{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T15:20:17Z","timestamp":1786548017014,"version":"build-2736575974"},"reference-count":5,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>\n                    <jats:bold>ABSTRACT<\/jats:bold>\n                  <\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>Tubulointerstitial nephritis (TIN) is not commonly associated in aminosalicylate-na\u00efve patients with Crohn's disease (CD). Our case describes the initial presentation, diagnosis, and management of an adolescent presenting with TIN and underlying CD. Our case emphasizes that CD should be considered in the differential diagnosis of interstitial nephritis as not only a medication-related effect, but also as an extraintestinal manifestation of CD. We also describe successful management of undiagnosed recurring and symptomatic CD-related TIN with infliximab.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.14309\/crj.2017.24","type":"journal-article","created":{"date-parts":[[2017,2,15]],"date-time":"2017-02-15T15:20:34Z","timestamp":1487172034000},"page":"e24","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":10,"title":["Tubulointerstitial Nephritis as the Initial Presentation of Crohn's Disease and Successful Treatment with Infliximab"],"prefix":"10.14309","volume":"4","author":[{"given":"Brielle","family":"Stanton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiffany","family":"Caza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongmei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirza B.","family":"Beg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"issue":"2","key":"R1-24-20260710","doi-asserted-by":"crossref","first-page":"265","DOI":"10.2215\/CJN.04660513","article-title":"The histopathologic spectrum of kidney biopsies in patients with inflammatory bowel disease.","volume":"9","author":"Ambruzs","year":"2016","journal-title":"Clin J Am Soc Nephrol"},{"key":"R2-24-20260710","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1053\/gast.2002.36613","article-title":"Primary chronic interstitial nephritis in Crohns disease.","volume":"123","author":"Izzedine","year":"2002","journal-title":"Gastroenterology"},{"issue":"3","key":"R3-24-20260710","doi-asserted-by":"crossref","first-page":"250","DOI":"10.5414\/CNP73250","article-title":"Relapsing tubulointerstitial nephritis in an adolescent with inflammatory bowel disease without aminosalicylate exposure.","volume":"73","author":"Shahrani Muhammad","year":"2010","journal-title":"Clin Nephrol"},{"issue":"12","key":"R4-24-20260710","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/ncpneph0955","article-title":"Tubulointerstitial nephritis as an extraintestinal manifestation of Crohns disease.","volume":"4","author":"Waters","year":"2008","journal-title":"Nat Clin Pract Nephrol"},{"key":"R5-24-20260710","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1097\/MPG.0b013e31806dc2c4","article-title":"Tubulointerstitial nephritis as an extraintestinal manifestation of Crohns disease in children.","volume":"46","author":"Marcus","year":"2008","journal-title":"J Pediatr Gastroenterol Nutr"}],"container-title":["ACG Case Reports Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/02075970-201704000-00024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T14:20:41Z","timestamp":1786544441000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/02075970-201704000-00024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":5,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017]]}},"URL":"https:\/\/doi.org\/10.14309\/crj.2017.24","relation":{},"ISSN":["2326-3253"],"issn-type":[{"value":"2326-3253","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1]]}}}