{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T15:01:51Z","timestamp":1786546911777,"version":"build-2736575974"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Am J Gastroenterol"],"published-print":{"date-parts":[[2024,3]]},"abstract":"\n INTRODUCTION:<\/jats:title>\n Convenient and objective noninvasive tools to monitor therapy response in patients with ulcerative colitis (UC) are needed. This study aimed to evaluate the performance of the Endoscopic Healing Index [EHI], a serum test originally developed to monitor mucosal inflammation in Crohn's disease, in patients with UC.<\/jats:p>\n <\/jats:sec>\n \n METHODS:<\/jats:title>\n Serum samples paired with endoscopic data from consecutive adult patients with UC initiating advanced therapy for active disease (Mayo Endoscopic Subscore [MES] > 1) were analyzed. EHI values were compared between groups showing endoscopic improvement, remission, and nonresponse, defined, respectively, as MES of \u22641, 0 and >1. We also assessed the association of EHI with longitudinal changes of MES and compared its performance with that of fecal calprotectin (FC) and C-reactive protein.<\/jats:p>\n <\/jats:sec>\n \n RESULTS:<\/jats:title>\n \n A total of 127 patients provided 303 samples. Median EHI increased significantly with increasing MES score (\n P<\/jats:italic>\n < 0.001). Median EHI was significantly lower in patients with endoscopic remission or improvement compared with patients with no response (\n P<\/jats:italic>\n < 0.001,\n P<\/jats:italic>\n < 0.001, respectively). A 10-point decrease in EHI was associated with 89% higher odds of 1-point decrease in MES (\n P<\/jats:italic>\n < 0.001). EHI detected MES 0\u20131 with an area under the receiver operating curve of 77.8%, which was comparable with that of FC and C-reactive protein (85.0% [\n P<\/jats:italic>\n = 0.076] and 70.6% [\n P<\/jats:italic>\n = 0.055], respectively).\n <\/jats:p>\n <\/jats:sec>\n \n DISCUSSION:<\/jats:title>\n EHI values are significantly responsive to changes in mucosal inflammation, also in patients with UC, and can confirm and\/or rule out mucosal inflammation with an almost similar accuracy to that of FC.<\/jats:p>\n <\/jats:sec>","DOI":"10.14309\/ajg.0000000000002518","type":"journal-article","created":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T08:01:27Z","timestamp":1695801687000},"page":"477-485","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["Utility of the Serum-Based Endoscopic Healing Index in Monitoring Therapeutic Response in Ulcerative Colitis"],"prefix":"10.14309","volume":"119","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6795-6328","authenticated-orcid":false,"given":"Dahham","family":"Alsoud","sequence":"first","affiliation":[{"name":"Translational Research in Gastrointestinal Disorders, Department of Chronic Diseases and Metabolism, KU Leuven, Leuven, Belgium;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-8192-6800","authenticated-orcid":false,"given":"Jessica","family":"Ho","sequence":"additional","affiliation":[{"name":"Prometheus Laboratories Inc, San Diego, California, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o","family":"Sabino","sequence":"additional","affiliation":[{"name":"Translational Research in Gastrointestinal Disorders, Department of Chronic Diseases and Metabolism, KU Leuven, Leuven, Belgium;"},{"name":"Department of Gastroenterology and Hepatology, University Hospitals Leuven, Leuven, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Ferrante","sequence":"additional","affiliation":[{"name":"Translational Research in Gastrointestinal Disorders, Department of Chronic Diseases and Metabolism, KU Leuven, Leuven, Belgium;"},{"name":"Department of Gastroenterology and Hepatology, University Hospitals Leuven, Leuven, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9verine","family":"Vermeire","sequence":"additional","affiliation":[{"name":"Translational Research in Gastrointestinal Disorders, Department of Chronic Diseases and Metabolism, KU Leuven, Leuven, Belgium;"},{"name":"Department of Gastroenterology and Hepatology, University Hospitals Leuven, Leuven, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3898-7093","authenticated-orcid":false,"given":"Bram","family":"Verstockt","sequence":"additional","affiliation":[{"name":"Translational Research in Gastrointestinal Disorders, Department of Chronic Diseases and Metabolism, KU Leuven, Leuven, Belgium;"},{"name":"Department of Gastroenterology and Hepatology, University Hospitals Leuven, Leuven, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,9,27]]},"reference":[{"issue":"6","key":"R1-20260630","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1093\/ecco-jcc\/jjaa232","article-title":"Outcome of ulcerative colitis 20 years after diagnosis in a prospective population-based inception cohort from South-Eastern Norway, the IBSEN study","volume":"15","author":"Monstad","year":"2021","journal-title":"J Crohns Colitis"},{"issue":"9","key":"R2-20260630","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1016\/j.cgh.2016.01.015","article-title":"Mucosal healing is associated with improved long-term outcomes of patients with ulcerative colitis: A systematic review and meta-analysis","volume":"14","author":"Shah","year":"2016","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"5","key":"R3-20260630","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1053\/j.gastro.2022.01.024","article-title":"Disease monitoring in inflammatory bowel disease: Evolving principles and possibilities","volume":"162","author":"Plevris","year":"2022","journal-title":"Gastroenterology"},{"issue":"4","key":"R4-20260630","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1093\/ecco-jcc\/jjaa176","article-title":"Clinical, endoscopic and histological outcomes in induction of moderate-to-severe ulcerative colitis: A systematic review with meta-analysis","volume":"15","author":"Magro","year":"2021","journal-title":"J Crohns Colitis"},{"issue":"5","key":"R5-20260630","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1053\/j.gastro.2020.12.031","article-title":"STRIDE-II: An update on the selecting therapeutic targets in inflammatory bowel disease (STRIDE) initiative of the international organization for the study of IBD (IOIBD): Determining therapeutic goals for treat-to-target strategies in IBD","volume":"160","author":"Turner","year":"2021","journal-title":"Gastroenterology"},{"issue":"8","key":"R6-20260630","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1097\/MIB.0000000000001140","article-title":"Comparative acceptability and perceived clinical utility of monitoring tools: A nationwide survey of patients with inflammatory bowel disease","volume":"23","author":"Buisson","year":"2017","journal-title":"Inflamm Bowel Dis"},{"issue":"4","key":"R7-20260630","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/s41575-021-00418-4","article-title":"Point-of-care intestinal ultrasonography in inflammatory bowel disease","volume":"18","author":"de Voogd","year":"2021","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"12","key":"R8-20260630","doi-asserted-by":"crossref","first-page":"2218","DOI":"10.1002\/ibd.22917","article-title":"Fecal calprotectin is a surrogate marker for endoscopic lesions in inflammatory bowel disease","volume":"18","author":"D'Haens","year":"2012","journal-title":"Inflamm Bowel Dis"},{"issue":"3","key":"R9-20260630","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1136\/gut.2005.069476","article-title":"Laboratory markers in IBD: Useful, magic, or unnecessary toys?","volume":"55","author":"Vermeire","year":"2006","journal-title":"Gut"},{"issue":"3","key":"R10-20260630","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1053\/j.gastro.2019.10.034","article-title":"Development and validation of a test to monitor endoscopic activity in patients with Crohn's disease based on serum levels of proteins","volume":"158","author":"D'Haens","year":"2020","journal-title":"Gastroenterology"},{"issue":"2","key":"R11-20260630","doi-asserted-by":"crossref","first-page":"otaa035","DOI":"10.1093\/crocol\/otaa035","article-title":"Use of the endoscopic healing index for monitoring of disease activity in patients with Crohn's disease in the COVID era","volume":"2","author":"Abreu","year":"2020","journal-title":"Crohns Colitis 360"},{"issue":"4","key":"R12-20260630","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1093\/ibd\/izac117","article-title":"A serum biomarker panel can accurately identify mucosal ulcers in patients with Crohn's disease","volume":"29","author":"Holmer","year":"2022","journal-title":"Inflamm Bowel Dis"},{"issue":"12","key":"R13-20260630","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1093\/ecco-jcc\/jjac076","article-title":"Non-invasive serological monitoring for Crohn's disease post-operative recurrence","volume":"16","author":"Hamilton","year":"2022","journal-title":"J Crohns Colitis"},{"key":"R14-20260630","first-page":"jjad077","article-title":"The serum-based endoscopic healing index can monitor therapeutic response in Crohn's disease","author":"Alsoud","year":"2023","journal-title":"J Crohns Colitis"},{"issue":"1","key":"R15-20260630","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/s12876-020-01229-8","article-title":"Serum amyloid A is a better predictive biomarker of mucosal healing than C-reactive protein in ulcerative colitis in clinical remission","volume":"20","author":"Wakai","year":"2020","journal-title":"BMC Gastroenterol"},{"issue":"4","key":"R16-20260630","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1002\/ibd.21410","article-title":"Angiogenin, angiopoietin-1, angiopoietin-2, and endostatin serum levels in inflammatory bowel disease","volume":"17","author":"Oikonomou","year":"2011","journal-title":"Inflamm Bowel Dis"},{"issue":"6","key":"R17-20260630","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1097\/MCG.0000000000000618","article-title":"Increased cell adhesion molecules, PECAM-1, ICAM-3, or VCAM-1, predict increased risk for flare in patients with quiescent inflammatory bowel disease","volume":"51","author":"Gu","year":"2017","journal-title":"J Clin Gastroenterol"},{"key":"R18-20260630","doi-asserted-by":"crossref","first-page":"655960","DOI":"10.3389\/fimmu.2021.655960","article-title":"Regulation of CEACAM family members by IBD-associated triggers in intestinal epithelial cells, their correlation to inflammation and relevance to IBD pathogenesis","volume":"12","author":"Saiz-Gonzalo","year":"2021","journal-title":"Front Immunol"},{"issue":"1","key":"R19-20260630","doi-asserted-by":"crossref","first-page":"e12962","DOI":"10.1111\/sji.12962","article-title":"Increased expression of extracellular matrix metalloproteinase inducer (EMMPRIN) and MMP10, MMP23 in inflammatory bowel disease: Cross-sectional study","volume":"93","author":"Fonseca-Camarillo","year":"2021","journal-title":"Scand J Immunol"},{"issue":"Suppl 1","key":"R20-20260630","doi-asserted-by":"crossref","first-page":"S304","DOI":"10.1093\/ecco-jcc\/jjz203.431","article-title":"P302 diagnostic accuracy of a serum-based biomarker panel for endoscopic activity in ulcerative colitis","volume":"14","author":"Holmer","year":"2020","journal-title":"J Crohns Colitis"},{"issue":"7","key":"R21-20260630","doi-asserted-by":"crossref","first-page":"S-615","DOI":"10.1016\/S0016-5085(22)61452-5","article-title":"Su1530: Utility of the endoscopic healing index in identifying active inflammation in inflammatory bowel disease patients\u2013real world data from a tertiary center","volume":"162","author":"Cohen","year":"2022","journal-title":"Gastroenterology"},{"issue":"20","key":"R22-20260630","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1093\/jnci\/djn326","article-title":"Pivotal evaluation of the accuracy of a biomarker used for classification or prediction: Standards for study design","volume":"100","author":"Pepe","year":"2008","journal-title":"J Natl Cancer Inst"},{"issue":"11","key":"R23-20260630","doi-asserted-by":"crossref","first-page":"e012799","DOI":"10.1136\/bmjopen-2016-012799","article-title":"STARD 2015 guidelines for reporting diagnostic accuracy studies: Explanation and elaboration","volume":"6","author":"Cohen","year":"2016","journal-title":"BMJ Open"},{"issue":"10","key":"R24-20260630","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1093\/ecco-jcc\/jjv111","article-title":"The modified Mayo endoscopic score (MMES): A new index for the assessment of extension and severity of endoscopic activity in ulcerative colitis patients","volume":"9","author":"Lobat\u00f3n","year":"2015","journal-title":"J Crohns Colitis"},{"issue":"Suppl 1","key":"R25-20260630","doi-asserted-by":"crossref","first-page":"i066","DOI":"10.1093\/ecco-jcc\/jjab232.056","article-title":"DOP17 Evaluating segmental healing with the modified Mayo endoscopic score (MMES) has a clear additional value in predicting long-term outcome in patients with Ulcerative Colitis: Results from a prospective cohort study","volume":"16","author":"Lenfant","year":"2022","journal-title":"J Crohns Colitis"}],"container-title":["American Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.14309\/ajg.0000000000002518","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T14:04:36Z","timestamp":1786543476000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.14309\/ajg.0000000000002518"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,27]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.14309\/ajg.0000000000002518","relation":{},"ISSN":["0002-9270","1572-0241"],"issn-type":[{"value":"0002-9270","type":"print"},{"value":"1572-0241","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,27]]},"assertion":[{"value":"2023-03-30","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-22","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}