{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T14:01:12Z","timestamp":1772114472234,"version":"3.50.1"},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACG Case Rep J","ACG Case Reports Journal"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>Combined hepatocellular-cholangiocarcinoma (cHCC-CC) is a unique entity that contains mixed elements of both hepatocellular carcinoma and cholangiocarcinoma. We report a 62-year-old woman with alcoholic cirrhosis with elevated \u03b1-fetoprotein of 25.3 ng\/mL. Abdominal computed tomography showed a poorly defined subcapsular nodular lesion in the VIII segment, showing enhancement during the arterial phase and washout in the delayed phase. Histological examination of hepatic segmentectomy revealed a malignant epithelial neoplasia constituted by 2 distinct components, consistent with the diagnosis of cHCC-CC, classical type. One year after surgical resection, the patient noticed a nodule in the right breast. Histological examination of core needle biopsy was compatible with a metastasis in the breast of the previously diagnosed liver cancer. To our knowledge, this is the first report of breast metastases from a cHCC-CC, denoting disseminated metastatic disease and poor prognosis.<\/jats:p>","DOI":"10.14309\/crj.0000000000000057","type":"journal-article","created":{"date-parts":[[2019,4,13]],"date-time":"2019-04-13T11:14:10Z","timestamp":1555154050000},"page":"e00057","source":"Crossref","is-referenced-by-count":4,"title":["Breast Metastasis From a Combined Hepatocellular\u2013Cholangiocarcinoma"],"prefix":"10.14309","volume":"6","author":[{"given":"Marco","family":"Silva","sequence":"first","affiliation":[{"name":"Gastroenterology, Centro Hospitalar de S\u00e3o Jo\u00e3o, Porto Medical School, Porto, Portugal"}]},{"given":"Rosa","family":"Coelho","sequence":"additional","affiliation":[{"name":"Gastroenterology, Centro Hospitalar de S\u00e3o Jo\u00e3o, Porto Medical School, Porto, Portugal"}]},{"given":"Elisabete","family":"Rios","sequence":"additional","affiliation":[{"name":"Pathology, Centro Hospitalar de S\u00e3o Jo\u00e3o, Porto Medical School, Porto, Portugal"}]},{"given":"Sara","family":"Gomes","sequence":"additional","affiliation":[{"name":"Emergency Department, Centro Hospitalar de S\u00e3o Jo\u00e3o, Porto Medical School, Porto, Portugal"}]},{"given":"F\u00e1tima","family":"Carneiro","sequence":"additional","affiliation":[{"name":"Pathology, Centro Hospitalar de S\u00e3o Jo\u00e3o, Porto Medical School, Porto, Portugal"}]},{"given":"Guilherme","family":"Macedo","sequence":"additional","affiliation":[{"name":"Gastroenterology, Centro Hospitalar de S\u00e3o Jo\u00e3o, Porto Medical School, Porto, Portugal"}]}],"member":"276","published-online":{"date-parts":[[2019,4,8]]},"reference":[{"key":"R1-20230717","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1007\/s00428-017-2196-x","article-title":"Histological heterogeneity in primary and metastatic classic combined hepatocellular-cholangiocarcinoma: A case series","volume":"471","author":"De Vito","year":"2017","journal-title":"Virchows Arch."},{"key":"R2-20230717","first-page":"647","article-title":"Combined liver cell and bile duct carcinoma","volume":"25","author":"Allen","year":"1949","journal-title":"Am J Pathol."},{"key":"R4-20230717","doi-asserted-by":"crossref","first-page":"2869","DOI":"10.1245\/s10434-012-2328-0","article-title":"Combined hepatocellular carcinoma and cholangio- carcinoma: Clinical features, treatment modalities, and prognosis","volume":"19","author":"Yin","year":"2012","journal-title":"Ann Surg Oncol."},{"key":"R5-20230717","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1007\/s00261-013-0069-6","article-title":"Combined hepatocellular-cholangiocarcinoma: What the radiologist needs to know about biphenotypic liver carcinoma","volume":"39","author":"Shetty","year":"2014","journal-title":"Abdom Imaging."},{"key":"R6-20230717","first-page":"283","article-title":"Combined hepatocellular and cholangiocarcinoma: A clinicopathologic study of 26 resected cases","volume":"33","author":"Yano","year":"2003","journal-title":"J Clin Oncol."},{"key":"R7-20230717","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1002\/cncr.10392","article-title":"Combined hepatocellular and cholangiocarcinoma: Demographic, clinical, and prognostic factors","volume":"94","author":"Jarnagin","year":"2002","journal-title":"Cancer"},{"key":"R8-20230717","first-page":"387","article-title":"Breast metastasis from hepatocellular carcinoma","volume":"51","author":"Lo","year":"2004","journal-title":"Hepatogastroenterology"},{"key":"R9-20230717","first-page":"3850","article-title":"Breast metastasis from hepatocellular carcinoma: A case report and literature review","volume":"10","author":"Han","year":"2017","journal-title":"Int J Clin Exp Med."},{"key":"R10-20230717","doi-asserted-by":"crossref","first-page":"4475","DOI":"10.1002\/cncr.25960","article-title":"Hepatocellular carcinoma with extrahepatic metastasis: Clinical features and prognostic factors","volume":"117","author":"Uchino","year":"2011","journal-title":"Cancer"}],"container-title":["ACG Case Reports Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/02075970-201904000-00008","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,18]],"date-time":"2023-07-18T00:04:52Z","timestamp":1689638692000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/02075970-201904000-00008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":9,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2019]]}},"URL":"https:\/\/doi.org\/10.14309\/crj.0000000000000057","relation":{},"ISSN":["2326-3253"],"issn-type":[{"value":"2326-3253","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4]]}}}