{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T23:26:04Z","timestamp":1793489164770,"version":"4.5.0"},"reference-count":48,"publisher":"The Korean Spinal Neurosurgery Society","issue":"4","license":[{"start":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T00:00:00Z","timestamp":1767139200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["YD9110002020"],"award-info":[{"award-number":["YD9110002020"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["e-neurospine.org"],"crossmark-restriction":true},"short-container-title":["Neurospine"],"published-print":{"date-parts":[[2025,12,31]]},"abstract":"<jats:p>Objective: To explore and validate clinical magnetic resonance spectroscopy (MRS) biomarkers associated with patient-reported symptoms in intervertebral disc degeneration, and to further elucidate the pathogenic mechanisms linking these symptoms to MRS biomarkers via an integrative multiomics approach.Methods: Patients categorized into the predominant lipids peak (pLP) group and the non-pLP group based on MRS spectrum lipids peak. Nucleus pulposus cells underwent lipidomics, proteomics and functional experiments. Outcome measures compared, and Pearson correlation coefficient evaluated relationships between symptoms, interleukin (IL)-17 immune-positive cells, and lipid contents. Multivariate linear analysis was employed to analyze the contributions of various variables to patient-reported symptoms.Results: The pLP group exhibited significantly higher preoperative visual analogue scale (VAS)-back scores (6.5 vs. 4.7, p&lt;0.01) and Oswestry Disability Index (ODI) scores (63.3% vs. 51.2%, p&lt;0.01) compared to the non-pLP group. The multiomics analysis revealed the pLP group was characterized by lipid droplets accumulation in nucleus pulposus cells, and the activation of interleukin-17 (IL-17) inflammatory pathway. Preoperative VAS-back and ODI scores showed positive correlations with the expressions of IL-17 (r=0.555, p&lt;0.001; r=0.566, p&lt;0.001) and the relative lipid contents (r=0.567, p&lt;0.001; r=0.561, p&lt;0.001). Multivariate linear analysis revealed that percentage of IL-17 positive cells and the relative triglyceride contents were associated with preoperative VAS-back pain (p=0.021, p=0.046).Conclusion: Patients with the MRS pLP spectrum showed reduced quality of life and upregulation of the lipid droplets-IL-17 inflammatory pathway in nucleus pulposus cells. Inflammatory factors contribute significantly to chronic low back pain development and progression, affecting patient-reported symptoms. The MRS lipids peak may serve as a potential biomarker for diagnosing and monitoring low back pain.<\/jats:p>","DOI":"10.14245\/ns.2519750.395","type":"journal-article","created":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T23:20:51Z","timestamp":1767136851000},"page":"918-933","update-policy":"https:\/\/doi.org\/10.14245\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Magnetic Resonance Spectroscopy Lipids Peak May Serve as a Potential Biomarker for Back Pain in Intervertebral Disc Degeneration: An Integrative Metabolomics and Proteomics Study Investigating the Role of the Lipid Droplets-Interleukin-17 Inflammatory 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