219\/jada.archive.2008.0351_bib34","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/j.archoralbio.2004.05.008","article-title":"Protective effect of the in situ formed short-term salivary pellicle","volume":"49","author":"Hannig","year":"2004","journal-title":"Arch Oral Biol"},{"issue":"7","key":"10.14219\/jada.archive.2008.0351_bib35","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1177\/154405910608500706","article-title":"Protective effect of the dental pellicle against erosive challenges in situ","volume":"85","author":"Hara","year":"2006","journal-title":"J Dent Res"},{"issue":"1","key":"10.14219\/jada.archive.2008.0351_bib36","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1177\/00220345430220010601","article-title":"A quantitative method for evaluating physical and chemical agents which modify production of acids in bacterial plaques on human teeth","volume":"22","author":"Stephan","year":"1943","journal-title":"J Dent Res"},{"issue":"1","key":"10.14219\/jada.archive.2008.0351_bib37","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1159\/000016432","article-title":"A mathematical model of the influence of salivary urea on the pH of fasted dental plaque and on the changes occurring during a cariogenic challenge","volume":"32","author":"Dibdin","year":"1998","journal-title":"Caries Res"},{"issue":"2","key":"10.14219\/jada.archive.2008.0351_bib38","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1177\/154411130201300208","article-title":"Interaction of plant polyphenols with salivary proteins","volume":"13","author":"Bennick","year":"2002","journal-title":"Crit Rev Oral Biol Med"},{"issue":"16","key":"10.14219\/jada.archive.2008.0351_bib39","doi-asserted-by":"crossref","first-page":"7472","DOI":"10.1016\/S0021-9258(18)68522-9","article-title":"Histatins, a novel family of histidine-rich proteins in human parotid secretion: isolation, characterization, primary structure, and fungistatic effects on Candida albicans","volume":"263","author":"Oppenheim","year":"1988","journal-title":"J Biol Chem"},{"issue":"9","key":"10.14219\/jada.archive.2008.0351_bib40","doi-asserted-by":"crossref","first-page":"2853","DOI":"10.1128\/IAI.57.9.2853-2863.1989","article-title":"Characterization of salivary alpha-amylase binding to Streptococcus sanguis","volume":"57","author":"Scannapieco","year":"1989","journal-title":"Infect Immun"},{"issue":"1","key":"10.14219\/jada.archive.2008.0351_bib41","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1128\/IAI.60.1.31-38.1992","article-title":"Adherence of oral streptococci to salivary glycoproteins","volume":"60","author":"Murray","year":"1992","journal-title":"Infect Immun"},{"issue":"2","key":"10.14219\/jada.archive.2008.0351_bib42","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1111\/j.1432-1033.1983.tb07456.x","article-title":"Characterization of a salivary agglutinin reacting with a serotype c strain of Streptococcus mutans","volume":"133","author":"Ericson","year":"1983","journal-title":"Eur J Biochem"},{"issue":"6","key":"10.14219\/jada.archive.2008.0351_bib43","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1177\/154411130201300606","article-title":"Salivary (SD-type) cystatins: over one billion years in the making\u2014but to what purpose?","volume":"13","author":"Dickinson","year":"2002","journal-title":"Crit Rev Oral Biol Med"},{"key":"10.14219\/jada.archive.2008.0351_bib44","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1196\/annals.1384.012","article-title":"Do salivary antibodies reliably reflect both mucosal and systemic immunity?","volume":"1098","author":"Brandtzaeg","year":"2007","journal-title":"Ann N Y Acad Sci"},{"issue":"1","key":"10.14219\/jada.archive.2008.0351_bib45","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/j.1601-5037.2004.00060.x","article-title":"Oral manifestations in selective IgA deficiency","volume":"2","author":"Nikfarjam","year":"2004","journal-title":"Int J Dent Hyg"},{"issue":"3","key":"10.14219\/jada.archive.2008.0351_bib46","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1177\/154405910708600305","article-title":"Oral mucosal immunity and HIV\/SIV infection","volume":"86","author":"Lu","year":"2007","journal-title":"J Dent Res"},{"issue":"suppl 32","key":"10.14219\/jada.archive.2008.0351_bib47","first-page":"1","article-title":"The gingival pocket fluid: studies of its occurrence, composition, and effect","volume":"20","author":"Brill","year":"1962","journal-title":"Acta Odontol Scand"},{"issue":"10","key":"10.14219\/jada.archive.2008.0351_bib48","first-page":"923","article-title":"Why does supragingival calculus form preferentially on the lingual surface of the 6 lower anterior teeth?","volume":"72","author":"Dawes","year":"2006","journal-title":"J Can Dent Assoc"}],"container-title":["The Journal of the American Dental Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002817714638782?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002817714638782?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,3,21]],"date-time":"2022-03-21T22:36:56Z","timestamp":1647902216000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002817714638782"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,5]]},"references-count":48,"alternative-id":["S0002817714638782"],"URL":"https:\/\/doi.org\/10.14219\/jada.archive.2008.0351","relation":{},"ISSN":["0002-8177"],"issn-type":[{"value":"0002-8177","type":"print"}],"subject":[],"published":{"date-parts":[[2008,5]]}}}