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Cells-basel, 11:779.","DOI":"10.3390\/cells11050779"},{"key":"key-10.14336\/AD.2025.0289-69","doi-asserted-by":"crossref","unstructured":"Yan Z, Zhao J, Gan L, Zhang Y, Guo R, Cao X, et al. (2017). CTRP3 is a novel biomarker for diabetic retinopathy and inhibits HGHL-induced VCAM-1 expression in an AMPK-dependent manner. PLoS ONE, 12:e0178253.","DOI":"10.1371\/journal.pone.0178253"},{"key":"key-10.14336\/AD.2025.0289-70","doi-asserted-by":"crossref","unstructured":"Zhu JY, Yao W, Ni XS, Yao MD, Bai W, Yang T-J, et al. (2023). Hyperglycemia-regulated tRNA-derived fragment tRF-3001a propels neurovascular dysfunction in diabetic mice. Cell Reports Medicine, 4:101209.","DOI":"10.1016\/j.xcrm.2023.101209"},{"key":"key-10.14336\/AD.2025.0289-71","doi-asserted-by":"crossref","unstructured":"Danesh-Meyer HV, Zhang J, Acosta ML, Rupenthal ID, Green CR (2016). Connexin43 in retinal injury and disease. 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Induction, amplification, and propagation of diabetic retinopathy-associated inflammatory cytokines between human retinal microvascular endothelial and M\u00fcller cells and in the mouse retina. Cell Signal, 124:111454.","DOI":"10.1016\/j.cellsig.2024.111454"},{"key":"key-10.14336\/AD.2025.0289-75","doi-asserted-by":"crossref","unstructured":"Ben S, Ma Y, Bai Y, Zhang Q, Zhao Y, Xia J, et al. (2024). Microglia-endothelial cross-talk regulates diabetes-induced retinal vascular dysfunction through remodeling inflammatory microenvironment. iScience, 27:109145.","DOI":"10.1016\/j.isci.2024.109145"},{"key":"key-10.14336\/AD.2025.0289-76","doi-asserted-by":"crossref","unstructured":"Zhou L, Xu Z, Lu H, Cho H, Xie Y, Lee G, et al. (2024). Suppression of inner blood-retinal barrier breakdown and pathogenic M\u00fcller glia activation in ischemia retinopathy by myeloid cell depletion. 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Liquid-biopsy proteomics combined with AI identifies cellular drivers of eye aging and disease in vivo. Cell, 186:4868-4884.e12.","DOI":"10.1016\/j.cell.2023.09.012"},{"key":"key-10.14336\/AD.2025.0289-86","doi-asserted-by":"crossref","unstructured":"Cheng Y, Zhang M, Xu R, Fu L, Xue M, Xu C, et al. (2024). p53 accelerates endothelial cell senescence in diabetic retinopathy by enhancing FoxO3a ubiquitylation and degradation via UBE2L6. Experimental Gerontology, 188:112391.","DOI":"10.1016\/j.exger.2024.112391"},{"key":"key-10.14336\/AD.2025.0289-87","doi-asserted-by":"crossref","unstructured":"Dumas SJ, Garc\u00eda-Caballero M, Carmeliet P (2020). Metabolic Signatures of Distinct Endothelial Phenotypes. Trends in Endocrinology & Metabolism, 31:580-595.","DOI":"10.1016\/j.tem.2020.05.009"},{"key":"key-10.14336\/AD.2025.0289-88","doi-asserted-by":"crossref","unstructured":"Zhang D, Tang Z, Huang H, Zhou G, Cui C, Weng Y, et al. (2019). 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H3K18 lactylation of senescent microglia potentiates brain aging and Alzheimer\u2019s disease through the NF\u03baB signaling pathway. J Neuroinflammation, 20:208.","DOI":"10.1186\/s12974-023-02879-7"},{"key":"key-10.14336\/AD.2025.0289-92","doi-asserted-by":"crossref","unstructured":"Chen J, He J, Wang X, Bai L, Yang X, Chen J, et al. (2025). Glis1 inhibits RTEC cellular senescence and renal fibrosis by downregulating histone lactylation in DKD. Life Sciences, 361:123293.","DOI":"10.1016\/j.lfs.2024.123293"},{"key":"key-10.14336\/AD.2025.0289-93","doi-asserted-by":"crossref","unstructured":"Zhang Y, Huang Z, Han W, Wu J, Li S, Qin T, et al. (2024). Glutamine suppresses senescence and promotes autophagy through glycolysis inhibition-mediated AMPK\u03b1 lactylation in intervertebral disc degeneration. 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(2019). miR-590-3p Inhibits Pyroptosis in Diabetic Retinopathy by Targeting NLRP1 and Inactivating the NOX4 Signaling Pathway. Invest Ophthalmol Vis Sci, 60:4215-4223.","DOI":"10.1167\/iovs.19-27825"},{"key":"key-10.14336\/AD.2025.0289-122","doi-asserted-by":"crossref","unstructured":"Kong H, Zhao H, Chen T, Song Y, Cui Y (2022). Targeted P2X7\/NLRP3 signaling pathway against inflammation, apoptosis, and pyroptosis of retinal endothelial cells in diabetic retinopathy. Cell Death Dis, 13:336.","DOI":"10.1038\/s41419-022-04786-w"},{"key":"key-10.14336\/AD.2025.0289-123","doi-asserted-by":"crossref","unstructured":"Zhao H, Dai Y, Li Y, Li J, Li H (2024). TNFSF15 inhibits progression of diabetic retinopathy by blocking pyroptosis via interacting with GSDME. Cell Death Dis, 15:118.","DOI":"10.1038\/s41419-024-06499-8"},{"key":"key-10.14336\/AD.2025.0289-124","doi-asserted-by":"crossref","unstructured":"American Diabetes Association Professional Practice Committee (2024). 12. 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Transcriptional Comparison of Human and Murine Retinal Neovascularization. Invest Ophthalmol Vis Sci, 64:46.","DOI":"10.1167\/iovs.64.15.46"},{"key":"key-10.14336\/AD.2025.0289-204","doi-asserted-by":"crossref","unstructured":"Cui Z, Zeng Q, Guo Y, Liu S, Chen J (2018). Integrated bioinformatic changes and analysis of retina with time in diabetic rats. PeerJ, 6:e4762.","DOI":"10.7717\/peerj.4762"},{"key":"key-10.14336\/AD.2025.0289-205","doi-asserted-by":"crossref","unstructured":"Wang J-H, Wong RCB, Liu G-S (2022). Retinal Transcriptome and Cellular Landscape in Relation to the Progression of Diabetic Retinopathy. Invest Ophthalmol Vis Sci, 63:26.","DOI":"10.1167\/iovs.63.9.26"},{"key":"key-10.14336\/AD.2025.0289-206","doi-asserted-by":"crossref","unstructured":"Donaghue KC, Liew G (2024). Measuring Outcomes of Diabetic Retinopathy Screening: What Is Important? 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Artificial Intelligence Applications in Diabetic Retinopathy: What We Have Now and What to Expect in the Future. Endocrinol Metab (Seoul), 39:416-424.","DOI":"10.3803\/EnM.2023.1913"},{"key":"key-10.14336\/AD.2025.0289-211","doi-asserted-by":"crossref","unstructured":"Kasturiarachi BM, Saeed O, Gachechiladze L, Alsbrook D, Singh S, Zaid G, et al. (2024). The effects of stress hyperglycemia in diabetic and nondiabetic patients with large vessel occlusions undergoing mechanical thrombectomy. Brain Circ, 10:162-167.","DOI":"10.4103\/bc.bc_97_23"},{"key":"key-10.14336\/AD.2025.0289-212","doi-asserted-by":"crossref","unstructured":"Geng T, Zhu K, Lu Q, Wan Z, Chen X, Liu L, et al. (2023). Healthy lifestyle behaviors, mediating biomarkers, and risk of microvascular complications among individuals with type 2 diabetes: A cohort study. 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Retinopathy and nephropathy in patients with type 1 diabetes four years after a trial of intensive insulin therapy, by The Diabetes Control and Complications Trial\/Epidemiology of Diabetes Interventions and Complications Research Group. N. Engl. J. Med 342:381-9, 2000. Surv Ophthalmol, 45:459-460.","DOI":"10.1016\/S0039-6257(01)00187-4"},{"key":"key-10.14336\/AD.2025.0289-216","doi-asserted-by":"crossref","unstructured":"Mohamed Q, Gillies MC, Wong TY (2007). Management of diabetic retinopathy: a systematic review. JAMA, 298:902-916.","DOI":"10.1001\/jama.298.8.902"},{"key":"key-10.14336\/AD.2025.0289-217","doi-asserted-by":"crossref","unstructured":"ADVANCE Collaborative Group, Patel A, MacMahon S, Chalmers J, Neal B, Billot L, et al. (2008). Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes. 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Fufang Xueshuantong alleviates diabetic retinopathy by activating the PPAR signalling pathway and complement and coagulation cascades. J Ethnopharmacol, 265:113324.","DOI":"10.1016\/j.jep.2020.113324"},{"key":"key-10.14336\/AD.2025.0289-227","doi-asserted-by":"crossref","unstructured":"Liu Y, Zhang H, Dai X, Zhu R, Chen B, Xia B, et al. (2021). A comprehensive review on the phytochemistry, pharmacokinetics, and antidiabetic effect of Ginseng. Phytomedicine, 92:153717.","DOI":"10.1016\/j.phymed.2021.153717"},{"key":"key-10.14336\/AD.2025.0289-228","doi-asserted-by":"crossref","unstructured":"Tang K, Qin W, Wei R, Jiang Y, Fan L, Wang Z, et al. (2022). Ginsenoside Rd ameliorates high glucose-induced retinal endothelial injury through AMPK-STRT1 interdependence. Pharmacol Res, 179:106123.","DOI":"10.1016\/j.phrs.2022.106123"},{"key":"key-10.14336\/AD.2025.0289-229","doi-asserted-by":"crossref","unstructured":"Xu X, Wang M, Zhang S, Wang J, Li X, Ma X, et al. (2024). 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Liraglutide prevents cellular senescence in human retinal endothelial cells (HRECs) mediated by SIRT1: an implication in diabetes retinopathy. Hum Cell, 37:666-674.","DOI":"10.1007\/s13577-024-01038-1"},{"key":"key-10.14336\/AD.2025.0289-244","doi-asserted-by":"crossref","unstructured":"Zhong L, Yang J, Syed JN, Zhang Y, Tian Y, Fu X (2025). Alpha-Glucosidase Inhibitors in Aging and Aging-Related Diseases: Clinical Applications and Relevant Mechanisms. Aging and disease, 0.","DOI":"10.14336\/AD.2024.1477"},{"key":"key-10.14336\/AD.2025.0289-245","doi-asserted-by":"crossref","unstructured":"Mi R, Cheng H, Chen R, Bai B, Li A, Gao F, et al. (2024). Effects and mechanisms of long-acting glucagon-like peptide-1 receptor agonist semaglutide on microglia phenotypic transformation and neuroinflammation after cerebral ischemia\/reperfusion in rats. 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Effects of thiamine and fenofibrate on high glucose and hypoxia-induced damage in cell models of the inner blood-retinal barrier. Acta Diabetol, 57:1423-1433.","DOI":"10.1007\/s00592-020-01565-x"},{"key":"key-10.14336\/AD.2025.0289-257","doi-asserted-by":"crossref","unstructured":"Zhang J-Z, Gao L, Widness M, Xi X, Kern TS (2003). Captopril inhibits glucose accumulation in retinal cells in diabetes. Invest Ophthalmol Vis Sci, 44:4001-4005.","DOI":"10.1167\/iovs.02-1193"},{"key":"key-10.14336\/AD.2025.0289-258","doi-asserted-by":"crossref","unstructured":"Inoguchi T, Umeda F, Ono H, Kunisaki M, Watanabe J, Nawata H (1989). Abnormality in prostacyclin-stimulatory activity in sera from diabetics. Metabolism, 38:837-842.","DOI":"10.1016\/0026-0495(89)90229-1"},{"key":"key-10.14336\/AD.2025.0289-259","doi-asserted-by":"crossref","unstructured":"Du Y, Miller CM, Kern TS (2003). Hyperglycemia increases mitochondrial superoxide in retina and retinal cells. 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Progressive Thinning of Retinal Nerve Fiber Layer\/Ganglion Cell Layer (RNFL\/GCL) as Biomarker and Pharmacological Target of Diabetic Retinopathy. Int J Mol Sci, 24:12672.","DOI":"10.3390\/ijms241612672"},{"key":"key-10.14336\/AD.2025.0289-266","doi-asserted-by":"crossref","unstructured":"Li Z, Yu H, Liu C, Wang C, Zeng X, Yan J, et al. (2023). Efficiency co-delivery of ellagic acid and oxygen by a non-invasive liposome for ameliorating diabetic retinopathy. Int J Pharm, 641:122987.","DOI":"10.1016\/j.ijpharm.2023.122987"},{"key":"key-10.14336\/AD.2025.0289-267","doi-asserted-by":"crossref","unstructured":"Amor AJ, G\u00f3mez-Guerrero C, Ortega E, Sala-Vila A, L\u00e1zaro I (2020). Ellagic Acid as a Tool to Limit the Diabetes Burden: Updated Evidence. Antioxidants (Basel), 9:1226.","DOI":"10.3390\/antiox9121226"},{"key":"key-10.14336\/AD.2025.0289-268","doi-asserted-by":"crossref","unstructured":"Ceci C, Lacal PM, Tentori L, De Martino MG, Miano R, Graziani G (2018). 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Hyaluronic-Coated Albumin Nanoparticles for the Non-Invasive Delivery of Apatinib in Diabetic Retinopathy. Int J Nanomedicine, 16:4481-4494.","DOI":"10.2147\/IJN.S316564"},{"key":"key-10.14336\/AD.2025.0289-277","doi-asserted-by":"crossref","unstructured":"Elshaer SL, Alwhaibi A, Mohamed R, Lemtalsi T, Coucha M, Longo FM, et al. (2019). Modulation of the p75 neurotrophin receptor using LM11A-31 prevents diabetes-induced retinal vascular permeability in mice via inhibition of inflammation and the RhoA kinase pathway. Diabetologia, 62:1488-1500.","DOI":"10.1007\/s00125-019-4885-2"},{"key":"key-10.14336\/AD.2025.0289-278","doi-asserted-by":"crossref","unstructured":"Xu X, Xu S, Gao Y, He S, He J, Chen X, et al. (2025). Remote ischemic conditioning slows blood-retinal barrier damage in type 1 diabetic rats. 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ACS Chem Biol, 13:3236-3242.","DOI":"10.1021\/acschembio.8b00909"},{"key":"key-10.14336\/AD.2025.0289-288","doi-asserted-by":"crossref","unstructured":"Gamez M, Elhegni HE, Fawaz S, Ho KH, Campbell NW, Copland DA, et al. (2024). Heparanase inhibition as a systemic approach to protect the endothelial glycocalyx and prevent microvascular complications in diabetes. Cardiovasc Diabetol, 23:50.","DOI":"10.1186\/s12933-024-02133-1"},{"key":"key-10.14336\/AD.2025.0289-289","doi-asserted-by":"crossref","unstructured":"Wang C, Li Y, Yang M, Zou Y, Liu H, Liang Z, et al. (2018). Efficient Differentiation of Bone Marrow Mesenchymal Stem Cells into Endothelial Cells in Vitro. Eur J Vasc Endovasc Surg, 55:257-265.","DOI":"10.1016\/j.ejvs.2017.10.012"},{"key":"key-10.14336\/AD.2025.0289-290","doi-asserted-by":"crossref","unstructured":"Motawea SM, Noreldin RI, Naguib YM (2020). Potential therapeutic effects of endothelial cells trans-differentiated from Wharton\u2019s Jelly-derived mesenchymal stem cells on altered vascular functions in aged diabetic rat model. Diabetol Metab Syndr, 12:40.","DOI":"10.1186\/s13098-020-00546-y"},{"key":"key-10.14336\/AD.2025.0289-291","doi-asserted-by":"crossref","unstructured":"Lechner J, Medina RJ, Lois N, Stitt AW (2022). Advances in cell therapies using stem cells\/progenitors as a novel approach for neurovascular repair of the diabetic retina. Stem Cell Res Ther, 13:388.","DOI":"10.1186\/s13287-022-03073-x"},{"key":"key-10.14336\/AD.2025.0289-292","doi-asserted-by":"crossref","unstructured":"Li Z, Xu Y, Lu S, Gao Y, Deng Y (2023). Bone mesenchymal stem cell extracellular vesicles delivered miR let-7-5p alleviate endothelial glycocalyx degradation and leakage via targeting ABL2. 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Front Cell Dev Biol, 12:1380059.","DOI":"10.3389\/fcell.2024.1380059"},{"key":"key-10.14336\/AD.2025.0289-296","doi-asserted-by":"crossref","unstructured":"Zhang T, Tian T, Lin Y (2022). Functionalizing Framework Nucleic-Acid-Based Nanostructures for Biomedical Application. Adv Mater, 34:e2107820.","DOI":"10.1002\/adma.202107820"},{"key":"key-10.14336\/AD.2025.0289-297","doi-asserted-by":"crossref","unstructured":"Wu Q, Zhu J, Zhang X, Xu X, Luo D, Lin Y, et al. (2024). The antioxidant effect of tetrahedral framework nucleic acid\u2010based delivery of small activating RNA targeting DJ\u20101 on retinal oxidative stress injury. Cell Prolif, 57:e13635.","DOI":"10.1111\/cpr.13635"},{"key":"key-10.14336\/AD.2025.0289-298","doi-asserted-by":"crossref","unstructured":"Zhou LY, He ZY, Xu T, Wei YQ (2018). Current Advances in Small Activating RNAs for Gene Therapy: Principles, Applications and Challenges. 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