{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T15:59:09Z","timestamp":1790265549290,"version":"4.1.0"},"reference-count":3,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Clin Transl Gastroenterol","Clinical and Translational Gastroenterology"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:sec>\n                    <jats:title>INTRODUCTION:<\/jats:title>\n                    <jats:p>Standard forceps biopsies often provide insufficient cellular yield for single-cell and spatial transcriptomic analyses. We assessed the feasibility of cold-snare resection in inflammatory bowel disease (IBD) and compared immune cell composition with standard forceps biopsies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>Patients with active IBD at endoscopy were included. One cold-snare resection and 2 standard biopsies were obtained from inflamed mucosa in the ileum, colon, or rectum. Sample quality and cell yield were evaluated using histology staining and flow cytometry. Adverse events (AEs) were recorded periprocedurally, at a 7-day follow-up, and up to 30 days.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      Thirty-four patients with IBD were included. Cold-snare resection was successful in all cases and yielded significantly higher number of T-cells (median 71 \u00d7 10\n                      <jats:sup>3<\/jats:sup>\n                      vs 17 \u00d7 10\n                      <jats:sup>3<\/jats:sup>\n                      ,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.016) and rare innate lymphoid cells (median 576 vs 127,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.016) compared with standard forceps biopsies. Four mild AEs were reported.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION:<\/jats:title>\n                    <jats:p>Cold-snare resection improves mucosal tissue integrity and cellular quality compared with standard biopsies, supporting its use for translational studies in IBD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.14309\/ctg.0000000000001069","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T20:00:38Z","timestamp":1782936038000},"page":"e01069","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["A Novel Endoscopic Biopsy Technique for Translational Research in Patients With Inflammatory Bowel Disease"],"prefix":"10.14309","volume":"17","author":[{"given":"S.","family":"van Zon","sequence":"first","affiliation":[{"name":"Department of Gastroenterology & Hepatology, Amsterdam University Medical Center, Amsterdam, the Netherlands;"},{"name":"Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam, the Netherlands;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6086-0964","authenticated-orcid":false,"given":"L.","family":"Oldenburg","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology & Hepatology, Amsterdam University Medical Center, Amsterdam, the Netherlands;"},{"name":"Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam, the Netherlands;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Nachataya","sequence":"additional","affiliation":[{"name":"Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam, the Netherlands;"},{"name":"Amsterdam Institute for Immunology and Infectious Diseases, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Goetgebuer","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology & Hepatology, Amsterdam University Medical Center, Amsterdam, the Netherlands;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"de Boer","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology & Hepatology, Amsterdam University Medical Center, Amsterdam, the Netherlands;"},{"name":"Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam, the Netherlands;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Bernink","sequence":"additional","affiliation":[{"name":"Amsterdam Institute for Immunology and Infectious Diseases, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Grootjans","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology & Hepatology, Amsterdam University Medical Center, Amsterdam, the Netherlands;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"D'Haens","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology & Hepatology, Amsterdam University Medical Center, Amsterdam, the Netherlands;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,7,1]]},"reference":[{"issue":"3","key":"R1-20260924","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/ni.2534","article-title":"Human type 1 innate lymphoid cells accumulate in inflamed mucosal tissues","volume":"14","author":"Bernink","year":"2013","journal-title":"Nat Immunol"},{"key":"R2-20260924","doi-asserted-by":"crossref","first-page":"a25032135","DOI":"10.1055\/a-2503-2135","article-title":"Optimizing duodenal tissue acquisition for mechanistic studies of duodenal ablation in type 2 diabetes","volume":"13","author":"Busch","year":"2025","journal-title":"Endosc Int Open"},{"issue":"1","key":"R3-20260924","doi-asserted-by":"crossref","first-page":"e55","DOI":"10.1002\/cpim.55","article-title":"Isolation of human innate lymphoid cells","volume":"122","author":"Krabbendam","year":"2018","journal-title":"Curr Protoc Immunol"}],"container-title":["Clinical and Translational Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.14309\/ctg.0000000000001069","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T15:00:31Z","timestamp":1790262031000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.14309\/ctg.0000000000001069"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,1]]},"references-count":3,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.14309\/ctg.0000000000001069","relation":{},"ISSN":["2155-384X","2155-384X"],"issn-type":[{"value":"2155-384X","type":"electronic"},{"value":"2155-384X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7,1]]},"assertion":[{"value":"2026-04-08","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-22","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}