{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T15:19:46Z","timestamp":1786547986687,"version":"build-2736575974"},"reference-count":12,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>\n                    <jats:bold>ABSTRACT<\/jats:bold>\n                  <\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>Cowden syndrome (CS) represents one possible phenotype of the PTEN gene mutation, and it can cause hamartomas throughout the gastrointestinal tract, with a predisposition for malignancy. Fibroblastic polyps have not been associated with CS. A 45-year-old woman with CS presenting for colonoscopic surveillance was found to have multiple sessile polyps throughout the transverse, descending, and sigmoid colon, all 2\u20135 mm in diameter. Based on the morphologic features and the immunohistochemical profile, these lesions were classified as fibroblastic polyps. This polyp subtype is recognized as a benign process of the colonic mucosa but is a novel histologic observation in the setting of CS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.14309\/crj.2017.113","type":"journal-article","created":{"date-parts":[[2017,10,11]],"date-time":"2017-10-11T12:24:40Z","timestamp":1507724680000},"page":"e113","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Fibroblastic Polyps: A Novel Polyp Subtype in Cowden Syndrome"],"prefix":"10.14309","volume":"4","author":[{"given":"Bradley","family":"Anderson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Smyrk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seth","family":"Sweester","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"issue":"3","key":"R1-113-20260710","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/sj.ejhg.5200289","article-title":"Novel PTEN mutations in patients with Cowden disease: Absence of clear genotype-phenotype correlations.","volume":"7","author":"Nelen","year":"1999","journal-title":"Eur J Hum Genet"},{"issue":"6","key":"R2-113-20260710","doi-asserted-by":"crossref","first-page":"489","DOI":"10.4065\/mcp.2010.0816","article-title":"Colonic polyposis and neoplasia in Cowden 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study.","volume":"28","author":"Eslami-Varzaneh","year":"2004","journal-title":"Am J Surg Pathol"},{"issue":"10","key":"R6-113-20260710","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1097\/01.pas.0000141397.49460.12","article-title":"Fibroblastic polyp of the colon shares features with vanek tumor.","volume":"28","author":"Zamecnik","year":"2004","journal-title":"Am J Surg Pathol"},{"issue":"9","key":"R7-113-20260710","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1097\/01.mcg.0000177242.51967.83","article-title":"Benign fibroblastic polyp of the colorectum.","volume":"39","author":"Kalof","year":"2005","journal-title":"J Clin Gastroenterol"},{"key":"R8-113-20260710","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.5858\/133.11.1872","article-title":"Benign fibroblastic polyps of the colon.","volume":"133","author":"Huber","year":"2009","journal-title":"Arch Pathol Lab Med"},{"issue":"21","key":"R9-113-20260710","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1093\/jnci\/djt277","article-title":"Cowden syndrome and the PTEN hamartoma tumor syndrome: Systematic review and revised diagnostic criteria.","volume":"105","author":"Pilarski","year":"2013","journal-title":"J Natl Cancer Inst"},{"issue":"8","key":"R10-113-20260710","doi-asserted-by":"crossref","first-page":"e131","DOI":"10.1016\/j.cgh.2016.12.006","article-title":"Diffue esophageal glycogenic acanthosis and colon polyposis in a patient with Cowden syndrome.","volume":"15","author":"Modi","year":"2016","journal-title":"Clin Gastroenterol Hepatol"},{"key":"R11-113-20260710","doi-asserted-by":"crossref","first-page":"e5","DOI":"10.1038\/ctg.2011.4","article-title":"Upper and lower gastrointestinal findings in PTEN mutation-positive Cowden syndrome patients participating in an active surveillance program.","volume":"2","author":"Levi","year":"2011","journal-title":"Clin Transl Gastroenterol"},{"issue":"36","key":"R12-113-20260710","doi-asserted-by":"crossref","first-page":"e767","DOI":"10.1200\/JCO.2010.32.7031","article-title":"Oncophenotypic review and clinical correlates of phosphatase and tensin homolog on chromosome 10 hamartoma tumor syndrome.","volume":"28","author":"Patnaik","year":"2010","journal-title":"J Clin Oncol"}],"container-title":["ACG Case Reports 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