{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T23:40:27Z","timestamp":1736466027724,"version":"3.32.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T00:00:00Z","timestamp":1726185600000},"content-version":"vor","delay-in-days":1351,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Frailty &amp; Aging"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.14283\/jfa.2020.36","type":"journal-article","created":{"date-parts":[[2021,2,25]],"date-time":"2021-02-25T04:29:47Z","timestamp":1614227387000},"page":"22-30","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Ongoing Research Protocols for the Pharmacological Treatment of Neuropsychiatric Symptoms in Dementia"],"prefix":"10.1016","volume":"10","author":[{"given":"Marco","family":"Canevelli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Remoli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Toccaceli Blasi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Tariciotti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Sarli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Valletta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"D'Antonio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Vanacore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Cesari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Bruno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"5","key":"10.14283\/jfa.2020.36_bib1","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.jalz.2011.05.2410","article-title":"Neuropsychiatric symptoms in Alzheimer's disease","volume":"7","author":"Lyketsos","year":"2011","journal-title":"Alzheimers Dement"},{"issue":"3","key":"10.14283\/jfa.2020.36_bib2","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jalz.2011.03.005","article-title":"The diagnosis of dementia due to Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease","volume":"7","author":"McKhann","year":"2011","journal-title":"Alzheimers Dement"},{"key":"10.14283\/jfa.2020.36_bib3","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.3389\/fphar.2019.01062","article-title":"Behavioral and Psychiatric Symptoms of Dementia and Rate of Decline in Alzheimer's Disease","volume":"10","author":"Gottesman","year":"2019","journal-title":"Front Pharmacol"},{"issue":"5","key":"10.14283\/jfa.2020.36_bib4","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1176\/appi.ajp.2014.14040480","article-title":"Neuropsychiatric symptoms as predictors of progression to severe Alzheimer's dementia and death: The Cache County Dementia Progression Study","volume":"172","author":"Peters","year":"2015","journal-title":"Am J Psychiatry"},{"issue":"10","key":"10.14283\/jfa.2020.36_bib5","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1001\/archneur.62.10.1601","article-title":"Delusions and hallucinations are associated with worse outcome in Alzheimer disease","volume":"62","author":"Scarmeas","year":"2005","journal-title":"Arch Neurol"},{"issue":"1","key":"10.14283\/jfa.2020.36_bib6","first-page":"105","article-title":"Neuropsychiatric symptoms as a predictor of caregiver burden in Alzheimer's disease","volume":"2","author":"Allegri","year":"2006","journal-title":"Neuropsychiatr Dis Treat"},{"issue":"2","key":"10.14283\/jfa.2020.36_bib7","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1111\/psyg.12197","article-title":"Neuropsychiatric symptoms in dementia may predict caregiver burden: a Sicilian exploratory study","volume":"17","author":"Torrisi","year":"2017","journal-title":"Psychogeriatrics"},{"issue":"3","key":"10.14283\/jfa.2020.36_bib8","first-page":"170","article-title":"Spousal Caregiving Is Associated with an Increased Risk of Frailty: A Case-Control Study","volume":"7","author":"Potier","year":"2018","journal-title":"J Frailty Aging"},{"issue":"10","key":"10.14283\/jfa.2020.36_bib9","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1002\/gps.1594","article-title":"The contribution of neuropsychiatric symptoms to the cost of dementia care","volume":"21","author":"Herrmann","year":"2006","journal-title":"Int J Geriatr Psychiatry"},{"key":"10.14283\/jfa.2020.36_bib10","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.trci.2019.01.002","article-title":"Neuropsychiatric symptoms in patients with dementia and the longitudinal costs of informal care in the Cache County population","volume":"5","author":"Rattinger","year":"2019","journal-title":"Alzheimers Dement Transl Res Clin Interv"},{"issue":"2","key":"10.14283\/jfa.2020.36_bib11","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.jamda.2019.08.027","article-title":"Optimizing Practices, Use, Care and Services-Antipsychotics (OPUS-AP) in Long-term Care Centers in Qu\u00e9bec, Canada: A Strategy for Best Practices","volume":"21","author":"Cossette","year":"2020","journal-title":"J Am Med Dir Assoc"},{"issue":"11","key":"10.14283\/jfa.2020.36_bib12","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1016\/j.jamda.2018.07.004","article-title":"Exploring Antipsychotic Prescribing Behaviors for Nursing Home Residents With Dementia: A Qualitative Study","volume":"19","author":"Walsh","year":"2018","journal-title":"J Am Med Dir Assoc"},{"issue":"4","key":"10.14283\/jfa.2020.36_bib13","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1111\/jgs.12730","article-title":"Detroit Expert Panel on Assessment and Management of Neuropsychiatric Symptoms of Dementia. Management of neuropsychiatric symptoms of dementia in clinical settings: recommendations from a multidisciplinary expert panel","volume":"62","author":"Kales","year":"2014","journal-title":"J Am Geriatr Soc"},{"issue":"19","key":"10.14283\/jfa.2020.36_bib14","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1001\/jama.2012.36918","article-title":"Nonpharmacologic management of behavioral symptoms in dementia","volume":"308","author":"Gitlin","year":"2012","journal-title":"JAMA"},{"issue":"2","key":"10.14283\/jfa.2020.36_bib15","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s40268-019-0272-1","article-title":"Neuropsychiatric Symptoms in Dementia: Considerations for Pharmacotherapy in the USA","volume":"19","author":"Phan","year":"2019","journal-title":"Drugs RD"},{"issue":"10","key":"10.14283\/jfa.2020.36_bib16","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.jamda.2014.05.013","article-title":"What is the impact of using outdoor spaces such as gardens on the physical and mental well-being of those with dementia? A systematic review of quantitative and qualitative evidence","volume":"15","author":"Whear","year":"2014","journal-title":"J Am Med Dir Assoc"},{"key":"10.14283\/jfa.2020.36_bib17","doi-asserted-by":"crossref","first-page":"h369","DOI":"10.1136\/bmj.h369","article-title":"Assessment and management of behavioral and psychological symptoms of dementia","volume":"350","author":"Kales","year":"2015","journal-title":"BMJ"},{"issue":"12","key":"10.14283\/jfa.2020.36_bib18","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/j.jamda.2014.07.012","article-title":"Use of antipsychotic drugs among residents with dementia in European long-term care facilities: results from the SHELTER study","volume":"15","author":"Foebel","year":"2014","journal-title":"J Am Med Dir Assoc"},{"issue":"5","key":"10.14283\/jfa.2020.36_bib19","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1001\/jamapsychiatry.2014.3018","article-title":"Antipsychotics, other psychotropics, and the risk of death in patients with dementia: number needed to harm","volume":"72","author":"Maust","year":"2015","journal-title":"JAMA Psychiatry"},{"issue":"1","key":"10.14283\/jfa.2020.36_bib20","first-page":"34","article-title":"Precipitants of Delirium in Older Inpatients Admitted in Surgery for Post-Fall Hip Fracture: An Observational Study","volume":"7","author":"Levinoff","year":"2018","journal-title":"J Frailty Aging"},{"issue":"12","key":"10.14283\/jfa.2020.36_bib21","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1016\/S1474-4422(16)30235-6","article-title":"Research priorities to reduce the global burden of dementia by 2025","volume":"15","author":"Shah","year":"2016","journal-title":"Lancet Neurol"},{"issue":"6","key":"10.14283\/jfa.2020.36_bib22","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1093\/ageing\/afv143","article-title":"Dementia priority setting partnership with the James Lind Alliance: using patient and public involvement and the evidence base to inform the research agenda","volume":"44","author":"Kelly","year":"2015","journal-title":"Age Ageing"},{"issue":"9","key":"10.14283\/jfa.2020.36_bib23","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1111\/jgs.14989","article-title":"Need to Recalibrate Research Outcomes in Alzheimer's Disease: Focus on Neuropsychiatric Symptoms","volume":"65","author":"Canevelli","year":"2017","journal-title":"J Am Geriatr Soc"},{"issue":"3","key":"10.14283\/jfa.2020.36_bib24","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.trci.2017.07.001","article-title":"Neuropsychiatric signs and symptoms of Alzheimer's disease: New treatment paradigms","volume":"3","author":"Lanct\u00f2t","year":"2017","journal-title":"Alzheimers Dement N Y N"},{"key":"10.14283\/jfa.2020.36_bib25","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.trci.2019.05.008","article-title":"Alzheimer's disease drug development pipeline: 2019","volume":"5","author":"Cummings","year":"2019","journal-title":"Alzheimers Dement Transl Res Clin Interv"},{"issue":"2","key":"10.14283\/jfa.2020.36_bib26","first-page":"120","article-title":"A Literature Review of Methodologies Used in Randomized Clinical Trials of Agitation in Alzheimer's Disease","volume":"5","author":"Dub\u00e9","year":"2018","journal-title":"J Prev Alzheimers Dis"},{"key":"10.14283\/jfa.2020.36_bib27","first-page":"1","article-title":"Medication Development for Agitation and Aggression in Alzheimer Disease: Review and Discussion of Recent Randomized Clinical Trial Design","author":"Soto","year":"2014","journal-title":"Int Psychogeriatr"},{"issue":"5","key":"10.14283\/jfa.2020.36_bib28","first-page":"S10","article-title":"The Neuropsychiatric Inventory: assessing psychopathology in dementia patients","volume":"48","author":"Cummings","year":"1997","journal-title":"Neurology"},{"issue":"3","key":"10.14283\/jfa.2020.36_bib29","doi-asserted-by":"crossref","first-page":"M77","DOI":"10.1093\/geronj\/44.3.M77","article-title":"A description of agitation in a nursing home","volume":"44","author":"Cohen-Mansfield","year":"1989","journal-title":"J Gerontol"},{"issue":"1","key":"10.14283\/jfa.2020.36_bib30","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1017\/S1041610214001963","article-title":"Agitation in cognitive disorders: International Psychogeriatric Association provisional consensus clinical and research definition","volume":"27","author":"Cummings","year":"2015","journal-title":"Int Psychogeriatr"},{"issue":"10","key":"10.14283\/jfa.2020.36_bib31","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1002\/gps.4933","article-title":"Course of neuropsychiatric symptoms in dementia: 5-year longitudinal study","volume":"33","author":"Vik-Mo","year":"2018","journal-title":"Int J Geriatr Psychiatry"},{"issue":"12","key":"10.14283\/jfa.2020.36_bib32","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/j.jamda.2018.07.005","article-title":"Advancing Research on Care Needs and Supportive Approaches for Persons With Dementia: Recommendations and Rationale","volume":"19","author":"Kolanowski","year":"2018","journal-title":"J Am Med Dir Assoc"},{"issue":"1","key":"10.14283\/jfa.2020.36_bib33","first-page":"18","article-title":"Reasoning about frailty in neurology: neurobiological correlates and clinical perspectives","volume":"3","author":"Canevelli","year":"2014","journal-title":"J Frailty Aging"},{"issue":"8","key":"10.14283\/jfa.2020.36_bib34","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1002\/gps.3904","article-title":"Behavioral and psychological subsyndromes in Alzheimer's disease using the Neuropsychiatric Inventory","volume":"28","author":"Canevelli","year":"2013","journal-title":"Int J Geriatr Psychiatry"},{"issue":"11","key":"10.14283\/jfa.2020.36_bib35","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1097\/JGP.0b013e3181d6b68d","article-title":"Neuropsychiatric symptoms and syndromes in a large cohort of newly diagnosed, untreated patients with Alzheimer disease","volume":"18","author":"Spalletta","year":"2010","journal-title":"Am J Geriatr Psychiatry"},{"issue":"12","key":"10.14283\/jfa.2020.36_bib36","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1001\/jama.2015.10214","article-title":"Effect of Dextromethorphan-Quinidine on Agitation in Patients With Alzheimer Disease Dementia: A Randomized Clinical Trial","volume":"314","author":"Cummings","year":"2015","journal-title":"JAMA"},{"issue":"11","key":"10.14283\/jfa.2020.36_bib37","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1016\/j.jagp.2019.05.002","article-title":"Randomized Placebo-Controlled Trial of Nabilone for Agitation in Alzheimer's Disease","volume":"27","author":"Herrmann","year":"2019","journal-title":"Am J Geriatr Psychiatry"},{"issue":"12","key":"10.14283\/jfa.2020.36_bib38","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1017\/S1041610215001106","article-title":"Change in agitation in Alzheimer's disease in the placebo arm of a nine-week controlled trial","volume":"27","author":"Rosenberg","year":"2015","journal-title":"Int Psychogeriatr"},{"issue":"15","key":"10.14283\/jfa.2020.36_bib39","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1056\/NEJMoa061240","article-title":"Effectiveness of Atypical Antipsychotic Drugs in Patients with Alzheimer's Disease","volume":"355","author":"Schneider","year":"2006","journal-title":"N Engl J Med"},{"issue":"4","key":"10.14283\/jfa.2020.36_bib40","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.3233\/JAD-171161","article-title":"A Survey of Patient and Partner Outcome and Treatment Preferences in Mild Cognitive Impairment","volume":"63","author":"Smith","year":"2018","journal-title":"J Alzheimers Dis"},{"key":"10.14283\/jfa.2020.36_bib41","unstructured":"European Medicines Agency. Guideline on the clinical investigation of medicines for the treatment of Alzheimer's disease. 2018;36."}],"container-title":["The Journal of Frailty &amp; Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2260134124002275?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2260134124002275?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T23:18:34Z","timestamp":1736464714000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2260134124002275"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["S2260134124002275"],"URL":"https:\/\/doi.org\/10.14283\/jfa.2020.36","relation":{},"ISSN":["2260-1341"],"issn-type":[{"type":"print","value":"2260-1341"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ongoing Research Protocols for the Pharmacological Treatment of Neuropsychiatric Symptoms in Dementia","name":"articletitle","label":"Article Title"},{"value":"The Journal of Frailty & Aging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.14283\/jfa.2020.36","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2020 THE AUTHORS. Published by Elsevier Masson SAS on behalf of SERDI Publisher. Published by Elsevier Masson SAS","name":"copyright","label":"Copyright"}]}}