{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T02:55:32Z","timestamp":1791428132592,"version":"4.3.3"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Transl Gastroenterol","Clinical and Translational Gastroenterology"],"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVES:<\/jats:title>\n                    <jats:p>To investigate the safety profile and diagnostic efficacy of transjugular liver biopsy (TJLB), with a focus on patients with severe coagulopathies and with multiple biopsies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>Clinical, laboratory, and demographic information was collected on 1,321 TJLBs in 932 patients (mean age 43.5 \u00b1 23.2 years) performed between January 2009 and May 2017 to determine the diagnostic success rate and incidence of both major and minor complications in the 3-day and 30-day period post-biopsies. These outcomes were also analyzed for severely coagulopathic patients and a subgroup of patients who underwent multiple biopsies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      The overall success rate (diagnostic yield) of the TJLB procedure was 97.7% (1,291\/1,321). Overall, the major and minor complication rates were 1.0% (13\/1,321) and 9.5% (126\/1,321), respectively. In patients with multiple biopsies, the overall complication rate was similar to the entire study cohort, which was 10.4% (57\/550). Patients were also stratified according to the platelet counts of 0\u201350, 51\u2013100, 101\u2013200, 201\u2013300 and &gt;300 \u00d7 10\n                      <jats:sup>3<\/jats:sup>\n                      platelets\/\u03bcL. The overall complication rates were 8.0% (10\/124), 11.6% (36\/310), 9.9% (54\/547), 11.9% (28\/235), and 14.3% (11\/77), respectively, and these were not statistically significant from each other. Patients were also stratified by international normalized ratio into 0\u20131, 1.1\u20132, 2.1\u20133, and &gt;3. The overall complication rates of these patients were 8.0% (19\/237), 11.8% (113\/954), 16.3% (7\/43), and 0% (0\/9), respectively, and were not statistically significant from each other.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION:<\/jats:title>\n                    <jats:p>TJLB is a highly efficacious, well-tolerated and safe procedure. It can be safely performed multiple times in the same patient or in critically ill, severely coagulopathic patients with no significant increase in the rate of complication while maintaining an extremely favorable diagnostic yield.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.14309\/ctg.0000000000000063","type":"journal-article","created":{"date-parts":[[2019,6,28]],"date-time":"2019-06-28T09:23:57Z","timestamp":1561713837000},"page":"e00063","source":"Crossref","is-referenced-by-count":42,"title":["Transjugular Liver Biopsy: Safe Even in Patients With Severe Coagulopathies and Multiple Biopsies"],"prefix":"10.14309","volume":"10","author":[{"given":"Megan J.","family":"Sue","sequence":"first","affiliation":[{"name":"Division of Interventional Radiology, Department of Radiology, UCLA Medical Center, David Geffen School of Medicine at UCLA, Los Angeles, California, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward 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Medicine at UCLA, Los Angeles, California, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Durazo","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Hepatology, Pfleger Liver Institute, University of California at Los Angeles, Los Angeles, California, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"El-Kabany","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Hepatology, Pfleger Liver Institute, University of California at Los Angeles, Los Angeles, California, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fady","family":"Kaldas","sequence":"additional","affiliation":[{"name":"Dumont-UCLA Transplant Center, Pfleger Liver Institute, Division of Liver and Pancreas Transplantation, Department of Surgery, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California, 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