{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T15:55:34Z","timestamp":1786550134900,"version":"build-2736575974"},"reference-count":5,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>\n                    <jats:bold>ABSTRACT<\/jats:bold>\n                  <\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>Systemic mastocytosis is a myeloproliferative disorder characterized by extracutaneous involvement of at least one organ. Although rare, infiltration of inflammatory mast cells within the portal vein may lead to obstruction of the sinusoids resulting in non-cirrhotic portal hypertension. We present a patient with known history of systemic mastocytosis with bone marrow involvement presenting with new-onset esophageal variceal bleeding. Although systemic mastocytosis is uncommon, the subsequent development of hepatic involvement and non-cirrhotic portal hypertension are discussed. Further highlighted is a lack of organization guidelines and the potential for gastrointestinal and hepatic screening of mastocytosis patients with known extracutaneous involvement.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.14309\/crj.2017.30","type":"journal-article","created":{"date-parts":[[2017,3,6]],"date-time":"2017-03-06T11:04:30Z","timestamp":1488798270000},"page":"e30","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["Systemic Mastocytosis Complicated by Non-Cirrhotic Portal Hypertension and Variceal Bleeding"],"prefix":"10.14309","volume":"4","author":[{"given":"Thomas R.","family":"McCarty","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adelina","family":"Hung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arpan","family":"Mohanty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John I.","family":"Allen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-30-20260710","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1146\/annurev.med.55.091902.103822","article-title":"Systemic mastocytosis.","volume":"55","author":"Akin","year":"2004","journal-title":"Annu Rev Med"},{"key":"R2-30-20260710","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1097\/PAS.0000000000000190","article-title":"A clinicopathologic study of 24 cases of systemic mastocytosis involving the gastrointestinal tract and assessment of mucosal mast cell density in irritable bowel syndrome and asymptomatic patients.","volume":"38","author":"Doyle","year":"2014","journal-title":"Am J Surg Pathol"},{"key":"R3-30-20260710","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/S0889-8588(05)70298-7","article-title":"Gastrointestinal abnormalities and involvement in systemic mastocytosis.","volume":"14","author":"Jensen","year":"2000","journal-title":"Hematol Oncol Clin North Am"},{"key":"R4-30-20260710","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/0016-5085(78)90303-7","article-title":"Portal hypertension in systemic mastocytosis.","volume":"74","author":"Capron","year":"1978","journal-title":"Gastroenterology"},{"key":"R5-30-20260710","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1093\/annonc\/mdu047","article-title":"Refined diagnostic criteria and classification of mast cell leukemia (MCL) and myelomastocytic leukemia (MML): A consensus proposal.","volume":"25","author":"Valent","year":"2014","journal-title":"Ann Oncol"}],"container-title":["ACG Case Reports Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/02075970-201704000-00030","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T15:15:28Z","timestamp":1786547728000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/02075970-201704000-00030"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":5,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017]]}},"URL":"https:\/\/doi.org\/10.14309\/crj.2017.30","relation":{},"ISSN":["2326-3253"],"issn-type":[{"value":"2326-3253","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1]]}}}