{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:04:38Z","timestamp":1787022278131,"version":"build-2736575974"},"reference-count":52,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T00:00:00Z","timestamp":1726790400000},"content-version":"vor","delay-in-days":385,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Prevention of Alzheimer's Disease"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.14283\/jpad.2023.28","type":"journal-article","created":{"date-parts":[[2023,3,16]],"date-time":"2023-03-16T07:00:57Z","timestamp":1678950057000},"page":"530-535","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Reproductive Markers in Alzheimer's Disease Progression: The Framingham Heart Study"],"prefix":"10.1016","volume":"10","author":[{"given":"Huitong","family":"Ding","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.F.A.","family":"Ang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Devine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Au","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.M.","family":"Doraiswamy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.14283\/jpad.2023.28_bib1","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/s41582-018-0032-9","article-title":"Sex differences in Alzheimer disease \u2014 the gateway to precision medicine","volume":"14","author":"Ferretti","year":"2018","journal-title":"Nat Rev Neurol"},{"issue":"4","key":"10.14283\/jpad.2023.28_bib2","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1016\/j.celrep.2019.03.099","article-title":"The major risk factors for Alzheimer's disease: age, sex, and genes modulate the microglia response to A\u03b2 plaques","volume":"27","author":"Frigerio","year":"2019","journal-title":"Cell reports"},{"key":"10.14283\/jpad.2023.28_bib3","first-page":"288","article-title":"When Mars Versus Venus is Not a Cliche: Gender Differences in the Neurobiology of Alzheimer's Disease","volume":"5","author":"Lin","year":"2014","journal-title":"Front Neurol"},{"issue":"11","key":"10.14283\/jpad.2023.28_bib4","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1016\/j.jalz.2016.08.004","article-title":"Sex biology contributions to vulnerability to Alzheimer's disease: A think tank convened by the Women's Alzheimer's Research Initiative","volume":"12","author":"Snyder","year":"2016","journal-title":"Alzheimers Dement"},{"issue":"4","key":"10.14283\/jpad.2023.28_bib5","first-page":"803","article-title":"Gender difference in apolipoprotein E-associated risk for familial Alzheimer disease: a possible clue to the higher incidence of Alzheimer disease in women","volume":"58","author":"Payami","year":"1996","journal-title":"American journal of human genetics"},{"issue":"1","key":"10.14283\/jpad.2023.28_bib6","first-page":"e12369","article-title":"Sex-specific biomarkers in Alzheimer's disease progression: Framingham Heart Study","volume":"14","author":"Liu","year":"2022","journal-title":"Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring"},{"issue":"4","key":"10.14283\/jpad.2023.28_bib7","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1159\/000439568","article-title":"Early life epidemiology of Alzheimer's disease-a critical review","volume":"45","author":"Seifan","year":"2015","journal-title":"Neuroepidemiology"},{"key":"10.14283\/jpad.2023.28_bib8","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.brainres.2008.03.079","article-title":"Females exhibit more extensive amyloid, but not tau, pathology in an Alzheimer transgenic model","volume":"1216","author":"Hirata-Fukae","year":"2008","journal-title":"Brain Res"},{"issue":"6","key":"10.14283\/jpad.2023.28_bib9","doi-asserted-by":"crossref","first-page":"2654","DOI":"10.1007\/s12035-020-01911-8","article-title":"Estrogen signaling in Alzheimer's disease: molecular insights and therapeutic targets for Alzheimer's dementia","volume":"57","author":"Uddin","year":"2020","journal-title":"Molecular Neurobiology"},{"issue":"3","key":"10.14283\/jpad.2023.28_bib10","first-page":"976","article-title":"Sex hormones, aging, and Alzheimer's disease","volume":"4","author":"Barron","year":"2012","journal-title":"Front Biosci (Elite Ed)"},{"key":"10.14283\/jpad.2023.28_bib11","series-title":"Estrogen receptor beta and neural development, in Vitamins and Hormones","first-page":"313","author":"Nalvarte","year":"2021"},{"key":"10.14283\/jpad.2023.28_bib12","doi-asserted-by":"crossref","first-page":"104691","DOI":"10.1016\/j.yhbeh.2020.104691","article-title":"Sexual differentiation of brain and other tissues: five questions for the next 50 years","volume":"120","author":"Arnold","year":"2020","journal-title":"Hormones and behavior"},{"issue":"11","key":"10.14283\/jpad.2023.28_bib13","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1001\/jama.285.11.1475","article-title":"Reproductive period and risk of dementia in postmenopausal women","volume":"285","author":"Geerlings","year":"2001","journal-title":"Jama"},{"issue":"1","key":"10.14283\/jpad.2023.28_bib14","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1159\/000330472","article-title":"Influence of variation in the follicle-stimulating hormone receptor gene (FSHR) and age at menopause on the development of Alzheimer's disease in women","volume":"32","author":"Corbo","year":"2011","journal-title":"Dementia and geriatric cognitive disorders"},{"issue":"2","key":"10.14283\/jpad.2023.28_bib15","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0197-4580(03)00046-0","article-title":"Elevated sex-hormone binding globulin in elderly women with Alzheimer's disease","volume":"25","author":"Hoskin","year":"2004","journal-title":"Neurobiology of aging"},{"issue":"10","key":"10.14283\/jpad.2023.28_bib16","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1016\/j.neurobiolaging.2008.10.001","article-title":"Sex hormone binding globulin and incident Alzheimer's disease in elderly men and women","volume":"31","author":"Muller","year":"2010","journal-title":"Neurobiology of aging"},{"issue":"3","key":"10.14283\/jpad.2023.28_bib17","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s10571-019-00733-0","article-title":"The impact of estradiol on neurogenesis and cognitive functions in Alzheimer's disease","volume":"40","author":"Sahab-Negah","year":"2020","journal-title":"Cellular and Molecular Neurobiology"},{"key":"10.14283\/jpad.2023.28_bib18","doi-asserted-by":"crossref","first-page":"e043110","DOI":"10.1002\/alz.043110","article-title":"Distinctive roles of estrone and estradiol in shaping verbal memory circuitry in postmenopausal women: Neuroimaging: Earlier life risk factors and imaging biomarkers","volume":"16","author":"Schroeder","year":"2020","journal-title":"Alzheimer's & Dementia"},{"issue":"12","key":"10.14283\/jpad.2023.28_bib19","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1001\/jama.292.12.1431-b","article-title":"Age-related testosterone depletion and the development of Alzheimer disease","volume":"292","author":"Rosario","year":"2004","journal-title":"Jama"},{"issue":"11\u201312","key":"10.14283\/jpad.2023.28_bib20","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1016\/j.exger.2004.06.019","article-title":"Low free testosterone is an independent risk factor for Alzheimer's disease","volume":"39","author":"Hogervorst","year":"2004","journal-title":"Experimental gerontology"},{"issue":"13","key":"10.14283\/jpad.2023.28_bib21","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1111\/1471-0528.12828","article-title":"Impact of a premature menopause on cognitive function in later life","volume":"121","author":"Ryan","year":"2014","journal-title":"BJOG: An International Journal of Obstetrics & Gynaecology"},{"key":"10.14283\/jpad.2023.28_bib22","doi-asserted-by":"crossref","first-page":"555","DOI":"10.2147\/NDT.S36622","article-title":"Reproductive life events and Alzheimer's disease in Italian women: a retrospective study","volume":"8","author":"Zucchella","year":"2012","journal-title":"Neuropsychiatric Disease and Treatment"},{"issue":"3","key":"10.14283\/jpad.2023.28_bib23","doi-asserted-by":"crossref","first-page":"279","DOI":"10.2105\/AJPH.41.3.279","article-title":"Epidemiological approaches to heart disease: the Framingham Study","volume":"41","author":"Dawber","year":"1951","journal-title":"American Journal of Public Health and the Nations Health"},{"issue":"4","key":"10.14283\/jpad.2023.28_bib24","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/0091-7435(75)90037-7","article-title":"The Framingham offspring study. Design and preliminary data","volume":"4","author":"Feinleib","year":"1975","journal-title":"Preventive medicine"},{"issue":"11","key":"10.14283\/jpad.2023.28_bib25","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1093\/aje\/kwm021","article-title":"The third generation cohort of the National Heart, Lung, and Blood Institute's Framingham Heart Study: design, recruitment, and initial examination","volume":"165","author":"Splansky","year":"2007","journal-title":"American journal of epidemiology"},{"issue":"6","key":"10.14283\/jpad.2023.28_bib26","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1056\/NEJMoa1504327","article-title":"Incidence of dementia over three decades in the Framingham Heart Study","volume":"374","author":"Satizabal","year":"2016","journal-title":"New England Journal of Medicine"},{"issue":"1","key":"10.14283\/jpad.2023.28_bib27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-019-14279-8","article-title":"Exceptionally low likelihood of Alzheimer's dementia in APOE2 homozygotes from a 5,000-person neuropathological study","volume":"11","author":"Reiman","year":"2020","journal-title":"Nature communications"},{"issue":"3","key":"10.14283\/jpad.2023.28_bib28","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1038\/s41588-019-0358-2","article-title":"Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates A\u03b2, tau, immunity and lipid processing","volume":"51","author":"Kunkle","year":"2019","journal-title":"Nature genetics"},{"issue":"7","key":"10.14283\/jpad.2023.28_bib29","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1002\/alz.12487","article-title":"The protective gene dose effect of the APOE \u03b52 allele on gray matter volume in cognitively unimpaired individuals","volume":"18","author":"Salvad\u00f3","year":"2022","journal-title":"Alzheimer's & Dementia"},{"issue":"1","key":"10.14283\/jpad.2023.28_bib30","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1212\/WNL.42.1.115","article-title":"Prevalence of dementia and probable senile dementia of the Alzheimer type in the Framingham Study","volume":"42","author":"Bachman","year":"1992","journal-title":"Neurology"},{"issue":"7","key":"10.14283\/jpad.2023.28_bib31","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1212\/WNL.34.7.939","article-title":"Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease","volume":"34","author":"McKhann","year":"1984","journal-title":"Neurology"},{"issue":"3part2","key":"10.14283\/jpad.2023.28_bib32","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1177\/0033294187060003-201.1","article-title":"Neuropsychological test performance in Framingham: a descriptive study","volume":"60","author":"Farmer","year":"1987","journal-title":"Psychological reports"},{"issue":"4","key":"10.14283\/jpad.2023.28_bib33","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1080\/03610730490484380","article-title":"New norms for a new generation: cognitive performance in the framingham offspring cohort","volume":"30","author":"Au","year":"2004","journal-title":"Experimental aging research"},{"key":"10.14283\/jpad.2023.28_bib34","unstructured":"Wilkinson, G.S., WRAT-3: Wide range achievement test administration manual. 1993: Wide Range, Incorporated."},{"key":"10.14283\/jpad.2023.28_bib35","series-title":"Wechsler Memory Scale (WMS)","author":"Wechsler","year":"1948"},{"key":"10.14283\/jpad.2023.28_bib36","unstructured":"Kaplan, E., et al., Boston Naming Test Lea & Febi. 1983, Philadelphia."},{"key":"10.14283\/jpad.2023.28_bib37","series-title":"A Compendium of Neuropsychological Tests: Administration, Norms and Commentary","author":"Spreen","year":"1991"},{"key":"10.14283\/jpad.2023.28_bib38","series-title":"Manual: Hooper visual organization test","author":"Hooper","year":"1958"},{"issue":"5","key":"10.14283\/jpad.2023.28_bib39","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1002\/ana.410340527","article-title":"The apolipoprotein \u03b54 allele in patients with Alzheimer's disease","volume":"34","author":"Mayeux","year":"1993","journal-title":"Annals of Neurology: Official Journal of the American Neurological Association and the Child Neurology Society"},{"issue":"3","key":"10.14283\/jpad.2023.28_bib40","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/S0021-9150(00)00570-0","article-title":"Apolipoprotein E genotype and cardiovascular disease in the Framingham Heart Study","volume":"154","author":"Lahoz","year":"2001","journal-title":"Atherosclerosis"},{"issue":"3","key":"10.14283\/jpad.2023.28_bib41","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.jalz.2014.07.001","article-title":"Plasma amyloid-\u03b2 and risk of Alzheimer's disease in the Framingham Heart Study","volume":"11","author":"Chouraki","year":"2015","journal-title":"Alzheimer's & Dementia"},{"issue":"5","key":"10.14283\/jpad.2023.28_bib42","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1111\/j.1365-2265.2010.03951.x","article-title":"Associations of endogenous testosterone and SHBG with glycated haemoglobin in middle-aged and older men","volume":"74","author":"Brand","year":"2011","journal-title":"Clinical endocrinology"},{"issue":"7","key":"10.14283\/jpad.2023.28_bib43","doi-asserted-by":"crossref","first-page":"e100409","DOI":"10.1371\/journal.pone.0100409","article-title":"Testosterone, sex hormone-binding globulin and the metabolic syndrome in men: an individual participant data meta-analysis of observational studies","volume":"9","author":"Brand","year":"2014","journal-title":"PloS one"},{"issue":"9","key":"10.14283\/jpad.2023.28_bib44","doi-asserted-by":"crossref","first-page":"3829","DOI":"10.1210\/jc.2013-1808","article-title":"Menopause effects on verbal memory: findings from a longitudinal community cohort","volume":"98","author":"Epperson","year":"2013","journal-title":"The Journal of clinical endocrinology & metabolism"},{"issue":"16","key":"10.14283\/jpad.2023.28_bib45","doi-asserted-by":"crossref","first-page":"3091","DOI":"10.1007\/s00213-015-3953-7","article-title":"New onset executive function difficulties at menopause: a possible role for lisdexamfetamine","volume":"232","author":"Epperson","year":"2015","journal-title":"Psychopharmacology"},{"issue":"7","key":"10.14283\/jpad.2023.28_bib46","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/nrendo.2015.82","article-title":"Perimenopause as a neurological transition state","volume":"11","author":"Brinton","year":"2015","journal-title":"Nature reviews endocrinology"},{"issue":"7","key":"10.14283\/jpad.2023.28_bib47","doi-asserted-by":"crossref","first-page":"2282","DOI":"10.1016\/j.neurobiolaging.2015.03.013","article-title":"The perimenopausal aging transition in the female rat brain: decline in bioenergetic systems and synaptic plasticity","volume":"36","author":"Yin","year":"2015","journal-title":"Neurobiology of aging"},{"issue":"4","key":"10.14283\/jpad.2023.28_bib48","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1038\/nrn1886","article-title":"Ageing and neuronal vulnerability","volume":"7","author":"Mattson","year":"2006","journal-title":"Nature reviews neuroscience"},{"issue":"4","key":"10.14283\/jpad.2023.28_bib49","first-page":"225","article-title":"Female sex and Alzheimer's risk: the menopause connection","volume":"5","author":"Scheyer","year":"2018","journal-title":"The journal of prevention of Alzheimer's disease"},{"issue":"3","key":"10.14283\/jpad.2023.28_bib50","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1212\/WNL.0000000000000033","article-title":"Age at surgical menopause influences cognitive decline and Alzheimer pathology in older women","volume":"82","author":"Bove","year":"2014","journal-title":"Neurology"},{"issue":"13","key":"10.14283\/jpad.2023.28_bib51","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1136\/heartjnl-2017-312289","article-title":"Women's reproductive factors and incident cardiovascular disease in the UK Biobank","volume":"104","author":"Peters","year":"2018","journal-title":"Heart"},{"issue":"7","key":"10.14283\/jpad.2023.28_bib52","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/j.jalz.2015.12.010","article-title":"Endogenous sex hormones and cognitive function in older women","volume":"12","author":"Koyama","year":"2016","journal-title":"Alzheimer's & Dementia"}],"container-title":["The Journal of Prevention of Alzheimer's Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2274580724002127?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2274580724002127?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T19:39:49Z","timestamp":1736451589000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2274580724002127"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":52,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["S2274580724002127"],"URL":"https:\/\/doi.org\/10.14283\/jpad.2023.28","relation":{},"ISSN":["2274-5807"],"issn-type":[{"value":"2274-5807","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Reproductive Markers in Alzheimer's Disease Progression: The Framingham Heart Study","name":"articletitle","label":"Article Title"},{"value":"The Journal of Prevention of Alzheimer's Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.14283\/jpad.2023.28","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2023 THE AUTHORS. Published by Elsevier Masson SAS on behalf of SERDI Publisher. Published by Elsevier Masson SAS","name":"copyright","label":"Copyright"}]}}