{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T15:57:21Z","timestamp":1786550241361,"version":"build-2736575974"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>\n                    <jats:bold>ABSTRACT<\/jats:bold>\n                  <\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>Common variable immunodeficiency (CVID) is an immunodeficiency disorder with a high incidence of gastrointestinal (GI) manifestations and an increased risk of gastric malignancy. We report a case of a CVID with mild anemia presenting with multiple GI manifestations: gastric low-grade dysplasia (LGD), enteropathy with villous atrophy, refractory Giardia infection, nodular lymphoid hyperplasia, and inflammatory bowel-like disease. The differential diagnosis with celiac sprue could be challenging because of CVID enteropathy with villous flattening. Gastric LGD in a patient with an increased risk for gastric malignancy makes the appropriate surveillance of gastric cancer in CVID challenging.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.14309\/crj.2017.106","type":"journal-article","created":{"date-parts":[[2017,8,31]],"date-time":"2017-08-31T13:43:55Z","timestamp":1504187035000},"page":"e106","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":6,"title":["Common Variable Immunodeficiency with Several Gastrointestinal Manifestations"],"prefix":"10.14309","volume":"4","author":[{"given":"Catarina","family":"Atalaia-Martins","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Barbeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Marcos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Cotrim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena","family":"Vasconcelos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"issue":"3","key":"R1-106-20260710","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1006\/clim.1999.4799","article-title":"Diagnostic criteria for primary immunodeficiencies. 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antibody deficiency syndromes.","volume":"124","author":"Agarwal","year":"2009","journal-title":"J Allergy Clin Immunol"},{"issue":"12","key":"R12-106-20260710","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1086\/320751","article-title":"Successful treatment of metronidazole- and albendazole-resistant giardiasis with nitazoxanide in a patient with acquired immunodeficiency syndrome.","volume":"32","author":"Abboud","year":"2001","journal-title":"Clin Infect Dis"},{"issue":"4","key":"R13-106-20260710","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.jinf.2008.01.013","article-title":"Treatmentladder and genetic characterisation of parasites in refractory giardiasis after an outbreak in Norway.","volume":"56","author":"Morch","year":"2008","journal-title":"J Infect"},{"issue":"10","key":"R14-106-20260710","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1097\/00000478-199610000-00010","article-title":"Gastrointestinal pathology in patients with 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