{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T11:37:11Z","timestamp":1790336231827,"version":"4.1.0"},"reference-count":65,"publisher":"Aging and Disease","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging and disease"],"published-print":{"date-parts":[[2019]]},"DOI":"10.14336\/ad.2018.0616","type":"journal-article","created":{"date-parts":[[2018,12,13]],"date-time":"2018-12-13T08:32:27Z","timestamp":1544689947000},"page":"483","source":"Crossref","is-referenced-by-count":30,"title":["Adipose-derived Stem Cells Attenuates Diabetic Osteoarthritis via Inhibition of Glycation-mediated Inflammatory Cascade"],"prefix":"10.14336","volume":"10","author":[{"given":"Navneet Kumar","family":"Dubey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Jian","family":"Wei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung-Hsun","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David F.","family":"Williams","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph R.","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue-Hua","family":"Deng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng-Chou","family":"Tsai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter D.","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Win-Ping","family":"Deng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5462","reference":[{"key":"key-10.14336\/AD.2018.0616-1","doi-asserted-by":"crossref","unstructured":"Shaw JE, Sicree RA, Zimmet PZ (2010). Global estimates of the prevalence of diabetes for 2010 and 2030. Diabetes Res Clin Pract, 87:4-14.","DOI":"10.1016\/j.diabres.2009.10.007"},{"key":"key-10.14336\/AD.2018.0616-2","doi-asserted-by":"crossref","unstructured":"Yu SH, Chen SY, Li WS, Dubey NK, Chen WH, Chuu JJ, et al. (2015). Hypoglycemic Activity through a Novel Combination of Fruiting Body and Mycelia of Cordyceps militaris in High-Fat Diet-Induced Type 2 Diabetes Mellitus Mice. J Diabetes Res, 2015:723190.","DOI":"10.1155\/2015\/723190"},{"key":"key-10.14336\/AD.2018.0616-3","doi-asserted-by":"crossref","unstructured":"Loeser RF, Goldring SR, Scanzello CR, Goldring MB (2012). Osteoarthritis: a disease of the joint as an organ. Arthritis Rheum, 64:1697-1707.","DOI":"10.1002\/art.34453"},{"key":"key-10.14336\/AD.2018.0616-4","doi-asserted-by":"crossref","unstructured":"Louati K, Vidal C, Berenbaum F, Sellam J (2015). Association between diabetes mellitus and osteoarthritis: systematic literature review and meta-analysis. RMD Open, 1:e000077.","DOI":"10.1136\/rmdopen-2015-000077"},{"key":"key-10.14336\/AD.2018.0616-5","doi-asserted-by":"crossref","unstructured":"Yoshinaga E, Kawada A, Ono K, Fujimoto E, Wachi H, Harumiya S, et al. (2012). N(varepsilon)-(carboxymethyl)lysine modification of elastin alters its biological properties: implications for the accumulation of abnormal elastic fibers in actinic elastosis. J Invest Dermatol, 132:315-323.","DOI":"10.1038\/jid.2011.298"},{"key":"key-10.14336\/AD.2018.0616-6","doi-asserted-by":"crossref","unstructured":"Schmidt AM, Vianna M, Gerlach M, Brett J, Ryan J, Kao J, et al. (1992). Isolation and characterization of two binding proteins for advanced glycosylation end products from bovine lung which are present on the endothelial cell surface. J Biol Chem, 267:14987-14997.","DOI":"10.1016\/S0021-9258(18)42137-0"},{"key":"key-10.14336\/AD.2018.0616-7","doi-asserted-by":"crossref","unstructured":"Yamagishi S, Fujimori H, Yonekura H, Yamamoto Y, Yamamoto H (1998). Advanced glycation endproducts inhibit prostacyclin production and induce plasminogen activator inhibitor-1 in human microvascular endothelial cells. Diabetologia, 41:1435-1441.","DOI":"10.1007\/s001250051089"},{"key":"key-10.14336\/AD.2018.0616-8","doi-asserted-by":"crossref","unstructured":"Bierhaus A, Haslbeck KM, Humpert PM, Liliensiek B, Dehmer T, Morcos M, et al. (2004). Loss of pain perception in diabetes is dependent on a receptor of the immunoglobulin superfamily. J Clin Invest, 114:1741-1751.","DOI":"10.1172\/JCI18058"},{"key":"key-10.14336\/AD.2018.0616-9","doi-asserted-by":"crossref","unstructured":"Tan AL, Forbes JM, Cooper ME (2007). AGE, RAGE, and ROS in diabetic nephropathy. Semin Nephrol, 27:130-143.","DOI":"10.1016\/j.semnephrol.2007.01.006"},{"key":"key-10.14336\/AD.2018.0616-10","doi-asserted-by":"crossref","unstructured":"Zhang W, Ouyang H, Dass CR, Xu J (2016). Current research on pharmacologic and regenerative therapies for osteoarthritis. Bone Res, 4:15040.","DOI":"10.1038\/boneres.2015.40"},{"key":"key-10.14336\/AD.2018.0616-11","doi-asserted-by":"crossref","unstructured":"El-Ftesi S, Chang EI, Longaker MT, Gurtner GC (2009). Aging and diabetes impair the neovascular potential of adipose-derived stromal cells. Plast Reconstr Surg, 123:475-485.","DOI":"10.1097\/PRS.0b013e3181954d08"},{"key":"key-10.14336\/AD.2018.0616-12","doi-asserted-by":"crossref","unstructured":"Yu SH, Dubey NK, Li WS, Liu MC, Chiang HS, Leu SJ, et al. (2016). Cordyceps militaris Treatment Preserves Renal Function in Type 2 Diabetic Nephropathy Mice. PLoS One, 11:e0166342.","DOI":"10.1371\/journal.pone.0166342"},{"key":"key-10.14336\/AD.2018.0616-13","doi-asserted-by":"crossref","unstructured":"Brini AT, Amodeo G, Ferreira LM, Milani A, Niada S, Moschetti G, et al. (2017). Therapeutic effect of human adipose-derived stem cells and their secretome in experimental diabetic pain. Sci Rep, 7:9904.","DOI":"10.1038\/s41598-017-09487-5"},{"key":"key-10.14336\/AD.2018.0616-14","doi-asserted-by":"crossref","unstructured":"Nambu M, Kishimoto S, Nakamura S, Mizuno H, Yanagibayashi S, Yamamoto N, et al. (2009). Accelerated wound healing in healing-impaired db\/db mice by autologous adipose tissue-derived stromal cells combined with atelocollagen matrix. Ann Plast Surg, 62:317-321.","DOI":"10.1097\/SAP.0b013e31817f01b6"},{"key":"key-10.14336\/AD.2018.0616-15","doi-asserted-by":"crossref","unstructured":"Mohsin S, Siddiqi S, Collins B, Sussman MA (2011). Empowering adult stem cells for myocardial regeneration. Circ Res, 109:1415-1428.","DOI":"10.1161\/CIRCRESAHA.111.243071"},{"key":"key-10.14336\/AD.2018.0616-16","doi-asserted-by":"crossref","unstructured":"Rocha B, Calamia V, Casas V, Carrascal M, Blanco FJ, Ruiz-Romero C (2014). Secretome analysis of human mesenchymal stem cells undergoing chondrogenic differentiation. J Proteome Res, 13:1045-1054.","DOI":"10.1021\/pr401030n"},{"key":"key-10.14336\/AD.2018.0616-17","doi-asserted-by":"crossref","unstructured":"Chiellini C, Cochet O, Negroni L, Samson M, Poggi M, Ailhaud G, et al. (2008). Characterization of human mesenchymal stem cell secretome at early steps of adipocyte and osteoblast differentiation. BMC Mol Biol, 9:26.","DOI":"10.1186\/1471-2199-9-26"},{"key":"key-10.14336\/AD.2018.0616-18","doi-asserted-by":"crossref","unstructured":"Lee YS, Eun HS, Kim SY, Jeong JM, Seo W, Byun JS, et al. (2016). Hepatic immunophenotyping for streptozotocin-induced hyperglycemia in mice. Sci Rep, 6:30656.","DOI":"10.1038\/srep30656"},{"key":"key-10.14336\/AD.2018.0616-19","doi-asserted-by":"crossref","unstructured":"Deeds MC, Anderson JM, Armstrong AS, Gastineau DA, Hiddinga HJ, Jahangir A, et al. (2011). Single dose streptozotocin-induced diabetes: considerations for study design in islet transplantation models. Lab Anim, 45:131-140.","DOI":"10.1258\/la.2010.010090"},{"key":"key-10.14336\/AD.2018.0616-20","doi-asserted-by":"crossref","unstructured":"Glasson SS, Chambers MG, Van Den Berg WB, Little CB (2010). The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in the mouse. Osteoarthritis Cartilage, 18 Suppl 3:S17-23.","DOI":"10.1016\/j.joca.2010.05.025"},{"key":"key-10.14336\/AD.2018.0616-21","doi-asserted-by":"crossref","unstructured":"Tsuji W, Rubin JP, Marra KG (2014). Adipose-derived stem cells: Implications in tissue regeneration. World J Stem Cells, 6:312-321.","DOI":"10.4252\/wjsc.v6.i3.312"},{"key":"key-10.14336\/AD.2018.0616-22","doi-asserted-by":"crossref","unstructured":"Kiani C, Chen L, Wu YJ, Yee AJ, Yang BB (2002). Structure and function of aggrecan. Cell Res, 12:19-32.","DOI":"10.1038\/sj.cr.7290106"},{"key":"key-10.14336\/AD.2018.0616-23","doi-asserted-by":"crossref","unstructured":"Gkogkolou P, Bohm M (2012). Advanced glycation end products: Key players in skin aging? Dermatoendocrinol, 4:259-270.","DOI":"10.4161\/derm.22028"},{"key":"key-10.14336\/AD.2018.0616-24","doi-asserted-by":"crossref","unstructured":"Chen CY, Abell AM, Moon YS, Kim KH (2012). An advanced glycation end product (AGE)-receptor for AGEs (RAGE) axis restores adipogenic potential of senescent preadipocytes through modulation of p53 protein function. J Biol Chem, 287:44498-44507.","DOI":"10.1074\/jbc.M112.399790"},{"key":"key-10.14336\/AD.2018.0616-25","doi-asserted-by":"crossref","unstructured":"Yamagishi S, Matsui T (2010). Advanced glycation end products, oxidative stress and diabetic nephropathy. Oxid Med Cell Longev, 3:101-108.","DOI":"10.4161\/oxim.3.2.11148"},{"key":"key-10.14336\/AD.2018.0616-26","doi-asserted-by":"crossref","unstructured":"Yang RL, Shi YH, Hao G, Li W, Le GW (2008). Increasing Oxidative Stress with Progressive Hyperlipidemia in Human: Relation between Malondialdehyde and Atherogenic Index. J Clin Biochem Nutr, 43:154-158.","DOI":"10.3164\/jcbn.2008044"},{"key":"key-10.14336\/AD.2018.0616-27","doi-asserted-by":"crossref","unstructured":"Wang X, Zhao X, Tang S (2015). Inhibitory effects of EGb761 on the expression of matrix metalloproteinases (MMPs) and cartilage matrix destruction. Cell Stress Chaperones, 20:781-786.","DOI":"10.1007\/s12192-015-0600-5"},{"key":"key-10.14336\/AD.2018.0616-28","doi-asserted-by":"crossref","unstructured":"Brownlee M (2001). Biochemistry and molecular cell biology of diabetic complications. Nature, 414:813-820.","DOI":"10.1038\/414813a"},{"key":"key-10.14336\/AD.2018.0616-29","doi-asserted-by":"crossref","unstructured":"Atkinson MA, Eisenbarth GS, Michels AW (2014). Type 1 diabetes. Lancet, 383:69-82.","DOI":"10.1016\/S0140-6736(13)60591-7"},{"key":"key-10.14336\/AD.2018.0616-30","doi-asserted-by":"crossref","unstructured":"Chatterjee S, Khunti K, Davies MJ (2017). Type 2 diabetes. Lancet, 389:2239-2251.","DOI":"10.1016\/S0140-6736(17)30058-2"},{"key":"key-10.14336\/AD.2018.0616-31","doi-asserted-by":"crossref","unstructured":"Kolaparthy LK, Sanivarapu S, Moogla S, Kutcham RS (2015). Adipose Tissue - Adequate, Accessible Regenerative Material. Int J Stem Cells, 8:121-127.","DOI":"10.15283\/ijsc.2015.8.2.121"},{"key":"key-10.14336\/AD.2018.0616-32","doi-asserted-by":"crossref","unstructured":"Sowa Y, Kishida T, Imura T, Numajiri T, Nishino K, Tabata Y, et al. (2016). Adipose-Derived Stem Cells Promote Peripheral Nerve Regeneration In Vivo without Differentiation into Schwann-Like Lineage. Plast Reconstr Surg, 137:318e-330e.","DOI":"10.1097\/01.prs.0000475762.86580.36"},{"key":"key-10.14336\/AD.2018.0616-33","doi-asserted-by":"crossref","unstructured":"Kreuger J, Kjellen L (2012). Heparan sulfate biosynthesis: regulation and variability. J Histochem Cytochem, 60:898-907.","DOI":"10.1369\/0022155412464972"},{"key":"key-10.14336\/AD.2018.0616-34","doi-asserted-by":"crossref","unstructured":"Unger E, Pettersson I, Eriksson UJ, Lindahl U, Kjellen L (1991). Decreased activity of the heparan sulfate-modifying enzyme glucosaminyl N-deacetylase in hepatocytes from streptozotocin-diabetic rats. J Biol Chem, 266:8671-8674.","DOI":"10.1016\/S0021-9258(18)31496-0"},{"key":"key-10.14336\/AD.2018.0616-35","doi-asserted-by":"crossref","unstructured":"Starkman BG, Cravero JD, Delcarlo M, Loeser RF (2005). IGF-I stimulation of proteoglycan synthesis by chondrocytes requires activation of the PI 3-kinase pathway but not ERK MAPK. Biochem J, 389:723-729.","DOI":"10.1042\/BJ20041636"},{"key":"key-10.14336\/AD.2018.0616-36","doi-asserted-by":"crossref","unstructured":"Sadat S, Gehmert S, Song YH, Yen Y, Bai X, Gaiser S, et al. (2007). The cardioprotective effect of mesenchymal stem cells is mediated by IGF-I and VEGF. Biochem Biophys Res Commun, 363:674-679.","DOI":"10.1016\/j.bbrc.2007.09.058"},{"key":"key-10.14336\/AD.2018.0616-37","doi-asserted-by":"crossref","unstructured":"Gehmert S, Wenzel C, Loibl M, Brockhoff G, Huber M, Krutsch W, et al. (2014). Adipose tissue-derived stem cell secreted IGF-1 protects myoblasts from the negative effect of myostatin. Biomed Res Int, 2014:129048.","DOI":"10.1155\/2014\/129048"},{"key":"key-10.14336\/AD.2018.0616-38","doi-asserted-by":"crossref","unstructured":"Singh VP, Bali A, Singh N, Jaggi AS (2014). Advanced glycation end products and diabetic complications. Korean J Physiol Pharmacol, 18:1-14.","DOI":"10.4196\/kjpp.2014.18.1.1"},{"key":"key-10.14336\/AD.2018.0616-39","doi-asserted-by":"crossref","unstructured":"Bohlender JM, Franke S, Stein G, Wolf G (2005). Advanced glycation end products and the kidney. Am J Physiol Renal Physiol, 289:F645-659.","DOI":"10.1152\/ajprenal.00398.2004"},{"key":"key-10.14336\/AD.2018.0616-40","doi-asserted-by":"crossref","unstructured":"Chen YJ, Sheu ML, Tsai KS, Yang RS, Liu SH (2013). Advanced glycation end products induce peroxisome proliferator-activated receptor gamma down-regulation-related inflammatory signals in human chondrocytes via Toll-like receptor-4 and receptor for advanced glycation end products. PLoS One, 8:e66611.","DOI":"10.1371\/journal.pone.0066611"},{"key":"key-10.14336\/AD.2018.0616-41","doi-asserted-by":"crossref","unstructured":"Rasheed Z, Akhtar N, Haqqi TM (2011). Advanced glycation end products induce the expression of interleukin-6 and interleukin-8 by receptor for advanced glycation end product-mediated activation of mitogen-activated protein kinases and nuclear factor-kappaB in human osteoarthritis chondrocytes. Rheumatology (Oxford), 50:838-851.","DOI":"10.1093\/rheumatology\/keq380"},{"key":"key-10.14336\/AD.2018.0616-42","doi-asserted-by":"crossref","unstructured":"Crisan M, Taulescu M, Crisan D, Cosgarea R, Parvu A, Catoi C, et al. (2013). Expression of advanced glycation end-products on sun-exposed and non-exposed cutaneous sites during the ageing process in humans. PLoS One, 8:e75003.","DOI":"10.1371\/journal.pone.0075003"},{"key":"key-10.14336\/AD.2018.0616-43","doi-asserted-by":"crossref","unstructured":"Gloire G, Legrand-Poels S, Piette J (2006). NF-kappaB activation by reactive oxygen species: fifteen years later. Biochem Pharmacol, 72:1493-1505.","DOI":"10.1016\/j.bcp.2006.04.011"},{"key":"key-10.14336\/AD.2018.0616-44","doi-asserted-by":"crossref","unstructured":"Creamer P, Hochberg MC (1997). Osteoarthritis. Lancet, 350:503-508.","DOI":"10.1016\/S0140-6736(97)07226-7"},{"key":"key-10.14336\/AD.2018.0616-45","doi-asserted-by":"crossref","unstructured":"Ghosh M, Aguirre V, Wai K, Felfly H, Dietrich WD, Pearse DD (2015). The interplay between cyclic AMP, MAPK, and NF-kappaB pathways in response to proinflammatory signals in microglia. Biomed Res Int, 2015:308461.","DOI":"10.1155\/2015\/308461"},{"key":"key-10.14336\/AD.2018.0616-46","doi-asserted-by":"crossref","unstructured":"Yang S, Kim J, Ryu JH, Oh H, Chun CH, Kim BJ, et al. (2010). Hypoxia-inducible factor-2alpha is a catabolic regulator of osteoarthritic cartilage destruction. Nat Med, 16:687-693.","DOI":"10.1038\/nm.2153"},{"key":"key-10.14336\/AD.2018.0616-47","doi-asserted-by":"crossref","unstructured":"Rigoglou S, Papavassiliou AG (2013). The NF-kappaB signalling pathway in osteoarthritis. Int J Biochem Cell Biol, 45:2580-2584.","DOI":"10.1016\/j.biocel.2013.08.018"},{"key":"key-10.14336\/AD.2018.0616-48","doi-asserted-by":"crossref","unstructured":"Yang WS, Seo JW, Han NJ, Choi J, Lee KU, Ahn H, et al. (2008). High glucose-induced NF-kappaB activation occurs via tyrosine phosphorylation of IkappaBalpha in human glomerular endothelial cells: involvement of Syk tyrosine kinase. Am J Physiol Renal Physiol, 294:F1065-1075.","DOI":"10.1152\/ajprenal.00381.2007"},{"key":"key-10.14336\/AD.2018.0616-49","doi-asserted-by":"crossref","unstructured":"Hattori Y, Hattori S, Sato N, Kasai K (2000). High-glucose-induced nuclear factor kappaB activation in vascular smooth muscle cells. Cardiovasc Res, 46:188-197.","DOI":"10.1016\/S0008-6363(99)00425-3"},{"key":"key-10.14336\/AD.2018.0616-50","doi-asserted-by":"crossref","unstructured":"Marcu KB, Otero M, Olivotto E, Borzi RM, Goldring MB (2010). NF-kappaB signaling: multiple angles to target OA. Curr Drug Targets, 11:599-613.","DOI":"10.2174\/138945010791011938"},{"key":"key-10.14336\/AD.2018.0616-51","doi-asserted-by":"crossref","unstructured":"Death AK, Fisher EJ, McGrath KC, Yue DK (2003). High glucose alters matrix metalloproteinase expression in two key vascular cells: potential impact on atherosclerosis in diabetes. Atherosclerosis, 168:263-269.","DOI":"10.1016\/S0021-9150(03)00140-0"},{"key":"key-10.14336\/AD.2018.0616-52","doi-asserted-by":"crossref","unstructured":"Tsai WC, Liang FC, Cheng JW, Lin LP, Chang SC, Chen HH, et al. (2013). High glucose concentration up-regulates the expression of matrix metalloproteinase-9 and -13 in tendon cells. BMC Musculoskelet Disord, 14:255.","DOI":"10.1186\/1471-2474-14-255"},{"key":"key-10.14336\/AD.2018.0616-53","doi-asserted-by":"crossref","unstructured":"Kadoglou NP, Daskalopoulou SS, Perrea D, Liapis CD (2005). Matrix metalloproteinases and diabetic vascular complications. Angiology, 56:173-189.","DOI":"10.1177\/000331970505600208"},{"key":"key-10.14336\/AD.2018.0616-54","doi-asserted-by":"crossref","unstructured":"Carballo CB, Nakagawa Y, Sekiya I, Rodeo SA (2017). Basic Science of Articular Cartilage. Clin Sports Med, 36:413-425.","DOI":"10.1016\/j.csm.2017.02.001"},{"key":"key-10.14336\/AD.2018.0616-55","doi-asserted-by":"crossref","unstructured":"Wu H, Du J, Zheng Q (2008). Expression of MMP-1 in cartilage and synovium of experimentally induced rabbit ACLT traumatic osteoarthritis: immunohistochemical study. Rheumatol Int, 29:31-36.","DOI":"10.1007\/s00296-008-0636-2"},{"key":"key-10.14336\/AD.2018.0616-56","doi-asserted-by":"crossref","unstructured":"English K (2013). Mechanisms of mesenchymal stromal cell immunomodulation. Immunol Cell Biol, 91:19-26.","DOI":"10.1038\/icb.2012.56"},{"key":"key-10.14336\/AD.2018.0616-57","doi-asserted-by":"crossref","unstructured":"Klinker MW, Wei CH (2015). Mesenchymal stem cells in the treatment of inflammatory and autoimmune diseases in experimental animal models. World J Stem Cells, 7:556-567.","DOI":"10.4252\/wjsc.v7.i3.556"},{"key":"key-10.14336\/AD.2018.0616-58","doi-asserted-by":"crossref","unstructured":"Nasef A, Mathieu N, Chapel A, Frick J, Francois S, Mazurier C, et al. (2007). Immunosuppressive effects of mesenchymal stem cells: involvement of HLA-G. Transplantation, 84:231-237.","DOI":"10.1097\/01.tp.0000267918.07906.08"},{"key":"key-10.14336\/AD.2018.0616-59","doi-asserted-by":"crossref","unstructured":"Rehman J, Traktuev D, Li J, Merfeld-Clauss S, Temm-Grove CJ, Bovenkerk JE, et al. (2004). Secretion of angiogenic and antiapoptotic factors by human adipose stromal cells. Circulation, 109:1292-1298.","DOI":"10.1161\/01.CIR.0000121425.42966.F1"},{"key":"key-10.14336\/AD.2018.0616-60","doi-asserted-by":"crossref","unstructured":"Sun L, Cui M, Wang Z, Feng X, Mao J, Chen P, et al. (2007). Mesenchymal stem cells modified with angiopoietin-1 improve remodeling in a rat model of acute myocardial infarction. Biochem Biophys Res Commun, 357:779-784.","DOI":"10.1016\/j.bbrc.2007.04.010"},{"key":"key-10.14336\/AD.2018.0616-61","doi-asserted-by":"crossref","unstructured":"Block GJ, Ohkouchi S, Fung F, Frenkel J, Gregory C, Pochampally R, et al. (2009). Multipotent stromal cells are activated to reduce apoptosis in part by upregulation and secretion of stanniocalcin-1. Stem Cells, 27:670-681.","DOI":"10.1002\/stem.20080742"},{"key":"key-10.14336\/AD.2018.0616-62","doi-asserted-by":"crossref","unstructured":"Imberti B, Morigi M, Tomasoni S, Rota C, Corna D, Longaretti L, et al. (2007). Insulin-like growth factor-1 sustains stem cell mediated renal repair. J Am Soc Nephrol, 18:2921-2928.","DOI":"10.1681\/ASN.2006121318"},{"key":"key-10.14336\/AD.2018.0616-63","doi-asserted-by":"crossref","unstructured":"Kim Y, Kim H, Cho H, Bae Y, Suh K, Jung J (2007). Direct comparison of human mesenchymal stem cells derived from adipose tissues and bone marrow in mediating neovascularization in response to vascular ischemia. Cell Physiol Biochem, 20:867-876.","DOI":"10.1159\/000110447"},{"key":"key-10.14336\/AD.2018.0616-64","doi-asserted-by":"crossref","unstructured":"Hyldig K, Riis S, Pennisi CP, Zachar V, Fink T (2017). Implications of Extracellular Matrix Production by Adipose Tissue-Derived Stem Cells for Development of Wound Healing Therapies. Int J Mol Sci, 18.","DOI":"10.3390\/ijms18061167"},{"key":"key-10.14336\/AD.2018.0616-65","doi-asserted-by":"crossref","unstructured":"Kocan B, Maziarz A, Tabarkiewicz J, Ochiya T, Banas-Zabczyk A (2017). Trophic Activity and Phenotype of Adipose Tissue-Derived Mesenchymal Stem Cells as a Background of Their Regenerative Potential. Stem Cells Int, 2017:1653254.","DOI":"10.1155\/2017\/1653254"}],"container-title":["Aging and disease"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.aginganddisease.org\/fileup\/2152-5250\/PDF\/ad-0-0-0-1807171008-1.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T03:34:30Z","timestamp":1627529670000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.aginganddisease.org\/EN\/10.14336\/AD.2018.0616"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":65,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019]]}},"URL":"https:\/\/doi.org\/10.14336\/ad.2018.0616","relation":{},"ISSN":["2152-5250"],"issn-type":[{"value":"2152-5250","type":"print"}],"subject":[],"published":{"date-parts":[[2019]]}}}