{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T14:14:18Z","timestamp":1753884858567,"version":"3.41.2"},"reference-count":49,"publisher":"Open Access Pub","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAPST"],"abstract":"<jats:p>Silver sulfadiazine is a topical medicine that belongs to sulfa antibiotics class of drugs and used in treating wound infections in burn patients. The aim of this study was to determine the effect of Consciousness Energy Healing Treatment (the Trivedi Effect\u00ae) on the various properties of silver sulfadiazine with the help of modern analytical techniques. The sample was divided into two parts; the first part was not given any treatment and considered as a control sample, while the second part was provided the Consciousness Energy Healing Treatment by the Biofield Energy Healer, Gopal Nayak remotely, named as the treated sample. The powder XRD data showed significant alterations in the peak intensities of the treated sample ranging from-30.71% to 47.54% compared to the control sample. The crystallite size was altered ranging from -78.12% to 1.47%; and the average crystallite size was significantly reduced by 31.62% in the treated sample compared to the control sample. The particle sizes were decreased in the treated sample by 12.75%(d10), 4.98%(d50), 0.89%(d90), and 2.92%{D(4,3)}; thus, the specific surface area was significantly increased by 17.31% compared with the control sample. The latent heat of fusion and latent heat of decomposition were profoundly increased by 24.62% and 156.28%, respectively in the treated sample compared to the control sample. The total weight loss was increased by 3.08% and the residue amount was reduced by 4.44% in the treated sample compared to the control sample. Thus, the Trivedi Effect\u00ae-Consciousness Energy Healing Treated sample might form a new polymorph of silver sulfadiazine that possesses reduced particle size and improved thermal properties compared to the untreated sample. Therefore, the Biofield Energy treated sample can be used in nutraceutical\/pharmaceutical formulation, which would show a better bioavailability and therapeutic response against various infections in comparison to the control sample.<\/jats:p>","DOI":"10.14302\/issn.2328-0182.japst-18-2517","type":"journal-article","created":{"date-parts":[[2018,12,28]],"date-time":"2018-12-28T05:56:10Z","timestamp":1545976570000},"page":"1-13","source":"Crossref","is-referenced-by-count":0,"title":["Consciousness Energy Healing Treatment: Impact on Physicochemical and Thermal Properties of Silver Sulfadiazine"],"prefix":"10.14302","volume":"2","author":[{"given":"Nayak","family":"Nayak","sequence":"first","affiliation":[{"name":"Trivedi Global, Inc., Henderson, USA"}]},{"given":"Mahendra Kumar","family":"Trivedi","sequence":"additional","affiliation":[{"name":"Trivedi Global, Inc., Henderson, USA"}]},{"given":"Alice","family":"Branton","sequence":"additional","affiliation":[{"name":"Trivedi Global, Inc., Henderson, USA"}]},{"given":"Dahryn","family":"Trivedi","sequence":"additional","affiliation":[{"name":"Trivedi Global, Inc., Henderson, USA"}]},{"given":"Snehasis","family":"Jana","sequence":"additional","affiliation":[{"name":"Trivedi Science Research Laboratory Pvt. Ltd.,Bhopal, India"}]}],"member":"5410","published-online":{"date-parts":[[2018,12,27]]},"reference":[{"key":"ref0","unstructured":"1.Marx J, Walls R, Hockberger R (2013) Rosen's Emergency Medicine-Concepts and Clinical Practice, Volume 2, 8th edn, Elsevier Health Sciences, US."},{"key":"ref1","unstructured":"2.Fox CL Jr. (1977) Pharmacology and clinical use of silver sulfadiazine and related topical antimicrobial agents. Pahlavi Med. J 8: 45-64."},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"3.Harrison HN (1979) Pharmacology of Sulfadiazine Silver Its Attachment to Burned Human and Rat Skin and Studies of Gastrointestinal Absorption and Extension. Arch Surg. 114: 281-285.","DOI":"10.1001\/archsurg.1979.01370270051008"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"4.Wysor MS, Zollinhofer RE (1972) On the Mode of Action of Silver Sulfadiazine. Pathobiology. 38: 296-308.","DOI":"10.1159\/000162423"},{"key":"ref4","unstructured":"5.Jasek W (2007) Austria-Codex 2 (62 ed.). Vienna:\u00d6sterreichischer Apothekerverlag."},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"6.Charles HN, James EA, Milo G (1971) Physiologic surface active agents and drug absorption VIII: Effect of bile flow on sulfadiazine absorption in the rat. J Pharm Sci. 60: 145-147.","DOI":"10.1002\/jps.2600600136"},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"7.Trivedi MK, Branton A, Trivedi D, Nayak G, Lee AC, et al. (2016) Impact of biofield energy treated herbomineral formulation (The Trivedi Effect\u00ae) on mouse dendritic and splenocyte cells for modulation of pro-inflammatory cytokines. International Journal of Immunology. 4: 35-45.","DOI":"10.11648\/j.iji.20160405.12"},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"8.Trivedi MK, Branton A, Trivedi D, Nayak G, Wellborn BD, et al. (2017) Effect of the energy of consciousness (The Trivedi Effect\u00ae) on the structural properties and isotopic abundance ratio of magnesium gluconate using LC-MS and NMR spectroscopy. Advances in Biochemistry. 5: 7-15.","DOI":"10.11648\/j.ab.20170501.12"},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"9.Trivedi MK, Branton A, Trivedi D, Nayak G, Afaganis AE, et al. (2017) An Impact of energy of consciousness (The Trivedi Effect\u00ae) on the physicochemical, thermal, structural, and behavioral properties of magnesium gluconate. Biomedical Sciences. 3: 42-54.","DOI":"10.11648\/j.bs.20170302.11"},{"key":"ref9","doi-asserted-by":"publisher","unstructured":"10.Trivedi MK, Mohan TRR (2016) Biofield energy signals, energy transmission and neutrinos. American Journal of Modern Physics. 5: 172-176.","DOI":"10.11648\/j.ajmp.20160506.12"},{"key":"ref10","doi-asserted-by":"publisher","unstructured":"11.Rubik B, Muehsam D, Hammerschlag R, Jain S (2015) Biofield science and healing: history, terminology, and concepts. Glob Adv Health Med. 4: 8-14.","DOI":"10.7453\/gahmj.2015.038.suppl"},{"key":"ref11","doi-asserted-by":"publisher","unstructured":"12.Barnes PM, Bloom B, Nahin RL (2008) Complementary and alternative medicine use among adults and children: United States,2007. Natl Health Stat Report. 12: 1-23.","DOI":"10.1037\/e623942009-001"},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"13.Koithan M (2009) Introducing complementary and alternative therapies. J Nurse Pract. 5: 18-20.","DOI":"10.1016\/j.nurpra.2008.10.012"},{"key":"ref13","doi-asserted-by":"publisher","unstructured":"14.Trivedi MK, Branton A, Trivedi D, Nayak G, Sethi KK, et al. (2016) Gas chromatography-mass spectrometry based isotopic abundance ratio analysis of biofield energy treated methyl-2-napthylether (Nerolin). American Journal of Physical Chemistry. 5: 80-86.","DOI":"10.11648\/j.ajpc.20160504.11"},{"key":"ref14","doi-asserted-by":"publisher","unstructured":"15.Trivedi MK, Branton A, Trivedi D, Nayak G, Bairwa K, et al. (2015) Spectroscopic characterization of disodium hydrogen orthophosphate and sodium nitrate after biofield treatment. J Chromatogr Sep Tech. 6: 282.","DOI":"10.4172\/2157-7064.1000282"},{"key":"ref15","doi-asserted-by":"publisher","unstructured":"16.Trivedi MK, Branton A, Trivedi D, Nayak G, Panda P, et al. (2016) Evaluation of the isotopic abundance ratio in biofield energy treated resorcinol using gas chromatography-mass spectrometry technique. Pharm Anal Acta. 7: 481.","DOI":"10.4172\/2153-2435.1000481"},{"key":"ref16","doi-asserted-by":"publisher","unstructured":"17.Trivedi MK, Tallapragada RM, Branton A, Trivedi D, Nayak G, et al. (2015) Characterization of physical and structural properties of aluminum carbide powder: Impact of biofield treatment. J Aeronaut Aerospace Eng. 4: 142.","DOI":"10.4172\/2168-9792.1000142"},{"key":"ref17","unstructured":"18.Trivedi MK, Patil S, Tallapragada RM (2013) Effect of biofield treatment on the physical and thermal characteristics of vanadium pentoxide powders. J Material Sci Eng. S 11: 001."},{"key":"ref18","doi-asserted-by":"publisher","unstructured":"19. MK, Trivedi, RM Tallapragada, A Branton, D Trivedi, G Nayak, et al. (2015) Potential impact of biofield treatment on atomic and physical characteristics of magnesium. Vitam Miner. 3: 129.","DOI":"10.4172\/2376-1318.1000129"},{"key":"ref19","doi-asserted-by":"publisher","unstructured":"20.Trivedi MK, Patil S, Shettigar H, Bairwa K, Jana S (2015) Effect of biofield treatment on spectral properties of paracetamol and piroxicam. Chem Sci. J 6: 98.","DOI":"10.4172\/2150-3494.100098"},{"key":"ref20","doi-asserted-by":"publisher","unstructured":"21.Trivedi MK, Branton A, Trivedi D, Nayak G, Charan S, et al. (2015) Phenotyping and 16S rDNA analysis after biofield treatment on Citrobacter braakii: A urinary pathogen. J Clin Med Genom. 3: 129.","DOI":"10.4172\/2332-0672.1000129"},{"key":"ref21","doi-asserted-by":"publisher","unstructured":"22.Trivedi MK, Patil S, Shettigar H, Mondal SC, Jana S (2015) Evaluation of biofield modality on viral load of Hepatitis B and C viruses. J Antivir Antiretrovir. 7: 083-088.","DOI":"10.4172\/jaa.1000123"},{"key":"ref22","doi-asserted-by":"publisher","unstructured":"23.Trivedi MK, Patil S, Shettigar H, Mondal SC, Jana S (2015) An impact of biofield treatment: Antimycobacterial susceptibility potential using BACTEC 460\/MGIT-TB System. Mycobact Dis. 5: 189.","DOI":"10.4172\/2161-1068.1000189"},{"key":"ref23","doi-asserted-by":"publisher","unstructured":"24.Kinney JP, Trivedi MK, Branton A, Trivedi D, Nayak G, et al. (2017) Overall skin health potential of the biofield energy healing based herbomineral formulation using various skin parameters. American Journal of Life Sciences. 5: 65-74.","DOI":"10.11648\/j.ajls.20170502.15"},{"key":"ref24","unstructured":"25.Singh J, Trivedi MK, Branton A, Trivedi D, Nayak G, et al. (2017) Consciousness energy healing treatment based herbomineral formulation: A safe and effective approach for skin health. American Journal of Pharmacology and Phytotherapy. 2: 1-10."},{"key":"ref25","doi-asserted-by":"publisher","unstructured":"26.Trivedi MK, Patil S, Shettigar H, Bairwa K, Jana S (2015) Phenotypic and biotypic characterization of Klebsiella oxytoca: An impact of biofield treatment. J Microb Biochem Technol. 7: 203-206.","DOI":"10.4172\/1948-5948.1000205"},{"key":"ref26","unstructured":"27.Nayak G, Altekar N (2015) Effect of biofield treatment on plant growth and adaptation. J Environ Health Sci. 1: 1-9."},{"key":"ref27","doi-asserted-by":"publisher","unstructured":"28.Anagnos D, Trivedi K, Branton A, Trivedi D, Nayak G, et al. (2018) Influence of biofield treated vitamin D3 on proliferation, differentiation, and maturation of bone-related parameters in MG-63 cell-line. International Journal of Biomedical Engineering and Clinical Science. 4: 6-14.","DOI":"10.14302\/issn.2379-7835.ijn-18-2301"},{"key":"ref28","doi-asserted-by":"publisher","unstructured":"29.Lee AC, Trivedi K, Branton A, Trivedi D, Nayak G, et al. (2018) The potential benefits of biofield energy treated vitamin D3 on bone mineralization in human bone osteosarcoma cells (MG-63). International Journal of Nutrition and Food Sciences. 7: 30-38.","DOI":"10.13188\/2469-4045.1000015"},{"key":"ref29","doi-asserted-by":"crossref","unstructured":"30.Stutheit ME, Trivedi K, Branton A, Trivedi D, Nayak G, et al. (2018) Biofield energy treated vitamin D3: Therapeutic implication on bone health using osteoblasts cells. American Journal of Life Sciences. 6: 13-21.","DOI":"10.11648\/j.ajls.20180601.13"},{"key":"ref30","doi-asserted-by":"publisher","unstructured":"31.Trivedi MK, Patil S, Shettigar H, Mondal SC, Jana S (2015) The potential impact of biofield treatment on human brain tumor cells: A time-lapse video microscopy. J Integr Oncol. 4: 141.","DOI":"10.4172\/2329-6771.1000141"},{"key":"ref31","doi-asserted-by":"publisher","unstructured":"32.Trivedi MK, Patil S, Shettigar H, Gangwar M, Jana S (2015) In vitro evaluation of biofield treatment on cancer biomarkers involved in endometrial and prostate cancer cell lines. J Cancer Sci Ther. 7: 253-257.","DOI":"10.4172\/1948-5956.1000358"},{"key":"ref32","doi-asserted-by":"publisher","unstructured":"33.Trivedi MK, Branton A, Trivedi D, Nayak G, Gangwar M, et al. (2015) Agronomic characteristics, growth analysis, and yield response of biofield treated mustard, cowpea, horse gram, and groundnuts. International Journal of Genetics and Genomics. 3: 74-80.","DOI":"10.11648\/j.ijgg.20150306.13"},{"key":"ref33","doi-asserted-by":"publisher","unstructured":"34.Trivedi MK, Branton A, Trivedi D, Nayak G, Mondal SC, et al. (2015) Evaluation of plant growth, yield and yield attributes of biofield energy treated mustard (Brassica juncea) and chick pea (Cicer arietinum) seeds. Agriculture, Forestry and Fisheries. 4: 291-295.","DOI":"10.11648\/j.aff.20150406.19"},{"key":"ref34","unstructured":"35.Desktop X-ray Diffractometer \u201cMiniFlex+\u201d. The Rigaku Journal 14: 29-36, 1997."},{"key":"ref35","doi-asserted-by":"publisher","unstructured":"36.Zhang T, Paluch K, Scalabrino G, Frankish N, Healy AM, et al. (2015) Molecular structure studies of (1S,2S)-2-benzyl-2,3-dihydro-2-(1Hinden-2-yl)- 1H- inden-1-ol. J Mol Struct. 1083: 286-299.","DOI":"10.1016\/j.molstruc.2014.12.018"},{"key":"ref36","doi-asserted-by":"publisher","unstructured":"37.Langford JI, Wilson AJC (1978) Scherrer after sixty years: A survey and some new results in the determination of crystallite size. J Appl Cryst. 11: 102-113.","DOI":"10.1107\/s0021889878012844"},{"key":"ref37","doi-asserted-by":"publisher","unstructured":"38.Trivedi MK, Sethi KK, Panda P, Jana S (2017) A comprehensive physicochemical, thermal, and spectroscopic characterization of zinc (II) chloride using X ray diffraction, particle size distribution, differential scanning calorimetry, thermogravimetric analysis\/differential thermogravimetric analysis, ultraviolet visible, and Fourier transform infrared spectroscopy. International Journal of Pharmaceutical Investigation. 7: 33-40.","DOI":"10.4103\/jphi.jphi_2_17"},{"key":"ref38","doi-asserted-by":"publisher","unstructured":"39.Trivedi MK, Sethi KK, Panda P, Jana S (2017) Physicochemical, thermal and spectroscopic characterization of sodium selenate using XRD, PSD, DSC, TGA\/DTG, UV-vis, and FT-IR. Marmara Pharmaceutical Journal. 21(2): 311-318.","DOI":"10.12991\/marupj.300796"},{"key":"ref39","doi-asserted-by":"publisher","unstructured":"40.Inoue M, Hirasawa I (2013) The relationship between crystal morphology and XRD peak intensity on CaSO4.2H2O. J Crystal Growth. 380: 169-175.","DOI":"10.1016\/j.jcrysgro.2013.06.017"},{"key":"ref40","doi-asserted-by":"crossref","unstructured":"41.Raza K, Kumar P, Ratan S, Malik R, Arora S (2014) Polymorphism: The phenomenon affecting the performance of drugs. SOJ Pharm Pharm Sci. 1: 10.","DOI":"10.15226\/2374-6866\/1\/1\/00111"},{"key":"ref41","unstructured":"42.Brittain HG (2009) Polymorphism in pharmaceutical solids in Drugs and Pharmaceutical Sciences, volume 192, 2nd Edn, Informa HealthcareUSA,Inc.,NewYork."},{"key":"ref42","doi-asserted-by":"publisher","unstructured":"43.Censi R, Martino PD (2015) Polymorph Impact on the Bioavailability and Stability of Poorly Soluble Drugs. Molecules. 20: 18759-18776.","DOI":"10.3390\/molecules201018759"},{"key":"ref43","doi-asserted-by":"publisher","unstructured":"44.Blagden N, deMatas M, Gavan PT, York P (2007) Crystal engineering of active pharmaceutical ingredients to improve solubility and dissolution rates. Adv Drug Deliv Rev. 59: 617-630.","DOI":"10.1016\/j.addr.2007.05.011"},{"key":"ref44","doi-asserted-by":"publisher","unstructured":"45.Zhao Z, Xie M, Li Y, Chen A, Li G, et al. (2015) Formation of curcumin nanoparticles via solution-enhanced dispersion by supercritical CO2. Int J Nanomedicine. 10: 3171-3181.","DOI":"10.2147\/ijn.s80434"},{"key":"ref45","doi-asserted-by":"publisher","unstructured":"46. Loh ZH, Samanta AK, Heng PWS (2015) Overview of milling techniques for improving the solubility of poorly water-soluble drugs. Asian J Pharm, 10: 255-274.","DOI":"10.1016\/j.ajps.2014.12.006"},{"key":"ref46","doi-asserted-by":"publisher","unstructured":"47.Khadkaa P, Roa J, Kim H, Kim I, Kim JT, et al. (2014) Pharmaceutical particle technologies: An approach to improve drug solubility, dissolution and bioavailability. Asian J Pharm. 9: 304-316.","DOI":"10.1016\/j.ajps.2014.05.005"},{"key":"ref47","doi-asserted-by":"publisher","unstructured":"48.Hu J, Johnston KP, Williams RO (2004) Nanoparticle engineering processes for enhancing the dissolution rates of poorly water soluble drugs. Drug Dev Ind Pharm. 30: 233-245.","DOI":"10.1081\/ddc-120030422"},{"key":"ref48","doi-asserted-by":"publisher","unstructured":"49.HuS, Li W (2018) Influence of Particle Size Distribution on Lifetime and Thermal Stability of Ostwald Ripening of Supported Particles. Chem Cat Chem. 10: 2900-2907.","DOI":"10.1002\/cctc.201800331"}],"container-title":["Journal of Advanced Pharmaceutical Science And Technology"],"original-title":[],"link":[{"URL":"https:\/\/openaccesspub.org\/japst\/article\/944","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,11,13]],"date-time":"2019-11-13T00:34:12Z","timestamp":1573605252000},"score":1,"resource":{"primary":{"URL":"https:\/\/openaccesspub.org\/japst\/article\/944"}},"subtitle":[],"editor":[{"given":"Syed Najmul","family":"Hejaz Azmi","sequence":"additional","affiliation":[{"name":"Department of Applied Sciences, Chemistry Section, Higher College of Technology, P. O. Box 74, Al-Khuwair-133, Muscat, Sultanate of Oman, Oman."}]}],"short-title":[],"issued":{"date-parts":[[2018,12,27]]},"references-count":49,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2018,12,27]]}},"URL":"https:\/\/doi.org\/10.14302\/issn.2328-0182.japst-18-2517","relation":{},"ISSN":["2328-0182"],"issn-type":[{"type":"electronic","value":"2328-0182"}],"subject":[],"published":{"date-parts":[[2018,12,27]]},"article-number":"944"}}