{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T19:40:05Z","timestamp":1735846805669,"version":"3.32.0"},"reference-count":0,"publisher":"Elsevier BV","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Prev Alz Dis"],"abstract":"<jats:p>BACKGROUND: Brain beta-amyloid status portends different trajectories of clinical decline. OBJECTIVE: Determine trajectories and predictive baseline variable(s). DESIGN: Longitudinal, up to 24 months. SETTING: ADNI sites. PARTICIPANTS: Healthy control (n=325), early and late mild cognitive impairment (n=279; n=372), and Alzheimer\u2019s dementia (n=216) subjects from ADNI-1\/GO\/2. MEASUREMENTS: Baseline amyloid status was based on first available CSF A\u03b21-42 or, [11C]PiB or [18F]florbetapir (FBP) PET. Alzheimer\u2019s Disease Assessment Scale\u2013Cognitive Subscale (ADAS-Cog13) and Functional Activities Questionnaire (FAQ) were co-analyzed using Growth Mixture Modeling (GMM) to define latent class trajectories for each amyloid group. Classification and Regression Tree (CART) analysis determined which variables best predicted trajectory class membership using a number of variables available to clinicians. RESULTS: GMMs found two trajectory classes (C1, C2) each for amyloid-positive (P; n=722) and negative (N; n=470) groups. Most (90%) in the negative group were C2N with mildly impaired baseline ADAS-Cog13, normal FAQ and nonprogression; 10% were C1N with moderately impaired baseline FAQ and ADAS-Cog13 and trajectory of moderately worsening scores on the FAQ. C1P (26%) had more impaired baseline FAQ and ADAS-Cog13 than C2P (74%) and a steeper declining trajectory. CART yielded 4 decision nodes (FAQ &lt;10.5, FAQ &lt;6.5, MMSE \u226526.5, age &lt;75.5) in positive and 1 node (FAQ &lt;6.5) in negative groups, with 91.4% and 92.8% accuracy for class assignments, respectively. CONSLUSIONS: The trajectory pattern of greater decline in amyloid positive subjects was predicted by greater baseline impairment of cognition and function. While most amyloid-negative subjects had nonprogression irrespective of their diagnosis, a subgroup declined similarly to the gradually declining amyloid-positive group. CART predicted likely trajectory class, with known amyloid status, using variables accessible in a clinical setting, but needs replication.<\/jats:p>","DOI":"10.14283\/jpad.2016.90","type":"journal-article","created":{"date-parts":[[2021,11,15]],"date-time":"2021-11-15T06:45:03Z","timestamp":1636958703000},"page":"1-9","source":"Crossref","is-referenced-by-count":0,"title":["LONGITUDINAL TRAJECTORIES OF CLINICAL DECLINE IN AMYLOID POSITIVE AND NEGATIVE POPULATIONS"],"prefix":"10.1016","author":[{"given":"P.T.","family":"Trzepacz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Hochstetler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Case","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.B.","family":"Henley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Degenhardt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.-M.","family":"Leoutsakos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.G.","family":"Lyketsos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","published-online":{"date-parts":[[2016]]},"container-title":["The Journal of Prevention of Alzheimer's Disease"],"original-title":[],"deposited":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T19:12:22Z","timestamp":1735845142000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jpreventionalzheimer.com\/all-issues.html?article=180"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":0,"URL":"https:\/\/doi.org\/10.14283\/jpad.2016.90","relation":{},"ISSN":["2274-5807"],"issn-type":[{"type":"print","value":"2274-5807"}],"subject":[],"published":{"date-parts":[[2016]]}}}