{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T14:59:32Z","timestamp":1775141972256,"version":"3.50.1"},"reference-count":51,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Am J Gastroenterol"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:sec>\n            <jats:title>INTRODUCTION:<\/jats:title>\n            <jats:p>The safety of <jats:italic toggle=\"yes\">Helicobacter pylori<\/jats:italic> eradication treatments and to what extent adverse events (AEs) influence therapeutic compliance in clinical practice are hardly known. Our aim was to assess the frequency, type, intensity, and duration of AEs, and their impact on compliance, for the most frequently used treatments in the \u201cEuropean Registry on <jats:italic toggle=\"yes\">Helicobacter pylori<\/jats:italic> management.\u201d<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>METHODS:<\/jats:title>\n            <jats:p>Systematic prospective noninterventional registry of the clinical practice of European gastroenterologists (27 countries, 300 investigators) on the management of <jats:italic toggle=\"yes\">H. pylori<\/jats:italic> infection in routine clinical practice. All prescribed eradication treatments and their corresponding safety profile were recorded. AEs were classified depending on the intensity of symptoms as mild\/moderate\/severe and as serious AEs. All data were subject to quality control.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS:<\/jats:title>\n            <jats:p>The different treatments prescribed to 22,492 patients caused at least 1 AE in 23% of the cases; the classic bismuth-based quadruple therapy was the worst tolerated (37% of AEs). Taste disturbance (7%), diarrhea (7%), nausea (6%), and abdominal pain (3%) were the most frequent AEs. The majority of AEs were mild (57%), 6% were severe, and only 0.08% were serious, with an average duration of 7 days. The treatment compliance rate was 97%. Only 1.3% of the patients discontinued treatment due to AEs. Longer treatment durations were significantly associated with a higher incidence of AEs in standard triple, concomitant, bismuth quadruple, and levofloxacin triple or quadruple therapies.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>DISCUSSION:<\/jats:title>\n            <jats:p>\n                                 <jats:italic toggle=\"yes\">Helicobacter pylori<\/jats:italic> eradication treatment frequently induces AEs, although they are usually mild and of limited duration. Their appearance does not interfere significantly with treatment compliance.<\/jats:p>\n          <\/jats:sec>","DOI":"10.14309\/ajg.0000000000001246","type":"journal-article","created":{"date-parts":[[2021,4,12]],"date-time":"2021-04-12T02:02:20Z","timestamp":1618192940000},"page":"1220-1229","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":77,"title":["Adverse Event Profile During the Treatment of Helicobacter pylori: A Real-World Experience of 22,000 Patients From the European Registry on H. pylori Management (Hp-EuReg)"],"prefix":"10.14309","volume":"116","author":[{"given":"Olga P.","family":"Nyssen","sequence":"first","affiliation":[{"name":"Gastroenterology Unit, Hospital Universitario de La Princesa, Instituto de Investigaci\u00f3n Sanitaria Princesa (IIS-IP), Universidad Aut\u00f3noma de Madrid, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD), Madrid, Spain;"}]},{"given":"Angeles","family":"Perez-Aisa","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Agencia Sanitaria Costa del Sol, Marbella, Red de Investigaci\u00f3n en Servicios de Salud en Enfermedades Cr\u00f3nicas (REDISSEC), M\u00e1laga, Spain;"}]},{"given":"Bojan","family":"Tepes","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, AM DC Rogaska, Rogaska Slatina, Slovenia;"}]},{"given":"Manuel","family":"Castro-Fernandez","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Hospital de Valme, Sevilla, Spain;"}]},{"given":"Juozas","family":"Kupcinskas","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Lithuanian University of Health Sciences, Kaunas, Lithuania;"}]},{"given":"Laimas","family":"Jonaitis","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Lithuanian University of Health Sciences, Kaunas, Lithuania;"}]},{"given":"Luis","family":"Bujanda","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Hospital Donostia\/Instituto Biodonostia, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd), Universidad del Pa\u00eds Vasco (UPV\/EHU), San Sebasti\u00e1n, Spain;"}]},{"given":"Alfredo","family":"Lucendo","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Hospital de Tomelloso, Ciudad Real, Spain;"}]},{"given":"Natasa Brglez","family":"Jurecic","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Diagnostic Center Bled, Slovenia;"}]},{"given":"Jorge","family":"Perez-Lasala","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, HM Sanchinarro, Madrid, Spain;"}]},{"given":"Oleg","family":"Shvets","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Internal Diseases Department No. 1, National Medical University named after O.O. Bogomolets, Kyiv, Ukraine;"}]},{"given":"Galina","family":"Fadeenko","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, National Ukrainian Academy of Medical Sciences, Ukraine;"}]},{"given":"Jose M.","family":"Huguet","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Consorci Hospital General Universitari Valencia, Spain;"}]},{"given":"Zdenki","family":"Kikec","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Hospital Slovenj Gradec, Slovenj Gradec, Slovenia;"}]},{"given":"Dmitry","family":"Bordin","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, A. S. Loginov Moscow Clinical Scientific Center, Moscow, Russia;"},{"name":"Gastroenterology Unit, Department of Outpatient Therapy and Family Medicine, Tver State Medical University, Tver, Russia;"},{"name":"Gastroenterology Unit, Department of Propaedeutic of Internal diseases and Gastroenterology, A.I. Yevdokimov Moscow State University of Medicine and Dentistry, Moscow, Russia;"}]},{"given":"Irina","family":"Voynovan","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, A. S. Loginov Moscow Clinical Scientific Center, Moscow, Russia;"}]},{"given":"Marcis","family":"Leja","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Digestive Diseases Center GASTRO, Riga, Latvia;"}]},{"given":"Jose Carlos","family":"Machado","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto, and Ipatimup\u2014Institute of Molecular Pathology and Immunology of the University of Porto, Portugal;"}]},{"given":"Miguel","family":"Areia","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Portuguese Oncology Institute of Coimbra, Portugal;"}]},{"given":"Luis","family":"Fernandez-Salazar","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Hospital Cl\u00ednico Universitario Valladolid, Spain;"}]},{"given":"Luis","family":"Rodrigo","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Hospital Universitario Central de Asturias, Oviedo, Spain;"}]},{"given":"Sergey","family":"Alekseenko","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Far Eastern State Medical University Khabarovsk, Russia;"}]},{"given":"Jesus","family":"Barrio","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Hospital Rio Hortega, Valladolid, Spain;"}]},{"given":"Juan","family":"Ortu\u00f1o","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Hospital Universitari I Polit\u00e8cnic La Fe Valencia, Spain;"}]},{"given":"Monica","family":"Perona","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Hospital Quiron Marbella, Spain;"}]},{"given":"Liudmila","family":"Vologzhanina","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Gastrocentr, Perm, Russia;"}]},{"given":"Pilar Mata","family":"Romero","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Hospital San Pedro de Alc\u00e1ntara, C\u00e1ceres, Spain;"}]},{"given":"Oleg","family":"Zaytsev","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, First Clinical Medical Center Kovrov, Russia;"}]},{"given":"Theodore","family":"Rokkas","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Henry Dunant Hospital, Athens, Greece;"}]},{"given":"Sotirios","family":"Georgopoulos","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Athens Medical Center, Paleo Faliron General Hospital Athens, Greece;"}]},{"given":"Rinaldo","family":"Pellicano","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Molinette Hospital Turin, Italy;"}]},{"given":"Gyorgy M.","family":"Buzas","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Ferencv\u00e1ros Policlinic, Budapest, Hungary;"}]},{"given":"Ines","family":"Modolell","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Consorci Sanitari Terrassa, Spain;"}]},{"given":"Blas Jose","family":"Gomez Rodriguez","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Hospital Universitario Virgen Macarena, Sevilla, Spain;"}]},{"given":"Ilkay","family":"Simsek","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Dokuz Eylul University School of Medicine, Izmir, Turkey;"}]},{"given":"Cem","family":"Simsek","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Hacettepe University Ankara, Turkey;"}]},{"given":"Marina Roldan","family":"Lafuente","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Hospital General Universitario de Castellon, Spain;"}]},{"given":"Tatiana","family":"Ilchishina","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, SM-clinic, Saint-Petersburg, Russia;"}]},{"given":"Judith Gomez","family":"Camarero","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Hospital Universitario de Burgos, Spain;"}]},{"given":"Manuel","family":"Dominguez-Cajal","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Hospital San Jorge Huesca, Spain;"}]},{"given":"Vassiliki","family":"Ntouli","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, General Hospital Pireaus, Greece;"}]},{"given":"Natalia Nikolaevna","family":"Dekhnich","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Institute of Antimicrobial Chemotherapy, Smolensk, Russia;"}]},{"given":"Perminder","family":"Phull","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Aberdeen Royal Infirmary Aberdeen, United Kingdom;"}]},{"given":"Oscar","family":"Nu\u00f1ez","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Hospital Universitario Sanitas La Moraleja, Madrid, Spain;"}]},{"given":"Frode","family":"Lerang","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Medical Department, Central Hospital Ostfold, Fredrikstad, Norway;"}]},{"given":"Marino","family":"Venerito","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke University Hospital, Magdeburg, Germany;"}]},{"given":"Frederic","family":"Heluwaert","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Center Hospitalier Annecy Genvois, Pringy, France;"}]},{"given":"Ante","family":"Tonkic","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, University Hospital of Split, School of Medicine, University of Split, Croatia;"}]},{"given":"Maria","family":"Caldas","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Hospital Universitario de La Princesa, Instituto de Investigaci\u00f3n Sanitaria Princesa (IIS-IP), Universidad Aut\u00f3noma de Madrid, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD), Madrid, 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