{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T18:20:02Z","timestamp":1790360402535,"version":"4.1.0"},"reference-count":49,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,6,30]],"date-time":"2023-06-30T00:00:00Z","timestamp":1688083200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Prevention of Alzheimer's Disease"],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.14283\/jpad.2023.84","type":"journal-article","created":{"date-parts":[[2023,6,22]],"date-time":"2023-06-22T11:06:03Z","timestamp":1687431963000},"page":"756-764","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Preferences about Future Alzheimer's Disease Treatments Elicited through an Online Survey Using the Threshold Technique"],"prefix":"10.1016","volume":"10","author":[{"given":"Sonia Roldan","family":"Munoz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.T.","family":"de Vries","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Lankester","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Pignatti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.C.","family":"van Munster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Radford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Guizzaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.G.M.","family":"Mol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Hillege","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Postmus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.14283\/jpad.2023.84_bib1","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.3233\/JAD-180903","article-title":"Present Algorithms and Future Treatments for Alzheimer's Disease","volume":"67","author":"Grossberg","year":"2019","journal-title":"J Alzheimers Dis"},{"issue":"3","key":"10.14283\/jpad.2023.84_bib3","doi-asserted-by":"crossref","first-page":"881","DOI":"10.3233\/JAD-210736","article-title":"The FDA Approves Aducanumab for Alzheimer's Disease, Raising Important Scientific Questions","volume":"82","author":"de la Torre","year":"2021","journal-title":"J Alzheimers Dis"},{"issue":"12","key":"10.14283\/jpad.2023.84_bib4","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1007\/s40265-021-01569-z","article-title":"Aducanumab: First Approval","volume":"81","author":"Dhillon","year":"2021","journal-title":"Drugs"},{"key":"10.14283\/jpad.2023.84_bib5","author":"European Medicines Agency"},{"issue":"3","key":"10.14283\/jpad.2023.84_bib6","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/s40271-017-0222-3","article-title":"Giving Patients' Preferences a Voice in Medical Treatment Life Cycle: The PREFER Public-Private Project","volume":"10","author":"de Bekker-Grob","year":"2017","journal-title":"Patient-Patient Centered Outcomes Research"},{"issue":"1","key":"10.14283\/jpad.2023.84_bib7","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1097\/WAD.0b013e318181e4c7","article-title":"Older Americans' Risk-benefit Preferences for Modifying the Course of Alzheimer Disease","volume":"23","author":"Hauber","year":"2009","journal-title":"Alz Dis Assoc Dis"},{"issue":"9","key":"10.14283\/jpad.2023.84_bib8","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/j.jval.2019.03.022","article-title":"Something Is Better Than Nothing: The Value of Active Intervention in Stated Preferences for Treatments to Delay Onset of Alzheimer's Disease Symptoms","volume":"22","author":"Johnson","year":"2019","journal-title":"Value Health"},{"issue":"2","key":"10.14283\/jpad.2023.84_bib9","doi-asserted-by":"crossref","first-page":"885","DOI":"10.3233\/JAD-191299","article-title":"Preferences of Cognitively Impaired Patients and Patients Living with Dementia: A Systematic Review of Quantitative Patient Preference Studies","volume":"77","author":"Lepper","year":"2020","journal-title":"J Alzheimers Dis"},{"issue":"5","key":"10.14283\/jpad.2023.84_bib10","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1007\/s40271-022-00576-w","article-title":"The Patient Voice: Exploring Treatment Preferences in Participants with Mild Cognitive Concerns to Inform Regulatory Decision Making","volume":"15","author":"Mansfield","year":"2022","journal-title":"Patient"},{"issue":"6","key":"10.14283\/jpad.2023.84_bib11","doi-asserted-by":"crossref","first-page":"687","DOI":"10.2165\/00019053-199813060-00005","article-title":"The influence of ill-health experience on the valuation of health","volume":"13","author":"Badia","year":"1998","journal-title":"Pharmacoeconomics"},{"issue":"9","key":"10.14283\/jpad.2023.84_bib12","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1016\/j.jval.2021.02.012","article-title":"To What Extent Do Patient Preferences Differ From General Population Preferences?","volume":"24","author":"Ludwig","year":"2021","journal-title":"Value Health"},{"issue":"6","key":"10.14283\/jpad.2023.84_bib13","first-page":"763","article-title":"Patient and Public Preferences for Treatment Attributes in Parkinson's Disease","volume":"10","author":"Weernink","year":"2017","journal-title":"Patient"},{"issue":"2","key":"10.14283\/jpad.2023.84_bib14","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.healthpol.2017.03.011","article-title":"Questioning the differences between general public vs. patient based preferences towards EQ-5D-5L defined hypothetical health states","volume":"123","author":"Ogorevc","year":"2019","journal-title":"Health Policy"},{"issue":"3","key":"10.14283\/jpad.2023.84_bib15","doi-asserted-by":"crossref","DOI":"10.1093\/geroni\/igab020","article-title":"Patient-Caregiver Treatment Preference Discordance and Its Association With Caregiving Burden and Esteem","volume":"5","author":"Ozdemir","year":"2021","journal-title":"Innov Aging"},{"issue":"2","key":"10.14283\/jpad.2023.84_bib16","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1002\/pon.3631","article-title":"Discordance among patient preferences, caregiver preferences, and caregiver predictions of patient preferences regarding disclosure of terminal status and end-of-life choices","volume":"24","author":"Shin","year":"2015","journal-title":"Psychooncology"},{"issue":"4","key":"10.14283\/jpad.2023.84_bib17","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1093\/geront\/gnr010","article-title":"Understanding discrepancy in perceptions of values: individuals with mild to moderate dementia and their family caregivers","volume":"51","author":"Reamy","year":"2011","journal-title":"Gerontologist"},{"issue":"4","key":"10.14283\/jpad.2023.84_bib18","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.jval.2018.12.007","article-title":"Understanding Patients' Preferences: A Systematic Review of Psychological Instruments Used in Patients' Preference and Decision Studies","volume":"22","author":"Russo","year":"2019","journal-title":"Value Health"},{"issue":"3","key":"10.14283\/jpad.2023.84_bib19","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1111\/ijcp.12781","article-title":"Beliefs about medicines are strongly associated with medicine-use patterns among the general population","volume":"70","author":"Andersson Sundell","year":"2016","journal-title":"Int J Clin Pract"},{"issue":"9","key":"10.14283\/jpad.2023.84_bib20","doi-asserted-by":"crossref","first-page":"e003551","DOI":"10.1136\/bmjopen-2013-003551","article-title":"The association between patients' beliefs about medicines and adherence to drug treatment after stroke: a cross-sectional questionnaire survey","volume":"3","author":"Sjolander","year":"2013","journal-title":"BMJ Open"},{"issue":"2","key":"10.14283\/jpad.2023.84_bib21","doi-asserted-by":"crossref","first-page":"e034529","DOI":"10.1136\/bmjopen-2019-034529","article-title":"Differences in medication beliefs between pregnant women using medication, or not, for chronic diseases: a cross-sectional, multinational, web-based study","volume":"10","author":"Roldan Munoz","year":"2020","journal-title":"BMJ Open"},{"issue":"8","key":"10.14283\/jpad.2023.84_bib22","first-page":"419","article-title":"A Brief Telephonic Instrument to Screen for Cognitive Impairment in a Managed Care Population","volume":"10","author":"Fillit","year":"2003","journal-title":"JCOM"},{"issue":"1","key":"10.14283\/jpad.2023.84_bib23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/08870449908407311","article-title":"The beliefs about medicines questionnaire: The development and evaluation of a new method for assessing the cognitive representation of medication","volume":"14","author":"Horne","year":"1999","journal-title":"Psychology & Health"},{"issue":"1","key":"10.14283\/jpad.2023.84_bib24","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s40258-019-00521-3","article-title":"Using the Threshold Technique to Elicit Patient Preferences: An Introduction to the Method and an Overview of Existing Empirical Applications","volume":"18","author":"Hauber","year":"2020","journal-title":"Appl Health Econ Health Policy"},{"issue":"6","key":"10.14283\/jpad.2023.84_bib25","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1007\/s11136-013-0620-5","article-title":"Understanding the relative importance of preserving functional abilities in Alzheimer's disease in the United States and Germany","volume":"23","author":"Hauber","year":"2014","journal-title":"Qual Life Res"},{"issue":"3","key":"10.14283\/jpad.2023.84_bib26","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1111\/hex.12876","article-title":"What matters to people with memory problems, healthy volunteers and health and social care professionals in the context of developing treatment to prevent Alzheimer's dementia? A qualitative study","volume":"22","author":"Watson","year":"2019","journal-title":"Health Expect"},{"issue":"10","key":"10.14283\/jpad.2023.84_bib28","doi-asserted-by":"crossref","first-page":"e26568","DOI":"10.1371\/journal.pone.0026568","article-title":"Adverse events of interferon beta-1a: a prospective multi-centre international ICH-GCP-based CRO-supported external validation study in daily practice","volume":"6","author":"Jongen","year":"2011","journal-title":"PLoS One"},{"key":"10.14283\/jpad.2023.84_bib29","series-title":"A Parallel-Group, Double Blind Long Term Safety Trial of MK-8931 in Subjects with Alzheimer's Disease. (Protocol No. MK-8931-017-21) (also known as SCH 900931, P07738)","first-page":"140","author":"Merck Sharp & Dohme Corp. asoMC, Inc","year":"2016"},{"key":"10.14283\/jpad.2023.84_bib31","article-title":"D2.2 Processes, conditions and contextual factors that influence the utility and role of patient preference studies in PREFER Patient Preferences in Benefit-Risk Assessments during the Drug","author":"Huys","year":"2017","journal-title":"Life Cycle"},{"issue":"7","key":"10.14283\/jpad.2023.84_bib32","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1016\/j.jalz.2019.04.001","article-title":"Duration of preclinical, prodromal, and dementia stages of Alzheimer's disease in relation to age, sex, and APOE genotype","volume":"15","author":"Vermunt","year":"2019","journal-title":"Alzheimers Dement"},{"key":"10.14283\/jpad.2023.84_bib33","series-title":"Survival Analyses","author":"Klein","year":"2003"},{"issue":"6","key":"10.14283\/jpad.2023.84_bib34","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1007\/s13300-017-0326-8","article-title":"Patient Preferences for Attributes of Type 2 Diabetes Mellitus Medications in Germany and Spain: An Online Discrete-Choice Experiment Survey","volume":"8","author":"Mansfield","year":"2017","journal-title":"Diabetes Ther"},{"key":"10.14283\/jpad.2023.84_bib35","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2020.617409","article-title":"Differences in Importance Attached to Drug Effects Between Patients With Type 2 Diabetes From the Netherlands and Turkey: A Preference Study","volume":"11","author":"Roldan Munoz","year":"2021","journal-title":"Frontiers in Pharmacology"},{"key":"10.14283\/jpad.2023.84_bib36","doi-asserted-by":"crossref","first-page":"710518","DOI":"10.3389\/fphar.2021.710518","article-title":"Key Determinants of Health-Related Quality of Life Among Advanced Lung Cancer Patients: A Qualitative Study in Belgium and Italy","volume":"12","author":"Janssens","year":"2021","journal-title":"Front Pharmacol"},{"issue":"34","key":"10.14283\/jpad.2023.84_bib37","doi-asserted-by":"crossref","first-page":"3895","DOI":"10.2217\/fon-2019-0396","article-title":"Patient preferences for attributes of tyrosine kinase inhibitor treatments for EGFR mutation-positive non-small-cell lung cancer","volume":"15","author":"Bridges","year":"2019","journal-title":"Future Oncol"},{"issue":"4","key":"10.14283\/jpad.2023.84_bib38","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1185\/03007991003657867","article-title":"Willingness to pay for health improvements associated with anti-diabetes treatments for people with type 2 diabetes","volume":"26","author":"Jendle","year":"2010","journal-title":"Curr Med Res Opin"},{"issue":"4","key":"10.14283\/jpad.2023.84_bib39","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/S1474-4422(08)70063-2","article-title":"Person-centred care of people with severe Alzheimer's disease: current status and ways forward","volume":"7","author":"Edvardsson","year":"2008","journal-title":"Lancet Neurol"},{"key":"10.14283\/jpad.2023.84_bib40","doi-asserted-by":"crossref","first-page":"2793","DOI":"10.2147\/PPA.S333923","article-title":"Priorities and Preferences of People Living with Dementia or Cognitive Impairment - A Systematic Review","volume":"15","author":"Wehrmann","year":"2021","journal-title":"Patient Prefer Adherence"},{"issue":"10","key":"10.14283\/jpad.2023.84_bib41","doi-asserted-by":"crossref","first-page":"e0139755","DOI":"10.1371\/journal.pone.0139755","article-title":"The Role of Patients' Age on Their Preferences for Choosing Additional Blood Pressure-Lowering Drugs: A Discrete Choice Experiment in Patients with Diabetes","volume":"10","author":"de Vries","year":"2015","journal-title":"PLoS One"},{"issue":"1","key":"10.14283\/jpad.2023.84_bib42","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1017\/S1930297500000346","article-title":"Gender Differences in Risk Assessment: Why do Women Take Fewer Risks than Men?","volume":"1","author":"Harris","year":"2006","journal-title":"Judgment and Decision Making"},{"key":"10.14283\/jpad.2023.84_bib43","first-page":"63","article-title":"The impact of gender on risk perception: Implications for EU member states' national risk assessment processes","author":"Brown","year":"2021","journal-title":"Int J Disast Risk Re"},{"issue":"4","key":"10.14283\/jpad.2023.84_bib44","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.3233\/JAD-171161","article-title":"A Survey of Patient and Partner Outcome and Treatment Preferences in Mild Cognitive Impairment","volume":"63","author":"Smith","year":"2018","journal-title":"Journal of Alzheimers Disease"},{"issue":"4","key":"10.14283\/jpad.2023.84_bib45","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1097\/WAD.0b013e3181a6bebc","article-title":"Missed and Delayed Diagnosis of Dementia in Primary Care Prevalence and Contributing Factors","volume":"23","author":"Bradford","year":"2009","journal-title":"Alz Dis Assoc Dis"},{"key":"10.14283\/jpad.2023.84_bib46","author":"GPS E"},{"issue":"2","key":"10.14283\/jpad.2023.84_bib47","first-page":"160","article-title":"Shared decision making in mild cognitive impairment","volume":"9","author":"Mejia","year":"2019","journal-title":"Neurology: Clinical Practice"},{"issue":"1","key":"10.14283\/jpad.2023.84_bib48","article-title":"Parkinson's Patients' Tolerance for Risk and Willingness to Wait for Potential Benefits of Novel Neurostimulation Devices: A Patient-Centered Threshold Technique Study","volume":"6","author":"Hauber","year":"2021","journal-title":"MDM Policy Pract"},{"issue":"2","key":"10.14283\/jpad.2023.84_bib49","doi-asserted-by":"crossref","first-page":"197","DOI":"10.14283\/jpad.2022.30","article-title":"Two Randomized Phase 3 Studies of Aducanumab in Early Alzheimer's Disease","volume":"9","author":"Haeberlein","year":"2022","journal-title":"Jpad-J Prev Alzheim"},{"issue":"1","key":"10.14283\/jpad.2023.84_bib50","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1001\/jamaneurol.2021.4161","article-title":"Amyloid-Related Imaging Abnormalities in 2 Phase 3 Studies Evaluating Aducanumab in Patients With Early Alzheimer Disease","volume":"79","author":"Salloway","year":"2022","journal-title":"Jama Neurol"},{"issue":"4","key":"10.14283\/jpad.2023.84_bib51","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1002\/pst.1690","article-title":"Structured Benefit-risk assessment: a review of key publications and initiatives on frameworks and methodologies","volume":"15","author":"Mt-Isa","year":"2016","journal-title":"Pharm Stat"},{"issue":"1","key":"10.14283\/jpad.2023.84_bib52","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s12910-020-00572-5","article-title":"The full spectrum of ethical issues in dementia research: findings of a systematic qualitative review","volume":"22","author":"Gotzelmann","year":"2021","journal-title":"BMC Med Ethics"}],"container-title":["The Journal of Prevention of Alzheimer's Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2274580724001651?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2274580724001651?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T02:10:02Z","timestamp":1737339002000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2274580724001651"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":49,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["S2274580724001651"],"URL":"https:\/\/doi.org\/10.14283\/jpad.2023.84","relation":{},"ISSN":["2274-5807"],"issn-type":[{"value":"2274-5807","type":"print"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Preferences about Future Alzheimer's Disease Treatments Elicited through an Online Survey Using the Threshold Technique","name":"articletitle","label":"Article Title"},{"value":"The Journal of Prevention of Alzheimer's Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.14283\/jpad.2023.84","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2023 THE AUTHORS. Published by Elsevier Masson SAS on behalf of SERDI Publisher. Published by Elsevier Masson SAS","name":"copyright","label":"Copyright"}]}}