{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:36:23Z","timestamp":1760189783171,"version":"3.41.2"},"reference-count":46,"publisher":"Open Access Pub","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAN"],"abstract":"<jats:p>Cholecalciferol (vitamin D3) is used nowadays in nutraceuticals regarding the prevention and treatment of vitamin D deficiency and associated diseases. This study was done to analyse the effect of the Trivedi Effect\u00ae - Energy of Consciousness Treatment on the physicochemical, thermal, and spectral properties of cholecalciferol using PSA, PXRD, DSC, TGA\/DTG, FT-IR, and UV-Vis analysis. For this study, the cholecalciferol sample was divided into control\/ untreated and Biofield Energy Treated vitamin D3. The treated vitamin D3 sample received Biofield Energy Treatment (the Trivedi Effect\u00ae) remotely for ~3 minutes by Mr. Mahendra Kumar Trivedi, who was located in the USA, while the test samples were located in the research laboratory in India. The treated sample was designated as the Biofield Energy Treated sample. The PSA analysis showed that the particle size values at d10, d50, d90, and D(4, 3) of the treated sample were significantly decreased by 5.80%, 16.49%, 17.52%, and 16.23%, respectively compared to the control sample. However, the specific surface area of the treated cholecalciferol was significantly increased by 7.26% compared to the control sample. Besides, the PXRD analysis revealed that the relative intensities regarding the characteristic diffraction peaks in the treated sample were significantly altered from -42.56% to 22.42%, along with -41.69% to 72.71% alterations in the crystallite sizes, compared with the control sample. Also, the treated sample showed 2.80% decrease in the average crystallite size. The DSC analysis showed a slight increase (0.24%) in the melting point of the treated sample along with 3.68% increase in the latent heat of fusion (\u0394H) compared to the control sample. Also, the decomposition temperature of the treated sample was decreased by 0.29%, whereas the \u0394H was increased by 5.79%, compared to the control sample. Moreover, the TGA\/DTG analysis revealed the significant decrease in weight loss in the 1st and 3rd step of degradation of the treated sample by 18.58% and 89.81%, respectively, along with 1.83% increase in the maximum thermal degradation temperature compared with the control sample. Overall, the thermal stability of the treated cholecalciferol sample was observed to be increased in comparison to the control sample. Thus, the Trivedi Effect\u00ae might be used to produce a different polymorph of cholecalciferol, which possesses the improved qualities in terms of appearance, dissolution, absorption, bioavailability, and thermal stability as compared with the untreated sample. Thus, the Biofield Energy Treated cholecalciferol might be used in designing of better nutraceutical and pharmaceutical formulations possessing improved therapeutic response regarding the treatment of vitamin D deficiency associated diseases.<\/jats:p>","DOI":"10.14302\/issn.2689-2855.jan-21-3745","type":"journal-article","created":{"date-parts":[[2021,5,4]],"date-time":"2021-05-04T04:55:45Z","timestamp":1620104145000},"page":"56-73","source":"Crossref","is-referenced-by-count":3,"title":["Assessment of Physical, Thermal and Spectral Properties of Consciousness Energy Treated Cholecalciferol"],"prefix":"10.14302","volume":"1","author":[{"given":"Mahendra Kumar","family":"Trivedi","sequence":"first","affiliation":[{"name":"Trivedi Global, Inc., Henderson, Nevada, USA"}]},{"given":"Snehasis","family":"Jana","sequence":"additional","affiliation":[{"name":"Trivedi Science Research Laboratory Pvt. Ltd., Thane (W), India"}]}],"member":"5410","published-online":{"date-parts":[[2021,2,15]]},"reference":[{"key":"ref0","doi-asserted-by":"crossref","unstructured":"1.Sunyecz J A. (2008) The use of calcium and vitamin D in the management of osteoporosis. , Ther Clin Risk Manag 4, 827-836.","DOI":"10.2147\/TCRM.S3552"},{"key":"ref1","doi-asserted-by":"crossref","unstructured":"2.Heaney R P. (2005) The vitamin D requirement in health and disease. , J Steroid Biochem Mol Biol 97, 13-19.","DOI":"10.1016\/j.jsbmb.2005.06.020"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"3.Bikle D D. (2012) Vitamin D and Bone. , Curr Osteoporos Rep 10, 151-159.","DOI":"10.1007\/s11914-012-0098-z"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"4.Adams J S, Modlin R L, Diz M M, Barnes P F. (1989) Potentiation of the macrophage 25-hydroxyvitamin D-1-hydroxylation reaction by human tuberculous pleural effusion fluid. , J Clin Endocrinol Metab 69, 457-460.","DOI":"10.1210\/jcem-69-2-457"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"5.Holick M F. (2004) Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. , Am J Clin Nutr 80, 1678-1688.","DOI":"10.1093\/ajcn\/80.6.1678s"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"6.Institute of Medicine (1997) Dietary reference intakes for calcium, phosphorus, magnesium, vitamin D, and fluoride. National Academy of Sciences. , Washington, DC","DOI":"10.17226\/5776"},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"7.Bikle D D. (2014) Vitamin D metabolism, mechanism of action, and clinical applications. , Chemistry & biology 21, 319-329.","DOI":"10.1016\/j.chembiol.2013.12.016"},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"8.Aloia J F, Patel M, Dimaano R, Li-Ng M, Talwar S A et al. (2008) Vitamin D intake to attain a desired serum 25-hydroxyvitamin D concentration. , Am J Clin Nutr 87, 1952-1958.","DOI":"10.1093\/ajcn\/87.6.1952"},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"9.Holick M F. (2007) Vitamin D deficiency. , N Engl J Med 357, 266-281.","DOI":"10.1056\/NEJMra070553"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"10.Bachrach S, Fisher J, Parks J S. (1979) An outbreak of vitamin D deficiency rickets in a susceptible population. , Pediatrics 64, 871-877.","DOI":"10.1542\/peds.64.6.871"},{"key":"ref10","doi-asserted-by":"publisher","unstructured":"11.Koshy K T, Beyer W F. (1984) . Vitamin D3(Cholecalciferol) in Analytical Profiles of Drug Substances, Florey K (Ed.) , Orlando, USA 13, 656-707.","DOI":"10.1016\/s0099-5428(08)60205-1"},{"key":"ref11","unstructured":"12.Collins E D, Norman A W. (2001) . Vitamin D in Handbook of Vitamins, 3rdEdn., Rucker RB, Suttie JW, McCormick DB, Machlin LJ , New York 51-114."},{"key":"ref12","unstructured":"13.Chereson R. (2009) Bioavailability, bioequivalence, and drug selection. In: Makoid CM, Vuchetich PJ, Banakar UV (Eds) Basic pharmacokinetics (1stEdn). , London"},{"key":"ref13","doi-asserted-by":"publisher","unstructured":"14.Hammerschlag R, Levin M, McCraty R, Bat N, Ives J A et al. (2015) Biofield Physiology: A Framework for an Emerging Discipline. , Glob Adv Health Med 4, 35-41.","DOI":"10.7453\/gahmj.2015.015.suppl"},{"key":"ref14","doi-asserted-by":"publisher","unstructured":"15.Trivedi M K, TRR Mohan. (2016) Biofield energy signals, energy transmission and neutrinos. , American Journal of Modern Physics 5, 172-176.","DOI":"10.11648\/j.ajmp.20160506.12"},{"key":"ref15","doi-asserted-by":"publisher","unstructured":"16.Warber S L, Cornelio D, Straughn J, Kile G. (2004) Biofield energy healing from the inside. , J Altern Complement Med 10, 1107-1113.","DOI":"10.1089\/acm.2004.10.1107"},{"key":"ref16","doi-asserted-by":"publisher","unstructured":"17.Rubik B, Muehsam D, Hammerschlag R, Jain S. (2015) Biofield science and healing: history, terminology, and concepts. , Glob Adv Health Med 4, 8-14.","DOI":"10.7453\/gahmj.2015.038.suppl"},{"key":"ref17","doi-asserted-by":"publisher","unstructured":"18.Barnes P M, Bloom B, Nahin R L. (2008) Complementary and alternative medicine use among adults and children: United States. , Natl Health Stat Report 12, 1-23.","DOI":"10.1037\/e623942009-001"},{"key":"ref18","doi-asserted-by":"publisher","unstructured":"19.Trivedi M K, Tallapragada R M, Branton A, Trivedi D, Nayak G et al. (2015) The potential impact of biofield energy treatment on the atomic and physical properties of antimony tin oxide nanopowder. , American Journal of Optics and Photonics 3, 123-128.","DOI":"10.4172\/2169-0022.1000198"},{"key":"ref19","doi-asserted-by":"publisher","unstructured":"20.Trivedi M K, Tallapragada R M, Branton A, Trivedi D, Nayak G et al. (2015) Physical, atomic and thermal Properties of Biofield Treated Lithium Powder. , J Adv Chem Eng 5, 136.","DOI":"10.4172\/2169-0316.1000177"},{"key":"ref20","doi-asserted-by":"publisher","unstructured":"21.Trivedi M K, Tallapragada R M, Branton A, Trivedi D, Nayak G et al. (2015) Characterization of physical and structural properties of aluminium carbide powder: Impact of biofield treatment. , J Aeronaut Aerospace Eng 4, 142.","DOI":"10.4172\/2168-9792.1000142"},{"key":"ref21","doi-asserted-by":"publisher","unstructured":"22.Trivedi M K, Branton A, Trivedi D, Shettigar H, Bairwa K et al. (2015) Fourier transform infrared and ultraviolet-visible spectroscopic characterization of biofield treated salicylic acid and sparfloxacin. , Nat Prod Chem Res 3, 186.","DOI":"10.4172\/2329-6836.1000186"},{"key":"ref22","unstructured":"23.Trivedi M K, Patil S, Shettigar H, Bairwa K, Jana S. (2015) Effect of biofield treatment on spectral properties of paracetamol and piroxicam. , ChemSci J 6, 98."},{"key":"ref23","doi-asserted-by":"publisher","unstructured":"24.Trivedi M K, Branton A, Trivedi D, Nayak G, Balmer A J et al. (2017) Study of the energy of consciousness healing treatment on physical, structural, thermal, and behavioral properties of zinc chloride. , Modern Chemistry 5, 19-28.","DOI":"10.11648\/j.mc.20170502.11"},{"key":"ref24","doi-asserted-by":"publisher","unstructured":"25.Trivedi M K, Branton A, Trivedi D, Nayak G, Wellborn B D et al. (2017) Characterization of physicochemical, thermal, structural, and behavioral properties of magnesium gluconate after treatment with the Energy of Consciousness. , International Journal of Pharmacy and Chemistry 3, 1-12.","DOI":"10.11648\/j.ijpc.20170301.11"},{"key":"ref25","doi-asserted-by":"publisher","unstructured":"26.Trivedi M K, Branton A, Trivedi D, Nayak G, Bairwa K et al. (2015) Physicochemical and spectroscopic characteristics of biofield treatedp-chlorobenzophenone. , American Journal of Physical Chemistry 4, 48-57.","DOI":"10.4172\/2380-2391.1000162"},{"key":"ref26","doi-asserted-by":"publisher","unstructured":"27.Trivedi M K, Branton A, Trivedi D, Nayak G, Bairwa K et al. (2015) Physical, thermal and spectroscopical characterization of biofield treated triphenylmethane: An impact of biofield treatment. , J Chromatogr Sep Tech 6, 292.","DOI":"10.4172\/2157-7064.1000292"},{"key":"ref27","doi-asserted-by":"publisher","unstructured":"28.Dodon J, Trivedi M K, Branton A, Trivedi D, Nayak G et al. (2017) The study of biofield energy treatment based herbomineral formulation in skin health and function. , American Journal of BioScience 5, 42-53.","DOI":"10.11648\/j.ajbio.20170503.12"},{"key":"ref28","doi-asserted-by":"publisher","unstructured":"29.Kinney J P, Trivedi M K, Branton A, Trivedi D, Nayak G et al. (2017) Overall skin health potential of the biofield energy healing based herbomineral formulation using various skin parameters. , American Journal of Life Sciences 5, 65-74.","DOI":"10.11648\/j.ajls.20170502.15"},{"key":"ref29","doi-asserted-by":"publisher","unstructured":"30.Trivedi M K, Branton A, Trivedi D, Nayak G, Mondal S C et al. (2015) Evaluation of biochemical marker - glutathione and DNA fingerprinting of biofield energy treatedOryza sativa. , American Journal of BioScience 3, 243-248.","DOI":"10.11648\/j.ajbio.20150306.16"},{"key":"ref30","doi-asserted-by":"publisher","unstructured":"31.Trivedi M K, Branton A, Trivedi D, Nayak G, Gangwar M et al. (2016) Molecular analysis of biofield treated eggplant and watermelon crops. , Adv Crop Sci Tech 4, 208.","DOI":"10.4172\/2329-8863.1000208"},{"key":"ref31","doi-asserted-by":"publisher","unstructured":"32.Trivedi M K, Branton A, Trivedi D, Nayak G, Mondal S C et al. (2015) Effect of Biofield treated energized water on the growth and health status in chicken (Gallusgallusdomesticus). , Poult Fish WildlSci 3, 140.","DOI":"10.4172\/2375-446x.1000140"},{"key":"ref32","unstructured":"33.Trivedi M K, Branton A, Trivedi D, Nayak G, Plikerd W D et al. (2017) A systematic study of the biofield energy healing treatment on physicochemical, thermal, structural, and behavioral properties of iron sulphate. , International Journal of Bioorganic Chemistry 2, 135-145."},{"key":"ref33","doi-asserted-by":"publisher","unstructured":"34.Suresh S, Karthikeyan S, Jayamoorthy K. (2016) FTIR and multivariate analysis to study the effect of bulk and nano copper oxide on peanut plant leaves. , Journal of Science: Advanced Materials and Devices 1(3), 343-350.","DOI":"10.1016\/j.jsamd.2016.08.004"},{"key":"ref34","doi-asserted-by":"publisher","unstructured":"35.Suresh S, Karthikeyan S, Jayamoorthy K. (2016) Effect of bulk and nano-Fe2O3 particles on peanut plant leaves studied by Fourier transform infrared spectral studies. , Journal of Advanced Research 7(5), 739-747.","DOI":"10.1016\/j.jare.2015.10.002"},{"key":"ref35","doi-asserted-by":"publisher","unstructured":"36.Suresh S, Jayamoorthy K, Karthikeyan S. (2018) Switch-on fluorescence of 5-amino-2- mercapto benzimidazole by Mn3O4nanoparticles: Experimental and theoretical approach. , Journal of Luminescence 198, 28-33.","DOI":"10.1016\/j.jlumin.2018.02.005"},{"key":"ref36","doi-asserted-by":"publisher","unstructured":"37.Jayabharathi J, Thanikachalam V, Kalaiarasi V, Jayamoorthy K. (2014) Enhancing photoluminescent behavior of 2-(naphthalen-1-yl)-1,4,5-triphenyl-1Himidazole by ZnO and Bi2O3, Spectrochim.Acta Part A. 118, 182-186.","DOI":"10.1016\/j.saa.2013.08.098"},{"key":"ref37","doi-asserted-by":"publisher","unstructured":"38.Zhao Z, Xie M, Li Y, Chen A, Li G et al. (2015) Formation of curcumin nanoparticlesviasolution enhanced dispersion by supercritical CO2. , Int J Nanomedicine 10, 3171-3181.","DOI":"10.2147\/ijn.s80434"},{"key":"ref38","unstructured":"39.Raza K, Kumar P, Ratan S, Malik R, Arora S. (2014) Polymorphism: The phenomenon affecting the performance of drugs. , SOJ Pharm Pharm Sci 1, 10."},{"key":"ref39","unstructured":"40.Brittain H G. (2009) Polymorphism in pharmaceutical solids. in Drugs and Pharmaceutical Sciences. (2ndEdn) Informa Healthcare , New York ."},{"key":"ref40","doi-asserted-by":"publisher","unstructured":"41.Mosharrof M, Nystrom C. (1995) The effect of particle size and shape on the surface specific dissolution rate of microsized practically insoluble drugs. , Int J Pharm 122, 35-47.","DOI":"10.1016\/0378-5173(95)00033-f"},{"key":"ref41","unstructured":"42.Chereson R. (2009) Bioavailability, bioequivalence, and drug selection. In: Makoid CM, Vuchetich PJ, Banakar UV (Eds) Basic pharmacokinetics (1stEdn). , London"},{"key":"ref42","doi-asserted-by":"publisher","unstructured":"43.Koshy K T, Beyer W F. (1984) Vitamin D3(Cholecalciferol) in Analytical Profiles of Drug Substances. , Orlando, USA, Florey K (Ed.), Vol 13, 656-707.","DOI":"10.1016\/s0099-5428(08)60205-1"},{"key":"ref43","doi-asserted-by":"publisher","unstructured":"44.Berthomieu C, Hienerwadel R. (2009) Fourier transform infrared (FTIR) spectroscopy. , Photosynth Res 101, 157-170.","DOI":"10.1007\/s11120-009-9439-x"},{"key":"ref44","doi-asserted-by":"publisher","unstructured":"45.Karunakaran C, Jayabharathi J, Sathishkumar R, Jayamoorthy K. (2013) Interaction of fluorescent sensor with superparamagnetic iron oxide nanoparticles. Spectrochim.Acta Part A:. 110, 151-156.","DOI":"10.1016\/j.saa.2013.03.042"},{"key":"ref45","doi-asserted-by":"publisher","unstructured":"46.M F S\u00e1nchez Rojas J. (2005) Cano Pav\u00f3n. in Encyclopedia of Analytical Science (Second Edition) Spectrophotometry, biochemical applications .","DOI":"10.1016\/b0-12-369397-7\/00722-6"}],"container-title":["Journal of Advances in Nanotechnology"],"original-title":[],"link":[{"URL":"https:\/\/openaccesspub.org\/jan\/article\/1585","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,26]],"date-time":"2022-12-26T08:33:06Z","timestamp":1672043586000},"score":1,"resource":{"primary":{"URL":"https:\/\/openaccesspub.org\/jan\/article\/1585"}},"subtitle":[],"editor":[{"given":"Adeshina","family":"Adekeye","sequence":"additional","affiliation":[{"name":"Nigeria"}]}],"short-title":[],"issued":{"date-parts":[[2021,2,15]]},"references-count":46,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2020,4,22]]}},"URL":"https:\/\/doi.org\/10.14302\/issn.2689-2855.jan-21-3745","relation":{},"ISSN":["2689-2855"],"issn-type":[{"type":"electronic","value":"2689-2855"}],"subject":[],"published":{"date-parts":[[2021,2,15]]},"article-number":"1585"}}