{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T14:12:34Z","timestamp":1753884754619,"version":"3.41.2"},"reference-count":38,"publisher":"Open Access Pub","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JHC"],"abstract":"<jats:p>Study was aimed to evaluate effect of Biofield Treated Proprietary Formulation and Biofield Treatment per se on cardiac performance on NG-nitro-L-arginine methyl ester hydrochloride (L-NAME) and high fat diet (HFD)-induced cardiovascular disorders in Sprague Dawley rats. Nine groups were assigned, in which four were preventive maintenance groups. The constituents of test formulation were divided into two parts; one section was defined as the untreated test formulation, while the other portion of the test formulation and three groups of animals received Biofield Energy Healing Treatment remotely for about 3 minutes by a renowned Biofield Energy Healer, Mr. Mahendra Kumar Trivedi. Systolic blood pressure (SBP) was significantly (p\u22640.001) decreased by 13.39%, 14.65%, 17.74%, 14.36%, and 14.69% in the G5, G6, G7, G8, and G9 groups, respectively as compared to disease control (G2) group. Diastolic blood pressure (DBP)was significantly (p\u22640.001) reduced by 25.95%, 24.41%, 30.79%, 24.67%, and 25.23% in G5, G6, G7, G8, and G9 groups, respectively than G2. Heart rate (HR) was significantly (p\u22640.05) reduced by 6.58%, 8.06%, and 6.99% in G7, G8, and G9 groups, respectively than G2. Total leucocyte count (TLC) count was increased by 12.8% and 17.45% in G5 and G8 groups, respectively than G2 group. Neutrophils and lymphocytes were increased by 60.11% (G8) and 11.49% (G5), respectively than G2. Eosinophils were reduced by 11.11%, 20%, and 15% in G6, G7, and G9 groups, respectively than G2. Total cholesterol was significantly decreased by 22.64% (p\u22640.05), 15.78%, 25.56% (p\u22640.05), 22.56%, and 34.27% in G5, G6, G7, G8, and G9 groups, respectively than G2. Triglyceride was significantly (p\u22640.001) reduced by 34.55%, 43.29%, 55.23%, 28.57%, and 37.28% in G5, G6, G7, G8, and G9 groups, respectively than G2. VLDL level was also significantly (p\u22640.001) reduced by 80.81%, 83.61%, 86.82%, 79.19%, and 81.63% in G5, G6, G7, G8, and G9 group, respectively; while LDL was reduced by 20.32% (G9) group than G2. Atherogenic index (AI) was significantly (p\u22640.001) decreased by 78.36%, 83.21%, 84.68%, 74.06%, and 72.98% in the G5, G6, G7, G8, and G9 groups, respectively than G2. The level of uric acid (UA) was significantly (p\u22640.001) decreased by 57.51%, 52.36%, 45.49%, 43.78%, and 40.77% in the G5, G6, G7, G8, and G9 groups respectively, as compared with the G2 group. Serum glutamate pyruvate transaminases (SGPT) was significantly (p\u22640.001) decreased by 45.96%, 48.01%, 37.19%, 37.69%, and 42.93% in the G5, G6, G7, G8, and G9 groups, respectively than G2. Creatine kinase myocardial band (CK-MB) level was significantly reduced by 10.19%, 21.97% (p\u22640.01), 10.47%, and 16.94% in the G5, G6, G7, and G9 groups, than G2. Overall, the data suggested significance improvement of heart-related hematology, hepatic, and lipid parameters with respect to various pathological conditions that might be beneficial various types of cardiovascular disorders. Therefore, the results showed the significant slowdown the cardiovascular disease progression and its complications\/symptoms in the preventive treatment groups viz. G6, G7, G8, and G9.<\/jats:p>","DOI":"10.14302\/issn.2329-9487.jhc-21-3848","type":"journal-article","created":{"date-parts":[[2021,7,31]],"date-time":"2021-07-31T09:53:30Z","timestamp":1627725210000},"page":"6-19","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of Cardiac Performance after Treatment with the Biofield Energy Treated Proprietary Test Formulation on L-NAME and High Fat Diet-Induced Cardiovascular Disorders in Sprague Dawley Rats"],"prefix":"10.14302","volume":"3","author":[{"given":"Mahendra Kumar","family":"Trivedi","sequence":"first","affiliation":[{"name":"Trivedi Global, Inc., Henderson, USA."}]},{"given":"Alice","family":"Branton","sequence":"additional","affiliation":[{"name":"Trivedi Global, Inc., Henderson, USA."}]},{"given":"Dahryn","family":"Trivedi","sequence":"additional","affiliation":[{"name":"Trivedi Global, Inc., Henderson, USA."}]}],"member":"5410","published-online":{"date-parts":[[2021,7,17]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"1.Wu C Y, Hu H Y, Chou Y J, Huang N, Chou Y C et al. (2015) . High Blood Pressure and All-Cause and Cardiovascular Disease Mortalities in Community-Dwelling Older Adults. Medicine , (Baltimore) 94(47), 2160.","DOI":"10.1097\/md.0000000000002160"},{"key":"ref1","doi-asserted-by":"publisher","unstructured":"2.Tampa M, Sarbu M I, Mitran M I, Mitran C I, Matei C et al. (2018) The pathophysiological mechanisms and the quest for biomarkers in psoriasis, a stress-related skin disease. Dis Markers. 5823684.","DOI":"10.1155\/2018\/5823684"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"3.McEwen B S. (2015) Biomarkers for assessing population and individual health and disease related to stress and adaptation. , Metabolism 64, 2-10.","DOI":"10.1016\/j.metabol.2014.10.029"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"4.Marco-Ramell A, de Almeida AM, Cristobal S, Rodrigues P, Roncada P. (2016) Bassols A. , Mol Biosyst 12, 2024-2035.","DOI":"10.1039\/c5mb00788g"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"5.Unato A K, Pontes W M, De Souza DMSD, Prazeres J, Marcucci-Barbosa L S et al. (2018) Strength training session induces important changes on physiological, immunological, and inflammatory biomarkers. , J Immunol Res 9675216.","DOI":"10.1155\/2018\/9675216"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"6.Hefnawy A, MAY Helal, Sabek A, Shousha S. (2018) Clinical, behavioral and biochemical alterations due to shearing stress in Ossimi sheep. , J Vet Med Sci 80, 1281-1286.","DOI":"10.1292\/jvms.18-0150"},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"7.Chacko S, Haseeb S, Glover B M, Wallbridge D, Harper A. (2018) The role of biomarkers in the diagnosis and risk stratification of acute coronary syndrome. , Future Sci OA 4, 251.","DOI":"10.4155\/fsoa-2017-0036"},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"8.Avci Eyup, Dolapoglu A, Didar E A. (2018) Role of Cholesterol as a Risk Factor in Cardiovascular Diseases, Cholesterol - Good, Bad and the Heart,MadanL.Nagpal,IntechOpen,DOI: 10.5772\/intechopen.76357. Available from:https:\/\/www.intechopen.com\/books\/cholesterol-good-bad-and-the-heart\/role-of-cholesterol-as-a-risk-factor-in-cardiovascular-diseases.","DOI":"10.5772\/intechopen.76357"},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"9.Cai G, Shi G, Xue S, Lu W. (2017) The atherogenic index of plasma is a strong and independent predictor for coronary artery disease in the Chinese Han population. , Medicine (Baltimore) 96(37), 8058.","DOI":"10.1097\/md.0000000000008058"},{"key":"ref9","doi-asserted-by":"publisher","unstructured":"10.Carvalho G, Rassi S. (2016) The Prognostic Value of CK-MB in Acute Myocardial Infarction in Developing Countries: A Descriptive Study. , Angiol 4, 183.","DOI":"10.4172\/2329-9495.1000183"},{"key":"ref10","doi-asserted-by":"publisher","unstructured":"11.Byrne J H, Voogt M, Turner K M, Eyles D W, McGrath J J et al. (2013) The impact of adult vitamin D deficiency on behaviour and brain function in male Sprague-Dawley rats. , PLoS One 8(8), 71593.","DOI":"10.1371\/journal.pone.0071593"},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"12.Rayman M P. (2000) The importance of selenium to human health. , Lancet 356, 233-241.","DOI":"10.1016\/S0140-6736(00)02490-9"},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"13.Beard J L, Connor J R. (2003) Iron status and neural functioning. , Ann Rev Nutr 23, 41-58.","DOI":"10.1146\/annurev.nutr.23.020102.075739"},{"key":"ref13","doi-asserted-by":"publisher","unstructured":"14.Peres F F, Lima A C, JEC Hallak, Crippa J A, Silva R H.Ab\u00edlio VC (2018) Cannabidiol as a Promising Strategy to Treat and Prevent Movement Disorders? Front Pharmacol 9:. 482.","DOI":"10.3389\/fphar.2018.00482"},{"key":"ref14","doi-asserted-by":"publisher","unstructured":"15.Nagarkatti P, Pandey R, Rieder S A, Hegde V L, Nagarkatti M. (2009) Cannabinoids as novel anti-inflammatory drugs. , Future Med Chem 1(7), 1333-1349.","DOI":"10.4155\/fmc.09.93"},{"key":"ref15","doi-asserted-by":"publisher","unstructured":"16.Kang S, Min H. (2012) Ginseng, the 'Immunity Boost': The effects ofPanax ginsengon immune system. , J Ginseng Res 36(4), 354-368.","DOI":"10.5142\/jgr.2012.36.4.354"},{"key":"ref16","doi-asserted-by":"publisher","unstructured":"17.Maizes V, Rakel D, Niemiec C. (2009) Integrative medicine and patient-centered care. , Explore (NY) 5(5), 277-289.","DOI":"10.1016\/j.explore.2009.06.008"},{"key":"ref17","doi-asserted-by":"publisher","unstructured":"18.Bischof M, Del Giudice E. (2013) Communication and the emergence of collective behavior in living organisms: a quantum approach. Mol Biol Int. 987549.","DOI":"10.1155\/2013\/987549"},{"key":"ref18","doi-asserted-by":"crossref","unstructured":"19.Cassidy C M. (2004) What does it mean to practice an energy medicine?. , J Altern Complement Med 10(1), 79-81.","DOI":"10.1089\/107555304322848986"},{"key":"ref19","doi-asserted-by":"publisher","unstructured":"20.Barnes P M, Bloom B, Nahin R L. (2008) Complementary and alternative medicine use among adults and children: United States. , Natl Health Stat Report 12, 1-23.","DOI":"10.1037\/e623942009-001"},{"key":"ref20","unstructured":"21.Fan K wai. (2005) National Center for Complementary and Alternative Medicine Website. , J Med Libr Assoc 93, 410-412."},{"key":"ref21","unstructured":"22.Wisneski L, Anderson L. (2009) The Scientific Basis of Integrative Medicine. , Boca Raton, FL: 205."},{"key":"ref22","doi-asserted-by":"crossref","unstructured":"23.Trivedi M K, Branton A, Trivedi D, Jana S. (2021) Isotopic abundance ratio analysis of consciousness energy healing treated folic acid. , Food Nutr Current Res 4(2), 290-295.","DOI":"10.14302\/issn.2576-6694.jbbs-21-3773"},{"key":"ref23","doi-asserted-by":"publisher","unstructured":"24.Trivedi M K, Branton A, Trivedi D, Nayak G, Mondal S C et al. (2015) Morphological characterization, quality, yield and DNA fingerprinting of biofield energy treated alphonso mango (Mangifera indicaL.). , Journal of Food and Nutrition Sciences 3, 245-250.","DOI":"10.11648\/j.jfns.20150306.18"},{"key":"ref24","doi-asserted-by":"publisher","unstructured":"25.Trivedi M K, Jana.S (2019)In vitroassessment of the biofield treated test item on cardiac function using rat cardiomyocytes cell line (H9c2)viamultiparametric analysis. , Journal of Hypertension and Cardiology 2(4), 1-12.","DOI":"10.14302\/issn.2329-9487.jhc-19-2582"},{"key":"ref25","doi-asserted-by":"crossref","unstructured":"26.Trivedi M K, Branton A, Trivedi D, Jana S. (2021) Effect of consciousness energy healing treatment on the metal profile and properties of tellurium. , Eng Technol Open Acc 3(5), 555623.","DOI":"10.19080\/ETOAJ.2021.03.555623"},{"key":"ref26","unstructured":"27.Mahendra K T, Alice B, Dahryn T, Snehasis J. (2021) Consciousness energy healing treatment impacted the isotopic abundance ratio of 6-Mercaptopurine (6-MP). Nov Appro Drug Des Dev. 5(5), 555673."},{"key":"ref27","doi-asserted-by":"publisher","unstructured":"28.Trivedi M K, Jana S. (2021) Anti-aging activity of biofield energy treated novel proprietary test formulation by assessment of vital biomarkers in cerebrospinal fluid (CSF) in Sprague Dawley rats. , On J Neur & Br Disord 5(2), 2021-000210.","DOI":"10.23880\/aabsc-16000163"},{"key":"ref28","unstructured":"29.Trivedi M K, Jana S. (2021) Evaluation of biofield energy healing treatment based proprietary test formulation on gut health potential in colon cancer cell line (HT-29). , J Pharmacol Clin Res 8(4), 555743."},{"key":"ref29","unstructured":"30.Trivedi M K, Branton A, Trivedi D, Jana S. (2020) The consciousness energy healing treatment and its impact on the isotopic abundance ratio analysis of flutamide. , Drug Des Int Prop Int J 3(5)."},{"key":"ref30","doi-asserted-by":"publisher","unstructured":"31.Bailey S A, Zidell R H, Perry R W. (2004) Relationships between organ weight and body\/brain weight in the rat: what is the best analytical endpoint?. , Toxicol Pathol 32, 448-466.","DOI":"10.1080\/01926230490465874"},{"key":"ref31","doi-asserted-by":"crossref","unstructured":"32.Balakrishnan K, Adams L E. (1995) The role of the lymphocyte in an immune response. , Immunol Invest 24, 233-244.","DOI":"10.3109\/08820139509062775"},{"key":"ref32","doi-asserted-by":"publisher","unstructured":"33.Bunglavan S J, Garg A K, Dass R S, Shrivastava S. (2014) Effect of supplementation of different levels of selenium as nanoparticles\/sodium selenite on blood biochemical profile and humoral immunity in male wistar rats. , Vet World 7, 1075-1081.","DOI":"10.14202\/vetworld.2014.1075-1081"},{"key":"ref33","doi-asserted-by":"publisher","unstructured":"34.Fox C, Ramsoomair D, Carter C. (2001) Magnesium: its proven and potential clinical significance. , South Med J 94, 1195-1201.","DOI":"10.1097\/00007611-200194120-00014"},{"key":"ref34","doi-asserted-by":"publisher","unstructured":"35.Payahoo L, Ostadrahimi A, Mobasseri M, Bishak Y K, Farrin N et al. (2013) Effects of zinc supplementation on the anthropometric measurements, lipid profiles and fasting blood glucose in the healthy obese adults. , Adv Pharm Bull 3, 161-165.","DOI":"10.5414\/tex01307"},{"key":"ref35","doi-asserted-by":"publisher","unstructured":"36.Sidhu P, Garg M L, Dhawan D K. (2005) Protective effects of zinc on oxidative stress enzymes in liver of protein-deficient rats. , Drug Chem Toxicol 28, 211-230.","DOI":"10.1081\/dct-52551"},{"key":"ref36","doi-asserted-by":"publisher","unstructured":"37.El-Boshy M E, Risha E F, Abdelhamid F M, Mubarak M S, Hadda T B. (2015) Protective effects of selenium against cadmium induced hematological disturbances, immunosuppressive, oxidative stress and hepatorenal damage in rats. , J Trace Elem Med Biol 29, 104-110.","DOI":"10.1016\/j.jtemb.2014.05.009"},{"key":"ref37","unstructured":"38.Karandish M, Tamimi M, Shayesteh A A, Haghighizadeh M H, Jalali M T. (2013) The effect of magnesium supplementation and weight loss on liver enzymes in patients with nonalcoholic fatty liver disease. , J Res Med Sci 18, 573-579."}],"container-title":["Journal Of Hypertension And Cardiology"],"original-title":[],"link":[{"URL":"https:\/\/openaccesspub.org\/jhc\/article\/1664","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,31]],"date-time":"2021-07-31T09:53:48Z","timestamp":1627725228000},"score":1,"resource":{"primary":{"URL":"https:\/\/openaccesspub.org\/jhc\/article\/1664"}},"subtitle":[],"editor":[{"given":"Snehasis","family":"Jana","sequence":"additional","affiliation":[{"name":"Trivedi Science Research Laboratory Pvt. Ltd., Thane (W), Maharashtra, India."}]}],"short-title":[],"issued":{"date-parts":[[2021,7,17]]},"references-count":38,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2021,3,11]]}},"URL":"https:\/\/doi.org\/10.14302\/issn.2329-9487.jhc-21-3848","relation":{},"ISSN":["2329-9487"],"issn-type":[{"type":"electronic","value":"2329-9487"}],"subject":[],"published":{"date-parts":[[2021,7,17]]},"article-number":"1664"}}