{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T14:24:12Z","timestamp":1794407052472,"version":"4.9.0"},"reference-count":65,"publisher":"Aging and Disease","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging and disease"],"published-print":{"date-parts":[[2021]]},"DOI":"10.14336\/ad.2021.0219","type":"journal-article","created":{"date-parts":[[2021,7,3]],"date-time":"2021-07-03T17:41:37Z","timestamp":1625334097000},"page":"1043","source":"Crossref","is-referenced-by-count":60,"title":["Pediatric Stroke: Overview and Recent Updates"],"prefix":"10.14336","volume":"12","author":[{"given":"Mary","family":"Hollist","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Au","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larry","family":"Morgan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Padmashri A","family":"Shetty","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riddhi","family":"Rane","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abraham","family":"Hollist","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Amaniampong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Batool F","family":"Kirmani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5462","reference":[{"key":"key-10.14336\/AD.2021.0219-1","doi-asserted-by":"crossref","unstructured":"Chiang KL, Cheng CY (2018). Epidemiology, risk factors and characteristics of pediatric stroke: a nationwide population-based study. QJM, 111:445-454.","DOI":"10.1093\/qjmed\/hcy066"},{"key":"key-10.14336\/AD.2021.0219-2","doi-asserted-by":"crossref","unstructured":"Meyer S, Poryo M, Flotats-Bastardas M, Ebrahimi-Fakhari D, Yilmaz U (2017). Schlaganfall bei Kindern und Jugendlichen [Stroke in children and adolescents]. Radiologe, 57:569-576.","DOI":"10.1007\/s00117-017-0265-4"},{"key":"key-10.14336\/AD.2021.0219-3","doi-asserted-by":"crossref","unstructured":"Kupferman JC, Zafeiriou DI, Lande MB, Kirkham FJ, Pavlakis SG (2017). Stroke and Hypertension in Children and Adolescents. J Child Neurol, 32:408-417.","DOI":"10.1177\/0883073816685240"},{"key":"key-10.14336\/AD.2021.0219-4","doi-asserted-by":"crossref","unstructured":"deVeber GA, Kirton A, Booth FA, Yager JY, Wirrell EC, Wood E, et al (2017). Epidemiology and Outcomes of Arterial Ischemic Stroke in Children: The Canadian Pediatric Ischemic Stroke Registry. Pediatr Neurol, 69:58-70.","DOI":"10.1016\/j.pediatrneurol.2017.01.016"},{"key":"key-10.14336\/AD.2021.0219-5","doi-asserted-by":"crossref","unstructured":"Kehrer M, Sch\u00f6ning M (2009). A longitudinal study of cerebral blood flow over the first 30 months. Pediatr Res, 66:560-4.","DOI":"10.1203\/PDR.0b013e3181ba1a29"},{"key":"key-10.14336\/AD.2021.0219-6","doi-asserted-by":"crossref","unstructured":"Braun KP, Kappelle LJ, Kirkham FJ, Deveber G (2006). Diagnostic pitfalls in paediatric ischaemic stroke. Dev Med Child Neurol, 48:985-90.","DOI":"10.1017\/S0012162206002167"},{"key":"key-10.14336\/AD.2021.0219-7","doi-asserted-by":"crossref","unstructured":"Gabis LV, Yangala R, Lenn NJ (2002). Time lag to diagnosis of stroke in children. Pediatrics, 110:924-8.","DOI":"10.1542\/peds.110.5.924"},{"key":"key-10.14336\/AD.2021.0219-8","doi-asserted-by":"crossref","unstructured":"Elbers J, deVeber G, Pontigon AM, Moharir M (2014). Long-term outcomes of pediatric ischemic stroke in adulthood. J Child Neurol, 29:782-8.","DOI":"10.1177\/0883073813484358"},{"key":"key-10.14336\/AD.2021.0219-9","doi-asserted-by":"crossref","unstructured":"Fullerton HJ, Wu YW, Zhao S, Johnston SC (2003). Risk of stroke in children: ethnic and gender disparities. Neurology, 61:189-94.","DOI":"10.1212\/01.WNL.0000078894.79866.95"},{"key":"key-10.14336\/AD.2021.0219-10","doi-asserted-by":"crossref","unstructured":"Riela AR, Roach ES (1993). Etiology of stroke in children. J Child Neurol, 8:201-20.","DOI":"10.1177\/088307389300800302"},{"key":"key-10.14336\/AD.2021.0219-11","doi-asserted-by":"crossref","unstructured":"Kimberly Atianzar, Peter Casterella, Ming Zhang, Sameer Gafoor (2017). Update on the Management of Patent Foramen Ovale in 2017: Indication for Closure and Literature Review. US Cardiology Review, 11:75-9.","DOI":"10.15420\/usc.2017:18:1"},{"key":"key-10.14336\/AD.2021.0219-12","doi-asserted-by":"crossref","unstructured":"Meier ER, Rampersad A (2017). Pediatric sickle cell disease: past successes and future challenges. Pediatr Res, 81:249-258.","DOI":"10.1038\/pr.2016.204"},{"key":"key-10.14336\/AD.2021.0219-13","unstructured":"Ohene-Frempong K, Weiner SJ, Sleeper LA, Miller ST, Embury S, Moohr JW, et al (1998). Cerebrovascular accidents in sickle cell disease: rates and risk factors. Blood, 91:288-94."},{"key":"key-10.14336\/AD.2021.0219-14","doi-asserted-by":"crossref","unstructured":"Switzer JA, Hess DC, Nichols FT, Adams RJ (2006). Pathophysiology and treatment of stroke in sickle-cell disease: present and future. Lancet Neurol, 5:501-12.","DOI":"10.1016\/S1474-4422(06)70469-0"},{"key":"key-10.14336\/AD.2021.0219-15","doi-asserted-by":"crossref","unstructured":"Powers WJ, Grubb RL Jr, Darriet D, Raichle ME (1985). Cerebral blood flow and cerebral metabolic rate of oxygen requirements for cerebral function and viability in humans. J Cereb Blood Flow Metab, 5:600-8.","DOI":"10.1038\/jcbfm.1985.89"},{"key":"key-10.14336\/AD.2021.0219-16","doi-asserted-by":"crossref","unstructured":"Guilliams KP, Fields ME, Dowling MM (2019). Advances in understanding ischemic stroke physiology and the impact of vasculopathy in children with sickle cell disease. Stroke, 50:266-273.","DOI":"10.1161\/STROKEAHA.118.020482"},{"key":"key-10.14336\/AD.2021.0219-17","doi-asserted-by":"crossref","unstructured":"Tsze DS, Valente JH (2011). Pediatric stroke: a review. Emerg Med Int, 2011:734506.","DOI":"10.1155\/2011\/734506"},{"key":"key-10.14336\/AD.2021.0219-18","doi-asserted-by":"crossref","unstructured":"Kenet G, L\u00fctkhoff LK, Albisetti M, Bernard T, Bonduel M, Brandao L, et al (2010). Impact of thrombophilia on risk of arterial ischemic stroke or cerebral sinovenous thrombosis in neonates and children: a systematic review and meta-analysis of observational studies. Circulation, 121:1838-47.","DOI":"10.1161\/CIRCULATIONAHA.109.913673"},{"key":"key-10.14336\/AD.2021.0219-19","doi-asserted-by":"crossref","unstructured":"Felling RJ, Sun LR, Maxwell EC, Goldenberg N, Bernard T (2017). Pediatric arterial ischemic stroke: Epidemiology, risk factors, and management. Blood Cells Mol Dis, 67:23-33.","DOI":"10.1016\/j.bcmd.2017.03.003"},{"key":"key-10.14336\/AD.2021.0219-20","doi-asserted-by":"crossref","unstructured":"Grotta JC, Albers G, Broderick JP, Kasner SE, Lo EH, Mendelow AD, et al (2016). Arterial dissections and fibromuscular dysplasia. In: Stroke: pathophysiology, diagnosis, and management. United States: Elsevier, 599-618.","DOI":"10.1016\/B978-0-323-29544-4.00035-9"},{"key":"key-10.14336\/AD.2021.0219-21","doi-asserted-by":"crossref","unstructured":"Miller EC, Elkind MS (2016). Infection and Stroke: an Update on Recent Progress. Curr Neurol Neurosci Rep, 16:2.","DOI":"10.1007\/s11910-016-0679-9"},{"key":"key-10.14336\/AD.2021.0219-22","doi-asserted-by":"crossref","unstructured":"Noje C, Cohen K, Jordan LC (2013). Hemorrhagic and ischemic stroke in children with cancer. Pediatr Neurol, 49:237-42.","DOI":"10.1016\/j.pediatrneurol.2013.04.009"},{"key":"key-10.14336\/AD.2021.0219-23","doi-asserted-by":"crossref","unstructured":"Santoro N, Giordano P, Del Vecchio GC, Guido G, Rizzari C, Varotto S, Masera G, De Mattia D (2005). Ischemic stroke in children treated for acute lymphoblastic leukemia: a retrospective study. J Pediatr Hematol Oncol, 27:153-7.","DOI":"10.1097\/01.mph.0000157379.44167.b5"},{"key":"key-10.14336\/AD.2021.0219-24","doi-asserted-by":"crossref","unstructured":"Zaorsky NG, Zhang Y, Tchelebi LT, Mackley HB, Chinchilli VM, Zacharia BE (2019). Stroke among cancer patients. Nat Commun, 10:5172.","DOI":"10.1038\/s41467-019-13120-6"},{"key":"key-10.14336\/AD.2021.0219-25","doi-asserted-by":"crossref","unstructured":"Mueller S, Fullerton HJ, Stratton K, Leisenring W, Weathers RE, Stovall M, et al (2013). Radiation, atherosclerotic risk factors, and stroke risk in survivors of pediatric cancer: a report from the Childhood Cancer Survivor Study. Int J Radiat Oncol Biol Phys, 86:649-55.","DOI":"10.1016\/j.ijrobp.2013.03.034"},{"key":"key-10.14336\/AD.2021.0219-26","doi-asserted-by":"crossref","unstructured":"Haddy N, Mousannif A, Tukenova M, Guibout C, Grill J, Dhermain F, et al (2011). Relationship between the brain radiation dose for the treatment of childhood cancer and the risk of long-term cerebrovascular mortality. Brain, 134:1362-72.","DOI":"10.1093\/brain\/awr071"},{"key":"key-10.14336\/AD.2021.0219-27","doi-asserted-by":"crossref","unstructured":"Sun LR, Linds A, Sharma M, Rafay M, Vadivelu S, Lee S, et al (2020). International Pediatric Stroke Study Group. Cancer and Tumor-Associated Childhood Stroke: Results From the International Pediatric Stroke Study. Pediatr Neurol, 111:59-65.","DOI":"10.1016\/j.pediatrneurol.2020.06.002"},{"key":"key-10.14336\/AD.2021.0219-28","doi-asserted-by":"crossref","unstructured":"Kyrnetskiy EE, Kun LE, Boop FA, Sanford RA, Khan RB (2005). Types, causes, and outcome of intracranial hemorrhage in children with cancer. J Neurosurg, 102:31-5.","DOI":"10.3171\/ped.2005.102.1.0031"},{"key":"key-10.14336\/AD.2021.0219-29","doi-asserted-by":"crossref","unstructured":"Rabia EA, Coull BM (2018). Thrombophilias. In: Caplan L Biller J, editors. Uncommon Causes of Stroke [Internet]. 3rd ed. Cambridge University Press, 336-46.","DOI":"10.1017\/9781316551684.045"},{"key":"key-10.14336\/AD.2021.0219-30","doi-asserted-by":"crossref","unstructured":"Cunha L, Sargento-Freitas J (2018). Marfan Syndrome. In: Caplan L Biller J, editors. Uncommon Causes of Stroke. 3rd ed. Cambridge: Cambridge University Press, 170-174.","DOI":"10.1017\/9781316551684.023"},{"key":"key-10.14336\/AD.2021.0219-31","doi-asserted-by":"crossref","unstructured":"Chung C-S, Lee MJ, Caplan LR (2018). Pseudoxanthoma Elasticum. In: Caplan L Biller J, editors. Uncommon Causes of Stroke. 3rd ed. Cambridge: Cambridge University Press, 175-180.","DOI":"10.1017\/9781316551684.024"},{"key":"key-10.14336\/AD.2021.0219-32","doi-asserted-by":"crossref","unstructured":"Roach ES (2018). Ehlers-Danlos Syndrome. In: Caplan L Biller J, editors. Uncommon Causes of Stroke. 3rd ed. Cambridge: Cambridge University Press, 181-186.","DOI":"10.1017\/9781316551684.025"},{"key":"key-10.14336\/AD.2021.0219-33","unstructured":"Grotta JC, Albers G, Broderick JP, Kasner SE, Lo EH, Mendelow AD, et al (2016). MELAS Syndrome and Other Mitochondrial Disorders. In: Stroke: pathophysiology, diagnosis, and management. United States: Elsevier, 194-9."},{"key":"key-10.14336\/AD.2021.0219-34","unstructured":"Grotta JC, Albers G, Broderick JP, Kasner SE, Lo EH, Mendelow AD, et al (2016). Genetic Basis of Stroke Occurrence, Prevention and Outcome. In: Stroke: pathophysiology, diagnosis, and management. United States: Elsevier, 271."},{"key":"key-10.14336\/AD.2021.0219-35","unstructured":"Grotta JC, Albers G, Broderick JP, Kasner SE, Lo EH, Mendelow AD, et al (2016). Von Hippel-Lindau Disease. In: Stroke: pathophysiology, diagnosis, and management. United States: Elsevier, 208-14."},{"key":"key-10.14336\/AD.2021.0219-36","unstructured":"Grotta JC, Albers G, Broderick JP, Kasner SE, Lo EH, Mendelow AD, et al (2016). Sturge - Weber Syndrome. In: Stroke: pathophysiology, diagnosis, and management. United States: Elsevier, 200-7."},{"key":"key-10.14336\/AD.2021.0219-37","doi-asserted-by":"crossref","unstructured":"Mitsias P, Levine SR (1996). Cerebrovascular complications of Fabry's disease. Ann Neurol, 40:8-17.","DOI":"10.1002\/ana.410400105"},{"key":"key-10.14336\/AD.2021.0219-38","doi-asserted-by":"crossref","unstructured":"Scott RM, Smith ER (2009). Moyamoya disease and moyamoya syndrome. N Engl J Med, 360:1226-37.","DOI":"10.1056\/NEJMra0804622"},{"key":"key-10.14336\/AD.2021.0219-39","doi-asserted-by":"crossref","unstructured":"Rafay MF, Pontigon AM, Chiang J, Adams M, Jarvis DA, Silver F, et al (2009). Delay to diagnosis in acute pediatric arterial ischemic stroke. Stroke, 40:58-64.","DOI":"10.1161\/STROKEAHA.108.519066"},{"key":"key-10.14336\/AD.2021.0219-40","doi-asserted-by":"crossref","unstructured":"Williamson C, Morgan L, Klein JP (2017). Imaging in Neurocritical Care Practice. Semin Respir Crit Care Med, 38:840-852.","DOI":"10.1055\/s-0037-1608770"},{"key":"key-10.14336\/AD.2021.0219-41","doi-asserted-by":"crossref","unstructured":"Roach ES, Golomb MR, Adams R, Biller J, Daniels S, Deveber G, et al (2008). American Heart Association Stroke Council; Council on Cardiovascular Disease in the Young. Management of stroke in infants and children: a scientific statement from a Special Writing Group of the American Heart Association Stroke Council and the Council on Cardiovascular Disease in the Young. Stroke, 39:2644-91.","DOI":"10.1161\/STROKEAHA.108.189696"},{"key":"key-10.14336\/AD.2021.0219-42","doi-asserted-by":"crossref","unstructured":"Rivkin MJ, deVeber G, Ichord RN, Kirton A, Chan AK, Hovinga CA, et al (2015). Thrombolysis in pediatric stroke study. Stroke, 46:880-5.","DOI":"10.1161\/STROKEAHA.114.008210"},{"key":"key-10.14336\/AD.2021.0219-43","doi-asserted-by":"crossref","unstructured":"Mackay MT, Slavova N, Pastore-Wapp M, Grunt S, Stojanovski B, Donath S, Steinlin M (2020). Pediatric ASPECTS predicts outcomes following acute symptomatic neonatal arterial stroke. Neurology, 94:e1259-e1270.","DOI":"10.1212\/WNL.0000000000009136"},{"key":"key-10.14336\/AD.2021.0219-44","doi-asserted-by":"crossref","unstructured":"Webb TN, Shatat IF, Miyashita Y (2014). Therapy of acute hypertension in hospitalized children and adolescents. Curr Hypertens Rep, 16:425.","DOI":"10.1007\/s11906-014-0425-0"},{"key":"key-10.14336\/AD.2021.0219-45","doi-asserted-by":"crossref","unstructured":"Tabone L, Mediamolle N, Bellesme C, Lesage F, Grevent D, Ozanne A, et al (2017). Regional Pediatric Acute Stroke Protocol: Initial Experience During 3 Years and 13 Recanalization Treatments in Children. Stroke, 48:2278-2281.","DOI":"10.1161\/STROKEAHA.117.016591"},{"key":"key-10.14336\/AD.2021.0219-46","doi-asserted-by":"crossref","unstructured":"Manco-Johnson MJ, Grabowski EF, Hellgreen M, Kemahli AS, Massicotte MP, Muntean W, et al (2002). Recommendations for tPA thrombolysis in children. On behalf of the Scientific Subcommittee on Perinatal and Pediatric Thrombosis of the Scientific and Standardization Committee of the International Society of Thrombosis and Haemostasis. Thromb Haemost, 88:157-8.","DOI":"10.1055\/s-0037-1613170"},{"key":"key-10.14336\/AD.2021.0219-47","doi-asserted-by":"crossref","unstructured":"Satti S, Chen J, Sivapatham T, Jayaraman M, Orbach D (2017). Mechanical thrombectomy for pediatric acute ischemic stroke: review of the literature. J Neurointerv Surg, 9:732-737.","DOI":"10.1136\/neurintsurg-2016-012320"},{"key":"key-10.14336\/AD.2021.0219-48","doi-asserted-by":"crossref","unstructured":"Bhatia K, Kortman H, Blair C, Parker G, Brunacci D, Ang T, Worthington J, et al (2019). Mechanical thrombectomy in pediatric stroke: systematic review, individual patient data meta-analysis, and case series. J Neurosurg Pediatr, 9:1-14.","DOI":"10.1136\/jnnp-2019-anzan.12"},{"key":"key-10.14336\/AD.2021.0219-49","doi-asserted-by":"crossref","unstructured":"Fragata I, Morais T, Silva R, Nunes AP, Loureiro P, Diogo Martins J, et al (2021). Endovascular treatment of pediatric ischemic stroke: A single center experience and review of the literature. Interv Neuroradiol, 27:16-24.","DOI":"10.1177\/1591019920958827"},{"key":"key-10.14336\/AD.2021.0219-50","doi-asserted-by":"crossref","unstructured":"Shoirah H, Shallwani H, Siddiqui AH, Levy EI, Kenmuir CL, Jovin TG, et al (2019). Endovascular thrombectomy in pediatric patients with large vessel occlusion. J Neurointerv Surg, 11:729-732.","DOI":"10.1136\/neurintsurg-2018-014320"},{"key":"key-10.14336\/AD.2021.0219-51","doi-asserted-by":"crossref","unstructured":"Adams RJ, McKie VC, Hsu L, Files B, Vichinsky E, Pegelow C, et al (1998). Prevention of a first stroke by transfusions in children with sickle cell anemia and abnormal results on transcranial Doppler ultrasonography. N Engl J Med, 339:5-11.","DOI":"10.1056\/NEJM199807023390102"},{"key":"key-10.14336\/AD.2021.0219-52","doi-asserted-by":"crossref","unstructured":"Adams RJ, McKie VC, Brambilla D, Carl E, Gallagher D, Nichols FT, et al (1998). Stroke prevention trial in sickle cell anemia. Control Clin Trials, 19:110-29.","DOI":"10.1016\/S0197-2456(97)00099-8"},{"key":"key-10.14336\/AD.2021.0219-53","doi-asserted-by":"crossref","unstructured":"Lee MT, Piomelli S, Granger S, Miller ST, Harkness S, Brambilla DJ, Adams RJ (2006). STOP Study Investigators. Stroke Prevention Trial in Sickle Cell Anemia (STOP): extended follow-up and final results. Blood, 108:847-52.","DOI":"10.1182\/blood-2005-10-009506"},{"key":"key-10.14336\/AD.2021.0219-54","doi-asserted-by":"crossref","unstructured":"Mack AK, Thompson AA (2017). Primary and secondary stroke prevention in children with sickle cell disease. J Pediatr Health Care, 31:145-154.","DOI":"10.1016\/j.pedhc.2016.06.005"},{"key":"key-10.14336\/AD.2021.0219-55","doi-asserted-by":"crossref","unstructured":"Estcourt LJ, Kimber C, Hopewell S, Trivella M, Doree C, Abboud MR (2020). Interventions for preventing silent cerebral infarcts in people with sickle cell disease. Cochrane Database Syst Rev, 4:CD012389.","DOI":"10.1002\/14651858.CD012389.pub3"},{"key":"key-10.14336\/AD.2021.0219-56","doi-asserted-by":"crossref","unstructured":"Roberts DO, Covert B, Rodeghier MJ, Parmar N, DeBaun MR, Thompson AA, Liem RI (2014). Randomization is not associated with socio-economic and demographic factors in a multi-center clinical trial of children with sickle cell anemia. Pediatr Blood Cancer, 61:1529-1535.","DOI":"10.1002\/pbc.25072"},{"key":"key-10.14336\/AD.2021.0219-57","doi-asserted-by":"crossref","unstructured":"Howard J (2016). Sickle cell disease: when and how to transfuse. Hematology Am Soc Hematol Educ Program, 2016:625-631.","DOI":"10.1182\/asheducation-2016.1.625"},{"key":"key-10.14336\/AD.2021.0219-58","doi-asserted-by":"crossref","unstructured":"Chou ST (2013). Transfusion therapy for sickle cell disease: a balancing act. Hematology Am Soc Hematol Educ Program, 2013:439-46.","DOI":"10.1182\/asheducation-2013.1.439"},{"key":"key-10.14336\/AD.2021.0219-59","doi-asserted-by":"crossref","unstructured":"Nevitt SJ, Jones AP, Howard J (2017). Hydroxyurea (hydroxycarbamide) for sickle cell disease. Cochrane Database Syst Rev, 4:CD002202.","DOI":"10.1002\/14651858.CD002202.pub2"},{"key":"key-10.14336\/AD.2021.0219-60","doi-asserted-by":"crossref","unstructured":"Ware RE, Helms RW (2012). SWiTCH Investigators. Stroke With Transfusions Changing to Hydroxyurea (SWiTCH). Blood, 119:3925-32.","DOI":"10.1182\/blood-2011-11-392340"},{"key":"key-10.14336\/AD.2021.0219-61","unstructured":"Ware RE, Davis BR, Schultz WH, Brown RC, Aygun B, Sarnaik S, et al (2016). Hydroxycarbamide versus chronic transfusion for maintenance of transcranial doppler flow velocities in children with sickle cell anaemia-TCD With Transfusions Changing to Hydroxyurea (TWiTCH): a multicentre, open-label, phase 3, non-inferiority trial. Lancet, 387:661-70."},{"key":"key-10.14336\/AD.2021.0219-62","doi-asserted-by":"crossref","unstructured":"Li Q, Gao Y, Xin W, Zhou Z, Rong H, Qin Y, et al (2019). Meta-Analysis of Prognosis of Different Treatments for Symptomatic Moyamoya Disease. World Neurosurg, 127:354-361.","DOI":"10.1016\/j.wneu.2019.04.062"},{"key":"key-10.14336\/AD.2021.0219-63","doi-asserted-by":"crossref","unstructured":"Macyszyn L, Attiah M, Ma TS, Ali Z, Faught R, Hossain A, et al (2017). Direct versus indirect revascularization procedures for moyamoya disease: a comparative effectiveness study. J Neurosurg, 126:1523-1529.","DOI":"10.3171\/2015.8.JNS15504"},{"key":"key-10.14336\/AD.2021.0219-64","unstructured":"Ravindran K, Wellons JC, Dewan MC (2019). Surgical outcomes for pediatric moyamoya: a systematic review and meta-analysis. J Neurosurg Pediatr, 13:1-10."},{"key":"key-10.14336\/AD.2021.0219-65","doi-asserted-by":"crossref","unstructured":"Zhao Y, Lu J, Yu S, Li J, Deng X, Zhang Y, et al (2019). Comparison of Long-Term Effect Between Direct and Indirect Bypass for Pediatric Ischemic-Type Moyamoya Disease: A Propensity Score-Matched Study. Front Neurol, 10:795.","DOI":"10.3389\/fneur.2019.00795"}],"container-title":["Aging and disease"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.aginganddisease.org\/fileup\/2152-5250\/PDF\/ad-0-0-0-2102230900-1.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T01:30:13Z","timestamp":1627522213000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.aginganddisease.org\/EN\/10.14336\/AD.2021.0219"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":65,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.14336\/ad.2021.0219","relation":{},"ISSN":["2152-5250"],"issn-type":[{"value":"2152-5250","type":"print"}],"subject":[],"published":{"date-parts":[[2021]]}}}