{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T20:32:48Z","timestamp":1788813168992,"version":"build-2803163510"},"reference-count":33,"publisher":"Aging and Disease","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging and disease"],"published-print":{"date-parts":[[2016]]},"DOI":"10.14336\/ad.2015.1020","type":"journal-article","created":{"date-parts":[[2021,8,4]],"date-time":"2021-08-04T00:52:31Z","timestamp":1628038351000},"page":"267","source":"Crossref","is-referenced-by-count":9,"title":["Proteolytic Cleavage of Apolipoprotein E in the Down Syndrome Brain"],"prefix":"10.14336","volume":"7","author":[{"given":"Ryan J.","family":"Day","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie L.","family":"McCarty","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kayla E.","family":"Ockerse","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Head","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Troy T.","family":"Rohn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5462","reference":[{"key":"key-10.14336\/AD.2015.1020-1","unstructured":"Lejeune J, Gautier M, Turpin R (1959). [Study of somatic chromosomes from 9 mongoloid children]. Comptes rendus hebdomadaires des seances de l\u2019Academie des sciences, 248: 1721-1722"},{"key":"key-10.14336\/AD.2015.1020-2","doi-asserted-by":"crossref","unstructured":"Sherman SL, Allen EG, Bean LH, Freeman SB (2007). Epidemiology of Down syndrome. Mental retardation and developmental disabilities research reviews, 13: 221-227","DOI":"10.1002\/mrdd.20157"},{"key":"key-10.14336\/AD.2015.1020-3","doi-asserted-by":"crossref","unstructured":"Weijerman ME, de Winter JP (2010). Clinical practice. The care of children with Down syndrome. European journal of pediatrics, 169: 1445-1452","DOI":"10.1007\/s00431-010-1253-0"},{"key":"key-10.14336\/AD.2015.1020-4","doi-asserted-by":"crossref","unstructured":"Vis JC, Duffels MG, Winter MM, Weijerman ME, Cobben JM, Huisman SA, et al. (2009). Down syndrome: a cardiovascular perspective. Journal of intellectual disability research : JIDR, 53: 419-425","DOI":"10.1111\/j.1365-2788.2009.01158.x"},{"key":"key-10.14336\/AD.2015.1020-5","doi-asserted-by":"crossref","unstructured":"Hilton JM, Fitzgerald DA, Cooper DM (1999). Respiratory morbidity of hospitalized children with Trisomy 21. Journal of paediatrics and child health, 35: 383-386","DOI":"10.1046\/j.1440-1754.1999.00386.x"},{"key":"key-10.14336\/AD.2015.1020-6","doi-asserted-by":"crossref","unstructured":"Gibson PA, Newton RW, Selby K, Price DA, Leyland K, Addison GM (2005). Longitudinal study of thyroid function in Down\u2019s syndrome in the first two decades. Archives of disease in childhood, 90: 574-578","DOI":"10.1136\/adc.2004.049536"},{"key":"key-10.14336\/AD.2015.1020-7","doi-asserted-by":"crossref","unstructured":"Caird MS, Wills BP, Dormans JP (2006). Down syndrome in children: the role of the orthopaedic surgeon. The Journal of the American Academy of Orthopaedic Surgeons, 14: 610-619","DOI":"10.5435\/00124635-200610000-00003"},{"key":"key-10.14336\/AD.2015.1020-8","doi-asserted-by":"crossref","unstructured":"American Academy of Pediatrics. Committee on G (2001). American Academy of Pediatrics: Health supervision for children with Down syndrome. Pediatrics, 107: 442-449","DOI":"10.1542\/peds.107.2.442"},{"key":"key-10.14336\/AD.2015.1020-9","doi-asserted-by":"crossref","unstructured":"Roizen NJ, Patterson D (2003). Down\u2019s syndrome. Lancet, 361: 1281-1289","DOI":"10.1016\/S0140-6736(03)12987-X"},{"key":"key-10.14336\/AD.2015.1020-10","doi-asserted-by":"crossref","unstructured":"Wisniewski KE, Dalton AJ, McLachlan C, Wen GY, Wisniewski HM (1985). Alzheimer\u2019s disease in Down\u2019s syndrome: clinicopathologic studies. Neurology, 35: 957-961","DOI":"10.1212\/WNL.35.7.957"},{"key":"key-10.14336\/AD.2015.1020-11","doi-asserted-by":"crossref","unstructured":"Mann DM, Esiri MM (1989). The pattern of acquisition of plaques and tangles in the brains of patients under 50 years of age with Down\u2019s syndrome. J Neurol Sci, 89: 169-179","DOI":"10.1016\/0022-510X(89)90019-1"},{"key":"key-10.14336\/AD.2015.1020-12","doi-asserted-by":"crossref","unstructured":"Hof PR, Bouras C, Perl DP, Sparks DL, Mehta N, Morrison JH (1995). Age-related distribution of neuropathologic changes in the cerebral cortex of patients with Down\u2019s syndrome. Quantitative regional analysis and comparison with Alzheimer\u2019s disease. Arch Neurol, 52: 379-391","DOI":"10.1001\/archneur.1995.00540280065020"},{"key":"key-10.14336\/AD.2015.1020-13","doi-asserted-by":"crossref","unstructured":"Zigman WB, Schupf N, Urv T, Zigman A, Silverman W (2002). Incidence and temporal patterns of adaptive behavior change in adults with mental retardation. American journal of mental retardation : AJMR, 107: 161-174","DOI":"10.1352\/0895-8017(2002)107<0161:IATPOA>2.0.CO;2"},{"key":"key-10.14336\/AD.2015.1020-14","doi-asserted-by":"crossref","unstructured":"Schupf N, Sergievsky GH (2002). Genetic and host factors for dementia in Down\u2019s syndrome. The British journal of psychiatry : the journal of mental science, 180: 405-410","DOI":"10.1192\/bjp.180.5.405"},{"key":"key-10.14336\/AD.2015.1020-15","doi-asserted-by":"crossref","unstructured":"Weisgraber KH, Rall SCJr., Mahley RW (1981). Human E apoprotein heterogeneity. Cysteine-arginine interchanges in the amino acid sequence of the apo-E isoforms. J Biol Chem, 256: 9077-9083","DOI":"10.1016\/S0021-9258(19)52510-8"},{"key":"key-10.14336\/AD.2015.1020-16","doi-asserted-by":"crossref","unstructured":"Eisenstein M (2011). Genetics: finding risk factors. Nature, 475: S20-22","DOI":"10.1038\/475S20a"},{"key":"key-10.14336\/AD.2015.1020-17","doi-asserted-by":"crossref","unstructured":"Genin E, Hannequin D, Wallon D, Sleegers K, Hiltunen M, Combarros O, et al. (2011). APOE and Alzheimer disease: a major gene with semi-dominant inheritance. Molecular psychiatry, 16: 903-907","DOI":"10.1038\/mp.2011.52"},{"key":"key-10.14336\/AD.2015.1020-18","doi-asserted-by":"crossref","unstructured":"Rohn TT, McCarty KL, Love JE, Head E (2014). Is Apolipoprotein E4 an Important Risk Factor for Dementia in Persons with Down Syndrome? Journal of Parkinson\u2019s disease and Alzheimer\u2019s disease, 1","DOI":"10.13188\/2376-922X.1000004"},{"key":"key-10.14336\/AD.2015.1020-19","doi-asserted-by":"crossref","unstructured":"Zigman WB, Jenkins EC, Tycko B, Schupf N, Silverman W (2005). Mortality is associated with apolipoprotein E epsilon4 in nondemented adults with Down syndrome. Neurosci Lett, 390: 93-97","DOI":"10.1016\/j.neulet.2005.08.002"},{"key":"key-10.14336\/AD.2015.1020-20","doi-asserted-by":"crossref","unstructured":"Prasher VP, Sajith SG, Rees SD, Patel A, Tewari S, Schupf N, et al. (2008). Significant effect of APOE epsilon 4 genotype on the risk of dementia in Alzheimer\u2019s disease and mortality in persons with Down syndrome. International journal of geriatric psychiatry, 23: 1134-1140","DOI":"10.1002\/gps.2039"},{"key":"key-10.14336\/AD.2015.1020-21","doi-asserted-by":"crossref","unstructured":"Rohn TT (2013). Proteolytic cleavage of apolipoprotein e4 as the keystone for the heightened risk associated with Alzheimer\u2019s disease. International journal of molecular sciences, 14: 14908-14922","DOI":"10.3390\/ijms140714908"},{"key":"key-10.14336\/AD.2015.1020-22","doi-asserted-by":"crossref","unstructured":"Rohn TT, Catlin LW, Coonse KG, Habig JW (2012). Identification of an amino-terminal fragment of apolipoprotein E4 that localizes to neurofibrillary tangles of the Alzheimer\u2019s disease brain. Brain Res, 1475: 106-115","DOI":"10.1016\/j.brainres.2012.08.003"},{"key":"key-10.14336\/AD.2015.1020-23","unstructured":"Rohn TT, Day RJ, Sheffield CB, Rajic AJ, Poon WW (2014). Apolipoprotein E pathology in vascular dementia. Int J Clin Exp Pathol, 7: 938-947"},{"key":"key-10.14336\/AD.2015.1020-24","doi-asserted-by":"crossref","unstructured":"Rohn TT, Day RJ, Catlin LW, Brown RJ, Rajic AJ, Poon WW (2013). Immunolocalization of an amino-terminal fragment of apolipoprotein E in the Pick\u2019s disease brain. PLoS One, 8: e80180","DOI":"10.1371\/journal.pone.0080180"},{"key":"key-10.14336\/AD.2015.1020-25","doi-asserted-by":"crossref","unstructured":"Montine TJ, Phelps CH, Beach TG, Bigio EH, Cairns NJ, Dickson DW, et al. (2012). National Institute on Aging-Alzheimer\u2019s Association guidelines for the neuropathologic assessment of Alzheimer\u2019s disease: a practical approach. Acta Neuropathol, 123: 1-11","DOI":"10.1007\/s00401-011-0910-3"},{"key":"key-10.14336\/AD.2015.1020-26","doi-asserted-by":"crossref","unstructured":"Goedert M, Jakes R, Vanmechelen E (1995). Monoclonal antibody AT8 recognises tau protein phosphorylated at both serine 202 and threonine 205. Neurosci Lett, 189: 167-169","DOI":"10.1016\/0304-3940(95)11484-E"},{"key":"key-10.14336\/AD.2015.1020-27","doi-asserted-by":"crossref","unstructured":"Goedert M, Jakes R, Crowther RA, Six J, Lubke U, Vandermeeren M, et al. (1993). The abnormal phosphorylation of tau protein at Ser-202 in Alzheimer disease recapitulates phosphorylation during development. Proc Natl Acad Sci U S A, 90: 5066-5070","DOI":"10.1073\/pnas.90.11.5066"},{"key":"key-10.14336\/AD.2015.1020-28","doi-asserted-by":"crossref","unstructured":"Greenberg SG, Davies P, Schein JD, Binder LI (1992). Hydrofluoric acid-treated tau PHF proteins display the same biochemical properties as normal tau. J Biol Chem, 267: 564-569","DOI":"10.1016\/S0021-9258(18)48531-6"},{"key":"key-10.14336\/AD.2015.1020-29","doi-asserted-by":"crossref","unstructured":"Huang Y, Liu XQ, Wyss-Coray T, Brecht WJ, Sanan DA, Mahley RW (2001). Apolipoprotein E fragments present in Alzheimer\u2019s disease brains induce neurofibrillary tangle-like intracellular inclusions in neurons. Proc Natl Acad Sci U S A, 98: 8838-8843","DOI":"10.1073\/pnas.151254698"},{"key":"key-10.14336\/AD.2015.1020-30","doi-asserted-by":"crossref","unstructured":"Harris FM, Brecht WJ, Xu Q, Tesseur I, Kekonius L, Wyss-Coray T, et al. (2003). Carboxyl-terminal-truncated apolipoprotein E4 causes Alzheimer\u2019s disease-like neurodegeneration and behavioral deficits in transgenic mice. Proc Natl Acad Sci U S A, 100: 10966-10971","DOI":"10.1073\/pnas.1434398100"},{"key":"key-10.14336\/AD.2015.1020-31","doi-asserted-by":"crossref","unstructured":"Serrano-Pozo A, Frosch MP, Masliah E, Hyman BT (2011). Neuropathological alterations in Alzheimer disease. Cold Spring Harbor perspectives in medicine, 1: a006189","DOI":"10.1101\/cshperspect.a006189"},{"key":"key-10.14336\/AD.2015.1020-32","doi-asserted-by":"crossref","unstructured":"Morrow JA, Segall ML, Lund-Katz S, Phillips MC, Knapp M, Rupp B, et al. (2000). Differences in stability among the human apolipoprotein E isoforms determined by the amino-terminal domain. Biochemistry, 39: 11657-11666","DOI":"10.1021\/bi000099m"},{"key":"key-10.14336\/AD.2015.1020-33","doi-asserted-by":"crossref","unstructured":"Verghese PB, Castellano JM, HoltzmanDM Apolipoprotein E in Alzheimer\u2019s disease and other neurological disorders. Lancet Neurol, 10: 241-252","DOI":"10.1016\/S1474-4422(10)70325-2"}],"container-title":["Aging and disease"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.aginganddisease.org\/fileup\/2152-5250\/PDF\/2152-5250-2016-3-267.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,4]],"date-time":"2021-08-04T00:52:31Z","timestamp":1628038351000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.aginganddisease.org\/EN\/10.14336\/AD.2015.1020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":33,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016]]}},"URL":"https:\/\/doi.org\/10.14336\/ad.2015.1020","relation":{},"ISSN":["2152-5250"],"issn-type":[{"value":"2152-5250","type":"print"}],"subject":[],"published":{"date-parts":[[2016]]}}}