{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T21:55:55Z","timestamp":1785102955787,"version":"3.55.0"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Hormones"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.14310\/horm.2002.1763","type":"journal-article","created":{"date-parts":[[2018,2,11]],"date-time":"2018-02-11T23:35:42Z","timestamp":1518392142000},"page":"423-428","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Medullary thyroid cancer, leukemia, mesothelioma and meningioma associated with germline APC and RASAL1 variants: a new syndrome?"],"prefix":"10.1007","volume":"16","author":[{"given":"Anna","family":"Angelousi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos","family":"Settas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio R.","family":"Faucz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charalampos","family":"Lyssikatos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha","family":"Quezado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narjes","family":"Nasiri-Ansari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constantine A.","family":"Stratakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Kassi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,12,30]]},"reference":[{"key":"16040423_CR1","doi-asserted-by":"crossref","unstructured":"Ball DW, 2000 Medullary thyroid carcinoma. Thyroid cancer. Springer: 365\u2013381.","DOI":"10.1007\/978-1-59259-199-2_42"},{"key":"16040423_CR2","volume-title":"GeneReviews\u00ae","author":"J Marquard","year":"2015","unstructured":"Marquard J, Eng C 2015 Multiple endocrine neoplasia type 2. In: Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Mefford HC, Stephens K, Amemiya A, Ledbetter N, (eds) GeneReviews\u00ae [Internet]. Seattle (WA): University of Washington, Seattle; 1993\u20132017."},{"key":"16040423_CR3","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1007\/s11864-003-0009-8","volume":"4","author":"JF Moley","year":"2003","unstructured":"Moley JF, 2003 Medullary thyroid carcinoma. Curr Treatm Options Oncol 4: 339\u2013347.","journal-title":"Curr Treatm Options Oncol"},{"key":"16040423_CR4","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1530\/EJE-10-0333","volume":"163","author":"C Romei","year":"2010","unstructured":"Romei C, Mariotti S, Fugazzola L, et al, 2010 Multiple endocrine neoplasia type 2 syndromes (MEN 2): results from the ItaMEN network analysis on the prevalence of different genotypes and phenotypes. Eur J Endocrinol 163: 301\u2013308.","journal-title":"Eur J Endocrinol"},{"key":"16040423_CR5","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/j.beem.2010.02.001","volume":"24","author":"N Wohllk","year":"2010","unstructured":"Wohllk N, Schweizer H, Erlic Z, et al, 2010 Multiple endocrine neoplasia type 2. Best Pract Res Clin Endocrinol Metab 24: 371\u2013387.","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"16040423_CR6","first-page":"177","volume":"83","author":"R DeLellis","year":"1976","unstructured":"DeLellis R, Wolfe H, Gagel R, et al, 1976 Adrenal medullary hyperplasia. A morphometric analysis in patients with familial medullary thyroid carcinoma. Am J Pathol 83: 177.","journal-title":"Am J Pathol"},{"key":"16040423_CR7","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1056\/NEJM198802253180804","volume":"318","author":"RF Gagel","year":"1988","unstructured":"Gagel RF, Tashjian AH, Jr, Cummings T, et al, 1988 The clinical outcome of prospective screening for multiple endocrine neoplasia type 2a. N Engl J Med 318: 478\u2013484.","journal-title":"N Engl J Med"},{"key":"16040423_CR8","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1097\/00005176-198212000-00027","volume":"1","author":"M Verdy","year":"1982","unstructured":"Verdy M, Weber AM, Roy CC, Morin CL, Cadotte M, Brochu P, 1982 Hirschsprung\u2019s disease in a family with multiple endocrine neoplasia type 2. J Pediatr Gastroenterol Nutr 1: 603\u2013608.","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"16040423_CR9","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1038\/modpathol.2010.147","volume":"24","author":"V Nose","year":"2011","unstructured":"Nose V, 2011 Familial thyroid cancer: a review. Modern Pathol 24: 19\u201333.","journal-title":"Modern Pathol"},{"key":"16040423_CR10","doi-asserted-by":"publisher","first-page":"2044","DOI":"10.1053\/j.gastro.2010.01.054","volume":"138","author":"KW Jasperson","year":"2010","unstructured":"Jasperson KW, Tuohy TM, Neklason DW, Burt RW, 2010 Hereditary and familial colon cancer. Gastroenterology 138: 2044\u20132058.","journal-title":"Gastroenterology"},{"key":"16040423_CR11","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1016\/j.soc.2015.06.006","volume":"24","author":"K Jasperson","year":"2015","unstructured":"Jasperson K, Burt RW, 2015 The Genetics of Colorectal Cancer. Surg Oncol Clin N Am 24: 683\u2013703.","journal-title":"Surg Oncol Clin N Am"},{"key":"16040423_CR12","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1097\/PPO.0b013e3182609300","volume":"18","author":"KW Jasperson","year":"2012","unstructured":"Jasperson KW, 2012 Genetic testing by cancer site: colon (polyposis syndromes). Cancer J 18: 328\u2013333.","journal-title":"Cancer J"},{"key":"16040423_CR13","doi-asserted-by":"publisher","first-page":"1316","DOI":"10.1210\/jc.2014-1225","volume":"99","author":"J Ngeow","year":"2014","unstructured":"Ngeow J, Ni Y, Tohme R, Song Chen F, Bebek G, Eng C, 2014 Germline alterations in RASAL1 in Cowden syndrome patients presenting with follicular thyroid cancer and in individuals with apparently sporadic epithelial thyroid cancer. J Clin Endocrinol Metab 99: 1316\u20131321.","journal-title":"J Clin Endocrinol Metab"},{"key":"16040423_CR14","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/S1383-5742(00)00043-0","volume":"470","author":"M Kubota","year":"2000","unstructured":"Kubota M, Lin YW, Hamahata K, et al, 2000 Cancer chemotherapy and somatic cell mutation. Mutat Res 470: 93\u2013102.","journal-title":"Mutat Res"},{"key":"16040423_CR15","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1001\/jamaoncol.2015.6053","volume":"2","author":"EM Swisher","year":"2016","unstructured":"Swisher EM, Harrell MI, Norquist BM, et al, 2016 Somatic Mosaic Mutations in PPM1D and TP53 in the Blood of Women With Ovarian Carcinoma. JAMA Oncol 2: 370\u2013372.","journal-title":"JAMA Oncol"},{"key":"16040423_CR16","doi-asserted-by":"publisher","first-page":"2984","DOI":"10.1073\/pnas.1119396109","volume":"109","author":"CD Glen","year":"2012","unstructured":"Glen CD, Dubrova YE, 2012 Exposure to anticancer drugs can result in transgenerational genomic instability in mice. Proc Natl Acad Sci U S A 109: 2984\u20132988.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"16040423_CR17","first-page":"51","volume":"15","author":"E Barg","year":"2009","unstructured":"Barg E, Godzi\u0144ski J, Wikiera B, G\u0142ab E, Jele\u0144 M, 2009 Papillary thyroid carcinoma and meningioma in 17-year-old boy \u2014 a late effect of acute lymphoblastic leukemia treatment or a new disease? Case report and literature review. Pediatr Endocrinol Diabetes Metab 15: 51\u201354.","journal-title":"Pediatr Endocrinol Diabetes Metab"},{"key":"16040423_CR18","doi-asserted-by":"publisher","first-page":"1574","DOI":"10.1016\/S0022-3468(03)00563-3","volume":"38","author":"KW Gow","year":"2003","unstructured":"Gow KW, Lensing S, Hill DA, et al, 2003 Thyroid carcinoma presenting in childhood or after treatment of childhood malignancies: An institutional experience and review of the literature. J Pediatr Surg 38: 1574\u20131580.","journal-title":"J Pediatr Surg"}],"container-title":["Hormones"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.14310\/horm.2002.1763.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.14310\/horm.2002.1763\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.14310\/horm.2002.1763.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,9]],"date-time":"2025-02-09T15:40:26Z","timestamp":1739115626000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.14310\/horm.2002.1763"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10]]},"references-count":18,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["16040423"],"URL":"https:\/\/doi.org\/10.14310\/horm.2002.1763","relation":{},"ISSN":["1109-3099","2520-8721"],"issn-type":[{"value":"1109-3099","type":"print"},{"value":"2520-8721","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10]]},"assertion":[{"value":"11 October 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 October 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 December 2017","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}