{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T14:26:32Z","timestamp":1773411992909,"version":"3.50.1"},"reference-count":73,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Am J Gastroenterol"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:p>In recent years, the therapeutic goals in ulcerative colitis (UC) have become increasingly stringent. Histological features seem to be a reliable predictor of disease outcomes after therapy, and histological remission (HR) is the new frontier in the treatment of UC. Here, we first provide a historical perspective before reviewing indexes in the era of biologics; histology as a treatment goal in UC trials; the poor correlation between symptoms, endoscopy, and histology; and the impact of histology on disease outcomes. HR seems to be a promising end point for the treatment of UC because it is typically associated with better outcomes. Two new validated indexes are available to assess histology more accurately in trials, and they may also be applicable to clinical practice. Additional interventional trials are now necessary to establish definitions of HR and its potential for disease modification.<\/jats:p>","DOI":"10.14309\/ajg.0000000000000437","type":"journal-article","created":{"date-parts":[[2019,12,6]],"date-time":"2019-12-06T19:57:46Z","timestamp":1575662266000},"page":"179-189","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":76,"title":["Histological Remission in Ulcerative Colitis: Under the Microscope Is the Cure"],"prefix":"10.14309","volume":"115","author":[{"given":"Thomas","family":"Chateau","sequence":"first","affiliation":[{"name":"Department of Hepato-Gastroenterology, University Hospital of Grenoble, University of Grenoble Alpes, Grenoble, France;"},{"name":"Department of Hepato-Gastroenterology and Inserm U954, University Hospital of Nancy, University of Lorraine, Vandoeuvre-l\u00e8s-Nancy, France;"}]},{"given":"Roger","family":"Feakins","sequence":"additional","affiliation":[{"name":"Department of Cellular Pathology, Royal Free Hospital, London, United Kingdom;"}]},{"given":"Aude","family":"Marchal-Bressenot","sequence":"additional","affiliation":[{"name":"Department of Pathology, University Hospital of Reims, Reims, France;"}]},{"given":"Fernando","family":"Magro","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hospital S\u00e3o Jo\u00e3o, Porto, Portugal;"},{"name":"Department of Biomedicine, Unit of Pharmacology and Therapeutics, Faculty of Medicine, University of Porto, Porto, Portugal;"},{"name":"MedInUP, Center for Drug Discovery and Innovative Medicines, Porto, Portugal;"}]},{"given":"Silvio","family":"Danese","sequence":"additional","affiliation":[{"name":"IBD Center, Humanitas Clinical and Research Center, Milan, Italy."}]},{"given":"Laurent","family":"Peyrin-Biroulet","sequence":"additional","affiliation":[{"name":"Department of Hepato-Gastroenterology and Inserm U954, University Hospital of Nancy, University of Lorraine, Vandoeuvre-l\u00e8s-Nancy, France;"}]}],"member":"276","published-online":{"date-parts":[[2019,12,5]]},"reference":[{"key":"R1-20250611","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1016\/S0140-6736(16)32126-2","article-title":"Ulcerative colitis","volume":"389","author":"Ungaro","year":"2017","journal-title":"Lancet"},{"key":"R2-20250611","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1002\/ibd.20797","article-title":"Therapeutic strategies for the management of ulcerative colitis","volume":"15","author":"Ng","year":"2009","journal-title":"Inflamm Bowel Dis"},{"key":"R3-20250611","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s00535-010-0219-3","article-title":"New pathophysiological insights and modern treatment of IBD","volume":"45","author":"Engel","year":"2010","journal-title":"J Gastroenterol"},{"key":"R4-20250611","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1097\/MOG.0b013e3281722271","article-title":"Inflammatory bowel disease diagnosis, evaluation and classification: State-of-the art approach","volume":"23","author":"Targan","year":"2007","journal-title":"Curr Opin Gastroenterol"},{"key":"R5-20250611","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.crohns.2011.06.009","article-title":"Results from the 2nd scientific workshop of the ECCO. 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