{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T09:41:07Z","timestamp":1787218867773,"version":"build-2736575974"},"reference-count":46,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T00:00:00Z","timestamp":1726790400000},"content-version":"vor","delay-in-days":628,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Prevention of Alzheimer's Disease"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.14283\/jpad.2022.83","type":"journal-article","created":{"date-parts":[[2022,9,30]],"date-time":"2022-09-30T10:47:13Z","timestamp":1664534833000},"page":"104-111","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Age- and Sex-Different Associations between Cognitive Performance and Inflammatory Biomarkers in Community Dwelling Older Adults: towards Precision Preventive Strategies"],"prefix":"10.1016","volume":"10","author":[{"given":"B.-A.","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.-J.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.-P.","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.-N.","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang-Kung","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.14283\/jpad.2022.83_bib1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/alzrt118","article-title":"Whether, when and how chronic inflammation increases the risk of developing late-onset Alzheimer's disease","volume":"4","author":"Eikelenboom","year":"2012","journal-title":"Alzheimers Res Ther"},{"issue":"6","key":"10.14283\/jpad.2022.83_bib2","doi-asserted-by":"crossref","first-page":"e0157877","DOI":"10.1371\/journal.pone.0157877","article-title":"Soluble ICAM-1, Independent of IL-6, Is Associated with Prevalent Frailty in Community- Dwelling Elderly Taiwanese People","volume":"11","author":"Lee","year":"2016","journal-title":"PLoS One"},{"issue":"9","key":"10.14283\/jpad.2022.83_bib3","volume":"7","year":"2018","journal-title":"J Clin Med"},{"issue":"7","key":"10.14283\/jpad.2022.83_bib4","doi-asserted-by":"crossref","first-page":"e0200447","DOI":"10.1371\/journal.pone.0200447","article-title":"Cognitive frailty predicting all-cause mortality among community-living older adults in Taiwan: A 4-year nationwide population-based cohort study","volume":"13","author":"Lee","year":"2018","journal-title":"PLoS One"},{"key":"10.14283\/jpad.2022.83_bib5","doi-asserted-by":"crossref","first-page":"100916","DOI":"10.1016\/j.arr.2019.100916","article-title":"Inflammation and cerebral small vessel disease: A systematic review","volume":"53","author":"Low","year":"2019","journal-title":"Ageing Res Rev"},{"key":"10.14283\/jpad.2022.83_bib6","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.nbd.2016.07.007","article-title":"The blood-brain barrier in Alzheimer's disease","volume":"107","author":"Zenaro","year":"2017","journal-title":"Neurobiol Dis"},{"issue":"3","key":"10.14283\/jpad.2022.83_bib7","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s00401-018-1815-1","article-title":"Functional morphology of the blood-brain barrier in health and disease","volume":"135","author":"Liebner","year":"2018","journal-title":"Acta Neuropathol"},{"issue":"1\u20132","key":"10.14283\/jpad.2022.83_bib8","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jns.2004.09.006","article-title":"Homocysteine, cerebrovascular disease and brain atrophy","volume":"226","author":"Sachdev","year":"2004","journal-title":"J Neurol Sci"},{"issue":"7","key":"10.14283\/jpad.2022.83_bib9","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1182\/blood-2011-02-338269","article-title":"Hyperhomocysteinemia increases permeability of the blood-brain barrier by NMDA receptor-dependent regulation of adherens and tight junctions","volume":"118","author":"Beard","year":"2011","journal-title":"Blood"},{"issue":"12","key":"10.14283\/jpad.2022.83_bib10","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1172\/JCI200318921","article-title":"C-reactive protein: a critical update","volume":"111","author":"Pepys","year":"2003","journal-title":"J Clin Invest"},{"issue":"1","key":"10.14283\/jpad.2022.83_bib11","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1001\/archneurol.2009.308","article-title":"Association of C-reactive protein with cognitive impairment","volume":"67","author":"Noble","year":"2010","journal-title":"Arch Neurol"},{"issue":"4","key":"10.14283\/jpad.2022.83_bib12","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/S0197-4580(03)00002-2","article-title":"Biological markers for therapeutic trials in Alzheimer's disease. Proceedings of the biological markers working group; NIA initiative on neuroimaging in Alzheimer's disease","volume":"24","author":"Frank","year":"2003","journal-title":"Neurobiol Aging"},{"issue":"1","key":"10.14283\/jpad.2022.83_bib13","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.neuron.2009.08.039","article-title":"Immune activation in brain aging and neurodegeneration: too much or too little?","volume":"64","author":"Lucin","year":"2009","journal-title":"Neuron"},{"key":"10.14283\/jpad.2022.83_bib14","doi-asserted-by":"crossref","first-page":"111138","DOI":"10.1016\/j.exger.2020.111138","article-title":"Handgrip strength, tumor necrosis factor-\u03b1, interlukin-6, and visfatin levels in oldest elderly patients with cognitive impairment","volume":"142","author":"Huang","year":"2020","journal-title":"Exp Gerontol"},{"issue":"5","key":"10.14283\/jpad.2022.83_bib15","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/nrn.2018.13","article-title":"Fibrinogen in neurological diseases: mechanisms, imaging and therapeutics","volume":"19","author":"Petersen","year":"2018","journal-title":"Nat Rev Neurosci"},{"issue":"12","key":"10.14283\/jpad.2022.83_bib16","doi-asserted-by":"crossref","first-page":"2637","DOI":"10.1161\/01.STR.0000189721.31432.26","article-title":"Fibrinogen is associated with an increased risk of Alzheimer disease and vascular dementia","volume":"36","author":"van Oijen","year":"2005","journal-title":"Stroke"},{"issue":"1","key":"10.14283\/jpad.2022.83_bib17","doi-asserted-by":"crossref","first-page":"413","DOI":"10.3233\/JAD-201558","article-title":"The Association Between Homocysteine and Memory in Older Adults","volume":"81","author":"Nelson","year":"2021","journal-title":"J Alzheimers Dis"},{"issue":"16","key":"10.14283\/jpad.2022.83_bib18","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1212\/WNL.0b013e3181f88162","article-title":"Homocysteine and holotranscobalamin and the risk of Alzheimer disease: a longitudinal study","volume":"75","author":"Hooshmand","year":"2010","journal-title":"Neurology"},{"key":"10.14283\/jpad.2022.83_bib19","author":"Weinstein","year":"2014","journal-title":"Data from: Social Environment and Biomarkers of Aging Study (SEBAS) in Taiwan"},{"issue":"10","key":"10.14283\/jpad.2022.83_bib20","doi-asserted-by":"crossref","first-page":"e0206118","DOI":"10.1371\/journal.pone.0206118","article-title":"Apolipoprotein E, cognitive function, and cognitive decline among older Taiwanese adults","volume":"13","author":"Todd","year":"2018","journal-title":"PLoS One"},{"issue":"6","key":"10.14283\/jpad.2022.83_bib21","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1160\/TH14-11-0938","article-title":"Clinical significance of circulating vascular cell adhesion molecule-1 to white matter disintegrity in Alzheimer's dementia","volume":"114","author":"Huang","year":"2015","journal-title":"Thromb Haemost"},{"key":"10.14283\/jpad.2022.83_bib22","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.bbi.2016.02.009","article-title":"T-cell brain infiltration and immature antigen-presenting cells in transgenic models of Alzheimer's disease-like cerebral amyloidosis","volume":"54","author":"Ferretti","year":"2016","journal-title":"Brain Behav Immun"},{"issue":"33","key":"10.14283\/jpad.2022.83_bib23","doi-asserted-by":"crossref","first-page":"27876","DOI":"10.1074\/jbc.M112.377549","article-title":"Apolipoprotein E4 impairs macrophage efferocytosis and potentiates apoptosis by accelerating endoplasmic reticulum stress","volume":"287","author":"Cash","year":"2012","journal-title":"J Biol Chem"},{"issue":"12","key":"10.14283\/jpad.2022.83_bib24","doi-asserted-by":"crossref","first-page":"3196","DOI":"10.1161\/STROKEAHA.117.018675","article-title":"Midlife Systemic Inflammation, Late-Life White Matter Integrity, and Cerebral Small Vessel Disease: The Atherosclerosis Risk in Communities Study","volume":"48","author":"Walker","year":"2017","journal-title":"Stroke"},{"issue":"7","key":"10.14283\/jpad.2022.83_bib25","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1016\/j.jalz.2019.04.001","article-title":"Duration of preclinical, prodromal, and dementia stages of Alzheimer's disease in relation to age, sex, and APOE genotype","volume":"15","author":"Vermunt","year":"2019","journal-title":"Alzheimers Dement"},{"issue":"3","key":"10.14283\/jpad.2022.83_bib26","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1159\/000068481","article-title":"Homocysteine as a risk factor for cognitive impairment in stroke patients","volume":"15","author":"Sachdev","year":"2003","journal-title":"Dement Geriatr Cogn Disord"},{"key":"10.14283\/jpad.2022.83_bib27","doi-asserted-by":"crossref","first-page":"733","DOI":"10.2147\/IJGM.S292171","article-title":"Increased Serum E-Selectin Levels Were Associated with Cognitive Decline in Patients with Stroke","volume":"14","author":"Li","year":"2021","journal-title":"Int J Gen Med"},{"issue":"2","key":"10.14283\/jpad.2022.83_bib28","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1002\/rth2.12078","article-title":"Fibrinogen concentrations predict long-term cognitive outcome in young ischemic stroke patients","volume":"2","author":"Pedersen","year":"2018","journal-title":"Res Pract Thromb Haemost"},{"issue":"2","key":"10.14283\/jpad.2022.83_bib29","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1182\/blood-2005-06-2506","article-title":"Elevated levels of homocysteine compromise blood-brain barrier integrity in mice","volume":"107","author":"Kamath","year":"2006","journal-title":"Blood"},{"issue":"16","key":"10.14283\/jpad.2022.83_bib30","volume":"288","year":"2002","journal-title":"Jama"},{"issue":"9","key":"10.14283\/jpad.2022.83_bib31","doi-asserted-by":"crossref","first-page":"999","DOI":"10.2169\/internalmedicine.50.4752","article-title":"Plasma fibrinogen, global cognitive function, and cerebral small vessel disease: results of a cross-sectional study in community-dwelling Japanese elderly","volume":"50","author":"Wada","year":"2011","journal-title":"Intern Med"},{"issue":"1","key":"10.14283\/jpad.2022.83_bib32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1748-1716.2009.02037.x","article-title":"Mechanisms of fibrinogeninduced microvascular dysfunction during cardiovascular disease","volume":"198","author":"Lominadze","year":"2010","journal-title":"Acta Physiol (Oxf)"},{"issue":"9a","key":"10.14283\/jpad.2022.83_bib33","doi-asserted-by":"crossref","first-page":"2911","DOI":"10.1111\/j.1582-4934.2008.00434.x","article-title":"A leaky blood-brain barrier, fibrinogen infiltration and microglial reactivity in inflamed Alzheimer's disease brain","volume":"13","author":"Ryu","year":"2009","journal-title":"J Cell Mol Med"},{"issue":"1","key":"10.14283\/jpad.2022.83_bib34","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s00281-011-0290-8","article-title":"Fibrinogen as a key regulator of inflammation in disease","volume":"34","author":"Davalos","year":"2012","journal-title":"Semin Immunopathol"},{"issue":"3","key":"10.14283\/jpad.2022.83_bib35","doi-asserted-by":"crossref","first-page":"599","DOI":"10.3233\/JAD-2012-120820","article-title":"Fibrinogen and altered hemostasis in Alzheimer's disease","volume":"32","author":"Cortes-Canteli","year":"2012","journal-title":"J Alzheimers Dis"},{"issue":"5","key":"10.14283\/jpad.2022.83_bib36","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1159\/000510420","article-title":"Fibrinogen Levels and Cognitive Profile Differences in Patients with Mild Cognitive Impairment","volume":"49","author":"Pyun","year":"2020","journal-title":"Dement Geriatr Cogn Disord"},{"issue":"10","key":"10.14283\/jpad.2022.83_bib37","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1038\/s41419-020-03137-x","article-title":"Age-related cerebral small vessel disease and inflammaging","volume":"11","author":"Li","year":"2020","journal-title":"Cell Death Dis"},{"key":"10.14283\/jpad.2022.83_bib38","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.brainres.2009.06.033","article-title":"Tobacco smoke: a critical etiological factor for vascular impairment at the blood-brain barrier","volume":"1287","author":"Hossain","year":"2009","journal-title":"Brain Res"},{"issue":"2","key":"10.14283\/jpad.2022.83_bib39","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1111\/j.1471-4159.2006.04245.x","article-title":"Alcohol-induced bloodbrain barrier dysfunction is mediated via inositol 1,4,5-triphosphate receptor (IP3R)-gated intracellular calcium release","volume":"100","author":"Haorah","year":"2007","journal-title":"J Neurochem"},{"issue":"1","key":"10.14283\/jpad.2022.83_bib40","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s12974-019-1403-x","article-title":"Blood-brain barrier permeability and physical exercise","volume":"16","author":"Ma\u0142kiewicz","year":"2019","journal-title":"J Neuroinflammation"},{"issue":"4","key":"10.14283\/jpad.2022.83_bib41","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1042\/cs1000459","article-title":"Effects of smoking and abstention from smoking on fibrinogen synthesis in humans","volume":"100","author":"Hunter","year":"2001","journal-title":"Clin Sci (Lond)"},{"issue":"2","key":"10.14283\/jpad.2022.83_bib42","doi-asserted-by":"crossref","first-page":"503","DOI":"10.3233\/JAD-150458","article-title":"Increased Total Homocysteine Levels Predict the Risk of Incident Dementia Independent of Cerebral Small-Vessel Diseases and Vascular Risk Factors","volume":"49","author":"Miwa","year":"2016","journal-title":"J Alzheimers Dis"},{"issue":"8","key":"10.14283\/jpad.2022.83_bib43","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1007\/s12603-011-0340-x","article-title":"Sex differences in the association between muscle quality, inflammatory markers, and cognitive decline","volume":"15","author":"Canon","year":"2011","journal-title":"J Nutr Health Aging"},{"key":"10.14283\/jpad.2022.83_bib44","doi-asserted-by":"crossref","first-page":"110986","DOI":"10.1016\/j.exger.2020.110986","article-title":"Sex-specific associations of inflammation markers with cognitive decline","volume":"138","author":"West","year":"2020","journal-title":"Exp Gerontol"},{"key":"10.14283\/jpad.2022.83_bib45","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.jad.2017.12.038","article-title":"Gender differences in C-reactive protein and homocysteine modulation of cognitive performance and real-world functioning in bipolar disorder","volume":"229","author":"Sanchez-Autet","year":"2018","journal-title":"J Affect Disord"},{"issue":"8","key":"10.14283\/jpad.2022.83_bib46","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.biopsych.2007.03.001","article-title":"Evolving knowledge of sex differences in brain structure, function, and chemistry","volume":"62","author":"Cosgrove","year":"2007","journal-title":"Biol Psychiatry"}],"container-title":["The Journal of Prevention of Alzheimer's Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S227458072400253X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S227458072400253X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T00:41:07Z","timestamp":1736469667000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S227458072400253X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":46,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["S227458072400253X"],"URL":"https:\/\/doi.org\/10.14283\/jpad.2022.83","relation":{},"ISSN":["2274-5807"],"issn-type":[{"value":"2274-5807","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Age- and Sex-Different Associations between Cognitive Performance and Inflammatory Biomarkers in Community Dwelling Older Adults: towards Precision Preventive Strategies","name":"articletitle","label":"Article Title"},{"value":"The Journal of Prevention of Alzheimer's Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.14283\/jpad.2022.83","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2022 THE AUTHORS. Published by Elsevier Masson SAS on behalf of SERDI Publisher. Published by Elsevier Masson SAS","name":"copyright","label":"Copyright"}]}}