{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T05:30:10Z","timestamp":1744349410070,"version":"3.37.3"},"reference-count":54,"publisher":"Endocrinology Research Centre","issue":"5","license":[{"start":{"date-parts":[[2020,12,25]],"date-time":"2020-12-25T00:00:00Z","timestamp":1608854400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.probl-endojournals.ru\/jour\/about\/editorialPolicies#openAccessPolicy"}],"content-domain":{"domain":["www.probl-endojournals.ru"],"crossmark-restriction":true},"short-container-title":["Probl Endokrinol (Mosk)"],"abstract":"<jats:p>Vitamin D insufficiency and deficiency in women with infertility is more common than in the population. However, we still do not know the exact mechanisms for the participation of vitamin D in the regulation of reproductive function. The purpose of this study is to analyze actual literature data on the role of vitamin D in the regulation of reproductive system and its influence on using of assisted reproductive technologies for the treatment of infertility. A search was carried out for literary sources published in the NSBI database PubMed, Medline, and others with a search depth of up to 20 years. 135 sources on this topic were studied, of which 54 were included in the analysis. The review presents data obtained in animal studies, in vitro and in clinical studies. Thus, the absence of vitamin D resulted in a dramatical decrease in fertility in both female and male rats and mice, due to the development of hypocalcemia. In vitro studies describe its involvement in the receptive transformation of the endometrium and in the regulation of the immune response during embryo implantation. However, clinical studies often show conflicting results. There is no unequivocal data on the effect of vitamin D levels on spermogram parameters, but a decrease in the pregnancy rate was shown when ovulation was induced in pairs, where a vitamin D deficiency was revealed in men. A meta-analysis published in 2017 showed a decrease in the pregnancy and live birth rate in women with low levels of vitamin D after the use of assisted reproductive technologies (ART). It was not possible to establish whether this decrease depends on oocyte quality or endometrium. There is an opportunity that the effect of vitamin D deficiency on fertility will not come with all forms of infertility. For example, in women with anovulation due to polycystic ovary syndrome, vitamin D deficiency is demonstrated to decrease pregnancy rate in ovulation induction cycles and in ART. Such relationship was not found in women with unexplained infertility.Thus, the role of vitamin D in the pathogenesis of infertility requires further study, as well as the possibilities of therapy in order to increase the effectiveness of infertility treatment methods and assisted reproductive technology programs.<\/jats:p>","DOI":"10.14341\/probl12468","type":"journal-article","created":{"date-parts":[[2020,12,28]],"date-time":"2020-12-28T10:57:25Z","timestamp":1609153045000},"page":"96-101","update-policy":"https:\/\/doi.org\/10.14341\/crossmarkpolicy2018","source":"Crossref","is-referenced-by-count":6,"title":["Vitamin D and reproductive health"],"prefix":"10.14341","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6098-1491","authenticated-orcid":true,"given":"I. V.","family":"Gorelova","sequence":"first","affiliation":[{"name":"Almazov National Medical Research Centre, Institute of Perinatology and Pediatrics"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3697-7791","authenticated-orcid":true,"given":"P. V.","family":"Popova","sequence":"additional","affiliation":[{"name":"Almazov National Medical Research Centre, Institute of Perinatology and Pediatrics"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7906-4634","authenticated-orcid":true,"given":"M. V.","family":"Rulev","sequence":"additional","affiliation":[{"name":"Almazov National Medical Research Centre, Institute of Perinatology and Pediatrics"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"5458","published-online":{"date-parts":[[2020,12,25]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Fichera M, Torok P, Tesarik J et al. Vitamin D, reproductive disorders 5. and assisted reproduction: evidences and perspectives. Int J Food Sci Nutr. 2020;71(3)276-285. doi: 10.1080\/09637486.2019.1661978","DOI":"10.1080\/09637486.2019.1661978"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Holick MF. The vitamin D deficiency pandemic: Approaches for diagnosis, treatment and prevention. Rev Endocr Metab Disord. 2017;18(2):153-165. doi: 10.1007\/s11154-017-9424-1 7.","DOI":"10.1007\/s11154-017-9424-1"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Pagliardini L, Vigano P, Molgora M et al. High Prevalence of Vitamin D Deficiency in Infertile Women Referring for Assisted Reproduction. Nutrients. 2015;7:9972-84. doi: 10.3390\/nu7125516","DOI":"10.3390\/nu7125516"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Dressier N, Chandra A, Aguirre Davila L et al. BMI and season are associated with vitamin D deficiency in women with impaired fertility: a two-centre analysis. 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Akusherstvo i ginekologiya\/Obstetrics and Gynecology. 2016;8:93-98. (in Russ.). doi: 10.18565\/aig.2016.8.93-98","DOI":"10.18565\/aig.2016.8.93-98"},{"key":"ref49","doi-asserted-by":"crossref","unstructured":"Polyzos NP, Anckaert E, Guzman L et al. Vitamin D deficiency and pregnancy rates in women undergoing single embryo, blastocyst stage, transfer (SET) for IVF\/ICSI. Hum Reprod. 2014;29(9):2032-40. doi: 10.1093\/humrep\/deu156","DOI":"10.1093\/humrep\/deu156"},{"key":"ref50","doi-asserted-by":"crossref","unstructured":"Rudick BJ, Ingles SA, Chung K et al. Influence of vitamin D levels on in vitro fertilization outcomes in donor-recipient cycles. Fertil Steril. 2014;101(2):447-52. doi: 10.1016\/j.fertnstert.2013.10.008","DOI":"10.1016\/j.fertnstert.2013.10.008"},{"key":"ref51","doi-asserted-by":"crossref","unstructured":"Fabris A, Pacheco A, Cruz M et al. Impact of circulating levels of total and bioavailable serum vitamin D on pregnancy rate in egg donation recipients. Fertil Steril. 2014;102(6):1608-12. doi: 10.1016\/j.fertnstert.2014.08.030","DOI":"10.1016\/j.fertnstert.2014.08.030"},{"key":"ref52","doi-asserted-by":"crossref","unstructured":"Butts SF, Seifer DB, Koelper N et al. Vitamin D Deficiency Is Associated With Poor Ovarian Stimulation Outcome in PCOS but No Unexplained Infertility. Clin Endocrinol Metab. 2019;104(2):369-378. doi: 10.1210\/jc.2018-00750","DOI":"10.1210\/jc.2018-00750"},{"key":"ref53","unstructured":"Pal L, Zhang H, Williams J et al. Vitamin D Status Relates to Reproductive Outcome in Women With Polycystic Ovary Syndrome: Secondary Analysis of a Multicenter Randomized Controlled Trial. J Clin Endocrinol Metab. 2016;101(8):3027-35. doi: 10.1210\/jc.2015"},{"key":"ref54","doi-asserted-by":"crossref","unstructured":"Zhao J, Liu S, Wang Y et al. Vitamin D improves in-vitro fertilization outcomes in infertile women with polycystic ovary syndrome and insulin resistance. Minerva Med. 2019;110(3):199-208. doi: 10.23736\/S0026-4806.18.05946-3","DOI":"10.23736\/S0026-4806.18.05946-3"}],"container-title":["Problems of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.probl-endojournals.ru\/jour\/article\/viewFile\/12468\/9837","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,12,28]],"date-time":"2020-12-28T10:57:39Z","timestamp":1609153059000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.probl-endojournals.ru\/jour\/article\/view\/12468"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,25]]},"references-count":54,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2020,12,25]]}},"URL":"https:\/\/doi.org\/10.14341\/probl12468","relation":{},"ISSN":["2308-1430","0375-9660"],"issn-type":[{"type":"electronic","value":"2308-1430"},{"type":"print","value":"0375-9660"}],"subject":[],"published":{"date-parts":[[2020,12,25]]}}}