{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T21:31:57Z","timestamp":1740173517641,"version":"3.37.3"},"reference-count":0,"publisher":"Endocrinology Research Centre","license":[{"start":{"date-parts":[[2020,2,6]],"date-time":"2020-02-06T00:00:00Z","timestamp":1580947200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["probl-endojournals.ru"],"crossmark-restriction":false},"short-container-title":["Probl Endokrinol (Mosk)"],"abstract":"<jats:p>Backgraund: The problem of differential diagnosis of constitutional delay of puberty\/CPD and hypogonadotropic hypogonadism\/HH in boys is discussed, as boys have similar genetic mechanisms and appearance.\r\nAims: to determine accuracy of the criteria for the differential diagnosis of CDP and HH.\r\nMaterials: The study included 56 boys14,40,7 years old with delayed puberty (G1P1-3\/testicular volume 3\u0441m3). We excluded patients with hypergonadotropic hypogonadism, treated with sex steroids or gonadotropins for 12 months, with endocrine\/somatic diseases affecting puberty.\r\nAt the first visit, we evaluated anthropometric data, bone age, testicular volume, hormones and the results of the gonadotropin-releasing hormone test\/GnRH agonist test and the human chorionic gonadotropin test\/hCG test.\r\nThe HH was defined by a testicular volume 3\u0441m3 after 2 years follow-up. The patients were divided into two groups: the first group with CDP and testicles 3cm3 (n=50) and the second group with HH and testicles 3cm3 (n=6).\r\nResults: At the first visit in boys with CDP corrected target height was less (Me SDS -1,8 vs -0,4, \u0440=0,02), bone age was less (\u041c\u0435 SDS -2,5 vs - 0,2 \u0440=0,03), testicular volume was more (\u041c\u0435 1,9 vs 0,5, p=0,0003), hormones were significantly higher, such as, LH (\u041c\u0435 1,1 vs 0,1mIU\/ml, p=0,0002), FSH (\u041c\u0435 1,9 vs 0,2IU\/l, p=0,00007), inhibinB (\u041c\u0435 142,3 vs 31,3pg\/ml, p=0,00009), maxLH (\u041c\u0435 18,9 vs 0,6mIU\/ml, p=0,00007), maxLH\/FSH (\u041c\u0435 2,3 vs 0,4, p=0,0002) on the GnRH agonist test and testosterone (\u041c\u0435 14,4 vs 1,1nmol\/l, p=0,0001) on the hCG test than in boys with HH.\r\nThe LH 0,3 mIU\/ml had 86% sensitivity, 100% specificity; maxLH\/FSH1- 92% sensitivity, 100% specificity; testosterone 2,7 nmol\/l on the hCG test - 98% sensitivity, 100% specificity for differential diagnosis of CDP and HH in boys. However, maxLH 3,5 mIU\/ml on the GnRH agonist test, FSH 0,5 IU\/l, inhibinB 58 pg\/ml had 100% sensitivity and specificity for diagnosis of CDP.\r\nConclusions: The inhibinB 58 pg\/ml, LH 0,3 mIU\/ml, FSH 0,5 IU\/l or maxLH 3,5 mIU\/ml, maxLH\/FSH 1,0 on the GnRH agonist test, testosterone 2,7 nmol\/l on the hCG test have an excellent accuracy for the differential diagnosis of CDP and HH in prepubertal boys with delayed puberty.<\/jats:p>","DOI":"10.14341\/probl10339","type":"journal-article","created":{"date-parts":[[2020,2,6]],"date-time":"2020-02-06T03:17:47Z","timestamp":1580959067000},"update-policy":"https:\/\/doi.org\/10.14341\/crossmarkpolicy2018","source":"Crossref","is-referenced-by-count":1,"title":["The differential diagnosis of constitutional delay of puberty and hypogonadotropic hypogonadism in boys"],"prefix":"10.14341","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4690-8095","authenticated-orcid":false,"given":"Oleg Yurevich","family":"Latyshev","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2136-6426","authenticated-orcid":false,"given":"Lubov Borisovna","family":"Brzhezinskaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1578-5870","authenticated-orcid":false,"given":"Goar Feliksovna","family":"Okminyan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3704-3699","authenticated-orcid":false,"given":"Elena Valentinovna","family":"Kiseleva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6115-8723","authenticated-orcid":false,"given":"Mikhail Ivanovich","family":"Pykov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4108-6878","authenticated-orcid":false,"given":"Elvira Petrovna","family":"Kasatkina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0208-4116","authenticated-orcid":false,"given":"Lubov Nikolaevna","family":"Samsonova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"5458","published-online":{"date-parts":[[2020,2,6]]},"container-title":["Problems of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/probl-endojournals.ru\/probl\/article\/viewFile\/10339\/9445","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/probl-endojournals.ru\/probl\/article\/viewFile\/10339\/9445","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,6]],"date-time":"2020-02-06T03:17:49Z","timestamp":1580959069000},"score":1,"resource":{"primary":{"URL":"https:\/\/probl-endojournals.ru\/probl\/article\/view\/10339"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,6]]},"references-count":0,"URL":"https:\/\/doi.org\/10.14341\/probl10339","relation":{},"ISSN":["2308-1430","0375-9660"],"issn-type":[{"type":"electronic","value":"2308-1430"},{"type":"print","value":"0375-9660"}],"subject":[],"published":{"date-parts":[[2020,2,6]]}}}