{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:53:25Z","timestamp":1791896005131,"version":"4.3.4"},"reference-count":32,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,3,6]],"date-time":"2020-03-06T00:00:00Z","timestamp":1583452800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Prevention of Alzheimer's Disease"],"published-print":{"date-parts":[[2020,6]]},"DOI":"10.14283\/jpad.2020.19","type":"journal-article","created":{"date-parts":[[2021,2,25]],"date-time":"2021-02-25T12:15:06Z","timestamp":1614255306000},"page":"158-164","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":96,"title":["Rationale for Early Diagnosis of Mild Cognitive Impairment (MCI) supported by Emerging Digital Technologies"],"prefix":"10.1016","volume":"7","author":[{"given":"Marwan N.","family":"Sabbagh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Boada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Borson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Chilukuri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.M.","family":"Doraiswamy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Dubois","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Ingram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Iwata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.P.","family":"Porsteinsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.L.","family":"Possin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.D.","family":"Rabinovici","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Vellas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Chao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Vergallo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Hampel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.14283\/jpad.2020.19_bib1","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1016\/S0140-6736(17)31833-0","article-title":"Global, regional, and national under-5 mortality, adult mortality, age-specific mortality, and life expectancy, 1970\u20132016: a systematic analysis for the Global Burden of Disease Study 2016","volume":"390","year":"2017","journal-title":"Lancet Lond Engl"},{"key":"10.14283\/jpad.2020.19_bib2","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1016\/S0140-6736(18)32335-3","article-title":"Global, regional, and national disability-adjusted life-years (DALYs) for 359 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990\u20132017: a systematic analysis for the Global Burden of Disease Study 2017","volume":"392","year":"2018","journal-title":"Lancet Lond Engl"},{"key":"10.14283\/jpad.2020.19_bib3","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.jalz.2011.03.008","article-title":"The diagnosis of mild cognitive impairment due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease","volume":"7","author":"Albert","year":"2011","journal-title":"Alzheimers Dement J Alzheimers Assoc"},{"key":"10.14283\/jpad.2020.19_bib4","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1111\/joim.12190","article-title":"Mild cognitive impairment: a concept in evolution","volume":"275","author":"Petersen","year":"2014","journal-title":"J Intern Med"},{"key":"10.14283\/jpad.2020.19_bib5","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.jalz.2018.02.018","article-title":"NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease","volume":"14","author":"Jack","year":"2018","journal-title":"Alzheimers Dement J Alzheimers Assoc"},{"key":"10.14283\/jpad.2020.19_bib6","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/s41582-018-0079-7","article-title":"Blood-based biomarkers for Alzheimer disease: mapping the road to the clinic","volume":"14","author":"Hampel","year":"2018","journal-title":"Nat Rev Neurol"},{"key":"10.14283\/jpad.2020.19_bib7","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.jalz.2019.01.010","article-title":"2019 Alzheimer's disease facts and figures","volume":"15","year":"2019","journal-title":"Alzheimers Dement J Alzheimers Assoc"},{"key":"10.14283\/jpad.2020.19_bib8","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1111\/j.1532-5415.2005.53221.x","article-title":"The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment","volume":"53","author":"Nasreddine","year":"2005","journal-title":"J Am Geriatr Soc"},{"key":"10.14283\/jpad.2020.19_bib9","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s13195-019-0474-3","article-title":"Brief cognitive screening instruments for early detection of Alzheimer's disease: a systematic review","volume":"11","author":"De Roeck","year":"2019","journal-title":"Alzheimers Res Ther"},{"key":"10.14283\/jpad.2020.19_bib10","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.jalz.2012.08.008","article-title":"Improving dementia care: The role of screening and detection of cognitive impairment","volume":"9","author":"Borson","year":"2013","journal-title":"Alzheimers Dement J Alzheimers Assoc"},{"key":"10.14283\/jpad.2020.19_bib11","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.jamda.2011.07.008","article-title":"Anticholinergic medications and cognition","volume":"12","author":"Morley","year":"2011","journal-title":"J Am Med Dir Assoc"},{"key":"10.14283\/jpad.2020.19_bib12","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1002\/gps.4626","article-title":"Cost effectiveness of using cognitive screening tests for detecting dementia and mild cognitive impairment in primary care: Cost effectiveness of cognitive screening tests in primary care","volume":"32","author":"Tong","year":"2017","journal-title":"Int J Geriatr Psychiatry"},{"key":"10.14283\/jpad.2020.19_bib13","unstructured":"Ton T, DeLeire T, May S, et al. Assessing the Financial Burden Associated with Mild Cognitive Impairment. 2015."},{"key":"10.14283\/jpad.2020.19_bib14","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.jalz.2016.08.009","article-title":"The financial burden and health care utilization patterns associated with amnestic mild cognitive impairment","volume":"13","author":"Ton","year":"2017","journal-title":"Alzheimers Dement J Alzheimers Assoc"},{"key":"10.14283\/jpad.2020.19_bib15","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1002\/gps.4641","article-title":"The cost of diagnosis and early support in patients with cognitive decline","volume":"33","author":"Pennington","year":"2018","journal-title":"Int J Geriatr Psychiatry"},{"key":"10.14283\/jpad.2020.19_bib16","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1002\/gps.5036","article-title":"Cost-effectiveness analysis of English memory assessment services 2 years after first consultation for patients with dementia","volume":"34","author":"Gomes","year":"2019","journal-title":"Int J Geriatr Psychiatry"},{"key":"10.14283\/jpad.2020.19_bib17","doi-asserted-by":"crossref","first-page":"2451","DOI":"10.2147\/NDT.S174517","article-title":"Subjective memory complaint as a useful tool for the early detection of Alzheimer's disease","volume":"14","author":"Choe","year":"2018","journal-title":"Neuropsychiatr Dis Treat"},{"key":"10.14283\/jpad.2020.19_bib18","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.jpsychires.2018.12.005","article-title":"Are subjective memory complaints indicative of objective cognitive decline or depressive symptoms? Findings from the English Longitudinal Study of Ageing","volume":"110","author":"Brailean","year":"2019","journal-title":"J Psychiatr Res"},{"key":"10.14283\/jpad.2020.19_bib19","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1370\/afm.2443","article-title":"Associations of Subjective Memory Complaints and Simple Memory Task Scores With Future Dementia in the Primary Care Setting","volume":"17","author":"Wanrooij","year":"2019","journal-title":"Ann Fam Med"},{"key":"10.14283\/jpad.2020.19_bib20","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/j.jalz.2015.12.013","article-title":"Subjective memory decline predicts greater rates of clinical progression in preclinical Alzheimer's disease","volume":"12","author":"Buckley","year":"2016","journal-title":"Alzheimers Dement J Alzheimers Assoc"},{"key":"10.14283\/jpad.2020.19_bib21","doi-asserted-by":"crossref","first-page":"e300","DOI":"10.1212\/WNL.0000000000005863","article-title":"Subjective cognitive decline and risk of MCI: The Mayo Clinic Study of Aging","volume":"91","author":"van Harten","year":"2018","journal-title":"Neurology"},{"key":"10.14283\/jpad.2020.19_bib22","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1016\/S0140-6736(06)68542-5","article-title":"Mild cognitive impairment","volume":"367","author":"Gauthier","year":"2006","journal-title":"Lancet Lond Engl"},{"key":"10.14283\/jpad.2020.19_bib23","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.jalz.2012.09.011","article-title":"Alzheimer's Association recommendations for operationalizing the detection of cognitive impairment during the Medicare Annual Wellness Visit in a primary care setting","volume":"9","author":"Cordell","year":"2013","journal-title":"Alzheimers Dement"},{"key":"10.14283\/jpad.2020.19_bib24","doi-asserted-by":"crossref","first-page":"791","DOI":"10.7326\/M14-0496","article-title":"Screening for Cognitive Impairment in Older Adults: U.S. Preventive Services Task Force Recommendation Statement","volume":"160","author":"Moyer","year":"2014","journal-title":"Ann Intern Med"},{"key":"10.14283\/jpad.2020.19_bib25","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.jamda.2015.06.017","article-title":"Brain Health: The Importance of Recognizing Cognitive Impairment: An IAGG Consensus Conference","volume":"16","author":"Morley","year":"2015","journal-title":"J Am Med Dir Assoc"},{"key":"10.14283\/jpad.2020.19_bib26","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/s13195-017-0312-4","article-title":"The Edinburgh Consensus: preparing for the advent of disease-modifying therapies for Alzheimer's disease","volume":"9","author":"Ritchie","year":"2017","journal-title":"Alzheimers Res Ther"},{"key":"10.14283\/jpad.2020.19_bib27","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1212\/WNL.0000000000004826","article-title":"Practice guideline update summary: Mild cognitive impairment: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology","volume":"90","author":"Petersen","year":"2018","journal-title":"Neurology"},{"key":"10.14283\/jpad.2020.19_bib28","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.trci.2019.05.008","article-title":"Alzheimer's disease drug development pipeline: 2019","volume":"5","author":"Cummings","year":"2019","journal-title":"Alzheimers Dement N Y N"},{"key":"10.14283\/jpad.2020.19_bib29","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1093\/brain\/awy132","article-title":"The cholinergic system in the pathophysiology and treatment of Alzheimer's disease","volume":"141","author":"Hampel","year":"2018","journal-title":"Brain J Neurol"},{"key":"10.14283\/jpad.2020.19_bib30","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1159\/000017238","article-title":"Metrifonate therapy in Alzheimer's disease: a pooled analysis of four randomized, double-blind, placebo-controlled trials","volume":"11","author":"Farlow","year":"2000","journal-title":"Dement Geriatr Cogn Disord"},{"key":"10.14283\/jpad.2020.19_bib31","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.1212\/WNL.54.12.2261","article-title":"Galantamine in AD: A 6-month randomized, placebo-controlled trial with a 6-month extension. The Galantamine USA-1 Study Group","volume":"54","author":"Raskind","year":"2000","journal-title":"Neurology"},{"key":"10.14283\/jpad.2020.19_bib32","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD009132.pub2","article-title":"Cholinesterase inhibitors for mild cognitive impairment","author":"Russ","year":"2012","journal-title":"Cochrane Database Syst Rev"}],"container-title":["The Journal of Prevention of Alzheimer's Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2274580724004382?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2274580724004382?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,19]],"date-time":"2025-01-19T21:13:13Z","timestamp":1737321193000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2274580724004382"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["S2274580724004382"],"URL":"https:\/\/doi.org\/10.14283\/jpad.2020.19","relation":{},"ISSN":["2274-5807"],"issn-type":[{"value":"2274-5807","type":"print"}],"subject":[],"published":{"date-parts":[[2020,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Rationale for Early Diagnosis of Mild Cognitive Impairment (MCI) supported by Emerging Digital Technologies","name":"articletitle","label":"Article Title"},{"value":"The Journal of Prevention of Alzheimer's Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.14283\/jpad.2020.19","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2020 THE AUTHORS. Published by Elsevier Masson SAS on behalf of SERDI Publisher. Published by Elsevier Masson SAS","name":"copyright","label":"Copyright"}]}}