{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T15:29:31Z","timestamp":1786548571062,"version":"build-2736575974"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Am J Gastroenterol"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:sec>\n                    <jats:title>Abstract:<\/jats:title>\n                    <jats:p>Functional dyspepsia (FD) is subdivided into epigastric pain syndrome and postprandial distress syndrome according to the Rome IV consensus. Based on the assumption that disordered gastric motility is a key pathophysiologic factor in postprandial distress syndrome, prokinetic agents are often proposed as the treatment of choice for this subgroup. Although a meta-analysis suggests that prokinetic agents may be efficacious and safe in FD, there is a lack of widely available agents of proven efficacy. This review analyzes some of the difficulties and challenges in establishing therapeutic efficacy of prokinetic drugs in FD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.14309\/ajg.0000000000000072","type":"journal-article","created":{"date-parts":[[2019,1,29]],"date-time":"2019-01-29T20:21:32Z","timestamp":1548793292000},"page":"204-206","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":23,"title":["The Unfulfilled Promise of Prokinetics for Functional Dyspepsia\/Postprandial Distress Syndrome"],"prefix":"10.14309","volume":"114","author":[{"given":"Jan","family":"Tack","sequence":"first","affiliation":[{"name":"Translational Research Center for Gastrointestinal Diseases (TARGID), University of Leuven, Leuven, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Van den Houte","sequence":"additional","affiliation":[{"name":"Translational Research Center for Gastrointestinal 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