{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T08:26:11Z","timestamp":1786955171116,"version":"build-2736575974"},"reference-count":0,"publisher":"Aging and Disease","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging Dis"],"abstract":"<jats:p>Late-life depression is associated with reduced treatment efficacy and age-related impairments in synaptic plasticity and stress responsiveness. Myo-inositol, an endogenous regulator of phosphoinositide signalling, has been proposed as candidate treatment for mood disorders, but its effects in age-related mood disorders remain unclear. Here, we investigated the impact of chronic myo-inositol supplementation on depressive behaviour and synaptic markers in aged male and female mice. Aged mice displayed reduced self-care behaviour in the sucrose splash test compared to young adults. Myo-inositol supplementation restored grooming behaviour in both sexes, an effect maintained following exposure to unpredictable chronic mild stress and independent of locomotor activity. Molecular analyses revealed sex-specific synaptic adaptations, with myo-inositol enhancing postsynaptic density protein 95 (PSD-95) levels in aged males, while increasing phosphorylation of the AMPA receptor subunit GluA1 at serine 845 and TARP expression in females. These findings demonstrate that myo-inositol dampens age-related apathetic alterations and is associated with sex-specific synaptic mechanisms, supporting its potential as a therapeutic strategy for late-life depression.<\/jats:p>","DOI":"10.14336\/ad.2026.0255","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T08:09:02Z","timestamp":1786954142000},"source":"Crossref","is-referenced-by-count":0,"title":["Myo-Inositol Dampens Apathetic Symptoms in Aged Mice and Is Associated with Sex-Specific Synapse Remodelling"],"prefix":"10.14336","member":"5462","published-online":{"date-parts":[[2026]]},"container-title":["Aging and Disease"],"original-title":[],"deposited":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T08:09:03Z","timestamp":1786954143000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aginganddisease.org\/EN\/10.14336\/AD.2026.0255"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":0,"URL":"https:\/\/doi.org\/10.14336\/ad.2026.0255","relation":{},"ISSN":["2152-5250"],"issn-type":[{"value":"2152-5250","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}