{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T11:07:06Z","timestamp":1792148826547,"version":"4.4.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Hormones"],"published-print":{"date-parts":[[2016,7]]},"DOI":"10.14310\/horm.2002.1681","type":"journal-article","created":{"date-parts":[[2016,7,9]],"date-time":"2016-07-09T14:03:56Z","timestamp":1468073036000},"page":"385-393","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["Low vitamin D status is associated with hypothyroid Hashimoto\u2019s thyroiditis"],"prefix":"10.1007","volume":"15","author":[{"given":"Dohee","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,7,1]]},"reference":[{"key":"15030385_CR1","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/j.ejim.2011.04.012","volume":"22","author":"S Makariou","year":"2011","unstructured":"Makariou S, Liberopoulos EN, Elisaf M, Challa A, 2011 Novel roles of vitamin D in disease: What is new in 2011? Eur J Intern Med 22: 355\u2013362.","journal-title":"Eur J Intern Med"},{"key":"15030385_CR2","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1038\/nrd3318","volume":"9","author":"LA Plum","year":"2010","unstructured":"Plum LA, DeLuca HF, 2010 Vitamin D, disease and therapeutic opportunities. Nat Rev Drug Discov 9: 941\u2013955.","journal-title":"Nat Rev Drug Discov"},{"key":"15030385_CR3","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1056\/NEJMra070553","volume":"357","author":"MF Holick","year":"2007","unstructured":"Holick MF, 2007 Vitamin D deficiency. N Engl J Med 357: 266\u2013281.","journal-title":"N Engl J Med"},{"key":"15030385_CR4","doi-asserted-by":"publisher","first-page":"1911","DOI":"10.1210\/jc.2011-0385","volume":"96","author":"MF Holick","year":"2011","unstructured":"Holick MF, Binkley NC, Bischoff-Ferrari HA, et al, 2011 Evaluation, treatment, and prevention of vitamin D deficiency: an endocrine society clinical practice guideline. J Clin Endocrinol Metab 96: 1911\u20131930.","journal-title":"J Clin Endocrinol Metab"},{"key":"15030385_CR5","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1038\/cmi.2010.73","volume":"8","author":"S Kivity","year":"2011","unstructured":"Kivity S, Agmon-Levin N, Zisappl M, et al, 2011 Vitamin D and autoimmune thyroid diseases. Cell Mol Immunol 8: 243\u2013247.","journal-title":"Cell Mol Immunol"},{"key":"15030385_CR6","doi-asserted-by":"publisher","first-page":"479","DOI":"10.4158\/EP12376.OR","volume":"19","author":"NC Bozkurt","year":"2013","unstructured":"Bozkurt NC, Karbek B, Ucan B, et al, 2013 The association between severity of vitamin D deficiency and Hashimoto\u2019s thyroiditis. Endocr Pract 19: 479\u2013484.","journal-title":"Endocr Pract"},{"key":"15030385_CR7","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1007\/s12020-012-9679-y","volume":"42","author":"T Yasuda","year":"2012","unstructured":"Yasuda T, Okamoto Y, Hamada N, et al, 2012 Serum vitamin D levels are decreased and associated with thyroid volume in female patients with newly onset Graves\u2019 disease. Endocrine 42: 739\u2013741.","journal-title":"Endocrine"},{"key":"15030385_CR8","first-page":"37","volume":"17","author":"EE Mazokopakis","year":"2014","unstructured":"Mazokopakis EE, Kotsiris DA, 2014 Hashimoto\u2019s autoimmune thyroiditis and vitamin D deficiency. Current aspects. Hell J Nucl Med 17: 37\u201340.","journal-title":"Hell J Nucl Med"},{"key":"15030385_CR9","doi-asserted-by":"publisher","first-page":"476","DOI":"10.3349\/ymj.2014.55.2.476","volume":"55","author":"DY Shin","year":"2014","unstructured":"Shin DY, Kim KJ, Kim D, Hwang S, Lee EJ, 2014 Low serum vitamin D is associated with anti-thyroid peroxidase antibody in autoimmune thyroiditis. Yonsei Med J 55: 476\u2013481.","journal-title":"Yonsei Med J"},{"key":"15030385_CR10","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1089\/thy.2009.0200","volume":"21","author":"G Tamer","year":"2011","unstructured":"Tamer G, Arik S, Tamer I, Coksert D, 2011 Relative vitamin D insufficiency in Hashimoto\u2019s thyroiditis. Thyroid 21: 891\u2013896.","journal-title":"Thyroid"},{"key":"15030385_CR11","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1017\/S0007114509220824","volume":"102","author":"R Goswami","year":"2009","unstructured":"Goswami R, Marwaha RK, Gupta N, et al, 2009 Prevalence of vitamin D deficiency and its relationship with thyroid autoimmunity in Asian Indians: a community-based survey. Br J Nutr 102: 382\u2013386.","journal-title":"Br J Nutr"},{"key":"15030385_CR12","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1530\/EJE-12-0048","volume":"167","author":"G Effraimidis","year":"2012","unstructured":"Effraimidis G, Badenhoop K, Tijssen JG, Wiersinga WM, 2012 Vitamin D deficiency is not associated with early stages of thyroid autoimmunity. Eur J Endocrinol 167: 43\u201348.","journal-title":"Eur J Endocrinol"},{"key":"15030385_CR13","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1016\/j.autrev.2014.10.008","volume":"14","author":"F D\u2019Aurizio","year":"2015","unstructured":"D\u2019Aurizio F, Villalta D, Metus P, Doretto P, Tozzoli R, 2015 Is vitamin D a player or not in the pathophysiology of autoimmune thyroid diseases? Autoimmun Rev 14: 363\u2013369.","journal-title":"Autoimmun Rev"},{"key":"15030385_CR14","first-page":"222","volume":"18","author":"EE Mazokopakis","year":"2015","unstructured":"Mazokopakis EE, Papadomanolaki MG, Tsekouras KC, Evangelopoulos AD, Kotsiris DA, Tzortzinis AA, 2015 Is vitamin D related to pathogenesis and treatment of Hashimoto\u2019s thyroiditis? Hell J Nucl Med 18: 222\u2013227.","journal-title":"Hell J Nucl Med"},{"key":"15030385_CR15","doi-asserted-by":"publisher","first-page":"3661","DOI":"10.1210\/jc.2011-1568","volume":"96","author":"A Kawashima","year":"2011","unstructured":"Kawashima A, Tanigawa K, Akama T, Yoshihara A, Ishii N, Suzuki K, 2011 Innate immune activation and thyroid autoimmunity. J Clin Endocrinol Metab 96: 3661\u20133671.","journal-title":"J Clin Endocrinol Metab"},{"key":"15030385_CR16","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1046\/j.1365-2265.2004.01978.x","volume":"60","author":"S Fountoulakis","year":"2004","unstructured":"Fountoulakis S, Tsatsoulis A, 2004 On the pathogenesis of autoimmune thyroid disease: a unifying hypothesis. Clin Endocrinol (Oxf) 60: 397\u2013409.","journal-title":"Clin Endocrinol (Oxf)"},{"key":"15030385_CR17","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1159\/000135626","volume":"15","author":"AJ Klecha","year":"2008","unstructured":"Klecha AJ, Barreiro Arcos ML, Frick L, Genaro AM, Cremaschi G, 2008 Immune-endocrine interactions in autoimmune thyroid diseases. Neuroimmunomodulation 15: 68\u201375.","journal-title":"Neuroimmunomodulation"},{"key":"15030385_CR18","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1016\/j.coph.2010.04.001","volume":"10","author":"F Baeke","year":"2010","unstructured":"Baeke F, Takiishi T, Korf H, Gysemans C, Mathieu C, 2010 Vitamin D: modulator of the immune system. Curr Opin Pharmacol 10: 482\u2013496.","journal-title":"Curr Opin Pharmacol"},{"key":"15030385_CR19","doi-asserted-by":"publisher","first-page":"2502","DOI":"10.3390\/nu5072502","volume":"5","author":"B Prietl","year":"2013","unstructured":"Prietl B, Treiber G, Pieber TR, Amrein K, 2013 Vitamin D and immune function. Nutrients 5: 2502\u20132521.","journal-title":"Nutrients"},{"key":"15030385_CR20","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1111\/j.1365-2265.2011.04261.x","volume":"76","author":"M Hewison","year":"2012","unstructured":"Hewison M, 2012 An update on vitamin D and human immunity. Clin Endocrinol (Oxf) 76: 315\u2013325.","journal-title":"Clin Endocrinol (Oxf)"},{"key":"15030385_CR21","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/S1471-4914(02)02294-3","volume":"8","author":"C Mathieu","year":"2002","unstructured":"Mathieu C, Adorini L, 2002 The coming of age of 1,25-dihydroxyvitamin D3 analogs as immunomodulatory agents. Trends Mol Med 8: 174\u2013179.","journal-title":"Trends Mol Med"},{"key":"15030385_CR22","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1089\/thy.2013.0460","volume":"24","author":"YM Choi","year":"2014","unstructured":"Choi YM, Kim WG, Kim TY, et al, 2014 Low levels of serum vitamin D3 are associated with autoimmune thyroid disease in pre-menopausal women. Thyroid 24: 655\u2013661.","journal-title":"Thyroid"},{"key":"15030385_CR23","first-page":"285290","volume":"2015","author":"X Wang","year":"2015","unstructured":"Wang X, Zynat J, Guo Y, et al, 2015 Low serum vitamin D is associated with anti-thyroid-globulin antibody in female individuals. Int J Endocrinol 2015: 285290.","journal-title":"Int J Endocrinol"},{"key":"15030385_CR24","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1007\/s40618-014-0064-y","volume":"37","author":"N Mansournia","year":"2014","unstructured":"Mansournia N, Mansournia MA, Saeedi S, Dehghan J, 2014 The association between serum 250HD levels and hypothyroid Hashimoto\u2019s thyroiditis. J Endocrinol Invest 37: 473\u2013476.","journal-title":"J Endocrinol Invest"},{"key":"15030385_CR25","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1007\/s10238-014-0290-9","volume":"15","author":"I Barchetta","year":"2015","unstructured":"Barchetta I, Baroni MG, Leonetti F, et al, 2015 TSH levels are associated with vitamin D status and seasonality in an adult population of euthyroid adults Clin Exp Med 15: 389\u2013396.","journal-title":"Clin Exp Med"},{"key":"15030385_CR26","doi-asserted-by":"publisher","first-page":"2485","DOI":"10.3390\/nu7042485","volume":"7","author":"J Wang","year":"2015","unstructured":"Wang J, Lv S, Chen G, et al, 2015 Meta-analysis of the association between vitamin D and autoimmune thyroid disease. Nutrients 7: 2485\u20132498.","journal-title":"Nutrients"},{"key":"15030385_CR27","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1007\/s12020-012-9789-6","volume":"43","author":"T Yasuda","year":"2013","unstructured":"Yasuda T, Okamoto Y, Hamada N, et al, 2013 Serum vitamin D levels are decreased in patients without remission of Graves\u2019 disease. Endocrine 43: 230\u2013232.","journal-title":"Endocrine"},{"key":"15030385_CR28","doi-asserted-by":"publisher","first-page":"258","DOI":"10.4158\/EP14191.OR","volume":"21","author":"H Zhang","year":"2015","unstructured":"Zhang H, Liang L, Xie Z, 2015 Low vitamin D status is associated with increased thyrotropin-receptor antibody titer in Graves\u2019 disease. Endocr Pract 21: 258\u2013263.","journal-title":"Endocr Pract"},{"key":"15030385_CR29","doi-asserted-by":"publisher","first-page":"3813","DOI":"10.3390\/nu7053813","volume":"7","author":"MY Xu","year":"2015","unstructured":"Xu MY, Cao B, Yin J, Wang DF, Chen KL, Lu QB, 2015 Vitamin D and Graves\u2019 disease: a meta-analysis update. Nutrients 7: 3813\u20133827.","journal-title":"Nutrients"},{"key":"15030385_CR30","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1210\/jc.2010-2133","volume":"96","author":"HS Choi","year":"2011","unstructured":"Choi HS, Oh HJ, Choi H, et al, 2011 Vitamin D insufficiency in Korea-a greater threat to younger generation: the Korea National Health and Nutrition Examination Survey (KNHANES) 2008. J Clin Endocrinol Metab 96: 643\u2013651.","journal-title":"J Clin Endocrinol Metab"}],"container-title":["Hormones"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.14310\/horm.2002.1681.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.14310\/horm.2002.1681\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.14310\/horm.2002.1681.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,9]],"date-time":"2025-02-09T10:39:45Z","timestamp":1739097585000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.14310\/horm.2002.1681"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["15030385"],"URL":"https:\/\/doi.org\/10.14310\/horm.2002.1681","relation":{},"ISSN":["1109-3099","2520-8721"],"issn-type":[{"value":"1109-3099","type":"print"},{"value":"2520-8721","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7]]},"assertion":[{"value":"18 June 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 March 2016","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 July 2016","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}