{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:44:29Z","timestamp":1791229469079,"version":"4.1.0"},"reference-count":0,"publisher":"Elsevier BV","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Prev Alz Dis"],"abstract":"<jats:p>Background: Both cognitive and functional deterioration are characteristic of the clinical progression of Alzheimer\u2019s disease (AD). Objectives: To systematically assess correlations between widely used measures of cognition and function across the spectrum of AD. Design: Spearman rank correlations were calculated for cognitive and functional measures across datasets from various AD patient populations. Setting: Post-hoc analysis from existing databases. Participants: Pooled data from placebo-treated patients with mild (MMSE score \u226520 and \u226426) and moderate (MMSE score \u226516 and \u226419) AD dementia from two Phase 3 solanezumab (EXPEDITION\/2) and two semagecesatat (IDENTITY\/2) studies and normal, late mild cognitive impairment (LMCI) and mild AD patients from the Alzheimer\u2019s Disease Neuroimaging Initiative 2-Grand Opportunity (ADNI-2\/GO). Intervention (if any): Placebo (EXPEDITION\/2 and IDENTITY\/2 subjects) Measurements: Cognitive and functional abilities were measured in all datasets. Data were collected at baseline and every three months for 18 months in EXPEDITION and IDENTITY studies; and at baseline, 6, 12, and 24 months in the ADNI dataset. Results: The relationship of cognition and function became stronger over time as AD patients progressed from preclinical to moderate dementia disease stages, with the magnitude of correlations dependent on disease stage and the complexity of functional task. The correlations were minimal in the normal control population, but became stronger with disease progression. Conclusions: This analysis found that measures of cognition and function become more strongly correlated with disease progression from preclinical to moderate dementia across multiple datasets. These findings improve the understanding of the relationship between cognitive and functional clinical measures during the course of AD progression and how cognition and function measures relate to each other in AD clinical trials.<\/jats:p>","DOI":"10.14283\/jpad.2016.99","type":"journal-article","created":{"date-parts":[[2021,11,14]],"date-time":"2021-11-14T08:23:07Z","timestamp":1636878187000},"page":"1-7","source":"Crossref","is-referenced-by-count":7,"title":["CORRELATION BETWEEN COGNITION AND FUNCTION ACROSS THE SPECTRUM OF ALZHEIMER\u2019S DISEASE"],"prefix":"10.1016","author":[{"given":"H.","family":"Liu-Seifert","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Siemers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Selzler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Sundell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Aisen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Cummings","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Raskin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Mohs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","published-online":{"date-parts":[[2016]]},"container-title":["The Journal of Prevention of Alzheimer's Disease"],"original-title":[],"deposited":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T19:16:09Z","timestamp":1735845369000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jpreventionalzheimer.com\/all-issues.html?article=202"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":0,"URL":"https:\/\/doi.org\/10.14283\/jpad.2016.99","relation":{},"ISSN":["2274-5807"],"issn-type":[{"value":"2274-5807","type":"print"}],"subject":[],"published":{"date-parts":[[2016]]}}}