{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T21:06:24Z","timestamp":1793307984230,"version":"4.5.0"},"reference-count":46,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","license":[{"start":{"date-parts":[[2019,5,10]],"date-time":"2019-05-10T00:00:00Z","timestamp":1557446400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Transl Gastroenterol","Clinical and Translational Gastroenterology"],"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVES:<\/jats:title>\n                    <jats:p>Celiac disease (CD) is a chronic enteropathy characterized by an autoimmune reaction in the small intestine of genetically susceptible individuals. The underlying causes of autoimmune reaction and its effect on host metabolism remain largely unknown. Herein, we apply lipidomics to elucidate the early events preceding clinical CD in a cohort of Finnish children, followed up in the Type 1 Diabetes Prediction and Prevention study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>Mass spectrometry\u2013based lipidomics profiling was applied to a longitudinal\/prospective series of 233 plasma samples obtained from CD progressors (n = 23) and healthy controls (n = 23), matched for human leukocyte antigen (HLA) risk, sex, and age. The children were followed from birth until diagnosis of clinical CD and subsequent introduction of a gluten-free diet.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>Twenty-three children progressed to CD at a mean age of 4.8 years. They showed increased amounts of triacylglycerols (TGs) of low carbon number and double bond count and a decreased level of phosphatidylcholines by age 3 months as compared to controls. These differences were exacerbated with age but were not observed at birth (cord blood). No significant differences were observed in the essential TGs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION:<\/jats:title>\n                    <jats:p>\n                      Our preliminary findings suggest that abnormal lipid metabolism associates with the development of clinical CD and occurs already before the first introduction of gluten to the diet. Moreover, our data suggest that the specific TGs found elevated in CD progressors may be due to a host response to compromised intake of essential lipids in the small intestine, requiring\n                      <jats:italic toggle=\"yes\">de novo<\/jats:italic>\n                      lipogenesis.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.14309\/ctg.0000000000000044","type":"journal-article","created":{"date-parts":[[2019,5,13]],"date-time":"2019-05-13T06:13:26Z","timestamp":1557728006000},"page":"e00044","source":"Crossref","is-referenced-by-count":37,"title":["Persistent Alterations in Plasma Lipid Profiles Before Introduction of Gluten in the Diet Associated With Progression to Celiac Disease"],"prefix":"10.14309","volume":"10","author":[{"given":"Partho","family":"Sen","sequence":"first","affiliation":[{"name":"Turku Centre for Biotechnology, University of Turku and \u00c5bo Akademi University, Turku, Finland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Carlsson","sequence":"additional","affiliation":[{"name":"Department of Chemistry, \u00d6rebro University, \u00d6rebro, Sweden;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suvi M.","family":"Virtanen","sequence":"additional","affiliation":[{"name":"Public Health Promotion Unit, National Institute for Health and Welfare, Helsinki, Helsinki, Finland;"},{"name":"Faculty of Social Sciences\/Health, University of Tampere, Tampere, Finland;"},{"name":"Center for Child Health Research, University of Tampere and Tampere University Hospital, Tampere, Finland;"},{"name":"Science Centre, Tampere University Hospital, Tampere, Finland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satu","family":"Simell","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine, Turku University Hospital, Turku, Finland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heikki","family":"Hy\u00f6ty","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland;"},{"name":"Fimlab Laboratories, Pirkanmaa Hospital District, Tampere, Finland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorma","family":"Ilonen","sequence":"additional","affiliation":[{"name":"Immunogenetics Laboratory, Institute of Biomedicine, University of Turku, Turku, Finland;"},{"name":"Clinical Microbiology, Turku University Hospital, Turku, Finland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorma","family":"Toppari","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine, Turku University Hospital, Turku, Finland;"},{"name":"Institute of Biomedicine, Centre for Integrative Physiology and Pharmacology, University of Turku, Turku, Finland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riitta","family":"Veijola","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, PEDEGO Research Unit, Medical Research Centre, University of Oulu, Oulu, Finland;"},{"name":"Department of Children and Adolescents, Oulu University Hospital, Oulu, Finland;"},{"name":"Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuulia","family":"Hy\u00f6tyl\u00e4inen","sequence":"additional","affiliation":[{"name":"Department of Chemistry, \u00d6rebro University, \u00d6rebro, Sweden;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikael","family":"Knip","sequence":"additional","affiliation":[{"name":"Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland;"},{"name":"Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland;"},{"name":"Tampere Centre for Child Health Research, Tampere University Hospital, Tampere, Finland; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matej","family":"Ore\u0161i\u010d","sequence":"additional","affiliation":[{"name":"Turku Centre for Biotechnology, University of Turku and \u00c5bo Akademi University, Turku, Finland;"},{"name":"School of Medical Sciences, \u00d6rebro University, \u00d6rebro, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2019,5,22]]},"reference":[{"key":"R1-20230814","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1136\/gutjnl-2011-301346","article-title":"The Oslo definitions for coeliac disease and related terms","volume":"62","author":"Ludvigsson","year":"2013","journal-title":"Gut"},{"key":"R2-20230814","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1053\/j.gastro.2009.05.040","article-title":"Analysis of HLA and non-HLA alleles can 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