{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T13:29:17Z","timestamp":1772112557886,"version":"3.50.1"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Hormones"],"published-print":{"date-parts":[[2015,7]]},"DOI":"10.14310\/horm.2002.1560","type":"journal-article","created":{"date-parts":[[2014,12,15]],"date-time":"2014-12-15T14:58:04Z","timestamp":1418655484000},"page":"438-441","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Severe resistant hypoglycemia in a patient with a pancreatic neuroendocrine tumor on sunitinib treatment"],"prefix":"10.1007","volume":"14","author":[{"given":"Athanasios","family":"Fountas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stelios","family":"Tigas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zoe","family":"Giotaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitrios","family":"Petrakis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Pentheroudakis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agathocles","family":"Tsatsoulis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,7,1]]},"reference":[{"key":"14030438_CR1","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1196\/annals.1294.002","volume":"1014","author":"G Kl\u00f6ppel","year":"2004","unstructured":"Kl\u00f6ppel G, Perren A, Heitz PU, 2004 The gastroenteropancreatic neuroendocrine cell system and its tumors: the WHO classification. Ann N Y Acad Sci 1014: 13\u201327.","journal-title":"Ann N Y Acad Sci"},{"key":"14030438_CR2","doi-asserted-by":"publisher","first-page":"167","DOI":"10.4158\/EP13262.RA","volume":"20","author":"JR Strosberg","year":"2014","unstructured":"Strosberg JR, 2014 Systemic treatment of gastroenteropancreatic neuroendocrine tumors (GEP-NETS): current approaches and future options. Endocr Pract 20: 167\u2013175.","journal-title":"Endocr Pract"},{"key":"14030438_CR3","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1056\/NEJMoa1003825","volume":"364","author":"E Raymond","year":"2011","unstructured":"Raymond E, Dahan L, Raoul JL, et al, 2011 Sunitinib malate for the treatment of pancreatic neuroendocrine tumors. N Engl J Med 364: 501\u2013513.","journal-title":"N Engl J Med"},{"key":"14030438_CR4","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1586\/era.13.45","volume":"13","author":"J Chen","year":"2013","unstructured":"Chen J, Wang C, Han J, et al, 2013 Therapeutic effect of sunitinib malate and its influence on blood glucose concentrations in a patient with metastatic insulinoma. Expert Rev Anticancer Ther 13: 737\u2013743.","journal-title":"Expert Rev Anticancer Ther"},{"key":"14030438_CR5","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1177\/1078155210378913","volume":"17","author":"NM Agostino","year":"2011","unstructured":"Agostino NM, Chinchilli VM, Lynch CJ, et al, 2011 Effect of the tyrosine kinase inhibitors (sunitinib, sorafenib, dasatinib, and imatinib) on blood glucose levels in diabetic and nondiabetic patients in general clinical practice. J Oncol Pharm Pract 17: 197\u2013202.","journal-title":"J Oncol Pharm Pract"},{"key":"14030438_CR6","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1210\/jc.2008-1410","volume":"94","author":"PE Cryer","year":"2009","unstructured":"Cryer PE, Axelrod L, Grossman AB, et al, 2009 Evaluation and management of adult hypoglycemic disorders: an Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab 94: 709\u2013728.","journal-title":"J Clin Endocrinol Metab"},{"key":"14030438_CR7","doi-asserted-by":"publisher","first-page":"884","DOI":"10.1200\/JCO.2006.06.3602","volume":"25","author":"LQ Chow","year":"2007","unstructured":"Chow LQ, Eckhardt SG, 2007 Sunitinib: from rational design to clinical efficacy. J Clin Oncol 25: 884\u2013896.","journal-title":"J Clin Oncol"},{"key":"14030438_CR8","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1186\/s13045-014-0052-x","volume":"7","author":"V Subbiah","year":"2014","unstructured":"Subbiah V, Meric-Bernstam F, Mills GB, et al, 2014 Next generation sequencing analysis of platinum refractory advanced germ cell tumor sensitive to Sunitinib (Sutent\u00ae) a VEGFR2\/PDGFR\u03b2\/c-kit\/FLT3\/RET\/CSF1R inhibitor in a phase II trial. J Hematol Oncol 7: 52.","journal-title":"J Hematol Oncol"},{"key":"14030438_CR9","first-page":"893","volume":"32","author":"M Kogan","year":"2012","unstructured":"Kogan M, Fischer-Smith T, Kaminsky R, Lehmicke G, Rappaport J, 2012 CSF-1R up-regulation is associated with response to pharmacotherapy targeting tyrosine kinase activity in AML cell lines. Anticancer Res 32: 893\u2013899.","journal-title":"Anticancer Res"},{"key":"14030438_CR10","doi-asserted-by":"publisher","first-page":"5260","DOI":"10.1158\/1078-0432.CCR-10-0994","volume":"16","author":"LL Carr","year":"2010","unstructured":"Carr LL, Mankoff DA, Goulart BH, et al, 2010 Phase II study of daily sunitinib in FDG-PET-positive, iodine-refractory differentiated thyroid cancer and metastatic medullary carcinoma of the thyroid with functional imaging correlation. Clin Cancer Res 16: 5260\u20135268.","journal-title":"Clin Cancer Res"},{"key":"14030438_CR11","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1530\/EJE-13-0825","volume":"170","author":"MH Massicotte","year":"2014","unstructured":"Massicotte MH, Brassard M, Claude-Desroches M, et al, 2014 Tyrosine kinase inhibitor treatments in patients with metastatic thyroid carcinomas: a retrospective study of the TUTHYREF network. Eur J Endocrinol 170: 575\u2013582.","journal-title":"Eur J Endocrinol"},{"key":"14030438_CR12","doi-asserted-by":"publisher","first-page":"1380","DOI":"10.1038\/sj.bjc.6604709","volume":"99","author":"B Billemont","year":"2008","unstructured":"Billemont B, Medioni J, Taillade L, et al, 2008 Blood glucose levels in patients with metastatic renal cell carcinoma treated with sunitinib. Br J Cancer 99: 1380\u20131382.","journal-title":"Br J Cancer"},{"key":"14030438_CR13","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1093\/jjco\/hys002","volume":"42","author":"JJ Oh","year":"2012","unstructured":"Oh JJ, Hong SK, Joo YM, et al, 2012. Impact of sunitinib treatment on blood glucose levels in patients with metastatic renal cell carcinoma. Jpn J Clin Oncol 42: 314\u2013317.","journal-title":"Jpn J Clin Oncol"},{"key":"14030438_CR14","doi-asserted-by":"publisher","first-page":"18895","DOI":"10.1073\/pnas.0810246105","volume":"105","author":"C Louvet","year":"2008","unstructured":"Louvet C, Szot GL, Lang J, et al, 2008 Tyrosine kinase inhibitors reverse type 1 diabetes in nonobese diabetic mice. Proc Natl Acad Sci USA 105: 18895\u201318900.","journal-title":"Proc Natl Acad Sci USA"},{"key":"14030438_CR15","doi-asserted-by":"publisher","first-page":"87","DOI":"10.2337\/dc13-2132","volume":"37","author":"MS Huda","year":"2014","unstructured":"Huda MS, Amiel SA, Ross P, Aylwin SJ, 2014 Tyrosine kinase inhibitor sunitinib allows insulin independence in long-standing type 1 diabetes. Diabetes Care 37: 87\u201388.","journal-title":"Diabetes Care"},{"key":"14030438_CR16","doi-asserted-by":"publisher","first-page":"824","DOI":"10.1093\/annonc\/mdn047","volume":"19","author":"A Templeton","year":"2008","unstructured":"Templeton A, Brandie M, Cerny T, Gillessen S, 2008 Remission of diabetes while on sunitinib treatment for renal cell carcinoma. Ann Oncol 19: 824\u2013825.","journal-title":"Ann Oncol"},{"key":"14030438_CR17","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1096\/fj.06-6910com","volume":"21","author":"R Hagerkvist","year":"2007","unstructured":"Hagerkvist R, Sandler S, Mokhtari D, Welsh N, 2007 Amelioration of diabetes by imatinib mesylate (Gleevec): role of beta-cell NF-kappaB activation and anti-apoptotic preconditioning. FASEB J 21: 618\u2013628.","journal-title":"FASEB J"},{"key":"14030438_CR18","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1056\/NEJM200503103521023","volume":"352","author":"D Veneri","year":"2005","unstructured":"Veneri D, Franchini M, Bonora E, 2005 Imatinib and regression of type 2 diabetes. N Engl J Med 352: 1049\u20131050.","journal-title":"N Engl J Med"},{"key":"14030438_CR19","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1042\/CS20070122","volume":"114","author":"R Hagerkvist","year":"2008","unstructured":"Hagerkvist R, Jansson L, Welsh N, 2008 Imatinib mesylate improves insulin sensitivity and glucose disposal rates in rats fed a high-fat diet. Clin Sci (Lond) 114: 65\u201371.","journal-title":"Clin Sci (Lond)"},{"key":"14030438_CR20","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1038\/nature10502","volume":"478","author":"H Chen","year":"2011","unstructured":"Chen H, Gu X, Liu Y, et al, 2011 PDGF signalling controls age-dependent proliferation in pancreatic beta-cells. Nature 478: 349\u2013355.","journal-title":"Nature"},{"key":"14030438_CR21","doi-asserted-by":"publisher","first-page":"149","DOI":"10.3803\/EnM.2013.28.2.149","volume":"28","author":"JH Ohn","year":"2013","unstructured":"Ohn JH, Kim YG, Lee SH, Jung HS, 2013 Transformation of nonfunctioning pancreatic neuroendocrine carcinoma cells into insulin producing cells after treatment with sunitinib. Endocrinol Metab (Seoul) 28: 149\u2013152.","journal-title":"Endocrinol Metab (Seoul)"},{"key":"14030438_CR22","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.diabres.2011.04.011","volume":"93","author":"Y Lee","year":"2011","unstructured":"Lee Y, Jung HS, Choi HJ, et al, 2011 Life-threatening hypoglycemia induced by a tyrosine kinase inhibitor in a patient with neuroendocrine tumor: a case report. Diabetes Res Clin Pract 93: 68\u201370.","journal-title":"Diabetes Res Clin Pract"}],"container-title":["Hormones"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.14310\/horm.2002.1560.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.14310\/horm.2002.1560\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.14310\/horm.2002.1560.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,9]],"date-time":"2025-02-09T15:38:24Z","timestamp":1739115504000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.14310\/horm.2002.1560"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7]]},"references-count":22,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["14030438"],"URL":"https:\/\/doi.org\/10.14310\/horm.2002.1560","relation":{},"ISSN":["1109-3099","2520-8721"],"issn-type":[{"value":"1109-3099","type":"print"},{"value":"2520-8721","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7]]},"assertion":[{"value":"28 August 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 September 2014","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 July 2015","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}