{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T21:31:50Z","timestamp":1740173510168,"version":"3.37.3"},"reference-count":20,"publisher":"Endocrinology Research Centre","issue":"6","license":[{"start":{"date-parts":[[2020,12,30]],"date-time":"2020-12-30T00:00:00Z","timestamp":1609286400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.probl-endojournals.ru\/jour\/about\/editorialPolicies#openAccessPolicy"}],"content-domain":{"domain":["www.probl-endojournals.ru"],"crossmark-restriction":true},"short-container-title":["Probl Endokrinol (Mosk)"],"abstract":"<jats:p>Idiopathic hypercalciuria is a heterogeneous generalized disorder caused by various defects in calcium transport and increased urinary calcium excretion. The main etiopathogenetic factors are violations of vitamin D metabolism, changes in the sensitivity of calcitriol receptors and violations of the processes of calcium reabsorption in the proximal tubules and in the ascending knee of the Henle loop. This article presents a clinical observation of patient with idiopathic hypercalciuria, initially high levels of parathyroid hormone (PTH) in the absence of hyperparathyroidism. Therapy with thiazide diuretics allowed to achieve normalization of daily urinary calcium excretion and reducing PTH. Despite the low prevalence of idiopathic hypercalciuria, differential diagnosis of this metabolic disorder should be carried out with mandatory consideration of clinical and laboratory data, as well as with diseases that may cause increased PTH production.<\/jats:p>","DOI":"10.14341\/probl12677","type":"journal-article","created":{"date-parts":[[2021,1,11]],"date-time":"2021-01-11T18:00:09Z","timestamp":1610388009000},"page":"13-17","update-policy":"https:\/\/doi.org\/10.14341\/crossmarkpolicy2018","source":"Crossref","is-referenced-by-count":1,"title":["Differential diagnosis of normocalcemic hyperparathyroidism and idiopathic hypercalciuria on the example of clinical case"],"prefix":"10.14341","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2144-8595","authenticated-orcid":true,"given":"G. E.","family":"Runova","sequence":"first","affiliation":[{"name":"I.M. Sechenov First Moscow State Medical University (Sechenov University)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2320-1051","authenticated-orcid":true,"given":"O. O.","family":"Golounina","sequence":"additional","affiliation":[{"name":"I.M. Sechenov First Moscow State Medical University (Sechenov University)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8505-5526","authenticated-orcid":true,"given":"I. V.","family":"Glinkina","sequence":"additional","affiliation":[{"name":"I.M. Sechenov First Moscow State Medical University (Sechenov University)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7000-0095","authenticated-orcid":true,"given":"Yu. P.","family":"Sych","sequence":"additional","affiliation":[{"name":"I.M. Sechenov First Moscow State Medical University (Sechenov University)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3026-6315","authenticated-orcid":true,"given":"V. V.","family":"Fadeev","sequence":"additional","affiliation":[{"name":"I.M. Sechenov First Moscow State Medical University (Sechenov University)"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"5458","published-online":{"date-parts":[[2020,12,30]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Coe FL, Worcester EM, Evan AP. Idiopathic hypercalciuria and formation of calcium renal stones. Nat Rev Nephrol. 2016;12(9):519-533. doi: https:\/\/doi.org\/10.1038\/nrneph.2016.101","DOI":"10.1038\/nrneph.2016.101"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Garc\u00eda Nieto VM, Luis Yanes MI, Tejera Carre\u00f1o P, Perez Suarez G, Moraleda Mesa T. La hipercalciuria idiop\u00e1tica revisada. \u00bfAnomal\u00eda metab\u00f3lica o enfermedad? Nefrolog\u00eda. 2019;39(6):592-602. doi: https:\/\/doi.org\/10.1016\/j.nefro.2019.02.011","DOI":"10.1016\/j.nefro.2019.02.011"},{"key":"ref3","unstructured":"Maltsev SV, Mikhailova TV, Kravtsova OA. Genetic and clinical aspects of nephrolithiasis and nephrocalcinosis in children with hypercalciuria. Practical Medicine 2014;85(9):118-125. (In Russ.)."},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Scales CD, Smith AC, Hanley JM, Saigal CS. Prevalence of Kidney Stones in the United States. Eur Urol. 2012;62(1):160-165. doi: https:\/\/doi.org\/10.1016\/j.eururo.2012.03.052","DOI":"10.1016\/j.eururo.2012.03.052"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"Trinchieri A, Montanari E. Prevalence of renal uric acid stones in the adult. Urolithiasis. 2017;45(6):553-562. doi: https:\/\/doi.org\/10.1007\/s00240-017-0962-5","DOI":"10.1007\/s00240-017-0962-5"},{"key":"ref6","doi-asserted-by":"crossref","unstructured":"Courbebaisse M, Prot-Bertoye C, Bertocchio J-P, et al. Lithiase r\u00e9nale de l\u2019adulte : des m\u00e9canismes au traitement m\u00e9dical pr\u00e9ventif. La Rev M\u00e9decine Interne. 2017;38(1):44-52. doi: https:\/\/doi.org\/10.1016\/j.revmed.2016.05.013","DOI":"10.1016\/j.revmed.2016.05.013"},{"key":"ref7","unstructured":"Mikheeva NM, Zverev YaF, Vykhodceva GI. Modern views on idiopathic hypercalciuria aetiology and pathogenesis. Nephrology 2015;19(4):29-40. (In Russ.)."},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"Worcester EM, Coe FL, Evan AP, et al. Evidence for increased postprandial distal nephron calcium delivery in hypercalciuric stone-forming patients. Am J Physiol Physiol. 2008;295(5):F1286-F1294. doi: https:\/\/doi.org\/10.1152\/ajprenal.90404.2008","DOI":"10.1152\/ajprenal.90404.2008"},{"key":"ref9","unstructured":"Baranova IA, Zykova TA. Normocalcemic primary hyperparathyroidism \u2014 \u00abnew era\u00bb in diagnosis of an old disease. Problems of Endocrinology. 2017;63(4):236-244. (In Russ.). doi: https:\/\/doi.org\/10.14341\/probl201763423.6-244"},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"Albright F, Henneman P, Benedict PH, et al. Idiopathic hypercalciuria: a preliminary report. Proc R Soc Med. 1953;46(12):1077\u20131081.","DOI":"10.1177\/003591575304601218"},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"Arcidiacono T, Simonini M, Lanzani C, et al. Claudin-14 Gene Polymorphisms and Urine Calcium Excretion. Clin J Am Soc Nephrol. 2018;13(10):1542-1549. doi: https:\/\/doi.org\/10.2215\/CJN.01770218","DOI":"10.2215\/CJN.01770218"},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"Wagner CA, Rubio-Aliaga I, Hernando N. Renal phosphate handling and inherited disorders of phosphate reabsorption: an update. Pediatr Nephrol. 2019;34(4):549\u2013559. doi: https:\/\/doi.org\/10.1007\/s00467-017-3873-3.","DOI":"10.1007\/s00467-017-3873-3"},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"Palsson R, Indridason OS, Edvardsson VO, et al. Genetics of common complex kidney stone disease: insights from genome-wide association studies. Urolithiasis. 2019;47(1):11\u201321. doi: https:\/\/doi.org\/10.1007\/s00240-018-1094-2","DOI":"10.1007\/s00240-018-1094-2"},{"key":"ref14","unstructured":"Favus M. Nephrolithiasis \/ In: Feingold KR, Anawalt B, Boyce A, et al., editors. Endotext. South Dartmouth (MA): MDText.com, Inc.; 2000."},{"key":"ref15","doi-asserted-by":"crossref","unstructured":"Grieff M, Bushinsky DA. Diuretics and disorders of calcium homeostasis. Semin Nephrol. 2011;31(6):535\u2013541. doi: https:\/\/doi.org\/10.1016\/j.semnephrol.2011.09.008","DOI":"10.1016\/j.semnephrol.2011.09.008"},{"key":"ref16","doi-asserted-by":"crossref","unstructured":"Laerum E, Larsen S. Thiazide Prophylaxis of Urolithiasis. Acta Med Scand. 1984;215(4):383-389. doi: https:\/\/doi.org\/10.1111\/j.0954-6820.1984.tb05023.x","DOI":"10.1111\/j.0954-6820.1984.tb05023.x"},{"key":"ref17","doi-asserted-by":"crossref","unstructured":"Fink HA, Wilt TJ, Eidman KE, et al. Medical Management to Prevent Recurrent Nephrolithiasis in Adults: A Systematic Review for an American College of Physicians Clinical Guideline. Ann Intern Med. 2013;158(7):535. doi: https:\/\/doi.org\/10.7326\/0003-4819-158-7-201304020-00005","DOI":"10.7326\/0003-4819-158-7-201304020-00005"},{"key":"ref18","doi-asserted-by":"crossref","unstructured":"Damasio PC, Amaro CR, Cunha NB, et al. The role of salt abuse on risk for hypercalciuria. Nutr J. 2011;10(1):3. doi: https:\/\/doi.org\/10.1186\/1475-2891-10-3","DOI":"10.1186\/1475-2891-10-3"},{"key":"ref19","unstructured":"Alon US. The Effects of Diuretics on Mineral and Bone Metabolism. Pediatr Endocrinol Rev. 2018;15(4):291-297. doi: https:\/\/doi.org\/10.17458\/per.vol15.2018.a.DiureticsMineralBoneMetabolism"},{"key":"ref20","doi-asserted-by":"crossref","unstructured":"Zavatta G, Clarke BL. Normocalcemic Hyperparathyroidism: A Heterogeneous Disorder Often Misdiagnosed? J BMR Plus. 2020;4(8):e10391. doi: https:\/\/doi.org\/10.1002\/jbm4.10391","DOI":"10.1002\/jbm4.10391"}],"container-title":["Problems of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.probl-endojournals.ru\/jour\/article\/viewFile\/12677\/9868","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,3,10]],"date-time":"2021-03-10T10:27:30Z","timestamp":1615372050000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.probl-endojournals.ru\/jour\/article\/view\/12677"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,30]]},"references-count":20,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2020,12,30]]}},"URL":"https:\/\/doi.org\/10.14341\/probl12677","relation":{},"ISSN":["2308-1430","0375-9660"],"issn-type":[{"type":"electronic","value":"2308-1430"},{"type":"print","value":"0375-9660"}],"subject":[],"published":{"date-parts":[[2020,12,30]]}}}