{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T19:13:19Z","timestamp":1791400399187,"version":"4.3.3"},"reference-count":38,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2009,7,1]],"date-time":"2009-07-01T00:00:00Z","timestamp":1246406400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of the American Dental Association"],"published-print":{"date-parts":[[2009,7]]},"DOI":"10.14219\/jada.archive.2009.0283","type":"journal-article","created":{"date-parts":[[2014,1,9]],"date-time":"2014-01-09T01:30:17Z","timestamp":1389231017000},"page":"896-905","source":"Crossref","is-referenced-by-count":40,"title":["Genetic Variations Associated With Red Hair Color and Fear of Dental Pain, Anxiety Regarding Dental Care and Avoidance of Dental Care"],"prefix":"10.1016","volume":"140","author":[{"given":"Catherine J.","family":"Binkley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abbie","family":"Beacham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Neace","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald G.","family":"Gregg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edwin B.","family":"Liem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel I.","family":"Sessler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.14219\/jada.archive.2009.0283_bib1","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1111\/j.1600-0528.1997.tb00945.x","article-title":"Gender and age differences in attitudes to dental pain and dental control","volume":"25","author":"Liddell","year":"1997","journal-title":"Community Dent Oral Epidemiol"},{"issue":"8","key":"10.14219\/jada.archive.2009.0283_bib2","first-page":"1101","article-title":"Fear of dental care: are we making any progress?","volume":"134","author":"Smith","year":"2003","journal-title":"JADA"},{"issue":"2","key":"10.14219\/jada.archive.2009.0283_bib3","first-page":"167","article-title":"Assessing the need for anesthesia and sedation in the general population","volume":"129","author":"Dionne","year":"1998","journal-title":"JADA"},{"issue":"2","key":"10.14219\/jada.archive.2009.0283_bib4","first-page":"247","article-title":"Dental fear and avoidance: causes, symptoms, and consequences","volume":"109","author":"Berggren","year":"1984","journal-title":"JADA"},{"issue":"7","key":"10.14219\/jada.archive.2009.0283_bib5","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/0005-7967(93)90119-F","article-title":"Anxiety, pain and discomfort associated with dental treatment","volume":"31","author":"Vassend","year":"1993","journal-title":"Behav Res Ther"},{"issue":"5","key":"10.14219\/jada.archive.2009.0283_bib6","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1080\/000163501750541156","article-title":"A comparison of cognitive therapy, applied relaxation, and nitrous oxide sedation in the treatment of dental fear","volume":"59","author":"Willumsen","year":"2001","journal-title":"Acta Odontol Scand"},{"issue":"2","key":"10.14219\/jada.archive.2009.0283_bib7","first-page":"188","article-title":"Predicting anxiety during dental treatment using patients' self-reports: less is more","volume":"138","author":"Heaton","year":"2007","journal-title":"JADA"},{"issue":"5","key":"10.14219\/jada.archive.2009.0283_bib8","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1038\/sj.bdj.4809583","article-title":"Assessing and managing dental phobia in general practice: some practical suggestions","volume":"184","author":"Freeman","year":"1998","journal-title":"Br Dent J"},{"issue":"1","key":"10.14219\/jada.archive.2009.0283_bib9","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/0005-7967(92)90090-4","article-title":"Is pain sensitivity associated with dental avoidance?","volume":"30","author":"Gross","year":"1992","journal-title":"Behav Res Ther"},{"issue":"2","key":"10.14219\/jada.archive.2009.0283_bib10","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/j.1600-0528.2006.00265.x","article-title":"Anxiety sensitivity as predictor of pain in patients undergoing restorative dental procedures","volume":"34","author":"Klages","year":"2006","journal-title":"Community Dent Oral Epidemiol"},{"issue":"2","key":"10.14219\/jada.archive.2009.0283_bib11","first-page":"86","article-title":"Negative dental experiences and their relationship to dental anxiety","volume":"13","author":"Locker","year":"1996","journal-title":"Community Dent Health"},{"key":"10.14219\/jada.archive.2009.0283_bib12","first-page":"16","article-title":"ADA convenes major summit on finding dental care access solutions","volume":"1","author":"Crozier","year":"2009","journal-title":"ADA News"},{"issue":"6","key":"10.14219\/jada.archive.2009.0283_bib13","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1111\/j.1600-0528.2006.00344.x","article-title":"Gender differences in reported dental fear and fear of dental pain","volume":"35","author":"Heft","year":"2007","journal-title":"Community Dent Oral Epidemiol"},{"issue":"9","key":"10.14219\/jada.archive.2009.0283_bib14","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1016\/j.joms.2006.05.030","article-title":"Dental anxiety before removal of a third molar and association with general trait anxiety","volume":"64","author":"Lago-Mendez","year":"2006","journal-title":"J Oral Maxillofac Surg"},{"issue":"3","key":"10.14219\/jada.archive.2009.0283_bib15","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.jbtep.2007.09.006","article-title":"One- vs. five-session treatment of dental phobia: a randomized controlled study","volume":"39","author":"Haukebo","year":"2008","journal-title":"J Behav Ther Exp Psychiatry"},{"issue":"1","key":"10.14219\/jada.archive.2009.0283_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0005-7967(86)90143-9","article-title":"Anxiety sensitivity, anxiety frequency and the prediction of fearfulness","volume":"24","author":"Reiss","year":"1986","journal-title":"Behav Res Ther"},{"issue":"4","key":"10.14219\/jada.archive.2009.0283_bib17","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1002\/da.20492","article-title":"Genetics of anxiety: would the genome recognize the DSM?","volume":"25","author":"Smoller","year":"2008","journal-title":"Depress Anxiety"},{"issue":"10","key":"10.14219\/jada.archive.2009.0283_bib18","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1016\/j.peptides.2004.11.029","article-title":"Involvement of melanocortin-4 receptor in anxiety and depression","volume":"26","author":"Chaki","year":"2005","journal-title":"Peptides"},{"issue":"11","key":"10.14219\/jada.archive.2009.0283_bib19","doi-asserted-by":"crossref","first-page":"5531","DOI":"10.1210\/en.2007-0745","article-title":"The melanocortinergic pathway is rapidly recruited by emotional stress and contributes to stress-induced anorexia and anxiety-like behavior","volume":"148","author":"Liu","year":"2007","journal-title":"Endocrinology"},{"issue":"12","key":"10.14219\/jada.archive.2009.0283_bib20","doi-asserted-by":"crossref","first-page":"2753","DOI":"10.1002\/ijc.23396","article-title":"MC1R variants, melanoma and red hair color phenotype: a meta-analysis","volume":"122","author":"Raimondi","year":"2008","journal-title":"Int J Cancer"},{"issue":"16","key":"10.14219\/jada.archive.2009.0283_bib21","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1097\/00001756-199511000-00022","article-title":"Expression of melanocortin 1 receptor in periaqueductal gray matter","volume":"6","author":"Xia","year":"1995","journal-title":"Neuroreport"},{"issue":"2","key":"10.14219\/jada.archive.2009.0283_bib22","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1097\/00000542-200408000-00006","article-title":"Anesthetic requirement is increased in redheads","volume":"101","author":"Liem","year":"2004","journal-title":"Anesthesiology"},{"issue":"3","key":"10.14219\/jada.archive.2009.0283_bib23","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1097\/00000542-200503000-00006","article-title":"Increased sensitivity to thermal pain and reduced subcutaneous lidocaine efficacy in redheads","volume":"102","author":"Liem","year":"2005","journal-title":"Anesthesiology"},{"key":"10.14219\/jada.archive.2009.0283_bib24","author":"Lei"},{"key":"10.14219\/jada.archive.2009.0283_bib25","author":"Harrell"},{"key":"10.14219\/jada.archive.2009.0283_bib26","series-title":"Statistical Power Analysis for the Behavioral Sciences","author":"Cohen","year":"1988"},{"key":"10.14219\/jada.archive.2009.0283_bib27","series-title":"Structured Clinical Interview for DSM-IV-TR Axis I Disorders, Research Version, Patient Edition With Psychotic Screen (SCID-I\/P W\/PSY SCREEN)","author":"First","year":"2002"},{"key":"10.14219\/jada.archive.2009.0283_bib28","series-title":"Users Guide for the Structured Clinical Interview for DSM-IV Axis-1 Disorders: Research Version","author":"First","year":"1996"},{"issue":"4","key":"10.14219\/jada.archive.2009.0283_bib29","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1177\/00220345690480041801","article-title":"Development of a dental anxiety scale","volume":"48","author":"Corah","year":"1969","journal-title":"J Dent Res"},{"issue":"1","key":"10.14219\/jada.archive.2009.0283_bib30","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1034\/j.1600-0722.2003.00005.x","article-title":"The Fear of Dental Pain questionnaire: construction and validity","volume":"111","author":"van Wijk","year":"2003","journal-title":"Eur J Oral Sci"},{"key":"10.14219\/jada.archive.2009.0283_bib31","series-title":"STAI Manual for the State-Trait Anxiety Inventory","author":"Spielberger","year":"1983"},{"issue":"10","key":"10.14219\/jada.archive.2009.0283_bib32","first-page":"1449","article-title":"Anxiety and pain measures in dentistry: a guide to their quality and application","volume":"131","author":"Newton","year":"2000","journal-title":"JADA"},{"issue":"3","key":"10.14219\/jada.archive.2009.0283_bib33","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/0005-7967(94)00063-P","article-title":"Anxiety sensitivity: theoretical perspectives and recent findings","volume":"33","author":"Taylor","year":"1995","journal-title":"Behav Res Ther"},{"issue":"6","key":"10.14219\/jada.archive.2009.0283_bib34","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1111\/j.1600-0749.2005.00278.x","article-title":"Melanocortin-1 receptor structure and functional regulation","volume":"18","author":"Garc\u00eda-Borr\u00f3n","year":"2005","journal-title":"Pigment Cell Res"},{"issue":"3","key":"10.14219\/jada.archive.2009.0283_bib35","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1007\/PL00000868","article-title":"Melanocortin receptors: their functions and regulation by physiological agonists and antagonists","volume":"58","author":"Abdel-Malek","year":"2001","journal-title":"Cell Mol Life Sci"},{"issue":"7","key":"10.14219\/jada.archive.2009.0283_bib36","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1136\/jmg.2004.027698","article-title":"Melanocortin-1 receptor gene variants affect pain and muopioid analgesia in mice and humans","volume":"42","author":"Mogil","year":"2005","journal-title":"J Med Genet"},{"issue":"1\u20132","key":"10.14219\/jada.archive.2009.0283_bib37","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.pain.2007.04.018","article-title":"Anxiety sensitivity and pain: generalisability across noxious stimuli","volume":"134","author":"Thompson","year":"2008","journal-title":"Pain"},{"issue":"4","key":"10.14219\/jada.archive.2009.0283_bib38","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.brat.2005.04.005","article-title":"Unique contributions of anxiety sensitivity to avoidance: a prospective study in adolescents","volume":"44","author":"Wilson","year":"2006","journal-title":"Behav Res Ther"}],"container-title":["The Journal of the American Dental Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002817714644755?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002817714644755?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T19:01:34Z","timestamp":1716404494000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002817714644755"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,7]]},"references-count":38,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2009,7]]}},"alternative-id":["S0002817714644755"],"URL":"https:\/\/doi.org\/10.14219\/jada.archive.2009.0283","relation":{},"ISSN":["0002-8177"],"issn-type":[{"value":"0002-8177","type":"print"}],"subject":[],"published":{"date-parts":[[2009,7]]}}}