{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T01:26:46Z","timestamp":1777598806728,"version":"3.51.4"},"reference-count":66,"publisher":"Aging and Disease","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging and disease"],"published-print":{"date-parts":[[2020]]},"DOI":"10.14336\/ad.2019.0507","type":"journal-article","created":{"date-parts":[[2020,1,15]],"date-time":"2020-01-15T17:45:26Z","timestamp":1579110326000},"page":"1","source":"Crossref","is-referenced-by-count":29,"title":["Neuropsychological Deficits Chronically Developed after Focal Ischemic Stroke and Beneficial Effects of Pharmacological Hypothermia in the Mouse"],"prefix":"10.14336","volume":"11","author":[{"given":"Zhong","family":"Weiwei","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Yan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gu","family":"Xiaohuan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kim","family":"Samuel In-young","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chin","family":"Ryan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Loye","family":"Modupe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dix","family":"Thomas A","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Ling","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Shan Ping","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"5462","reference":[{"key":"key-10.14336\/AD.2019.0507-1","doi-asserted-by":"crossref","unstructured":"Folstein MF, Maiberger R, McHugh PR (1977). Mood disorder as a specific complication of stroke. J Neurol Neurosurg Psychiatry, 40: 1018-1020","DOI":"10.1136\/jnnp.40.10.1018"},{"key":"key-10.14336\/AD.2019.0507-2","doi-asserted-by":"crossref","unstructured":"Chun HY, Whiteley WN, Dennis MS, Mead GE, Carson AJ (2018). Anxiety After Stroke: The Importance of Subtyping. Stroke, 49: 556-564","DOI":"10.1161\/STROKEAHA.117.020078"},{"key":"key-10.14336\/AD.2019.0507-3","doi-asserted-by":"crossref","unstructured":"Ayerbe L, Ayis S, Wolfe CD, Rudd AG (2013). Natural history, predictors and outcomes of depression after stroke: systematic review and meta-analysis. Br J Psychiatry, 202: 14-21","DOI":"10.1192\/bjp.bp.111.107664"},{"key":"key-10.14336\/AD.2019.0507-4","doi-asserted-by":"crossref","unstructured":"Kim JS (2016). Post-stroke Mood and Emotional Disturbances: Pharmacological Therapy Based on Mechanisms. J Stroke, 18: 244-255","DOI":"10.5853\/jos.2016.01144"},{"key":"key-10.14336\/AD.2019.0507-5","doi-asserted-by":"crossref","unstructured":"Kronenberg G, Balkaya M, Prinz V, Gertz K, Ji S, Kirste I, et al. (2012). Exofocal dopaminergic degeneration as antidepressant target in mouse model of poststroke depression. Biol Psychiatry, 72: 273-281","DOI":"10.1016\/j.biopsych.2012.02.026"},{"key":"key-10.14336\/AD.2019.0507-6","doi-asserted-by":"crossref","unstructured":"Boyko M, Kutz R, Gruenbaum BF, Cohen H, Kozlovsky N, Gruenbaum SE, et al. (2013). The influence of aging on poststroke depression using a rat model via middle cerebral artery occlusion. Cogn Affect Behav Neurosci, 13: 847-859","DOI":"10.3758\/s13415-013-0177-3"},{"key":"key-10.14336\/AD.2019.0507-7","doi-asserted-by":"crossref","unstructured":"Wei L, Rovainen CM, Woolsey TA (1995). Ministrokes in rat barrel cortex. Stroke, 26: 1459-1462","DOI":"10.1161\/01.STR.26.8.1459"},{"key":"key-10.14336\/AD.2019.0507-8","doi-asserted-by":"crossref","unstructured":"Wang LL, Li J, Gu X, Wei L, Yu SP (2017). Delayed treatment of 6-Bromoindirubin-3'-oxime stimulates neurogenesis and functional recovery after focal ischemic stroke in mice. Int J Dev Neurosci, 57: 77-84","DOI":"10.1016\/j.ijdevneu.2017.01.002"},{"key":"key-10.14336\/AD.2019.0507-9","doi-asserted-by":"crossref","unstructured":"Chen D, Wei L, Liu ZR, Yang JJ, Gu X, Wei ZZ, et al. (2018). Pyruvate Kinase M2 Increases Angiogenesis, Neurogenesis, and Functional Recovery Mediated by Upregulation of STAT3 and Focal Adhesion Kinase Activities After Ischemic Stroke in Adult Mice. Neurotherapeutics, 15: 770-784","DOI":"10.1007\/s13311-018-0635-2"},{"key":"key-10.14336\/AD.2019.0507-10","doi-asserted-by":"crossref","unstructured":"Miller EL, Murray L, Richards L, Zorowitz RD, Bakas T, Clark P, et al. (2010). Comprehensive overview of nursing and interdisciplinary rehabilitation care of the stroke patient: a scientific statement from the American Heart Association. Stroke, 41: 2402-2448","DOI":"10.1161\/STR.0b013e3181e7512b"},{"key":"key-10.14336\/AD.2019.0507-11","doi-asserted-by":"crossref","unstructured":"Robinson RG, Jorge RE (2016). Post-Stroke Depression: A Review. Am J Psychiatry, 173: 221-231","DOI":"10.1176\/appi.ajp.2015.15030363"},{"key":"key-10.14336\/AD.2019.0507-12","doi-asserted-by":"crossref","unstructured":"Coupland C, Dhiman P, Morriss R, Arthur A, Barton G, Hippisley-Cox J (2011). Antidepressant use and risk of adverse outcomes in older people: population based cohort study. BMJ, 343: d4551","DOI":"10.1136\/bmj.d4551"},{"key":"key-10.14336\/AD.2019.0507-13","doi-asserted-by":"crossref","unstructured":"Lee JH, Wei L, Gu X, Wei Z, Dix TA, Yu SP (2014). Therapeutic effects of pharmacologically induced hypothermia against traumatic brain injury in mice. J Neurotrauma, 31: 1417-1430","DOI":"10.1089\/neu.2013.3251"},{"key":"key-10.14336\/AD.2019.0507-14","doi-asserted-by":"crossref","unstructured":"Lee JH, Wei ZZ, Cao W, Won S, Gu X, Winter M, et al. (2016). Regulation of therapeutic hypothermia on inflammatory cytokines, microglia polarization, migration and functional recovery after ischemic stroke in mice. Neurobiol Dis, 96: 248-260","DOI":"10.1016\/j.nbd.2016.09.013"},{"key":"key-10.14336\/AD.2019.0507-15","doi-asserted-by":"crossref","unstructured":"Lee JH, Zhang J, Yu SP (2017). Neuroprotective mechanisms and translational potential of therapeutic hypothermia in the treatment of ischemic stroke. Neural Regen Res, 12: 341-350","DOI":"10.4103\/1673-5374.202915"},{"key":"key-10.14336\/AD.2019.0507-16","doi-asserted-by":"crossref","unstructured":"Choi KE, Hall CL, Sun JM, Wei L, Mohamad O, Dix TA, et al. (2012). A novel stroke therapy of pharmacologically induced hypothermia after focal cerebral ischemia in mice. FASEB J, 26: 2799-2810","DOI":"10.1096\/fj.11-201822"},{"key":"key-10.14336\/AD.2019.0507-17","doi-asserted-by":"crossref","unstructured":"Eagle AL, Gajewski PA, Yang M, Kechner ME, Al Masraf BS, Kennedy PJ, et al. (2015). Experience-Dependent Induction of Hippocampal DeltaFosB Controls Learning. J Neurosci, 35: 13773-13783","DOI":"10.1523\/JNEUROSCI.2083-15.2015"},{"key":"key-10.14336\/AD.2019.0507-18","doi-asserted-by":"crossref","unstructured":"Eagle AL, Mazei-Robison M, Robison AJ (2016). Sucrose Preference Test to Measure Stress-induced Anhedonia. Bio-protocol, 6: e1822","DOI":"10.21769\/BioProtoc.1822"},{"key":"key-10.14336\/AD.2019.0507-19","doi-asserted-by":"crossref","unstructured":"Yankelevitch-Yahav R, Franko M, Huly A, Doron R (2015). The forced swim test as a model of depressive-like behavior. J Vis Exp","DOI":"10.3791\/52587"},{"key":"key-10.14336\/AD.2019.0507-20","doi-asserted-by":"crossref","unstructured":"Misrani A, Tabassum S, Chen X, Tan SY, Wang JC, Yang L, et al. (2018). Differential effects of citalopram on sleep-deprivation-induced depressive-like behavior and memory impairments in mice. Prog Neuropsychopharmacol Biol Psychiatry, 88: 102-111","DOI":"10.1016\/j.pnpbp.2018.07.013"},{"key":"key-10.14336\/AD.2019.0507-21","doi-asserted-by":"crossref","unstructured":"Jiang MQ, Zhao YY, Cao W, Wei ZZ, Gu X, Wei L, et al. (2017). Long-term survival and regeneration of neuronal and vasculature cells inside the core region after ischemic stroke in adult mice. Brain Pathol, 27: 480-498","DOI":"10.1111\/bpa.12425"},{"key":"key-10.14336\/AD.2019.0507-22","doi-asserted-by":"crossref","unstructured":"Lee JH, Zhang JY, Wei ZZ, Yu SP (2018). Impaired social behaviors and minimized oxytocin signaling of the adult mice deficient in the N-methyl-d-aspartate receptor GluN3A subunit. Exp Neurol, 305: 1-12","DOI":"10.1016\/j.expneurol.2018.02.015"},{"key":"key-10.14336\/AD.2019.0507-23","doi-asserted-by":"crossref","unstructured":"Song M, Mohamad O, Gu X, Wei L, Yu SP (2013). Restoration of intracortical and thalamocortical circuits after transplantation of bone marrow mesenchymal stem cells into the ischemic brain of mice. Cell Transplant, 22: 2001-2015","DOI":"10.3727\/096368912X657909"},{"key":"key-10.14336\/AD.2019.0507-24","doi-asserted-by":"crossref","unstructured":"Wei L, Ying DJ, Cui L, Langsdorf J, Yu SP (2004). Necrosis, apoptosis and hybrid death in the cortex and thalamus after barrel cortex ischemia in rats. Brain Res, 1022: 54-61","DOI":"10.1016\/j.brainres.2004.06.080"},{"key":"key-10.14336\/AD.2019.0507-25","doi-asserted-by":"crossref","unstructured":"Calhoon GG, Tye KM (2015). Resolving the neural circuits of anxiety. Nat Neurosci, 18: 1394-1404","DOI":"10.1038\/nn.4101"},{"key":"key-10.14336\/AD.2019.0507-26","doi-asserted-by":"crossref","unstructured":"Marsden WN (2013). Synaptic plasticity in depression: molecular, cellular and functional correlates. Prog Neuropsychopharmacol Biol Psychiatry, 43: 168-184","DOI":"10.1016\/j.pnpbp.2012.12.012"},{"key":"key-10.14336\/AD.2019.0507-27","doi-asserted-by":"crossref","unstructured":"Sweatt JD (2016). Neural plasticity and behavior - sixty years of conceptual advances. J Neurochem, 139 Suppl 2: 179-199","DOI":"10.1111\/jnc.13580"},{"key":"key-10.14336\/AD.2019.0507-28","doi-asserted-by":"crossref","unstructured":"Pittenger C (2013). Disorders of memory and plasticity in psychiatric disease. Dialogues Clin Neurosci, 15: 455-463","DOI":"10.31887\/DCNS.2013.15.4\/cpittenger"},{"key":"key-10.14336\/AD.2019.0507-29","doi-asserted-by":"crossref","unstructured":"Wang LL, Chen D, Lee J, Gu X, Alaaeddine G, Li J, et al. (2014). Mobilization of endogenous bone marrow derived endothelial progenitor cells and therapeutic potential of parathyroid hormone after ischemic stroke in mice. PLoS One, 9: e87284","DOI":"10.1371\/journal.pone.0087284"},{"key":"key-10.14336\/AD.2019.0507-30","doi-asserted-by":"crossref","unstructured":"Kokko KP, Hadden MK, Price KL, Orwig KS, See RE, Dix TA (2005). In vivo behavioral effects of stable, receptor-selective neurotensin[8-13] analogues that cross the blood-brain barrier. Neuropharmacology, 48: 417-425","DOI":"10.1016\/j.neuropharm.2004.10.008"},{"key":"key-10.14336\/AD.2019.0507-31","doi-asserted-by":"crossref","unstructured":"Bissette G, Nemeroff CB, Loosen PT, Prange AJJr, Lipton MA (1976). Hypothermia and intolerance to cold induced by intracisternal administration of the hypothalamic peptide neurotensin. Nature, 262: 607-609","DOI":"10.1038\/262607a0"},{"key":"key-10.14336\/AD.2019.0507-32","doi-asserted-by":"crossref","unstructured":"Sladojevic N, Stamatovic SM, Keep RF, Grailer JJ, Sarma JV, Ward PA, et al. (2014). Inhibition of junctional adhesion molecule-A\/LFA interaction attenuates leukocyte trafficking and inflammation in brain ischemia\/reperfusion injury. Neurobiol Dis, 67: 57-70","DOI":"10.1016\/j.nbd.2014.03.010"},{"key":"key-10.14336\/AD.2019.0507-33","doi-asserted-by":"crossref","unstructured":"Yenari MA, Kauppinen TM, Swanson RA (2010). Microglial activation in stroke: therapeutic targets. Neurotherapeutics, 7: 378-391","DOI":"10.1016\/j.nurt.2010.07.005"},{"key":"key-10.14336\/AD.2019.0507-34","doi-asserted-by":"crossref","unstructured":"Gelderblom M, Leypoldt F, Lewerenz J, Birkenmayer G, Orozco D, Ludewig P, et al. (2012). The flavonoid fisetin attenuates postischemic immune cell infiltration, activation and infarct size after transient cerebral middle artery occlusion in mice. J Cereb Blood Flow Metab, 32: 835-843","DOI":"10.1038\/jcbfm.2011.189"},{"key":"key-10.14336\/AD.2019.0507-35","doi-asserted-by":"crossref","unstructured":"Wei S, Sun J, Li J, Wang L, Hall CL, Dix TA, et al. (2013). Acute and delayed protective effects of pharmacologically induced hypothermia in an intracerebral hemorrhage stroke model of mice. Neuroscience, 252: 489-500","DOI":"10.1016\/j.neuroscience.2013.07.052"},{"key":"key-10.14336\/AD.2019.0507-36","doi-asserted-by":"crossref","unstructured":"Gu X, Wei ZZ, Espinera A, Lee JH, Ji X, Wei L, et al. (2015). Pharmacologically induced hypothermia attenuates traumatic brain injury in neonatal rats. Exp Neurol, 267: 135-142","DOI":"10.1016\/j.expneurol.2015.02.029"},{"key":"key-10.14336\/AD.2019.0507-37","doi-asserted-by":"crossref","unstructured":"Lee JH, Wei L, Gu X, Won S, Wei ZZ, Dix TA, et al. (2016). Improved Therapeutic Benefits by Combining Physical Cooling With Pharmacological Hypothermia After Severe Stroke in Rats. Stroke, 47: 1907-1913","DOI":"10.1161\/STROKEAHA.116.013061"},{"key":"key-10.14336\/AD.2019.0507-38","doi-asserted-by":"crossref","unstructured":"Loubinoux I, Kronenberg G, Endres M, Schumann-Bard P, Freret T, Filipkowski RK, et al. (2012). Post-stroke depression: mechanisms, translation and therapy. J Cell Mol Med, 16: 1961-1969","DOI":"10.1111\/j.1582-4934.2012.01555.x"},{"key":"key-10.14336\/AD.2019.0507-39","doi-asserted-by":"crossref","unstructured":"Sugerman NT, Abella BS (2009). Hospital-based use of therapeutic hypothermia after cardiac arrest in adults. J Neurotrauma, 26: 371-376","DOI":"10.1089\/neu.2008.0588"},{"key":"key-10.14336\/AD.2019.0507-40","doi-asserted-by":"crossref","unstructured":"Liu W, Ge T, Leng Y, Pan Z, Fan J, Yang W, et al. (2017). The Role of Neural Plasticity in Depression: From Hippocampus to Prefrontal Cortex. Neural Plast, 2017: 6871089","DOI":"10.1155\/2017\/6871089"},{"key":"key-10.14336\/AD.2019.0507-41","doi-asserted-by":"crossref","unstructured":"Janak PH, Tye KM (2015). From circuits to behaviour in the amygdala. Nature, 517: 284-292","DOI":"10.1038\/nature14188"},{"key":"key-10.14336\/AD.2019.0507-42","doi-asserted-by":"crossref","unstructured":"Ochsner KN, Bunge SA, Gross JJ, Gabrieli JD (2002). Rethinking feelings: an FMRI study of the cognitive regulation of emotion. J Cogn Neurosci, 14: 1215-1229","DOI":"10.1162\/089892902760807212"},{"key":"key-10.14336\/AD.2019.0507-43","doi-asserted-by":"crossref","unstructured":"Kim MJ, Loucks RA, Palmer AL, Brown AC, Solomon KM, Marchante AN, et al. (2011). The structural and functional connectivity of the amygdala: from normal emotion to pathological anxiety. Behav Brain Res, 223: 403-410","DOI":"10.1016\/j.bbr.2011.04.025"},{"key":"key-10.14336\/AD.2019.0507-44","doi-asserted-by":"crossref","unstructured":"Egorova N, Cumming T, Shirbin C, Veldsman M, Werden E, Brodtmann A (2018). Lower cognitive control network connectivity in stroke participants with depressive features. Transl Psychiatry, 7: 4","DOI":"10.1038\/s41398-017-0038-x"},{"key":"key-10.14336\/AD.2019.0507-45","doi-asserted-by":"crossref","unstructured":"Shi Y, Zeng Y, Wu L, Liu W, Liu Z, Zhang S, et al. (2017). A Study of the Brain Abnormalities of Post-Stroke Depression in Frontal Lobe Lesion. Sci Rep, 7: 13203","DOI":"10.1038\/s41598-017-13681-w"},{"key":"key-10.14336\/AD.2019.0507-46","doi-asserted-by":"crossref","unstructured":"Vahid-Ansari F, Lagace DC, Albert PR (2016). Persistent post-stroke depression in mice following unilateral medial prefrontal cortical stroke. Transl Psychiatry, 6: e863","DOI":"10.1038\/tp.2016.124"},{"key":"key-10.14336\/AD.2019.0507-47","doi-asserted-by":"crossref","unstructured":"Brecht S, Waetzig V, Hidding U, Hanisch UK, Walther M, Herdegen T, et al. (2009). FK506 protects against various immune responses and secondary degeneration following cerebral ischemia. Anat Rec (Hoboken), 292: 1993-2001","DOI":"10.1002\/ar.20994"},{"key":"key-10.14336\/AD.2019.0507-48","doi-asserted-by":"crossref","unstructured":"Nordborg C, Johansson BB (1996). Secondary thalamic lesions after ligation of the middle cerebral artery: an ultrastructural study. Acta Neuropathol, 91: 61-66","DOI":"10.1007\/s004010050392"},{"key":"key-10.14336\/AD.2019.0507-49","doi-asserted-by":"crossref","unstructured":"Tennant KA, Taylor SL, White ER, Brown CE (2017). Optogenetic rewiring of thalamocortical circuits to restore function in the stroke injured brain. Nat Commun, 8: 15879","DOI":"10.1038\/ncomms15879"},{"key":"key-10.14336\/AD.2019.0507-50","doi-asserted-by":"crossref","unstructured":"Najjar S, Pearlman DM, Alper K, Najjar A, Devinsky O (2013). Neuroinflammation and psychiatric illness. J Neuroinflammation, 10: 43","DOI":"10.1186\/1742-2094-10-43"},{"key":"key-10.14336\/AD.2019.0507-51","doi-asserted-by":"crossref","unstructured":"Bonaccorso S, Puzella A, Marino V, Pasquini M, Biondi M, Artini M, et al. (2001). Immunotherapy with interferon-alpha in patients affected by chronic hepatitis C induces an intercorrelated stimulation of the cytokine network and an increase in depressive and anxiety symptoms. Psychiatry Res, 105: 45-55","DOI":"10.1016\/S0165-1781(01)00315-8"},{"key":"key-10.14336\/AD.2019.0507-52","doi-asserted-by":"crossref","unstructured":"Dowlati Y, Herrmann N, Swardfager W, Liu H, Sham L, Reim EK, et al. (2010). A meta-analysis of cytokines in major depression. Biol Psychiatry, 67: 446-457","DOI":"10.1016\/j.biopsych.2009.09.033"},{"key":"key-10.14336\/AD.2019.0507-53","doi-asserted-by":"crossref","unstructured":"Eyre HA, Air T, Pradhan A, Johnston J, Lavretsky H, Stuart MJ, et al. (2016). A meta-analysis of chemokines in major depression. Prog Neuropsychopharmacol Biol Psychiatry, 68: 1-8","DOI":"10.1016\/j.pnpbp.2016.02.006"},{"key":"key-10.14336\/AD.2019.0507-54","doi-asserted-by":"crossref","unstructured":"Merendino RA, Di Rosa AE, Di Pasquale G, Minciullo PL, Mangraviti C, Costantino A, et al. (2002). Interleukin-18 and CD30 serum levels in patients with moderate-severe depression. Mediators Inflamm, 11: 265-267","DOI":"10.1080\/096293502900000131"},{"key":"key-10.14336\/AD.2019.0507-55","doi-asserted-by":"crossref","unstructured":"Owen BM, Eccleston D, Ferrier IN, Young AH (2001). Raised levels of plasma interleukin-1beta in major and postviral depression. Acta Psychiatr Scand, 103: 226-228","DOI":"10.1034\/j.1600-0447.2001.00162.x"},{"key":"key-10.14336\/AD.2019.0507-56","doi-asserted-by":"crossref","unstructured":"Gertz K, Kronenberg G, Kalin RE, Baldinger T, Werner C, Balkaya M, et al. (2012). Essential role of interleukin-6 in post-stroke angiogenesis. Brain, 135: 1964-1980","DOI":"10.1093\/brain\/aws075"},{"key":"key-10.14336\/AD.2019.0507-57","unstructured":"Hewett SJ, Jackman NA, Claycomb RJ (2012). Interleukin-1beta in Central Nervous System Injury and Repair. Eur J Neurodegener Dis, 1: 195-211"},{"key":"key-10.14336\/AD.2019.0507-58","doi-asserted-by":"crossref","unstructured":"Spalletta G, Cravello L, Imperiale F, Salani F, Bossu P, Picchetto L, et al. (2013). Neuropsychiatric symptoms and interleukin-6 serum levels in acute stroke. J Neuropsychiatry Clin Neurosci, 25: 255-263","DOI":"10.1176\/appi.neuropsych.12120399"},{"key":"key-10.14336\/AD.2019.0507-59","doi-asserted-by":"crossref","unstructured":"Kronenberg G, Gertz K, Heinz A, Endres M (2014). Of mice and men: modelling post-stroke depression experimentally. Br J Pharmacol, 171: 4673-4689","DOI":"10.1111\/bph.12775"},{"key":"key-10.14336\/AD.2019.0507-60","doi-asserted-by":"crossref","unstructured":"Yang L, Zhang Z, Sun D, Xu Z, Yuan Y, Zhang X, et al. (2011). Low serum BDNF may indicate the development of PSD in patients with acute ischemic stroke. Int J Geriatr Psychiatry, 26: 495-502","DOI":"10.1002\/gps.2552"},{"key":"key-10.14336\/AD.2019.0507-61","doi-asserted-by":"crossref","unstructured":"Zhou Z, Lu T, Xu G, Yue X, Zhu W, Ma M, et al. (2011). Decreased serum brain-derived neurotrophic factor (BDNF) is associated with post-stroke depression but not with BDNF gene Val66Met polymorphism. Clin Chem Lab Med, 49: 185-189","DOI":"10.1515\/CCLM.2011.039"},{"key":"key-10.14336\/AD.2019.0507-62","doi-asserted-by":"crossref","unstructured":"Frijling JL (2017). Preventing PTSD with oxytocin: effects of oxytocin administration on fear neurocircuitry and PTSD symptom development in recently trauma-exposed individuals. Eur J Psychotraumatol, 8: 1302652","DOI":"10.1080\/20008198.2017.1302652"},{"key":"key-10.14336\/AD.2019.0507-63","doi-asserted-by":"crossref","unstructured":"Nemeroff CB, Bissette G, Manberg PJ, Osbahr AJ3rd, Breese GR, Prange AJJr (1980). Neurotensin-induced hypothermia: evidence for an interaction with dopaminergic systems and the hypothalamic--pituitary--thyroid axis. Brain Res, 195: 69-84","DOI":"10.1016\/0006-8993(80)90867-7"},{"key":"key-10.14336\/AD.2019.0507-64","doi-asserted-by":"crossref","unstructured":"Boules M, Li Z, Smith K, Fredrickson P, Richelson E (2013). Diverse roles of neurotensin agonists in the central nervous system. Front Endocrinol (Lausanne), 4: 36","DOI":"10.3389\/fendo.2013.00036"},{"key":"key-10.14336\/AD.2019.0507-65","doi-asserted-by":"crossref","unstructured":"Orwig KS, Lassetter MR, Hadden MK, Dix TA (2009). Comparison of N-terminal modifications on neurotensin(8-13) analogues correlates peptide stability but not binding affinity with in vivo efficacy. J Med Chem, 52: 1803-1813","DOI":"10.1021\/jm801072v"},{"key":"key-10.14336\/AD.2019.0507-66","doi-asserted-by":"crossref","unstructured":"Lokk J, Delbari A (2010). Management of depression in elderly stroke patients. Neuropsychiatr Dis Treat, 6: 539-549","DOI":"10.2147\/NDT.S7637"}],"container-title":["Aging and disease"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.aginganddisease.org\/fileup\/2152-5250\/PDF\/ad-0-0-0-1905131112-1.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T03:07:27Z","timestamp":1627528047000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.aginganddisease.org\/EN\/10.14336\/AD.2019.0507"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":66,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020]]}},"URL":"https:\/\/doi.org\/10.14336\/ad.2019.0507","relation":{},"ISSN":["2152-5250"],"issn-type":[{"value":"2152-5250","type":"print"}],"subject":[],"published":{"date-parts":[[2020]]}}}