{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T04:53:19Z","timestamp":1790484799636,"version":"4.1.0"},"reference-count":37,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T00:00:00Z","timestamp":1727222400000},"content-version":"vor","delay-in-days":998,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Prevention of Alzheimer's Disease"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.14283\/jpad.2022.5","type":"journal-article","created":{"date-parts":[[2022,1,6]],"date-time":"2022-01-06T05:16:56Z","timestamp":1641446216000},"page":"40-48","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"title":["The SINgapore GERiatric Intervention Study to Reduce Cognitive Decline and Physical Frailty (SINGER): Study Design and Protocol"],"prefix":"10.1016","volume":"9","author":[{"given":"X.","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.A.","family":"Chew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.X.","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.K.S.","family":"Phua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.J.Y.","family":"Chong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.K.L.","family":"Teo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Sathe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.C.","family":"Chooi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.P.F.","family":"Chia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.J.","family":"Henry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Chew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.B.","family":"Maier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Kandiah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher Li-Hsian","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.14283\/jpad.2022.5_bib1","article-title":"Alzheimer's Disease International","year":"2014","journal-title":"Dementia in the Asia Pacific Region"},{"key":"10.14283\/jpad.2022.5_bib2","author":"Chen"},{"key":"10.14283\/jpad.2022.5_bib3","unstructured":"United Nations General Assembly. Resolution adopted by the General Assembly on 14 December 2020: United Nations Decade of Healthy Ageing (2021\u20132030). 2020."},{"key":"10.14283\/jpad.2022.5_bib4","unstructured":"Ministry of Health Singapore. Speech By Dr Amy Khor, Senior Minister Of State For Health, At The 13th International Congress Of The Asian Society Against Dementia, Held On Thursday 29 August 2019, At The Shangri-La Hotel Singapore. In 13th International Congress Of The Asian Society Against Dementia. 2019. Singapore."},{"key":"10.14283\/jpad.2022.5_bib5","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.1016\/S0140-6736(17)31363-6","article-title":"Dementia prevention, intervention, and care","volume":"390","author":"Livingston","year":"2017","journal-title":"The Lancet Commissions"},{"key":"10.14283\/jpad.2022.5_bib6","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/S1474-4422(14)70136-X","article-title":"Potential for primary prevention of Alzheimer's disease: an analysis of population-based data","volume":"13","author":"Norton","year":"2014","journal-title":"Lancet Neurology"},{"issue":"6","key":"10.14283\/jpad.2022.5_bib7","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1111\/joim.13227","article-title":"How can dementia and disability be prevented in older adults: where are we today and where are we going?","volume":"289","author":"Lisko","year":"2020","journal-title":"Journal of Internal Medicine"},{"key":"10.14283\/jpad.2022.5_bib8","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/S0140-6736(16)30950-3","article-title":"Effectiveness of a 6-year multidomain vascular care intervention to prevent dementia (preDIVA): a cluster-randomised controlled trial","volume":"388","author":"Moll van Charante","year":"2016","journal-title":"Lancet"},{"key":"10.14283\/jpad.2022.5_bib9","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/S1474-4422(17)30040-6","article-title":"Effect of long-term omega 3 polyunsaturated fatty acid supplementation with or without multidomain intervention on cognitive function in elderly adults with memory complaints (MAPT): a randomised, placebo-controlled trial","volume":"16","author":"Andrieu","year":"2017","journal-title":"Lancet Neurology"},{"issue":"9984","key":"10.14283\/jpad.2022.5_bib10","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1016\/S0140-6736(15)60461-5","article-title":"A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial","volume":"385","author":"Ngandu","year":"2015","journal-title":"The Lancet"},{"key":"10.14283\/jpad.2022.5_bib11","first-page":"142","article-title":"A Web-Based Multidomain Lifestyle Intervention for Older Adults: The eMIND Randomized Controlled Trial","volume":"8","author":"de Souto Barreto","year":"2020","journal-title":"The Journal of Prevention of Alzheimer's Disease ((PAD)"},{"issue":"2","key":"10.14283\/jpad.2022.5_bib12","first-page":"112","article-title":"Effects of a Group-Based 8-Week Multicomponent Cognitive Training on Cognition, Mood and Activities of Daily Living among Healthy Older Adults: A One-Year Follow-Up of a Randomized Controlled Trial","volume":"7","author":"Srisuwan","year":"2019","journal-title":"The Journal of Prevention of Alzheimer's Disease (JPAD)"},{"issue":"7","key":"10.14283\/jpad.2022.5_bib13","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1002\/alz.12123","article-title":"World-Wide FINGERS Network: A global approach to risk reduction and prevention of dementia","volume":"16","author":"Kivipelto","year":"2020","journal-title":"Alzheimers Dement"},{"issue":"1","key":"10.14283\/jpad.2022.5_bib14","first-page":"29","article-title":"Multidomain Interventions to Prevent Cognitive Impairment, Alzheimer's Disease, and Dementia: From FINGER to World-Wide FINGERS","volume":"7","author":"Rosenberg","year":"2019","journal-title":"The Journal of Prevention of Alzheimer's Disease (JPAD)"},{"issue":"1","key":"10.14283\/jpad.2022.5_bib15","first-page":"e12141","article-title":"SINgapore GERiatric intervention study to reduce physical frailty and cognitive decline (SINGER)-pilot: A feasibility study","volume":"7","author":"Chew","year":"2021","journal-title":"Alzheimers Dement TRCI"},{"key":"10.14283\/jpad.2022.5_bib16","author":"World Health Organization"},{"key":"10.14283\/jpad.2022.5_bib17","unstructured":"National Nutrition Council. Finnish nutrition recommendations - Diet and physical activity in balance. 2005, Edita: Oy, Finland."},{"key":"10.14283\/jpad.2022.5_bib18","series-title":"What national and subnational interventions and policies based on Mediterranean and Nordic diets are recommended or implemented in the WHO European Region, and is there evidence of effectiveness in reducing noncommunicable diseases?","author":"Renzella","year":"2018"},{"key":"10.14283\/jpad.2022.5_bib19","author":"Health Promotion Board"},{"issue":"6","key":"10.14283\/jpad.2022.5_bib20","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.jalz.2012.09.012","article-title":"The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER): study design and progress","volume":"9","author":"Kivipelto","year":"2013","journal-title":"Alzheimers Dement"},{"key":"10.14283\/jpad.2022.5_bib21","author":"Ministry of Health Singapore"},{"key":"10.14283\/jpad.2022.5_bib22","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1056\/NEJMoa1511939","article-title":"A Randomized Trial of Intensive versus Standard Blood-Pressure Control","volume":"373","author":"The SPRINT Research Group","year":"2015","journal-title":"N Engl J Med"},{"issue":"3","key":"10.14283\/jpad.2022.5_bib23","first-page":"158","article-title":"Validation of an Alzheimer's disease assessment battery in Asian participants with mild to moderate Alzheimer's disease","volume":"3","author":"Shen","year":"2014","journal-title":"Am J Neurodegener Dis"},{"issue":"9","key":"10.14283\/jpad.2022.5_bib24","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1001\/archneur.64.9.1323","article-title":"A neuropsychological test battery for use in Alzheimer disease clinical trials","volume":"64","author":"Harrison","year":"2007","journal-title":"Arch Neurol"},{"key":"10.14283\/jpad.2022.5_bib25","doi-asserted-by":"crossref","first-page":"2412","DOI":"10.1212\/WNL.43.11.2412-a","article-title":"The Clinical Dementia Rating (CDR): current version and scoring rules","volume":"43","author":"Morris","year":"1993","journal-title":"Neurology"},{"issue":"8","key":"10.14283\/jpad.2022.5_bib26","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1007\/s12603-010-0102-1","article-title":"Functional evaluation distinguishes MCI patients from healthy elderly people\u2014the ADCS\/MCI\/ADL scale","volume":"14","author":"Pedrosa","year":"2010","journal-title":"J Nutr Health Aging"},{"issue":"6","key":"10.14283\/jpad.2022.5_bib27","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1111\/j.1532-5415.1990.tb01438.x","article-title":"Validity of the geriatric depression scale","volume":"38","author":"Snowdon","year":"1990","journal-title":"Am Geriatr Soc"},{"issue":"2","key":"10.14283\/jpad.2022.5_bib28","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0165-1781(89)90047-4","article-title":"Pittsburgh sleep quality index (PSQI)","volume":"28","author":"Buysse","year":"1989","journal-title":"Psychiatry Res"},{"issue":"5","key":"10.14283\/jpad.2022.5_bib29","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1080\/09658210050117735","article-title":"Prospective and retrospective memory in normal ageing and dementia: A questionnaire study","volume":"8","author":"Smith","year":"2000","journal-title":"Memory"},{"issue":"6","key":"10.14283\/jpad.2022.5_bib30","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1123\/jpah.6.6.790","article-title":"Global Physical Activity Questionnaire (GPAQ): Nine Country Reliability and Validity Study","volume":"6","author":"Bull","year":"2009","journal-title":"Journal of Physical Activity and Health"},{"issue":"2","key":"10.14283\/jpad.2022.5_bib31","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1159\/000089919","article-title":"Mental, physical and social components in leisure activities equally contribute to decrease dementia risk","volume":"21","author":"Karp","year":"2006","journal-title":"Dementia and Geriatric Cognitive Disorders"},{"issue":"1","key":"10.14283\/jpad.2022.5_bib32","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1191\/0269215506cr885oa","article-title":"The Physical Performance Test as a predictor of frequent fallers: a prospective community-based cohort study","volume":"20","author":"Delbaere","year":"2006","journal-title":"Clin Rehabil"},{"issue":"3","key":"10.14283\/jpad.2022.5_bib33","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1097\/00005650-199303000-00006","article-title":"The MOS 36-Item Short-Form Health Survey (SF-36): II. Psychometric and clinical tests of validity in measuring physical and mental health constructs","volume":"31","author":"McHorney","year":"1993","journal-title":"Med Care"},{"issue":"5","key":"10.14283\/jpad.2022.5_bib34","doi-asserted-by":"crossref","first-page":"328","DOI":"10.3109\/07853890109002086","article-title":"The 15D instrument of health-related quality of life: properties and applications","volume":"33","author":"Sintonen","year":"2001","journal-title":"Ann Med"},{"key":"10.14283\/jpad.2022.5_bib35","first-page":"S191","article-title":"ADCS Prevention Instrument Project: pharmacoeconomics: assessing health-related resource use among healthy elderly","volume":"20","author":"Sano","year":"2006","journal-title":"Alzheimer Dis Assoc Disord"},{"key":"10.14283\/jpad.2022.5_bib36","first-page":"806","article-title":"Cognitive Effects of Multi-Domain Interventions Among Pre-Frail and Frail Community-Living Older Persons: Randomized Controlled Trial","volume":"73","author":"Ng","year":"2018","journal-title":"Journals of Gerontology: Medical Sciences"},{"key":"10.14283\/jpad.2022.5_bib37","author":"World-Wide FINGERS"}],"container-title":["The Journal of Prevention of Alzheimer's Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2274580724003595?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2274580724003595?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T19:44:35Z","timestamp":1736451875000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2274580724003595"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["S2274580724003595"],"URL":"https:\/\/doi.org\/10.14283\/jpad.2022.5","relation":{},"ISSN":["2274-5807"],"issn-type":[{"value":"2274-5807","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The SINgapore GERiatric Intervention Study to Reduce Cognitive Decline and Physical Frailty (SINGER): Study Design and Protocol","name":"articletitle","label":"Article Title"},{"value":"The Journal of Prevention of Alzheimer's Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.14283\/jpad.2022.5","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2022 THE AUTHORS. Published by Elsevier Masson SAS on behalf of SERDI Publisher. Published by Elsevier Masson SAS","name":"copyright","label":"Copyright"}]}}