{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:18:38Z","timestamp":1790709518815,"version":"4.1.0"},"reference-count":0,"publisher":"Elsevier BV","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Frailty Aging"],"abstract":"<jats:p>Rapamycin,  an  mTOR  inhibitor  affects  senescence  through  suppression  of  senescence-associated  secretory phenotype (SASP). We studied the safety and feasibility of low-dose rapamycin and its effect on SASP and frailty in elderly undergoing cardiac rehabilitation (CR). 13 patients; 6 (0.5mg), 6 (1.0mg), and 1 patient received 2mg oral rapamycin (serum rapamycin &lt;6ng\/ml) daily for 12 weeks. Median age was 73.9\u00b17.5 years and 12 were men. Serum interleukin-6 decreased (2.6 vs 4.4 pg\/ml) and MMP-3 (26 vs 23.5 ng\/ml) increased. Adipose tissue expression of mRNAs (arbitrary units) for MCP-1 (3585 vs 2020, p=0.06), PPAR-\u03b3 (1257 vs 1166), PAI-1 (823 vs 338, p=0.08) increased, whereas interleukin-8 (163 vs 312), TNF-\u03b1 (75 vs 94) and p16 (129 vs 169) decreased. Cellular senescence-associated beta galactosidase activity (2.2% vs 3.6%, p=0.18) tended to decrease. We observed some correlation between some senescence markers and physical performance but no improvement in frailty with rapamycin was noted. (NCT01649960).<\/jats:p>","DOI":"10.14283\/jfa.2016.112","type":"journal-article","created":{"date-parts":[[2021,6,15]],"date-time":"2021-06-15T03:49:09Z","timestamp":1623728949000},"page":"1-4","source":"Crossref","is-referenced-by-count":16,"title":["EFFECT OF LOW-DOSE RAPAMYCIN ON SENESCENCE MARKERS AND PHYSICAL FUNCTIONING IN OLDER ADULTS WITH CORONARY ARTERY DISEASE: RESULTS OF A PILOT STUDY"],"prefix":"10.1016","author":[{"given":"M.","family":"SINGH","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.D.","family":"JENSEN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"LERMAN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"KUSHWAHA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.S.","family":"RIHAL","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.J.","family":"GERSH","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"BEHFAR","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"TCHKONIA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.J.","family":"THOMAS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.J.","family":"LENNON","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.R.","family":"KEENAN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.G.","family":"MOORE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.L.","family":"KIRKLAND","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","published-online":{"date-parts":[[2016]]},"container-title":["Journal of Frailty &amp; Aging"],"original-title":[],"deposited":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T14:13:37Z","timestamp":1735827217000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jfrailtyaging.com\/all-issues.html?article=469"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":0,"URL":"https:\/\/doi.org\/10.14283\/jfa.2016.112","relation":{"is-cited-by":[{"id-type":"doi","id":"10.1007\/s11357-019-00113-y","asserted-by":"object"}]},"ISSN":["2273-4309"],"issn-type":[{"value":"2273-4309","type":"print"}],"subject":[],"published":{"date-parts":[[2016]]}}}