{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T14:55:54Z","timestamp":1786546554988,"version":"build-2736575974"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["ACG Case Rep J","ACG Case Reports Journal"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Colorectal cancer (CRC) metastasizing to the stomach and duodenum is rare. Even rarer is when the CRC subtype is signet-ring cell carcinoma (SRCC). Endoscopic findings of CRC metastasis to the stomach have been described as solitary and submucosal while duodenal metastasis has been observed to be exophytic. In this report, we describe a case of a middle-aged man with colon SRCC presenting with oral intolerance. He was found to have concurrent metastases to the stomach and duodenum and died 8 months after his SRCC diagnosis.<\/jats:p>","DOI":"10.14309\/crj.0000000000001239","type":"journal-article","created":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T08:00:37Z","timestamp":1703145637000},"page":"e01239","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["The Travels of Signet-Ring Cell Carcinoma: From Colon to Stomach and Duodenum"],"prefix":"10.14309","volume":"10","author":[{"given":"Chloe K.","family":"Tom","sequence":"first","affiliation":[{"name":"Division of Gastrointestinal and Liver Diseases, University of Southern California, Los Angeles, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Placone","sequence":"additional","affiliation":[{"name":"Division of Gastrointestinal and Liver Diseases, University of Southern California, Los Angeles, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evan","family":"Yung","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Southern California, Los Angeles, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anisa","family":"Shaker","sequence":"additional","affiliation":[{"name":"Division of Gastrointestinal and Liver Diseases and Swallowing and Esophageal Disorders Center, University of Southern California, Los Angeles, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,12]]},"reference":[{"issue":"3","key":"R2-20240805","doi-asserted-by":"crossref","first-page":"233","DOI":"10.3322\/caac.21772","article-title":"Colorectal cancer statistics, 2023","volume":"73","author":"Siegel","year":"2023","journal-title":"CA Cancer J Clin"},{"issue":"41","key":"R3-20240805","doi-asserted-by":"crossref","first-page":"11767","DOI":"10.3748\/wjg.v21.i41.11767","article-title":"Colorectal cancer: Metastases to a single organ","volume":"21","author":"Vatandoust","year":"2015","journal-title":"World J Gastroenterol"},{"issue":"45","key":"R4-20240805","doi-asserted-by":"crossref","first-page":"7326","DOI":"10.3748\/wjg.v12.i45.7326","article-title":"Metastatic tumors to the stomach: Clinical and endoscopic features","volume":"12","author":"De Palma","year":"2006","journal-title":"World J Gastroenterol"},{"issue":"2","key":"R5-20240805","first-page":"102","article-title":"Recurrent adenocarcinoma of colon presenting as duodenal metastasis with partial gastric outlet obstruction: A case report with review of literature","volume":"4","author":"Brahmbhatt","year":"2013","journal-title":"World J Oncol"},{"issue":"3","key":"R6-20240805","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1093\/annonc\/mdt591","article-title":"Metastatic pattern in colorectal cancer is strongly influenced by histological subtype","volume":"25","author":"Hugen","year":"2014","journal-title":"Ann Oncol"},{"key":"R7-20240805","doi-asserted-by":"crossref","first-page":"1609859","DOI":"10.3389\/pore.2021.1609859","article-title":"Clinicopathological and molecular characteristics of colorectal signet ring cell carcinoma: A Review","volume":"27","author":"An","year":"2021","journal-title":"Pathol Oncol Res"},{"issue":"26","key":"R8-20240805","doi-asserted-by":"crossref","first-page":"3455","DOI":"10.1038\/s41388-022-02350-6","article-title":"Molecular profiling of signet-ring-cell carcinoma (SRCC) from the stomach and colon reveals potential new therapeutic targets","volume":"41","author":"Puccini","year":"2022","journal-title":"Oncogene"},{"issue":"3","key":"R9-20240805","first-page":"2","article-title":"Colorectal cancer metastasis to the gastric mucosa","volume":"1","author":"Goel","year":"2021","journal-title":"Am Coll Surg Case Rev"},{"issue":"2","key":"R10-20240805","first-page":"37","article-title":"Long-term survival after resection of a gastric metastasis from transverse colon cancer: A case report","volume":"65","author":"Terashima","year":"2019","journal-title":"J Med Sci"},{"issue":"2","key":"R11-20240805","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1055\/s-2007-1005437","article-title":"Endoscopic features of metastatic tumors in the upper gastrointestinal tract","volume":"28","author":"Hsu","year":"1996","journal-title":"Endoscopy"},{"issue":"6","key":"R12-20240805","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1055\/s-2001-14960","article-title":"Metastatic tumors to the stomach: Analysis of 54 patients diagnosed at endoscopy and 347 autopsy cases","volume":"33","author":"Oda","year":"2001","journal-title":"Endoscopy"},{"issue":"2","key":"R13-20240805","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1159\/000508414","article-title":"Gastric metastasis from colorectal cancer mimicking a submucosal tumor","volume":"14","author":"Iwai","year":"2020","journal-title":"Case Rep Gastroenterol"},{"issue":"5","key":"R14-20240805","first-page":"327","article-title":"Signet ring cell carcinoma of the duodenal bulb with metastases to the ovaries and the colon: A case report","volume":"4","author":"Henry","year":"2013","journal-title":"J Med Cases"},{"issue":"6","key":"R15-20240805","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.3390\/cancers12061544","article-title":"Epidemiology of signet ring cell adenocarcinomas","volume":"12","author":"Benesch","year":"2020","journal-title":"Cancers (Basel)"},{"issue":"40","key":"R17-20240805","doi-asserted-by":"crossref","first-page":"11428","DOI":"10.3748\/wjg.v21.i40.11428","article-title":"Signet-ring cell carcinoma of the stomach: Impact on prognosis and specific therapeutic challenge","volume":"21","author":"Pernot","year":"2015","journal-title":"World J Gastroenterol"},{"issue":"5","key":"R18-20240805","doi-asserted-by":"crossref","first-page":"979","DOI":"10.21037\/jgo.2019.06.07","article-title":"Trends of incidence and survival in patients with gastroenteropancreatic signet ring cell carcinoma: An analysis from the surveillance, epidemiology, and end results program","volume":"10","author":"Li","year":"2019","journal-title":"J Gastrointest Oncol"},{"key":"R19-20240805","doi-asserted-by":"crossref","first-page":"2913493","DOI":"10.1155\/2016\/2913493","article-title":"Younger age is associated with poorer survival in patients with signet-ring cell carcinoma of the colon without distant metastasis","volume":"2016","author":"Huang","year":"2016","journal-title":"Gastroenterol Res Pract"},{"issue":"6","key":"R20-20240805","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/s41416-019-0548-9","article-title":"Signet ring cell colorectal cancer: Genomic insights into a rare subpopulation of colorectal adenocarcinoma","volume":"121","author":"Korphaisarn","year":"2019","journal-title":"Br J Cancer"},{"key":"R21-20240805","doi-asserted-by":"crossref","first-page":"109380","DOI":"10.1016\/j.mehy.2019.109380","article-title":"Selective targeting of signet ring cell adenocarcinomas","volume":"133","author":"Olgun","year":"2019","journal-title":"Med Hypotheses"},{"issue":"6","key":"R22-20240805","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.21037\/jgo-20-344","article-title":"Highly expressed Claudin18.2 as a potential therapeutic target in advanced gastric signet-ring cell carcinoma (SRCC)","volume":"11","author":"Xu","year":"2020","journal-title":"J Gastrointest Oncol"}],"container-title":["ACG Case Reports Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.14309\/crj.0000000000001239","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T13:59:07Z","timestamp":1786543147000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.14309\/crj.0000000000001239"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":20,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.14309\/crj.0000000000001239","relation":{},"ISSN":["2326-3253"],"issn-type":[{"value":"2326-3253","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"2023-08-09","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-16","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}