{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T22:31:52Z","timestamp":1790721112627,"version":"4.1.0"},"reference-count":41,"publisher":"Aging and Disease","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging and disease"],"published-print":{"date-parts":[[2025]]},"DOI":"10.14336\/ad.2024.0167","type":"journal-article","created":{"date-parts":[[2024,6,23]],"date-time":"2024-06-23T21:31:56Z","timestamp":1719178316000},"page":"2360","source":"Crossref","is-referenced-by-count":2,"title":["Establishing Predictors of Acute Sarcopenia: A Proof-Of-Concept Study Utilising Network Analysis"],"prefix":"10.14336","volume":"16","author":[{"given":"Carly","family":"Welch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Bravo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios","family":"Gkoutos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn","family":"Greig","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Lewis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet","family":"Lord","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeinab","family":"Majid","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tahir","family":"Masud","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsty","family":"McGee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Moorey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Pinkney","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Stanley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Jackson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5462","reference":[{"key":"key-10.14336\/AD.2024.0167-1","doi-asserted-by":"crossref","unstructured":"Cruz-Jentoft A (2016). Sarcopenia, the last organ insufficiency. European Geriatric Medicine, 7:195-196.","DOI":"10.1016\/j.eurger.2016.01.003"},{"key":"key-10.14336\/AD.2024.0167-2","doi-asserted-by":"crossref","unstructured":"Welch C. 2021. Acute Sarcopenia: Definition and Actual Issues. In Sarcopenia: Research and Clinical Implications. Veronese N. , Beaudart C. , and Sabico S. , editors. Cham: Springer International Publishing. 133-143.","DOI":"10.1007\/978-3-030-80038-3_10"},{"key":"key-10.14336\/AD.2024.0167-3","doi-asserted-by":"crossref","unstructured":"Welch C, Hassan-Smith ZK, Greig CA, Lord JM, Jackson TA (2018). Acute Sarcopenia Secondary to Hospitalisation - An Emerging Condition Affecting Older Adults. Aging and disease, 9:151-164.","DOI":"10.14336\/AD.2017.0315"},{"key":"key-10.14336\/AD.2024.0167-4","doi-asserted-by":"crossref","unstructured":"Cruz-Jentoft AJ, Bahat G, Bauer J, Boirie Y, Bruy\u00e8re O, Cederholm T, et al. (2019). Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing, 48:16-31.","DOI":"10.1093\/ageing\/afy169"},{"key":"key-10.14336\/AD.2024.0167-5","doi-asserted-by":"crossref","unstructured":"Hartley P, Romero-Ortuno R, Wellwood I, Deaton C (2020). Changes in muscle strength and physical function in older patients during and after hospitalisation: a prospective repeated-measures cohort study. Age and Ageing, 50:153-160.","DOI":"10.1093\/ageing\/afaa103"},{"key":"key-10.14336\/AD.2024.0167-6","doi-asserted-by":"crossref","unstructured":"Van Ancum JM, Scheerman K, Jonkman NH, Smeenk HE, Kruizinga RC, Meskers CGM, et al. (2017). Change in muscle strength and muscle mass in older hospitalized patients: A systematic review and meta-analysis. Exp Gerontol, 92:34-41.","DOI":"10.1016\/j.exger.2017.03.006"},{"key":"key-10.14336\/AD.2024.0167-7","doi-asserted-by":"crossref","unstructured":"Van Ancum JM, Scheerman K, Pierik VD, Numans ST, Verlaan S, Smeenk HE, et al. (2017). Muscle Strength and Muscle Mass in Older Patients during Hospitalization: The EMPOWER Study. Gerontology, 63:507-514.","DOI":"10.1159\/000478777"},{"key":"key-10.14336\/AD.2024.0167-8","doi-asserted-by":"crossref","unstructured":"Patel HP, Al-Shanti N, Davies LC, Barton SJ, Grounds MD, Tellam RL, et al. (2014). Lean Mass, Muscle Strength and Gene Expression in Community Dwelling Older Men: Findings from the Hertfordshire Sarcopenia Study (HSS). Calcified Tissue International, 95:308-316.","DOI":"10.1007\/s00223-014-9894-z"},{"key":"key-10.14336\/AD.2024.0167-9","doi-asserted-by":"crossref","unstructured":"Kealy J, Murray C, Griffin EW, Lopez-Rodriguez AB, Healy D, Tortorelli LS, et al. (2020). Acute Inflammation Alters Brain Energy Metabolism in Mice and Humans: Role in Suppressed Spontaneous Activity, Impaired Cognition, and Delirium. The Journal of Neuroscience, 40:5681-5696.","DOI":"10.1523\/JNEUROSCI.2876-19.2020"},{"key":"key-10.14336\/AD.2024.0167-10","doi-asserted-by":"crossref","unstructured":"Welch C, Majid Z, Greig C, Gladman J, Masud T, Jackson T (2020). Interventions to ameliorate reductions in muscle quantity and function in hospitalised older adults: a systematic review towards acute sarcopenia treatment. Age and Ageing.","DOI":"10.1093\/ageing\/afaa209"},{"key":"key-10.14336\/AD.2024.0167-11","doi-asserted-by":"crossref","unstructured":"Welch C, Greig CA, Masud T, Pinkney T, Jackson TA (2020). Protocol for understanding acute sarcopenia: a cohort study to characterise changes in muscle quantity and physical function in older adults following hospitalisation. BMC Geriatrics, 20:239.","DOI":"10.1186\/s12877-020-01626-4"},{"key":"key-10.14336\/AD.2024.0167-12","doi-asserted-by":"crossref","unstructured":"Wilson DV, Moorey H, Stringer H, Sahbudin I, Filer A, Lord JM, et al. (2019). Bilateral Anterior Thigh Thickness: A New Diagnostic Tool for the Identification of Low Muscle Mass? Journal of the American Medical Directors Association, 20:1247-1253. e1242.","DOI":"10.1016\/j.jamda.2019.04.005"},{"key":"key-10.14336\/AD.2024.0167-13","doi-asserted-by":"crossref","unstructured":"Sergi G, De Rui M, Veronese N, Bolzetta F, Berton L, Carraro S, et al. (2015). Assessing appendicular skeletal muscle mass with bioelectrical impedance analysis in free-living Caucasian older adults. Clin Nutr, 34:667-673.","DOI":"10.1016\/j.clnu.2014.07.010"},{"key":"key-10.14336\/AD.2024.0167-14","doi-asserted-by":"crossref","unstructured":"Janssen I, Heymsfield SB, Baumgartner RN, Ross R (2000). Estimation of skeletal muscle mass by bioelectrical impedance analysis. J Appl Physiol (1985), 89:465-471.","DOI":"10.1152\/jappl.2000.89.2.465"},{"key":"key-10.14336\/AD.2024.0167-15","doi-asserted-by":"crossref","unstructured":"Guralnik JM, Simonsick EM, Ferrucci L, Glynn RJ, Berkman LF, Blazer DG, et al. (1994). A short physical performance battery assessing lower extremity function: association with self-reported disability and prediction of mortality and nursing home admission. J Gerontol, 49:M85-94.","DOI":"10.1093\/geronj\/49.2.M85"},{"key":"key-10.14336\/AD.2024.0167-16","doi-asserted-by":"crossref","unstructured":"American Psychiatric Association. 2013. Diagnostic and Statistical Manual of Mental Disorders.","DOI":"10.1176\/appi.books.9780890425596"},{"key":"key-10.14336\/AD.2024.0167-17","doi-asserted-by":"crossref","unstructured":"Tatsuoka C, DeMarco L, Smyth KA, Wilkes S, Howland M, Lerner AJ, et al. (2016). Evaluating PROMIS Physical Function Measures in Older Adults at Risk for Alzheimer's Disease. Gerontology & geriatric medicine, 2:2333721416665502-2333721416665502.","DOI":"10.1177\/2333721416665502"},{"key":"key-10.14336\/AD.2024.0167-18","doi-asserted-by":"crossref","unstructured":"Tibshirani R (1996). Regression Shrinkage and Selection via the Lasso. Journal of the Royal Statistical Society. Series B (Methodological), 58:267-288.","DOI":"10.1111\/j.2517-6161.1996.tb02080.x"},{"key":"key-10.14336\/AD.2024.0167-19","doi-asserted-by":"crossref","unstructured":"Chen X, Gole J, Gore A, He Q, Lu M, Min J, et al. (2020). Non-invasive early detection of cancer four years before conventional diagnosis using a blood test. Nature Communications, 11:3475.","DOI":"10.1038\/s41467-020-17316-z"},{"key":"key-10.14336\/AD.2024.0167-20","unstructured":"Csardi G, Nepusz T (2006). The igraph software package for complex network research. InterJournal, Complex Systems, 1695."},{"key":"key-10.14336\/AD.2024.0167-21","doi-asserted-by":"crossref","unstructured":"Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, et al. (2003). Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res, 13:2498-2504.","DOI":"10.1101\/gr.1239303"},{"key":"key-10.14336\/AD.2024.0167-22","doi-asserted-by":"crossref","unstructured":"Welch C, Greig C, Majid Z, Masud T, Moorey H, Pinkney T, et al. (2021). The feasibility of conducting acute sarcopenia research in hospitalised older patients: a prospective cohort study. European Geriatric Medicine.","DOI":"10.1007\/s41999-021-00565-6"},{"key":"key-10.14336\/AD.2024.0167-23","doi-asserted-by":"crossref","unstructured":"Paddon-Jones D, Sheffield-Moore M, Cree MG, Hewlings SJ, Aarsland A, Wolfe RR, et al. (2006). Atrophy and Impaired Muscle Protein Synthesis during Prolonged Inactivity and Stress. The Journal of Clinical Endocrinology & Metabolism, 91:4836-4841.","DOI":"10.1210\/jc.2006-0651"},{"key":"key-10.14336\/AD.2024.0167-24","doi-asserted-by":"crossref","unstructured":"Bodine SC, Latres E, Baumhueter S, Lai VK-M, Nunez L, Clarke BA, et al. (2001). Identification of Ubiquitin Ligases Required for Skeletal Muscle Atrophy. Science, 294:1704-1708.","DOI":"10.1126\/science.1065874"},{"key":"key-10.14336\/AD.2024.0167-25","doi-asserted-by":"crossref","unstructured":"Yousuf Y, Datu A, Barnes B, Amini-Nik S, Jeschke MG (2020). Metformin alleviates muscle wasting post-thermal injury by increasing Pax7-positive muscle progenitor cells. Stem Cell Research & Therapy, 11:18.","DOI":"10.1186\/s13287-019-1480-x"},{"key":"key-10.14336\/AD.2024.0167-26","doi-asserted-by":"crossref","unstructured":"Walton RG, Dungan CM, Long DE, Tuggle SC, Kosmac K, Peck BD, et al. (2019). Metformin blunts muscle hypertrophy in response to progressive resistance exercise training in older adults: A randomized, double-blind, placebo-controlled, multicenter trial: The MASTERS trial. Aging Cell, 18:e13039.","DOI":"10.1111\/acel.13039"},{"key":"key-10.14336\/AD.2024.0167-27","doi-asserted-by":"crossref","unstructured":"Watkinson RE, Sutton M, Turner AJ (2021). Ethnic inequalities in health-related quality of life among older adults in England: secondary analysis of a national cross-sectional survey. The Lancet Public Health, 6:e145-e154.","DOI":"10.1016\/S2468-2667(20)30287-5"},{"key":"key-10.14336\/AD.2024.0167-28","doi-asserted-by":"crossref","unstructured":"Haugen F, Norheim F, Lian H, Wensaas AJ, Dueland S, Berg O, et al. (2010). IL-7 is expressed and secreted by human skeletal muscle cells. Am J Physiol Cell Physiol, 298:C807-816.","DOI":"10.1152\/ajpcell.00094.2009"},{"key":"key-10.14336\/AD.2024.0167-29","doi-asserted-by":"crossref","unstructured":"Beaudart C, Zaaria M, Pasleau F, Reginster J-Y, Bruy\u00e8re O (2017). Health Outcomes of Sarcopenia: A Systematic Review and Meta-Analysis. PLOS ONE, 12:e0169548.","DOI":"10.1371\/journal.pone.0169548"},{"key":"key-10.14336\/AD.2024.0167-30","doi-asserted-by":"crossref","unstructured":"Vetrano DL, Landi F, Volpato S, Corsonello A, Meloni E, Bernabei R, et al. (2014). Association of Sarcopenia With Short- and Long-term Mortality in Older Adults Admitted to Acute Care Wards: Results From the CRIME Study. The Journals of Gerontology: Series A, 69:1154-1161.","DOI":"10.1093\/gerona\/glu034"},{"key":"key-10.14336\/AD.2024.0167-31","doi-asserted-by":"crossref","unstructured":"Junnila RK, List EO, Berryman DE, Murrey JW, Kopchick JJ (2013). The GH\/IGF-1 axis in ageing and longevity. Nat Rev Endocrinol, 9:366-376.","DOI":"10.1038\/nrendo.2013.67"},{"key":"key-10.14336\/AD.2024.0167-32","doi-asserted-by":"crossref","unstructured":"Ross R, Miell J, Freeman E, Jones J, Matthews D, Preece M, et al. (1991). Critically ill patients have high basal growth hormone levels with attenuated oscillatory activity associated with low levels of insulin-like growth factor-I. Clinical Endocrinology, 35:47-54.","DOI":"10.1111\/j.1365-2265.1991.tb03495.x"},{"key":"key-10.14336\/AD.2024.0167-33","doi-asserted-by":"crossref","unstructured":"Fryburg DA, Barrett EJ (1993). Growth hormone acutely stimulates skeletal muscle but not whole-body protein synthesis in humans. Metabolism, 42:1223-1227.","DOI":"10.1016\/0026-0495(93)90285-V"},{"key":"key-10.14336\/AD.2024.0167-34","doi-asserted-by":"crossref","unstructured":"Mosk CA, van Vugt JLA, de Jonge H, Witjes CD, Buettner S, Ijzermans JN, et al. (2018). Low skeletal muscle mass as a risk factor for postoperative delirium in elderly patients undergoing colorectal cancer surgery. Clinical interventions in aging, 13:2097-2106.","DOI":"10.2147\/CIA.S175945"},{"key":"key-10.14336\/AD.2024.0167-35","doi-asserted-by":"crossref","unstructured":"Bellelli G, Zambon A, Volpato S, Abete P, Bianchi L, Bo M, et al. (2018). The association between delirium and sarcopenia in older adult patients admitted to acute geriatrics units: Results from the GLISTEN multicenter observational study. Clinical Nutrition, 37:1498-1504.","DOI":"10.1016\/j.clnu.2017.08.027"},{"key":"key-10.14336\/AD.2024.0167-36","doi-asserted-by":"crossref","unstructured":"Fisher SR, Goodwin JS, Protas EJ, Kuo Y-F, Graham JE, Ottenbacher KJ, et al. (2011). Ambulatory Activity of Older Adults Hospitalized with Acute Medical Illness. Journal of the American Geriatrics Society, 59:91-95.","DOI":"10.1111\/j.1532-5415.2010.03202.x"},{"key":"key-10.14336\/AD.2024.0167-37","doi-asserted-by":"crossref","unstructured":"Kortebein P, Ferrando A, Lombeida J, Wolfe R, Evans WJ (2007). Effect of 10 days of bed rest on skeletal muscle in healthy older adults. Jama, 297:1772-1774.","DOI":"10.1001\/jama.297.16.1772-b"},{"key":"key-10.14336\/AD.2024.0167-38","doi-asserted-by":"crossref","unstructured":"Huang N, Kny M, Riediger F, Busch K, Schmidt S, Luft FC, et al. (2017). Deletion of Nlrp3 protects from inflammation-induced skeletal muscle atrophy. Intensive Care Medicine Experimental, 5:3.","DOI":"10.1186\/s40635-016-0115-0"},{"key":"key-10.14336\/AD.2024.0167-39","doi-asserted-by":"crossref","unstructured":"Cape E, Hall RJ, van Munster BC, de Vries A, Howie SEM, Pearson A, et al. (2014). Cerebrospinal fluid markers of neuroinflammation in delirium: a role for interleukin-1\u03b2 in delirium after hip fracture. Journal of psychosomatic research, 77:219-225.","DOI":"10.1016\/j.jpsychores.2014.06.014"},{"key":"key-10.14336\/AD.2024.0167-40","doi-asserted-by":"crossref","unstructured":"Levey AS, Coresh J, Greene T, Stevens LA, Zhang YL, Hendricksen S, et al. (2006). Using Standardized Serum Creatinine Values in the Modification of Diet in Renal Disease Study Equation for Estimating Glomerular Filtration Rate. Annals of Internal Medicine, 145:247-254.","DOI":"10.7326\/0003-4819-145-4-200608150-00004"},{"key":"key-10.14336\/AD.2024.0167-41","doi-asserted-by":"crossref","unstructured":"Cockcroft DW, Gault MH (1976). Prediction of creatinine clearance from serum creatinine. Nephron, 16:31-41.","DOI":"10.1159\/000180580"}],"container-title":["Aging and disease"],"original-title":[],"language":"en","deposited":{"date-parts":[[2025,7,5]],"date-time":"2025-07-05T03:07:45Z","timestamp":1751684865000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aginganddisease.org\/EN\/10.14336\/AD.2024.0167"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":41,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.14336\/ad.2024.0167","relation":{},"ISSN":["2152-5250"],"issn-type":[{"value":"2152-5250","type":"print"}],"subject":[],"published":{"date-parts":[[2025]]}}}