{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:35:42Z","timestamp":1787164542021,"version":"build-2736575974"},"reference-count":0,"publisher":"Aging and Disease","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["aging dis"],"abstract":"<jats:p>Cellular senescence and immunosenescence drive chronic tissue damage via persistent senescence-associated secretory phenotype (SASP)-mediated inflammation, particularly through pro-inflammatory cytokines, including interleukin-6 (IL-6), interleukin-1 beta (IL-1\u03b2), tumor necrosis factor-alpha (TNF-\u03b1). In osteoarthritis (OA), senescent chondrocytes promote cartilage degradation, while in rheumatoid arthritis (RA), aged immune cells impair self-tolerance. Emerging therapies targeting these mechanisms - including senolytics and cytokine inhibitors-demonstrate potential to break this pathological cycle. These findings emphasize the necessity of combined anti-inflammatory and anti-aging approaches for managing age-related rheumatic diseases.<\/jats:p>","DOI":"10.14336\/ad.2025.1182","type":"journal-article","created":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T17:05:51Z","timestamp":1768583151000},"source":"Crossref","is-referenced-by-count":2,"title":["Chronic Inflammation and Aging in Rheumatic Diseases"],"prefix":"10.14336","member":"5462","published-online":{"date-parts":[[2025]]},"container-title":["aging and disease"],"original-title":[],"deposited":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T17:05:52Z","timestamp":1768583152000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aginganddisease.org\/EN\/10.14336\/AD.2025.1182"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":0,"URL":"https:\/\/doi.org\/10.14336\/ad.2025.1182","relation":{},"ISSN":["2152-5250"],"issn-type":[{"value":"2152-5250","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]}}}