{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T13:20:53Z","timestamp":1784035253145,"version":"3.55.0"},"reference-count":0,"publisher":"Aging and Disease","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging dis"],"abstract":"<jats:p>Aging induces a series of alterations, specifically a decline in the stature and number of villi and crypts in the small intestine, thus compromising the absorbent capability of the villi. This investigation employed a senolytic combination of dasatinib and quercetin (D+Q) to examine its impact on the intestinal tract of elderly mice. Our findings demonstrate that D+Q treatment leads to a decrease in the expression of p21, p16, and Ki67, while concurrently triggering removal of apoptotic cells within the villi. Additionally, D+Q treatment exhibits the ability to promote growth in both the height and quantity of villi and crypts, along with stimulating nitric oxide (NO) production in aged mice. The study presented a model to assess strategies to alleviate age-related senescence in the intestinal tract of elderly mice. Importantly, D+Q showcases promising potential in enhancing intestinal functionality within the aging.<\/jats:p>","DOI":"10.14336\/ad.2023.0920","type":"journal-article","created":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T16:33:06Z","timestamp":1696869186000},"source":"Crossref","is-referenced-by-count":5,"title":["Senolytic Treatment Improve Small Intestine Regeneration in Aging"],"prefix":"10.14336","member":"5462","published-online":{"date-parts":[[2023]]},"container-title":["aging and disease"],"original-title":[],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T16:33:16Z","timestamp":1696869196000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aginganddisease.org\/EN\/10.14336\/AD.2023.0920"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":0,"URL":"https:\/\/doi.org\/10.14336\/ad.2023.0920","relation":{},"ISSN":["2152-5250"],"issn-type":[{"value":"2152-5250","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023]]}}}