{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T21:30:32Z","timestamp":1772227832916,"version":"3.50.1"},"reference-count":0,"publisher":"Elsevier BV","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Frailty Aging"],"abstract":"<jats:p>Background:Cancer  cachexia  is  characterized  by  skeletal  muscle  loss.  A  feature  of  muscle  wasting,reduction in the mean muscle attenuation from computed tomography images is believed to reflect pathologicalinfiltration of fat into muscle. It is a reported prognostic indicator in cancer patients. Objectives:To develop anexplanatory  multivariate  model  of  muscle  attenuation  of  cancer  patients  incorporating  age,  sex,  diseasecharacteristics, body composition. Time to death \u226492 days was included in the model as the demarcation of end-stage disease. Design:Multivariate general linear model regression analysis of total mean muscle attenuation andchange  in  muscle  attenuation. Setting:Regional  cancer  center  (Alberta,  Canada). Participants: Patients  withgastrointestinal and respiratory tract cancers (mean age 64\u00b111 years, 44% female). Measurements: Total adiposetissue  and  skeletal  muscle  cross  sectional  area,  and  mean  muscle  attenuation  at  the  3rd  lumbar  vertebra  wereassessed  from  baseline  computed  tomography  (n=1719),  and  a  subset  with  repeated  measures  (n=246  patientswith a total of 871 images). Results:At baseline, muscle attenuation associated with total skeletal muscle (\u03b2 0.09;95% CI 0.07 to 0.11; p&lt;0.001) and adipose tissue (\u03b2 -0.032; 95% CI -0.035 to -0.029; p&lt;0.001) cross sectionalareas,  age  (\u03b2  -0.28;  95% CI  -0.32  to  -0.24;  p&lt;0.001),  time  to  death  \u226492  days  (\u03b2  -1.9;  95% CI  -3.1  to  -0.7;p=0.003) and male sex (\u03b2 -2.3; 95% CI \u20133.5 to -1.1; p&lt;0.001). Change in muscle attenuation over time associatedwith total adipose tissue cross sectional area (\u03b2 -0.008; 95% CI -0.012 to -0.004; p&lt;0.001) and time to death \u226492days (\u03b2 -1.6; 95% CI -3.0 to -0.2; p=0.03). Conclusions:The radiation attenuation of skeletal muscle is lowest inindividuals who are older, less muscular, have a higher fat mass and are within 92 days of death. Men had lowermuscle attenuation than women when controlled for other variables.<\/jats:p>","DOI":"10.14283\/jfa.2014.1","type":"journal-article","created":{"date-parts":[[2021,7,26]],"date-time":"2021-07-26T04:00:08Z","timestamp":1627272008000},"page":"1-6","source":"Crossref","is-referenced-by-count":0,"title":["AGE, OBESITY, SARCOPENIA, AND PROXIMITY TO DEATH EXPLAIN REDUCED MEAN MUSCLE ATTENUATION IN PATIENTS WITH ADVANCED CANCER"],"prefix":"10.1016","author":[{"given":"N.","family":"ESFANDIARI","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"GHOSH","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.M.M.","family":"PRADO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"MARTIN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"MAZURAK","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.E.","family":"BARACOS","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","published-online":{"date-parts":[[2014]]},"container-title":["Journal of Frailty &amp; Aging"],"original-title":[],"deposited":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T14:16:23Z","timestamp":1735827383000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jfrailtyaging.com\/all-issues.html?article=153"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":0,"URL":"https:\/\/doi.org\/10.14283\/jfa.2014.1","relation":{"is-cited-by":[{"id-type":"doi","id":"10.1038\/s41430-018-0325-5","asserted-by":"object"}]},"ISSN":["2273-4309"],"issn-type":[{"value":"2273-4309","type":"print"}],"subject":[],"published":{"date-parts":[[2014]]}}}