{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T13:47:27Z","timestamp":1782481647380,"version":"3.54.5"},"reference-count":0,"publisher":"Aging and Disease","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging Dis"],"abstract":"<jats:p>The concept of ferro-aging has been proposed as an evolutionarily conserved, iron-driven aging trajectory orchestrated by acyl-coenzyme A (CoA) synthetase long-chain family member 4 (ACSL4), which links lipid peroxidation, cellular senescence, and systemic organ decline in primates. Emerging evidence from non-human primate studies suggests that vitamin C (VC), traditionally viewed as a broad-spectrum antioxidant, has been proposed to interact with and inhibit ACSL4 activity at supraphysiological concentrations, potentially reversing multi-omic markers of biological age and preserving neural architecture, functional connectivity, and metabolic homeostasis in aged individuals. However, the precise molecular mechanism of VC-mediated ACSL4 inhibition remains unconfirmed, and the geroprotective efficacy of VC in humans is yet to be validated. This Perspectives critically critically discusses the mechanistic underpinnings of the VC-ACSL4-ferro-aging axis, examines key limitations of current evidence, and highlights the translational potential and unresolved challenges of targeting ferro-aging for promoting healthy aging.<\/jats:p>","DOI":"10.14336\/ad.2026.0371","type":"journal-article","created":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T12:57:22Z","timestamp":1782478642000},"source":"Crossref","is-referenced-by-count":0,"title":["Vitamin C, ACSL4, and Ferro-Aging: Mechanistic Insights and Translational Perspectives from Primate Studies"],"prefix":"10.14336","member":"5462","published-online":{"date-parts":[[2026]]},"container-title":["Aging and Disease"],"original-title":[],"deposited":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T12:57:23Z","timestamp":1782478643000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aginganddisease.org\/EN\/10.14336\/AD.2026.0371"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":0,"URL":"https:\/\/doi.org\/10.14336\/ad.2026.0371","relation":{},"ISSN":["2152-5250"],"issn-type":[{"value":"2152-5250","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}