{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T13:56:49Z","timestamp":1790517409528,"version":"4.1.0"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Transl Gastroenterol","Clinical and Translational Gastroenterology"],"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVES:<\/jats:title>\n                    <jats:p>Anti-cytolethal distending toxin B (CdtB) and anti-vinculin antibodies have been proposed as biomarkers that discriminate irritable bowel syndrome (IBS) diarrhea from inflammatory bowel disease; however, it is unknown whether they can also discriminate patients with IBS and IBS subtypes and functional dyspepsia (FD) from healthy individuals in the general population. We aimed to determine whether anti-CdtB and anti-vinculin can discriminate IBS and FD from health and from organic gastrointestinal (GI) disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>Adults were enrolled from 2 Australian studies: (i) a random, population-based study (n = 331) with subjects diagnosed with IBS (n = 63) or FD (n = 61) by modified Rome III criteria or healthy control subjects (n = 246) who did not meet criteria for IBS and\/or FD and (ii) an outpatient-based study with subjects diagnosed with IBS (n = 256) and\/or FD (n = 55) or organic GI disease (n = 182) by an independent clinician. Serum levels of anti-CdtB\/anti-vinculin antibodies were determined by enzyme-linked immunosorbent assay.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      There was a significantly higher mean value of anti-CdtB in FD vs healthy controls (mean = 2.46 [SD = 0.72] vs mean = 2.14 [SD = 0.77];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.005) and IBS\/FD overlap vs healthy controls (mean = 2.47 [SD = 0.78] vs mean = 2.14 [SD = 0.77];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.02). There were no significant differences in anti-CdtB in IBS and FD outpatients or IBS\/FD subgroups compared with patients with organic GI disease. In terms of anti-vinculin, there were no significant differences between IBS and FD and healthy controls or between IBS and FD and organic GI disease controls.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION:<\/jats:title>\n                    <jats:p>We did not confirm that anti-CdtB\/anti-vinculin discriminated IBS diarrhea from organic GI disease in Australian subjects. However, we did find higher anti-CdtB in FD and IBS\/FD overlap vs healthy controls. Postinfectious FD may be more common than currently recognized.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.14309\/ctg.0000000000000064","type":"journal-article","created":{"date-parts":[[2019,7,29]],"date-time":"2019-07-29T09:34:30Z","timestamp":1564392870000},"page":"e00064","source":"Crossref","is-referenced-by-count":45,"title":["Circulating Anti-cytolethal Distending Toxin B and Anti-vinculin Antibodies as Biomarkers in Community and Healthcare Populations With Functional Dyspepsia and Irritable Bowel Syndrome"],"prefix":"10.14309","volume":"10","author":[{"given":"Nicholas J.","family":"Talley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald","family":"Holtmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjorie M.","family":"Walker","sequence":"additional","affiliation":[{"name":"Faculty of Health and Medicine, University of Newcastle, Callaghan, New South Wales, Australia;"},{"name":"Australian Gastrointestinal Research Alliance (AGIRA);"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace","family":"Burns","sequence":"additional","affiliation":[{"name":"Faculty of Health and Medicine, University of Newcastle, Callaghan, New South Wales, Australia;"},{"name":"Australian Gastrointestinal Research Alliance (AGIRA);"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Potter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayesha","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Jones","sequence":"additional","affiliation":[{"name":"Australian Gastrointestinal Research Alliance (AGIRA);"},{"name":"Macquarie University, Ryde, New South Wales, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasha A.","family":"Koloski","sequence":"additional","affiliation":[{"name":"Faculty of Health and Medicine, University of Newcastle, Callaghan, New South Wales, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Keely","sequence":"additional","affiliation":[{"name":"Faculty of Health and Medicine, University of Newcastle, Callaghan, New South Wales, Australia;"},{"name":"Australian Gastrointestinal Research Alliance (AGIRA);"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2019,7,24]]},"reference":[{"issue":"9","key":"R1-20230814","doi-asserted-by":"crossref","first-page":"2290","DOI":"10.1111\/j.1572-0241.2002.05783.x","article-title":"Epidemiology and health care seeking in the functional GI disorders: A population-based study","volume":"97","author":"Koloski","year":"2002","journal-title":"Am J 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