{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T14:51:26Z","timestamp":1786546286151,"version":"build-2736575974"},"reference-count":37,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/CreativeCommonsAttributionLicense4.0(CCBY)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Transl Gastroenterol","Clinical and Translational Gastroenterology"],"abstract":"\n INTRODUCTION:<\/jats:title>\n \n HLA class II allele,\n DRB1*03:01<\/jats:italic>\n , is the most common genetic risk factor for autoimmune hepatitis (AIH), but other unrecognized HLA related risks exist.\n <\/jats:p>\n <\/jats:sec>\n \n METHODS:<\/jats:title>\n \n We compared the HLA class I (A, B, C) and class II (DR, DQ, DP) typing between patients with well-characterized AIH and healthy controls by high resolution sequencing of the HLA region. Seventy-three patients with AIH and 87 healthy controls were included. Association between HLA alleles and AIH was considered singly and in clusters and adjusted for age, gender, and\n DRB1*03:01<\/jats:italic>\n .\n <\/jats:p>\n <\/jats:sec>\n \n RESULTS:<\/jats:title>\n \n DRB1*03:01<\/jats:italic>\n was singly associated with AIH among whites (odds ratio [OR]: 3.09,\n P<\/jats:italic>\n = 0.002) and carriers of\n DRB1*03:01<\/jats:italic>\n also carried\n DQA*05:01 and DQB1*02:01.<\/jats:italic>\n Significant HLA class I alleles were associated with AIH including those belonging to the A03 (OR: 0.4,\n P<\/jats:italic>\n = 0.01) and B44 supertype (OR: 0.44,\n P<\/jats:italic>\n = 0.03). Further refinement of HLA-A by binding pocket structure revealed that the sequence Y(F\/T)AVMENV(H\/Q)Y, corresponding to HLA-A alleles A*03:01-02; *31:01; *32:02, was protective for AIH (OR: 0.3,\n P<\/jats:italic>\n = 0.002). A protective association also existed for alleles belonging to the HLA-B binding pocket structure Y(H\/Y)TVKEISNY (OR: 0.35,\n P<\/jats:italic>\n = 0.01), corresponding to HLA-B alleles: B*40:01-02; *41:02; *44:02-03; *45:01; *49:01; *50:01-02. Associations with specific class I alleles belonging to the 8.1 ancestral haplotype (\n HLA-A*01:01<\/jats:italic>\n ,\n HLA-B*08:01<\/jats:italic>\n ,\n HLA-C*07:01<\/jats:italic>\n ) were not significant when considered jointly with\n DRB1*03:01<\/jats:italic>\n and reported protective class I alleles.\n <\/jats:p>\n <\/jats:sec>\n \n DISCUSSION:<\/jats:title>\n Our study identified novel supertypes and HLA-A and B peptide binding structures protective against AIH. Further risk assessment of class I molecules remains important in AIH as they are key mediators of adaptive immunity.<\/jats:p>\n <\/jats:sec>","DOI":"10.14309\/ctg.0000000000000032","type":"journal-article","created":{"date-parts":[[2019,6,18]],"date-time":"2019-06-18T11:58:08Z","timestamp":1560859088000},"page":"e00032","source":"Crossref","is-referenced-by-count":7,"title":["Novel HLA Class I Alleles Outside the Extended DR3 Haplotype Are Protective against Autoimmune Hepatitis"],"prefix":"10.14309","volume":"10","author":[{"given":"Craig","family":"Lammert","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Indiana University School of Medicine, Indianapolis, Indiana, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth J.","family":"McKinnon","sequence":"additional","affiliation":[{"name":"Institute for Immunology and Infectious Disease, Murdoch University, Murdoch, Washington, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naga","family":"Chalasani","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Indiana University School of Medicine, Indianapolis, Indiana, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth J.","family":"Phillips","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Vanderbilt University Medical Centre, Nashville, Tennessee, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2019,6]]},"reference":[{"key":"R1-20230814","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1080\/00365529850166284","article-title":"Incidence and prevalence of primary biliary cirrhosis, primary sclerosing cholangitis, and autoimmune hepatitis in a Norwegian population","volume":"33","author":"Boberg","year":"1998","journal-title":"Scand J 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