{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T15:56:40Z","timestamp":1786550200004,"version":"build-2736575974"},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>\n                    <jats:bold>ABSTRACT<\/jats:bold>\n                  <\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>Although new heptatis C virus treatments have increased efficacy and improved safety profiles, they also come with risk. We describe a 66-year-old white man with Child-Pugh A cirrhosis secondary to heptatis C virus genotype 3, who suffered from an acute kidney injury after treatment with sofosbuvir and daclatasvir. Kidney biopsy demonstrated evidence of acute tubular interstitial nephritis consistent with a drug reaction. A trial of steroid therapy was effective, and his creatinine continues to improve significantly. Our case is the first report in the literature that highlights potentially serious interstitial nephritis associated with sofosbuvir and daclatasvir use.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.14309\/crj.2017.84","type":"journal-article","created":{"date-parts":[[2017,7,7]],"date-time":"2017-07-07T16:30:39Z","timestamp":1499445039000},"page":"e84","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":16,"title":["Acute Interstitial Nephritis Associated with Sofosbuvir and Daclatasvir"],"prefix":"10.14309","volume":"4","author":[{"given":"Taha","family":"Ashraf","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Majoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"issue":"11","key":"R1-84-20260710","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1038\/ki.2010.89","article-title":"Acute interstitial nephritis.","volume":"77","author":"Praga","year":"2010","journal-title":"Kidney Int"},{"key":"R2-84-20260710","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0272-6386(87)80053-7","article-title":"Cirrhotic glomerulonephritis: Incidence, morphology, clinical features, and pathogenesis.","volume":"9","author":"Newell","year":"1987","journal-title":"Am J Kidney Dis"},{"key":"R3-84-20260710","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1111\/j.1365-2559.1984.tb02413.x","article-title":"Heterogeneous IgA glomerulonephropathy in liver cirrhosis.","volume":"8","author":"Sinniah","year":"1984","journal-title":"Histopathology"},{"key":"R4-84-20260710","first-page":"327","article-title":"Detection of monomeric and polymeric IgA containing immune complexes in serum and kidney from patients with alcoholic liver disease.","volume":"47","author":"Sancho","year":"1982","journal-title":"Clin Exp Immunol"},{"issue":"10","key":"R5-84-20260710","doi-asserted-by":"crossref","first-page":"735","DOI":"10.7326\/0003-4819-144-10-200605160-00007","article-title":"Brief communication: Glomerulonephritis in patients with hepatitis C cirrhosis undergoing liver transplantation.","volume":"144","author":"McGuire","year":"2006","journal-title":"Ann Intern Med"},{"issue":"11","key":"R6-84-20260710","first-page":"943","article-title":"Frequency of mesangial IgA deposits in a non-selected autopsy series.","volume":"4","author":"Waldherr","year":"1989","journal-title":"Nephrol DialTransplant"},{"issue":"6","key":"R7-84-20260710","doi-asserted-by":"crossref","first-page":"2286","DOI":"10.1046\/j.1523-1755.63.6s.2.x","article-title":"Incidence of latent mesangial IgA deposition in renal allograft donors in japan.","volume":"63","author":"Suzuki","year":"2003","journal-title":"Kidney Int"},{"issue":"1","key":"R8-84-20260710","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/ajg.2015.391","article-title":"Harvoni (ledipasvir with sofosbuvir)-induced renal injury.","volume":"111","author":"Wanchoo","year":"2016","journal-title":"Am J Gastroenterol"},{"issue":"9","key":"R9-84-20260710","doi-asserted-by":"crossref","first-page":"e148","DOI":"10.1002\/phar.1803","article-title":"Nephrotoxicity associated with concomitant use of ledipasvir-sofosbuvir and tenofovir in a patient with hepatitis C virus and human immunodeficiency virus coinfection.","volume":"36","author":"Bunnell","year":"2016","journal-title":"Pharmacotherapy"}],"container-title":["ACG Case Reports Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/02075970-201704000-00084","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T15:18:12Z","timestamp":1786547892000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/02075970-201704000-00084"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":9,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017]]}},"URL":"https:\/\/doi.org\/10.14309\/crj.2017.84","relation":{},"ISSN":["2326-3253"],"issn-type":[{"value":"2326-3253","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1]]}}}