{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T18:14:15Z","timestamp":1793297655358,"version":"4.5.0"},"reference-count":42,"publisher":"Aging and Disease","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging and disease"],"published-print":{"date-parts":[[2022]]},"DOI":"10.14336\/ad.2021.0617","type":"journal-article","created":{"date-parts":[[2022,1,22]],"date-time":"2022-01-22T02:10:46Z","timestamp":1642817446000},"page":"284","source":"Crossref","is-referenced-by-count":65,"title":["Pharmacological Blockade of NLRP3 Inflammasome\/IL-1\u03b2-Positive Loop Mitigates Endothelial Cell Senescence and Dysfunction"],"prefix":"10.14336","volume":"13","author":[{"given":"Alejandra","family":"Romero","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Dongil","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In\u00e9s","family":"Valencia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana","family":"Vallejo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1lvaro San","family":"Hip\u00f3lito-Luengo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillermo","family":"D\u00edaz-Araya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 L","family":"Bartha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda M","family":"Gonz\u00e1lez-Arlanz\u00f3n","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Rivilla","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"de la Cuesta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos F","family":"S\u00e1nchez-Ferrer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Concepci\u00f3n","family":"Peir\u00f3","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5462","reference":[{"key":"key-10.14336\/AD.2021.0617-1","doi-asserted-by":"crossref","unstructured":"Sabbatinelli J, Ramini D, Giuliani A, Recchioni R, Spazzafumo L, Olivieri F. (2021). Connecting vascular aging and frailty in Alzheimer's disease. Mech Ageing. 195:111444.","DOI":"10.1016\/j.mad.2021.111444"},{"key":"key-10.14336\/AD.2021.0617-2","doi-asserted-by":"crossref","unstructured":"Costantino S, Paneni F, Cosentino F (2016). Ageing, metabolism and cardiovascular disease. J Physiol, 594(8): 2061-2073.","DOI":"10.1113\/JP270538"},{"key":"key-10.14336\/AD.2021.0617-3","doi-asserted-by":"crossref","unstructured":"Erusalimsky JD (2009). Vascular endothelial senescence: from mechanisms to pathophysiology. [J] Appl Physiol. 106(1): 326-32.","DOI":"10.1152\/japplphysiol.91353.2008"},{"key":"key-10.14336\/AD.2021.0617-4","doi-asserted-by":"crossref","unstructured":"Botto F, Obregon S, Rubinstein F, Scuteri A, Nilsson P, Kotliar C (2018). Frequency of early vascular aging and associated risk factors among an adult population in Latin America: the OPTIMO study. Journal of Human Hypertension, 32(3): 219-227.","DOI":"10.1038\/s41371-018-0038-1"},{"key":"key-10.14336\/AD.2021.0617-5","doi-asserted-by":"crossref","unstructured":"Franceschi C, Garagnani P, Parini P, Giuliani C, Santoro A (2018). Inflammaging: a new immune-metabolic viewpoint for age-related diseases. Nat Rev Endocrinol. 14(10): 576-590.","DOI":"10.1038\/s41574-018-0059-4"},{"key":"key-10.14336\/AD.2021.0617-6","doi-asserted-by":"crossref","unstructured":"Donato A, Morgan R, Walker AE, Lesniewski AL (2015). Cellular and molecular biology of aging endothelial cells. [J] Mol Cell Cardiol. 89(Pt B):122-35.","DOI":"10.1016\/j.yjmcc.2015.01.021"},{"key":"key-10.14336\/AD.2021.0617-7","doi-asserted-by":"crossref","unstructured":"Ridker PM, Everett BM, Thuren T, MacFadyen JG, Chang WH, Ballantyne C, et al. CANTOS Trial Group (2017). N Engl J Med. 21; 377(12):1119-1131.","DOI":"10.1056\/NEJMoa1707914"},{"key":"key-10.14336\/AD.2021.0617-8","doi-asserted-by":"crossref","unstructured":"Grebe A, Hoss F, Latz E (2018). NLRP3 Inflammasome and the IL-1 Pathway in Atherosclerosis. Circulation Research, 122(12): 1722-1740.","DOI":"10.1161\/CIRCRESAHA.118.311362"},{"key":"key-10.14336\/AD.2021.0617-9","doi-asserted-by":"crossref","unstructured":"Takahashi M (2021). NLRP3 inflammasome as a key driver of vascular disease. Cardiovasc Res, 23.","DOI":"10.1093\/cvr\/cvab010"},{"key":"key-10.14336\/AD.2021.0617-10","doi-asserted-by":"crossref","unstructured":"Romero A, San Hip\u00f3lito-Luengo A, Villalobos L, Vallejo S, Valencia I, Michalska P, Pajuelo-Lozano , et al. (2019). The angiotensin-(1-7)\/Mas receptor axis protects from endothelial cell senescence via klotho and Nrf2 activation. Aging Cell, 18(3).","DOI":"10.1111\/acel.12913"},{"key":"key-10.14336\/AD.2021.0617-11","doi-asserted-by":"crossref","unstructured":"Santos R, da Silva R (2014). Treatment with Angiotensin-(1-7) reduces inflammation in carotid atherosclerotic plaques. Thrombosis and Haemostasis, 111(4): 736-747.","DOI":"10.1160\/TH13-06-0448"},{"key":"key-10.14336\/AD.2021.0617-12","doi-asserted-by":"crossref","unstructured":"Stutz A, Gabor L Horvath, Brian G, Eicke Latz (2013). ASC speck formation as a readout for inflammasome activation. Methods Mol Biol. 1040:91-101.","DOI":"10.1007\/978-1-62703-523-1_8"},{"key":"key-10.14336\/AD.2021.0617-13","doi-asserted-by":"crossref","unstructured":"Romacho T, Valencia I, Gonz\u00e1lez-Ramos M, Vallejo S, L\u00f3pez-Esteban M, Lorenzo O, et al. (2020). Visfatin\/enampt induces endothelial dysfunction in vivo: a. Scientific Report, 10: 5386.","DOI":"10.1038\/s41598-020-62190-w"},{"key":"key-10.14336\/AD.2021.0617-14","doi-asserted-by":"crossref","unstructured":"Peir\u00f3 C, Vallejo S, Gembardt F, Palacios E, Novella S, Azcutia , et al. (2013). Complete blockade of the vasorelaxant effects of angiotensin-(1-7) and bradykinin in murine microvessels by antagonists of the receptor Mas. J Physiol, 591(Pt 9): 2275-2285.","DOI":"10.1113\/jphysiol.2013.251413"},{"key":"key-10.14336\/AD.2021.0617-15","doi-asserted-by":"crossref","unstructured":"Yuan H, Hideki H, Gabriel N (2016). Mechanism and Regulation of NLRP3 Inflammasome Activation Trends Biochem Sci, 41(12):1012-1021.","DOI":"10.1016\/j.tibs.2016.09.002"},{"key":"key-10.14336\/AD.2021.0617-16","doi-asserted-by":"crossref","unstructured":"Bent R, Moll L, Grabbe S, Bros M (2018). Interleukin-1 Beta-A Friend or Foe in Malignancies? International Journal of Molecular Sciences, 19(8).","DOI":"10.3390\/ijms19082155"},{"key":"key-10.14336\/AD.2021.0617-17","doi-asserted-by":"crossref","unstructured":"Palomo J, Dietrich D, Martin P, Palmer G, Gabay C (2015). The interleukin (IL)-1 cytokine family - Balance between agonists and antagonists in inflammatory diseases. Cytokine, 76(1): 25-37.","DOI":"10.1016\/j.cyto.2015.06.017"},{"key":"key-10.14336\/AD.2021.0617-18","doi-asserted-by":"crossref","unstructured":"El Assar M, Angulo J, Vallejo S, Peir\u00f3 C, S\u00e1nchez-Ferrer CF, Rodr\u00edguez-Ma\u00f1as L (2012). Mechanisms involved in the aging-induced vascular dysfunction. Frontiers in Physiology.","DOI":"10.3389\/fphys.2012.00132"},{"key":"key-10.14336\/AD.2021.0617-19","doi-asserted-by":"crossref","unstructured":"Endemann D, Schiffrin E (2004). Endothelial Dysfunction. Journal of the American Society of Nephrology: JASN, 15(8): 1983-1992.","DOI":"10.1097\/01.ASN.0000132474.50966.DA"},{"key":"key-10.14336\/AD.2021.0617-20","doi-asserted-by":"crossref","unstructured":"Ridker P, Thuren T, Zalewski A, Libby P (2011). Interleukin-1\u03b2 inhibition and the prevention of recurrent cardiovascular events: Rationale and Design of the Canakinumab Anti-inflammatory Thrombosis Outcomes Study (CANTOS). American Heart Journal, 162(4): 597-605.","DOI":"10.1016\/j.ahj.2011.06.012"},{"key":"key-10.14336\/AD.2021.0617-21","unstructured":"Ridker P, MacFadyen J, Everett B, Libby P, Thuren T, Glynn R, et al. (2018). Relationship of C-reactive protein reduction to cardiovascular event reduction following treatment with canakinumab: a secondary analysis from the CANTOS randomised controlled trial. Lancet, 391(10118): 319-328."},{"key":"key-10.14336\/AD.2021.0617-22","doi-asserted-by":"crossref","unstructured":"Fraga-Silva R, Savergnini S, Montecucco F, Nencioni A, Caffa I, Soncini D, et al. (2014). Treatment with Angiotensin-(1-7) reduces inflammation in carotid atherosclerotic plaques. Europe PMC, 111(4):736-747.","DOI":"10.1160\/TH13-06-0448"},{"key":"key-10.14336\/AD.2021.0617-23","doi-asserted-by":"crossref","unstructured":"Fan C, Guowei J, Hui L, Zemin L, Yuxin P, Hehai P, Haowen C, et al. (2020). Melatonin alleviates intervertebral disc degeneration by disrupting the IL-1\u03b2\/NF-\u03baB-NLRP3 inflammasome positive feedback loop. Bone Res. 18; 8:10.","DOI":"10.1038\/s41413-020-0087-2"},{"key":"key-10.14336\/AD.2021.0617-24","doi-asserted-by":"crossref","unstructured":"Jingzeng C, Haoyue G, Jiaoc J, Yanga X, Chena , et al. (2021). NLRP3 inflammasome mediated pyroptosis is involved in cadmium exposure-induced neuroinflammation through the IL-1\u03b2\/IkB-\u03b1-NF-\u03baB-NLRP3 feedback loop in swine. Toxicology, 453: 152720.","DOI":"10.1016\/j.tox.2021.152720"},{"key":"key-10.14336\/AD.2021.0617-25","doi-asserted-by":"crossref","unstructured":"Coll R, O\u2019Neill L, Schroder K (2016). Questions and controversies in innate immune research: what is the physiological role of NLRP3? Cell Death Discovery 2, 16019.","DOI":"10.1038\/cddiscovery.2016.19"},{"key":"key-10.14336\/AD.2021.0617-26","doi-asserted-by":"crossref","unstructured":"Yin Y, Zhou Z, Liu W, Chang Q, Sun G, Dai Y (2017). Vascular endothelial cells senescence is associated with NOD-like receptor family pyrin domain-containing 3 inflammasome activation via reactive oxygen species pathway. Int J Biochem Cell Biol, 84: 22.","DOI":"10.1016\/j.biocel.2017.01.001"},{"key":"key-10.14336\/AD.2021.0617-27","doi-asserted-by":"crossref","unstructured":"Youm Y, Grant R, McCabe L, Albarado D, Nguyen K, Ravussin A (2013). Canonical Nlrp3 Inflammasome Links Systemic Low-Grade Inflammation to Functional Decline in Aging. Cell Metabolism, 18(4): 519-532.","DOI":"10.1016\/j.cmet.2013.09.010"},{"key":"key-10.14336\/AD.2021.0617-28","doi-asserted-by":"crossref","unstructured":"Xuelian L, Zhiyang L, Bingong L, Zhu X, Lai X (2019). Klotho improves diabetic cardiomyopathy by suppressing the NLRP3 inflammasome pathway. Life Sci, 234:116773.","DOI":"10.1016\/j.lfs.2019.116773"},{"key":"key-10.14336\/AD.2021.0617-29","doi-asserted-by":"crossref","unstructured":"Villalobos L, San Hip\u00f3lito-Luengo A, Ramos-Gonz\u00e1lez M, Cercas E, Vallejo S, Romero A, et al. (2016). The Angiotensin-(1-7)\/Mas Axis Counteracts Angiotensin II-Dependent and -Independent Pro-in?ammatory Signaling in Human Vascular Smooth Muscle Cells. Frontiers in Pharmacology, 7: 482.","DOI":"10.3389\/fphar.2016.00482"},{"key":"key-10.14336\/AD.2021.0617-30","doi-asserted-by":"crossref","unstructured":"Rodr\u00edguez-Ma\u00f1as L, El-Assar M, Vallejo S, L\u00f3pez-D\u00f3riga P, Sol\u00eds J, Montes M (2009). Endothelial dysfunction in aged humans is related with oxidative stress and vascular inflammation. Aging Cell, 8(3):226-38","DOI":"10.1111\/j.1474-9726.2009.00466.x"},{"key":"key-10.14336\/AD.2021.0617-31","doi-asserted-by":"crossref","unstructured":"Fadini G, Ceolotto G, Pagnin E, de Kreutzenberg S, Avogaro A (2011). At the crossroads of longevity and metabolism: the metabolic syndrome and lifespan determinant pathways. Aging Cell, 10(1): 10-17.","DOI":"10.1111\/j.1474-9726.2010.00642.x"},{"key":"key-10.14336\/AD.2021.0617-32","doi-asserted-by":"crossref","unstructured":"Gimbrone M, Garc\u00eda-Carde\u00f1a G (2016). Endothelial Cell Dysfunction and the Pathobiology of Atherosclerosis. Cir Res118(4): 620-636.","DOI":"10.1161\/CIRCRESAHA.115.306301"},{"key":"key-10.14336\/AD.2021.0617-33","doi-asserted-by":"crossref","unstructured":"B\u0103dulescu O, B\u0103descu C, Ciocoiu M, B\u0103descu M (2013). Interleukin-1-beta and dyslipidemic syndrome as major risk factors for thrombotic complications in type 2 diabetes mellitus. Mediators Inflamm, 169420.","DOI":"10.1155\/2013\/169420"},{"key":"key-10.14336\/AD.2021.0617-34","doi-asserted-by":"crossref","unstructured":"Ehses JA, Lacraz G, Giroix MH, Schmidlin F, Coulaud J, Kassis N, et al (2009). IL-1 antagonism reduces hyperglycemia and tissue inflammation in the type 2 diabetic GK rat. Proc Natl Acad Sci USA, 106(33): 13998-4003.","DOI":"10.1073\/pnas.0810087106"},{"key":"key-10.14336\/AD.2021.0617-35","doi-asserted-by":"crossref","unstructured":"Santos-Moreno P, Burgos-Angulo G, Martinez-Ceballos MA, Pizano A, Echeverri D, Bautista-Ni\u00f1o PK, et al (2021). Inflammaging as a link between autoimmunity and cardiovascular disease: the case of rheumatoid arthritis. RMD Open, 7:e001470.","DOI":"10.1136\/rmdopen-2020-001470"},{"key":"key-10.14336\/AD.2021.0617-36","doi-asserted-by":"crossref","unstructured":"Santos RAS, Oudit GY, Verano-Braga T, Canta G, Steckelings UM, Bader M (2019). The renin-angiotensin system: going beyond the classical paradigms. Am J Physiol Heart Circ Physiol, 316(5):H958-H970.","DOI":"10.1152\/ajpheart.00723.2018"},{"key":"key-10.14336\/AD.2021.0617-37","doi-asserted-by":"crossref","unstructured":"Sun N, Yu C, Pan M, Zhang Y, Zheng B, Yang Q, et al (2017). Mir-21 Mediates the Inhibitory Effect of Ang (1-7) on AngII-induced NLRP3 Inflammasome Activation by Targeting Spry1 in lung fibroblasts. Scientific Reports, 7(1): 14369-11.","DOI":"10.1038\/s41598-017-13305-3"},{"key":"key-10.14336\/AD.2021.0617-38","doi-asserted-by":"crossref","unstructured":"Zhu L, Stein L, Kim D, Ho K, Yu G, Zhan L, et al (2018). Klotho controls the brain-immune system interface in the choroid plexus. Proc Natl Acad Sci U S A, 115(48): E11388-E11396.","DOI":"10.1073\/pnas.1808609115"},{"key":"key-10.14336\/AD.2021.0617-39","doi-asserted-by":"crossref","unstructured":"Cai S, Yang R, Li Y, Ning Z, Zhang L, Zhou G, et al (2016). Angiotensin-(1-7) Improves Liver Fibrosis by Regulating the NLRP3 Inflammasome via Redox Balance Modulation. Antioxidants & Redox Signaling, 24(14): 795-812.","DOI":"10.1089\/ars.2015.6498"},{"key":"key-10.14336\/AD.2021.0617-40","doi-asserted-by":"crossref","unstructured":"Zhang Y, Zhang W, Zhang L, Huang S, Ma X, Wang D, et al (2016). Angiotensin (1-7) attenuated Angiotensin II-induced hepatocyte EMT by inhibiting NOX-derived H2O2-activated NLRP3 inflammasome\/IL-1\u03b2\/Smad circuit. Free Radical Biology and Medicine, 97: 531-543.","DOI":"10.1016\/j.freeradbiomed.2016.07.014"},{"key":"key-10.14336\/AD.2021.0617-41","doi-asserted-by":"crossref","unstructured":"Rodgers K, Oliver J, diZerega G (2006). Phase I\/II dose escalation study of angiotensin 1-7 [A(1-7)] administered before and after chemotherapy in patients with newly diagnosed breast cancer. Cancer Chemotherapy and Pharmacology, 57(5): 559-568.","DOI":"10.1007\/s00280-005-0078-4"},{"key":"key-10.14336\/AD.2021.0617-42","doi-asserted-by":"crossref","unstructured":"Marques F, Melo M, Souza L, Irigoyen M, Sinisterra R, de Sousa F, et al. (2012). Beneficial Effects of Long-Term Administration of an Oral Formulation of Angiotensin-(1-7) in Infarcted Rats. International Journal of Hypertension, 2012: 795452-12.","DOI":"10.1155\/2012\/795452"}],"container-title":["Aging and disease"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.aginganddisease.org\/fileup\/2152-5250\/PDF\/ad-0-0-0-2107160826-1.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,22]],"date-time":"2022-01-22T02:25:16Z","timestamp":1642818316000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.aginganddisease.org\/EN\/10.14336\/AD.2021.0617"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.14336\/ad.2021.0617","relation":{},"ISSN":["2152-5250"],"issn-type":[{"value":"2152-5250","type":"print"}],"subject":[],"published":{"date-parts":[[2022]]}}}