{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T05:37:54Z","timestamp":1735882674318,"version":"3.32.0"},"reference-count":0,"publisher":"Elsevier BV","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Frailty Aging"],"abstract":"<jats:p>An epidemiological transition is occurring regarding Human Immunodeficiency Virus (HIV) infection.This phenomenon, explained by several mechanisms (e.g.: physiologic changes, pharmacologic advances, sexualbehaviors), is demonstrated by a significant increase in the number of patients aged 50 years and older diagnosedwith this infection. The immunological changes observed in HIV-infected patients may prompt the appearance ofan accelerated aging process as well as that of comorbidities and other pathological entities commonly diagnosedin  older  adults.  Frailty  is  a  biologic  syndrome  characterized  by  a  multi-systemic  decrease  of  the  individual\u2019sphysiologic  and  homeostatic  reserves,  leading  to  diminished  resistance  against  stressors  and  increasedvulnerability.  The  purpose  of  this  review  is  to  describe  the  common  molecular  changes  seen  in  both  frailty  andHIV-1 infection, offering an in-depth analysis of their pathophysiology and specifying common processes wheretheir pathways meet.<\/jats:p>","DOI":"10.14283\/jfa.2014.7","type":"journal-article","created":{"date-parts":[[2021,7,12]],"date-time":"2021-07-12T03:19:45Z","timestamp":1626059985000},"page":"1-8","source":"Crossref","is-referenced-by-count":0,"title":["MOLECULAR CROSSROADS OF FRAILTY AND HIV"],"prefix":"10.1016","author":[{"given":"O.","family":"TAMEZ-RIVERA","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"MARTINEZ-AYALA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.P.","family":"NAVARRETE-REYES","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"AMIEVA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.A.","family":"AVILA-FUNES","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","published-online":{"date-parts":[[2014]]},"container-title":["Journal of Frailty &amp; Aging"],"original-title":[],"deposited":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T19:16:15Z","timestamp":1735845375000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jfrailtyaging.com\/all-issues.html?article=147"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":0,"URL":"https:\/\/doi.org\/10.14283\/jfa.2014.7","relation":{},"ISSN":["2273-4309"],"issn-type":[{"type":"print","value":"2273-4309"}],"subject":[],"published":{"date-parts":[[2014]]}}}